Michael Wink

Michael Wink
Universität Heidelberg · Institute of Pharmacy and Molecular Biotechnology (IPMB)

Prof. Dr.

About

1,392
Publications
368,410
Reads
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40,533
Citations
Additional affiliations
March 2013 - December 2020
Instituto Politécnico Nacional
Position
  • Professor
October 1989 - present
Universität Heidelberg
October 1989 - present
Heidelberg University
Position
  • Head of Department

Publications

Publications (1,392)
Article
Flamingos are highly mobile waterbirds that can be found in tropical and subtropical regions worldwide. The large distribution range of flamingos, the inaccessibility of most of their breeding sites and the lack of species-specific molecular markers, such as microsatellites, have hampered population genetics studies of these majestic birds. Here, w...
Article
Full-text available
The Chukar Partridge (Alectoris chukar, Galliformes) is one of the most important game birds in its native range, spanning from the Balkans to eastern Asia, and the regions of Europe, North America and New Zealand where it was introduced. Previous studies found two main genetic lineages of the species forming an eastern and a western clade. Chukar...
Article
Partial mitochondrial cytochrome b gene sequences reveal two deeply differentiated mtDNA lineages in anoa dwarf buffaloes (Bubalus depressicornis) from the studbook herd in European zoos. Three matrilinear lineages of lowland anoas (depressicornis type) contributed three rather similar sequence haplotypes, but one remarkably distinct haplotype was...
Article
Full-text available
The metabolic syndrome (MS) is a multifactorial syndrome associated with a significant economic burden and healthcare costs. MS management often requires multiple treatments (polydrug) to ameliorate conditions such as diabetes mellitus, insulin resistance, obesity, cardiovascular diseases, hypertension, and non-alcoholic fatty liver disease (NAFLD)...
Preprint
Die Evolution des Lebens, also biologische Evolution, wird in diesem Kapitel aus verschiedenen Perspektiven behandelt. Dieser Artikel bietet einen Überblick über den Stand des Wissens um die drei gültigen Artkonzepte, die Entstehung von Arten, Meilensteine der Evolution des Lebens in der Erdgeschichte, unterschiedliche Geschwindigkeiten von Evoluti...
Article
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Extra-pair copulation (EPC) occurred in most socially monogamous bird species. The mechanisms leading to the frequent occurrence of extra-pair offspring (EPO, EPY) in socially monogamous couples, as well as the ‘function’ of EPC, are the subjects of strong debates and raise many unanswered questions. We studied the relationship between extra-pair p...
Article
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We previously annotated the phytochemical constituents of a root extract from Ximenia americana var. caffra and highlighted its hepatoprotective and hypoglycemic properties. We here extended our study on the leaf extract and identified its phytoconstituents using HPLC-PDA-ESI-MS/MS. In addition, we explored its antioxidant, antibacterial, and antia...
Article
Plants produce a diversity of plant secondary metabolites (PSMs), which function as defense chemicals against herbivores and microorganisms but also as signal compounds. An individual plant produces and accumulates mixtures of PSMs with different structural features using different biosynthetic pathways. Almost all PSMs exert one or several biologi...
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This is the first complete breeding record of this owl and it also confirms the taxonomic status of the Greyish Eagle Owl Bubo cinerascens through the sequencing of the mitochondrial cytochrome b gene by using the owls from The Gambia, Mali, Ethiopia and South Africa.
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The Red-backed Shrike (Lanius collurio) is a medium-sized, carnivorous passerine, occurring throughout the western Palearctic. As with numerous other bird species, its numbers are declining, mainly due to anthropogenic factors. Therefore, revealing the population structure and genetic diversity is paramount in ensuring the survival of the species....
Article
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Ethnopharmacological relevance The genus Warburgia (family Canellaceae) is widely distributed over Afrotropical and Neotropical realms. Traditionally, W. salutaris (G. Bertol.) Chiov., and other Warburgia species are used as anti-inflammatory, antimalarial, antimicrobial, and for wound healing, and treating several skin complaints as well. Specific...
Article
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Ellagic acid (EA) is a bioactive polyphenolic compound naturally occurring as secondary metabolite in many plant taxa. EA content is considerable in pomegranate (Punica granatum L.) and in wood and bark of some tree species. Structurally, EA is a dilactone of hexahydroxydiphenic acid (HHDP), a dimeric gallic acid derivative, produced mainly by hydr...
Article
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We investigated the antioxidant activity of the total methanol extract of C. speciosum leaves (CST), the ethyl acetate (CSE), and the remaining aqueous (CSR) fractions in vitro, in vivo using Caenorhabditis elegans model, and in silico. LC-ESI-MS/MS analysis was employed for metabolic profiling of CST. ADME/TOPAKT prediction was performed to determ...
Article
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The plant family Caryophyllaceae, commonly known as the pink family, is divided into 3 subfamilies and contains over 80 genera with more than 2600 species that are widely distributed in temperate climate zones. Plants belonging to this family produce a variety of secondary metabolites important in an ecological context; however, some of these metab...
Article
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The liver plays a principal role in avian migration. Here, we characterised the liver transcriptome of a long-distance migrant, the Northern Wheatear (Oenanthe oenanthe), sampled at different migratory stages, looking for molecular processes linked with adaptations to migration. Analysis of the differentially expressed genes suggested changes in th...
Preprint
Background: Lycorine, an isoquinoline alkaloid, exhibits anti-breast cancer activity, but its mechanism of action remains unclear. Purpose: This work was conducted to investigate the mechanism of lycorine on breast cancer cell line MDA-MB-231 and MCF-7. Methods: Tandem Mass Tag (TMT) analysis identified differentially expressed proteins and the sig...
Article
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Une population auparavant inconnue de la Bouscarle caqueteuse Bradypterus baboecala en Gambie. En juin 2019 une espèce de Bradypterus prise au filet dans une petite zone humide à Kuntaur, Gambie, a été tuée par un Coucal du Sénégal Centropus senegalensis. D'après les plumes, les parties nues, et l'analyse génétique, l'oiseau a été identifié comme u...
Book
Die Evolution des Lebens, also biologische Evolution, wird in diesem Kapitel aus verschiedenen Perspektiven behandelt. Dieser Artikel bietet einen Überblick über den Stand des Wissens um die drei gültigen Artkonzepte, die Entstehung von Arten, Meilensteine der Evolution des Lebens in der Erdgeschichte, unterschiedliche Geschwindigkeiten von Evoluti...
Article
Full-text available
Fenugreek (Trigonella foenum-graecum L.) is one of the oldest cultivated plants grown for its leaves and seeds that are used for both culinary and medicinal purpose. This study aims to evaluate the effect of ethanol concentration (30, 50, 70 and 96% (v/v) of ethanol in water) as a solvent for the extraction of total phenolic content (TPC) and antio...
Article
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Objective We investigated the anti-proliferative or cytotoxic activities of five nutraceutical compounds: allyl isothiocyanate, β-carotene, caffeine, capsaicin, and lupanine that we consume respectively, for example, from mustard seeds, carrot, coffee, pepper, and lupin seeds against cancer cell lines (human colon: HCT 116 p53 wild type, HCT 116 p5...
Article
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The article from Wang et al. claims, that “phorbol esters are absent in jatropha seed cake”, and draws a conclusion that “phorbol esters are not responsible for toxicity in conventional jatropha kernel cake”. In our opinion, such claims and the conclusions are not sufficiently substantiated by the results presented in the paper. We have analysed so...
Article
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Objective Cisplatin is a conventional anticancer drug that generates reactive oxygen species and causes apoptosis. However, many cancer cells develop alterations in the ATP binding cassette transporter responsible for the uptake and efflux process, which leads to resistance. Many natural products have shown potential to compete with ATP binding cas...
Article
Diabetes mellitus (DM) is a metabolic disorder with growing global incidence, as 387 million people were diagnosed in 2014 with an expected projection of 642 million in 2040. Several complications are associated with DM including heart attack, stroke, kidney failure, blindness, and cancer. The latter is the second leading cause of death worldwide a...
Article
Full-text available
Diabetes mellitus (DM) is a metabolic disorder with growing global incidence, as 387 million people were diagnosed in 2014 with an expected projection of 642 million in 2040. Several complications are associated with DM including heart attack, stroke, kidney failure, blindness, and cancer. The latter is the second leading cause of death worldwide a...
Data
The fueling capacity of migratory birds and their ability to avoid health conditions derived from the subsequent fat overload are exceptional among vertebrates. In this work, we screen the expression of the genes involved in the production of ketone bodies in the liver of Northern Wheatears (Oenanthe oenanthe) during the development and resolution...
Book
Im vorliegenden sechsten Band der Heidelberger Jahrbücher Online (HDJBO), den die „Gesellschaft der Freunde Universität Heidelberg e.V.“ unter Federführung der drei Editoren Rainer M. Holm-Hadulla, Joachim Funke und Michael Wink herausgibt, haben sich die Autorinnen und Autoren des Bandes diesmal mit dem Konzept der Intelligenz als fächerübergreife...
Article
Full-text available
This study evaluated the efficacy of Turraea fischeri leaf extract for maintaining the viability of cryopreserved goat sperm. Ejaculated semen was collected from 5 mature Baladi bucks (50-60 kg, 2-4 years of age) and those samples with mass motility ≥ 70% and sperm concentration ≥ 2.5 × 10 9 /mL were selected, pooled, and divided into 4 aliquots. E...
Article
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The black kite Milvus migrans, one of the most common raptor species, shows great flexibility as regards food resources and breeding sites. While black kite subspecies are found all over Eurasia, Africa and Australia, it has been poorly studied outside of Europe, with virtually nothing known about the phylogeny of populations in Asia, India, Africa...
Article
The innate immune response of insects provides a robust line of defense against pathogenic microbes and eukaryotic parasites. It consists of two types of overlapping immune responses, named humoral and cellular, which share protective molecules and regulatory mechanisms that closely coordinate to prevent the spread and replication of pathogens with...
Article
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Oxidative stress plays a crucial role in the development of age-related neurodegenerative diseases. Previously, Glochidion zeylanicum methanol (GZM) extract has been reported to have antioxidant and anti-aging properties. However, the effect of GZM on neuroprotection has not been reported yet; furthermore, the mechanism involved in its antioxidant...
Article
Full-text available
Quinolizidine alkaloids (QAs) are synthesized by the genus Lupinus as a defense against herbivores. Synthesis of QAs in lupins is species- and organ-specific. Knowledge about their biosynthesis and their corresponding pathways are still fragmentary, in part because lupins of commercial importance were mainly investigated, representing a small sampl...
Book
Full-text available
The book writes on birds as challenges and opportunities for business, conservation and research. The main chapter explains how the new genetic research has and will change the taxonomy and number of bird species in the world.
Article
Full-text available
The fuelling capacity of migratory birds and their ability to avoid health conditions derived from the subsequent fat overload are exceptional among vertebrates. In this work, we screen the expression of the genes involved in the production of ketone bodies (KB) in the liver of northern wheatears (Oenanthe oenanthe) during the development and resol...
Poster
Full-text available
WINK M, COLE TCH, FERNANDES AM (2021) TREE OF BIRDS – AVIAN PHYLOGENY POSTER (Neornithes, Aves), Systematics, Classification, Features • hypothetical tree based on phylogenetic data (as of 2020) • branch lengths deliberate, not reflecting true time spans; figures at nodes are approx. divergence times (shaded circles: x Mya = million years ago) from...
Poster
Full-text available
WINK M, COLE TCH, FREITAS GL, FERNANDES AM (2021) FILOGENIA das AVES (Neornithes) – Sistemática e Classificação • árvore hipotética com base em dados filogenéticos (publicados até 2020) • comprimentos de ramificação deliberados, não refletindo extensões de tempo reais; os números nos nós são de aprox. tempos de divergência (círculos sombreados: x M...
Article
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Aluminum (Al) is an omnipresent mineral element in the environment. The brain is a central target of Al toxicity, being highly susceptible to oxidative damage. Therefore, recognition of drugs or natural products that guard against Al-mediated neuronal cell death is a powerful strategy for prevention and treatment of neurodegenerative disorders. Thi...
Article
Full-text available
Vitis vinifea has been used for traditional medicines, food, beverages, and dietary antioxidant supplements. The chemical compositions and biological activities of the fruits and seeds have been extensively investigated. However, the biological effects of the leaves are limited, and its anti-neurodegeneration or antiaging activities are little know...
Article
Full-text available
The potential of secondary metabolites as systematic markers to get new insights in an intricate phylogeny of a recent evolutionary radiation is explored. A chemosystematic study of the genus Lupinus (Fabaceae) was performed, using quinolizidine (QA) and piperidine alkaloids (ammodendrine) as diagnostic characters. Seven major QA and the piperidine...
Article
We report on the development of a set of microsatellite markers for the Eurasian Sparrowhawk, Accipiter nisus (Linnaeus, 1758), using an enrichment / high-throughput sequencing approach. Out of 9328 potential microsatellites identified, we established 24 tetrameric markers and assessed allelic variation based on samples from continental Europe and...
Article
Full-text available
This study aims to comprehensively explore the phytoconstituents as well as investigate the different biological activities of Chasmanthe aethiopica (Iridaceae) for the first time. Metabolic profiling of the leaf methanol extract of C. aethiopica (CAL) was carried out using HPLC-PDA-ESI-MS/MS. Twenty-nine compounds were annotated belonging to vario...
Article
Full-text available
A plethora of studies have offered crucial insights in the phylogeographic status of Western Palearctic bird species. However, an overview integrating all this information and analyzing the combined results is still missing. In this study, we compiled all published peer-reviewed and grey literature available on the phylogeography of Western Palearc...
Article
Full-text available
Plant secondary metabolites (SMs) common natural occurrences and the significantly lower toxicities of many SM have led to the approaching development and use of these compounds as effective pharmaceutical agents; especially in cancer therapy. A combination of two or three of plant secondary metabolites together or of one SM with specific anticance...
Chapter
Production of the anticancer drug camptothecin (CPT) was examined in Ophiorrhiza mungos with regard to concentration and localization of CPT and CPT derivatives within all plant parts. First, morphology and histology studies of all organs were examined by light and confocal laser scanning microscopy to localize the accumulation of CPTs down to the...
Article
Full-text available
Neurodegenerative diseases are linked to neuronal cell death and neurite outgrowth impairment that are often caused by oxidative stress. Natural products, which have neuroprotective against oxidative stress and neurite outgrowth inducing activity, could be potential candidates for alternative treatment of neurodegenerative diseases. This study aims...
Article
Full-text available
Apple, Malus domestica Borkh., a fruit-producing and medicinal plant, is reported to have a wide array of biological effects including a neuroprotective potential. In this work, the phytochemical composition of the leaf extract from M. domestica was thoroughly investigated using LC-MS/MS. Phlorizin, the major secondary metabolite was also isolated...
Article
Full-text available
This work presents an updated and more complete version of the transcriptome of a long-distance migrant, the Northern Wheatear (Oenanthe oenanthe). The improved transcriptome was produced from the independent mRNA sequencing of adipose tissue, brain, intestines, liver, skin, and muscle tissues sampled during the autumnal migratory season. This new...
Chapter
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Whereas Linné aimed to classify all species of our planet by a unique binomial Latin name, later generations of taxonomists and systematicists intended to place the taxa in a natural system according to their phylogeny. This also happened in ornithology and still scientists are on the way to find the ultimate “Avian Tree of Life”. Formerly, systema...
Article
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The parasite Trypanosoma brucei is the main cause of the sleeping sickness threatening millions of populations in many African countries. The parasitic infection is currently managed by some synthetic medications, most of them suffer limited activity spectrum and/or serious adverse effects. Some studies have pointed out the promising therapeutic po...
Article
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The Willows (genus Salix), with more than 330–500 species and 200 hybrids, are trees, shrubs or prostrate plants that are widely distributed in Africa, North America, Europe, and Asia. The genus is traditionally used in folk medicine and represents a valuable source of biologically active compounds among them salicin, a prodrug for salicylic acid....
Article
Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a declin...
Article
Full-text available
The tiger milk mushroom, Lignosus rhinocerus (LR), exhibits antioxidant properties, as shown in a few in vitro experiments. The aim of this research was to study whether three LR extracts exhibit antioxidant activities in Caenorhabditis elegans. In wild-type N2 nematodes, we determined the survival rate under oxidative stress caused by increased in...
Technical Report
Full-text available
Evaluation of bird oberservations in SW Germany from October to Dezember 2020
Article
The broccoli-derived isothiocyanate sulforaphane inhibits inflammation, oxidative stress and cancer, but its effect on healthspan and longevity are unclear. We used the C. elegans nematode model and fed the wildtype and 9 mutant strains ±sulforaphane. The lifespan, phenotype, pharyngeal pumping, mobility, lipofuscin accumulation, and RNA and protei...
Article
Full-text available
The genus Lagochilus (Lamiaceae) is native to Central, South-Central, and Eastern Asia. It comprises 44 species, which have been commonly used as herbal medicines for the reatments of various ailments for thousands of years, especially in Asian countries. This review aims to summarize the chemical constituents and pharmacological activities of spec...
Article
Full-text available
Despite the Tiger Milk Mushroom Lignosus rhinocerus (LR) having been used as a traditional medicine, little is known about the neuroprotective effects of LR extracts. This study aims to investigate the neuroprotective effect of three extracts of LR against glutamate-induced oxidative stress in mouse hippocampal (HT22) cells as well as to determine...
Article
Full-text available
In the previously published mitochondrial genome sequence of Artemia urmiana (NC_021382 [JQ975176]), the taxonomic status of the examined Artemia had not been determined, due to parthenogenetic populations coexisting with A. urmiana in Urmia Lake. Additionally, NC_021382 [JQ975176] has been obtained with pooled cysts of Artemia (0.25 g cysts consis...
Article
Full-text available
The Splinter bean, Entada abyssinica, is widely used in folk medicine. In the current work, we profiled the secondary metabolites from E. abyssinica bark extract using LC-MS and investigated its effect on cryopreserved ram semen. Twenty-eight compounds, including tannins and gallic acid derivatives that prevailed in the extract, were tentatively id...
Article
Background: In continuation of a previous work concerned with the anticancer activity of some 8-alkyl-2,4-bisarylidene-8-nortropan-3-ones, this work focuses on further modification to the tropane/pyran fused skeleton aiming to obtain improved anticancer activity. Methodology: Reaction of 8-alkyl-2,4-bisarylidene-8-nortropan-3-ones 1–21 with malonon...
Technical Report
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Bird report for the month July to October 2020 in Nordbaden, Germany
Technical Report
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Bird report for April to July 2020 in Nordbaden
Technical Report
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Bird report for Nordbaden Jan - March 2020
Technical Report
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Ornithologischer Rundbrief für Nordbaden und angrenzende Gebiete Nr. 84: Juli bis September 2019 Bird report
Technical Report
Full-text available
Ornithologischer Rundbrief für Nordbaden und angrenzende Gebiete Nr. 83: April bis Juni 2019 Bird report