
Michail SarafidisKarolinska Institutet | KI · Department of Oncology-Pathology
Michail Sarafidis
Doctor of Engineering
Postdoctoral Researcher at Karolinska Institutet
About
27
Publications
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169
Citations
Introduction
Bioinformatics | Health Informatics | Digital Health
Additional affiliations
January 2023 - present
October 2016 - December 2022
Education
October 2016 - November 2022
October 2008 - June 2015
Publications
Publications (27)
Bladder cancer (BCa) is one of the most prevalent cancers worldwide and accounts for high morbidity and mortality. This study intended to elucidate potential key biomarkers related to the occurrence, development, and prognosis of BCa through an integrated bioinformatics analysis. In this context, a systematic meta-analysis, integrating 18 microarra...
Sterile alpha motif and HD domain‐containing protein 1 (SAMHD1) is a dNTP hydrolase important for intracellular dNTP homeostasis and serves as tumor suppressor and modulator of antimetabolite efficacy in cancer, though largely unexplored in breast cancer (BC). A cohort of patients with early BC (n = 564) with available gene expression data (GEP) wa...
Tinnitus is a highly prevalent condition, affecting more than 1 in 7 adults in the EU and causing negative effects on sufferers’ quality of life. In this study, we utilised data collected within the “UNITI” project, the largest EU tinnitus-related research programme. Initially, we extracted characteristics from both auditory brainstem response (ABR...
Auditory evoked potentials (AEPs) are brain-derived electrical signals, following an auditory stimulus, utilised to examine any obstructions along the brain neural-pathways and to diagnose hearing impairment. The clinical evaluation of AEPs is based on the measurements of the latencies and amplitudes of waves of interest; hence, their identificatio...
Tinnitus is the perception of sound when no actual external noise is present. Tinnitus is highly prevalent, with more than 1 in 7 adults in the EU having tinnitus, and it causes negative effects on quality of life for many individuals. However, there is currently no cure for tinnitus and its pathophysiology and genesis are unknown. Auditory evoked...
Tinnitus is the conscious perception of a phantom sound in absence of an external or internal stimulus. More than 1 in 7 adults in the EU experience tinnitus and for a large proportion of them tinnitus is an intrusive, persistent, and disabling condition, which impairs their life quality. Therefore, tinnitus is posed as a major global burden, which...
Tinnitus is the perception of a phantom sound and the individual's reaction to it. Although much progress has been made, tinnitus remains an unresolved scientific and clinical issue, affecting more than 10% of the general population and having a high prevalence and socioeconomic burden. Clinical decision support systems (CDSS) are used to assist cl...
OCCUPATIONAL APPLICATIONS
This study demonstrates the applicability of multicriteria tools to solve occupational health and safety (OSH) problems related to cost management in the healthcare sector. To the best of our knowledge, this is the first work in which linear programming and established methods for risk assessment of work-related musculoske...
The prediction of possible future incidents or accidents and the efficiency assessment of the Occupational Safety and Health (OSH) interventions are essential for the effective protection of healthcare workers, as the occupational risks in their workplace are multiple and diverse. Machine learning algorithms have been utilized for classifying post-...
In this paper, we describe the serious games, integrated into PROPHETIC which is an innovating personal healthcare service for a holistic remote management of Parkinson's disease (PD) patients. The main objective of the three developed serious games is to allow health professionals to remotely monitor and appraise the overall physical status of the...
Tinnitus is a common symptom of a phantom sound perception with a considerable socioeconomic impact. Tinnitus pathophysiology is enigmatic and its significant heterogeneity reflects a wide spectrum of clinical manifestations, severity and annoyance among tinnitus sufferers. Although several interventions have been suggested, currently there is no u...
Tinnitus is the perception of a phantom sound and the patient's reaction to it. Although much progress has been made, tinnitus remains a scientific and clinical enigma of high prevalence and high economic burden, with an estimated prevalence of 10%–20% among the adult population.
The EU is funding a new collaborative project entitled “Unification o...
This paper discusses the topic of data quality, which concerns the global research and business community and constitutes a challenging task. The data quality prerequisite becomes even more critical when it pertains to critical and sensitive data, such as the healthcare domain data. To begin with, the paper outlines the basic definitions and concep...
The main objective of the article is to employ cloud computing technology in order to develop the decision support system of an integrated platform aimed to aid decision makers in natural disaster incidents. This specific platform refers to the most commonly occurred natural disasters in Europe. The decision support system included in the cloud-bas...
Hospitals are considered a field of logistic robotics of high commercial potential and therefore a handful of mobile robot solutions exist. However, they have failed to trigger widespread acceptance by the market. The ENDORSE system will pursue 4 innovation pillars: an infrastructure-less multi-robot navigation, i.e. minimum installation of sensors...
Pediatric Central Nervous System (CNS) neoplasms are the second most prevalent tumors of childhood. CNS malignancies are considered as the most notorious type of tumors, due to their anatomic position manifesting an imminent threat to the patients' life. miRNAs are molecules that play a significant role in CNS tumor biology. At the same time diagno...
There are numerous theories concerning carcinogenesis. Starting from the Warburg effect, which was one of the first theories concerning the mitochondrial dysfunction in tumor cells. Further on, the "two-hit" theory, where tumors were considered to be the outcome of genetic aberrations or mutations and more specifically of a certain number of "hits"...
The prevalence of chronic illness and the disabilities they cause are strongly associated with age. According to the United Nations, in most countries around the world, 8-10% of the population has some form of disability. Carers are helping subjects who have severe or profound core activity limitations in the community and hospice facilities. The s...
Balance disorders affect a large number of older people, leading to falls. To promote independence, self-care and the quality of living of the long-lived population, an innovative solution is devoped to act as a virtual trainer for people that suffer from vestibular dysfunction related balance disorders. Our solution offers a virtual balance therap...