Michael Tirant

Skin microbiota is an integral part of the human immune system. Staphylococcus aureus is one of the essential components of the normal flora. Approximately 20-30% of healthy individuals are persistently colonized with S. aureus, whereas the remainders are considered low-level intermittent carriers. Despite these natural aspects of existence, S. aur...

Background Narrowband UVB (NBUVB) has recently been used in Vietnam for the treatment of psoriasis. However, there are no data on Vietnamese patients to adopt a uniform national protocol. Objectives This study aimed to establish an optimal NBUVB therapy for the treatment of psoriasis in Vietnamese patients. Materials and Methods One hundred and t...

Skin is a complex and dynamic organ, which shows different physiological and pathological characteristics through age, due to the continuous interaction of intrinsic (e.g., genetic factors, hormones, and others) and extrinsic factors (e.g., infections, irritative or sensitizing factors, and others).

A 5-month-old baby boy was admitted to our hospital with scattered pigmented papules. The onset was at the age of 3 months with many papules on his scalp, then progressed to his abdomen, back and groins. Some papules were self-healing although new lesions had continued to develop.He is the third child of his parents, by normal vaginal delivery and...

An 18-year-old male patient was admitted to the hospital with many asymptomatic hyperpigmentation on his face. This condition began about 2 years ago, when he initially developed many abnormal skin pigmentations. They were all concentrated in light-exposed areas such as the face, neck and forearms with increasing number of lesions. During the exami...

A four-month male presents with uniform papules on his forehead and back, which had been evident for about 1 month. There was no history of similar lesions in family members. Cutaneous examinations revealed relatively equal papules, 1 mm in diameter with some depressed lesions. Lesions focus on forehead, back and a little bit lesions on abdomen. Fu...

Squamous cell carcinoma (SCC) is a common malignancy in adults but are exceptionally rare in children. However, children with certain disease condition, for example, xeroderma pigmentosum (XP), a rare inherited disease, is highly susceptible to the development of skin malignancy including SCC.We report a case of XP in an 18-years old boy with clini...

A 16-year-old boy presented to our hospital because of a huge mass on the face and a large ulcer on the scalp. Physical examination revealed a giant necrotic, ulcerating mass involving the two third upper part of the face (Fig. 23.1) and an ulcer sized 10 × 7 cm on the cranial vertex of the scalp (Fig. 23.2). The mass covered almost the two eyes an...

A 17-year-old girl presents with a 3-year history of a slow-growing brown papule on the forehead. The patient describes that the lesion had begun as a small ‘spot’, which had gradually enlarged and recently been ulcerated and intermittently bleeding. She is a high school student. There is no previous history of skin disease excluding acne and no fa...

A 15-year-old female presented with recurrent hyper-pigmented papule on her left cheek. The lesion appeared when she was 10 years old. It was diagnosed as benign tumor at many hospitals and excised two years ago. However, the lesion reappeared at the same area. The patient self-treated by an unknown topical medicine from a pharmacy. The lesion grew...

An 18-year-old male was referred to our hospital due to a cauliflower-like lesion, which was approximately 8 centimeter in size (Fig. 15.1), pruritic with a foul odor. The disease course was about 4 months, associated with hyaline secretion through the urethra with mild febrile episodes without gauging and weight loss. Physical examination revealed...

An Elderly Male with an Exophytic Ulcerated Lesion on Toenail

An 82 year-old female presented to the hospital complaining of a gradually increasing size of macule on her left sole. The lesion was a flat hyperpigmented macule from the onset of two years ago. The patient reported no pain and no itching, thus she did not seek for any medical treatment. Recently, the lesion has had significant rise in size and sh...

A 50-year-old female farmer presented with a bleeding ulcerative nodule on the right litle toe that developed for 3 months. She reported history of plantar wart on this site that was treated by four times of minor surgery. On cutaneous examination, there was a firm, 1 × 1.5 cm, dome-shaped, pink, nodule with a central ulceration covered by a yellow...

A 54-year-old female presented with an irregular hyperpigmented lesion on her right sole that quickly progressively developed for 1 year. Her lesion was itchy, painless, and about 1.5 cm in diameter with a central ulceration that produced clear discharge (see Fig. 30.1). Before admitted, she went to private clinical and had unknown diagnosis and tr...

A 54-year-old male farmer presented with a hyperpigmented macule on his right heel that developed for 3 years ago. His lesion was non-itchy, painless and increased in size rapidly and changed in color for 1 year. After that, he became hospitalized in National Hospital of Dermatology and Vereneology. Physical examination revealed not well-defined, i...

A 71-year-old woman presented with an 18-month history of slow-extending pigmented lesion on her left heel. The patient described that the lesion initially appeared as a papule, then enlarged and recently has increased rapidly in size and has developed intermittently bleeding. Topical mupirocin prescribed by GP, had been ineffective so she was refe...

A 62-year-old male presented to National Hospital of Dermatology and Vereneology with a 10-year history of a hyperpigmented patch on his right sole. 6 months before admitted, his lesion increased in size, and discharged. The lesion was painless, non-itchy, about 2 × 1.5 cm in size with irregular border (Fig. 31.1).

A 43-year-old female was admitted to surgery department with a painless tumor developing at hypogastric region for the past 4 years (Fig. 27.1). In the last 4 months, the lesion developed very quickly in size and became ulcerated and bleeding easily. She denied fatigue and weigh loss.

A 54-years-old female patient admitted to the hospital with a mild painful hyperpigmentation. The lesion began 3 year ago, initially with some hyperpigmented macules near her right heel. She scratched the lesion by a needle, then it spread widely. The patient was treated with laser therapy 2 years ago, but it was not completely cured. In this year,...

A 39-year-old man presented with a hyperpigmented macule on his left heel that progressively developed for 3 years. This lesion was non-itchy, painless and about 1 cm in diameter. He became hospitalized after that (Fig. 29.1).

A 66-year-old male patient presented to the hospital with a gradually changing size of macule on the lateral side of heel (Fig. 35.1). The onset was 5 years ago with a flat hyperpigmentation macule. The lesion were painless and non-itchy so he did not seek for any treatment. Over the last 2 years, the lesion have gradually increased in size and app...

A 27-year-old woman presented with hyperpigmented patches on the forehead and bilateral cheeks. The onset was one year earlier. Initially, she had erythematous macules then turned spontaneously into hyperpigmented patches. She was diagnosed with allergic contact dermatitites, treated with topical corticosteroid but there was no improvement. She has...

A 48-year-old patient presented to our clinic with some hypopigmented patches on her face evolved since 3 months. She reported no functional symptom as well as no exposure to any new substance or new condition recently and she did not have any treatment before.

A 51-year-old male presented to NHDV with patchy brown spots on his upper cheek. He is a farmer and exposed to a lot of sunshine. He has never had a treatment and seems a little apprehensive during the consultation. He reported that he has previously experienced melasma and his family has a history of the condition-but it quickly went away without...

A 57-year-old female presented to the hospital with a 6-month history of a dyspigmentation of the skin on her face, neck, back, bilateral arms and legs. The lesion was non-itchy and painless. She denied using any medication within 3 months before the onset of the disease. She is a farmer and often has to be exposed to sunlight. No one in her family...

A 20-year-old female presented to the clinic because of hyperpigmented macules on the trunk for 1 month, with symmetric distribution and mild pruritus, no lesions on the face, mucosa, limbs and nails. She denied having any erythematous lesions before, her medical history was significant with hepatitis C virus infection for 1 year.

A 40-year-old woman presented with progressive diffuse symmetric spotted hypopigmentation on non-atrophic hypopigmented macules, that appeared firstly on the face, developing over 4 years. The lesion was mildly itchy, but no pain. Patient had no history of significant medical problems or disease. She denied using any long-term medications, topical...

A 23-year-old man presented with hyper and hypopigmented macules on the dorsal aspects of the extremities that had appeared early since his childhood. On examination, skin lesions were asymptomatic but they became more pronounced (obvious) after exposure to the sun. His development was normal and there was no particular past medical history except...

A 36-year-old Vietnamese woman presented to the clinic because of hypopigmented lesions on her face developed over 1 month. She denied having any pruritus or pain.

A 7-year-old boy presented with hypopigmented patches on his face 5 months ago. The lesions started as small hypopigmented macules on the cheeks and gradually increased in number and size. The lesions were asymptomatic with no preceding erythema or inflammation, so his mother did not pay much attention.

A 24-year-old Vietnamese woman presented to the clinic because of hypopigmented lesions on her upper extremities for 2 weeks. She denied any preceding changes such as erythema, blisters or erosion.

Atypical vascular proliferations (AVP) are a late complication after radiotherapy. Most cases have been reported in female breast cancer patients on the chest wall. These lesions are mostly of the lymphatic type. Herein, we report a blood vascular-type AVP in a male on the neck 60 years after radiotherapy for a benign hemangioma, which makes this c...

Introduction Hydrogels based on hyaluronic acid are used to restore volume, hydration and skin tone, as well as to correct scars, asymmetries or defects of the soft tissue. Hyaluronic acid is often chemically crosslinked with different crosslinking agents in order to improve its mechanical and biological properties. Here we focused on defining the...

The use of donkey milk has a long history in external dermal application for cosmetic and medical purposes. The encapsulation of different drugs into nanoliposomes and nutrients may have many benefits for the delivery of the targeted substance. The aim of the present study is to test creams with nanoliposomes encapsulated with skimmed donkey milk,...

BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions. Human leukocyte antigens (HLA) may play an important role in the pathogenesis of SJS/TEN. AIMS: This study aims to identify HLA-B alleles in Vietnamese patients with SJS/TEN and to investigate the possible link between HLA-B...

BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute, life-threatening drug reactions, which lead to massive epidermal necrolysis. Granulysin plays an important role as a key mediator for keratinocyte apoptosis in these conditions. Erythema multiforme (EM) may have skin manifestation similar to SJS/TEN. AIMS: T...

Recently, it has been shown that DNA could emit some waves which carry main information about its evolution. Using this idea, we design a new method to image the behavior of skin cells, especially melanocytes, and diagnose their damage. In this method, we make use of a circuit which is formed from DNAs within the damaged melanocytes, a graphene she...

AIM The aim of this study was to investigate the relationship between the ABO blood, groups and triggers, including food, of psoriasis. METHODS A total of 683 psoriasis patients were included in the retrospective study and divided into groups based on their blood group (ABO). Patients were asked to complete a series questions related to the effect...

Recently great attention has been paid to the rejuvenation of the face, neck and décolleté of women with advanced radial fractional radiofrequency. We aimed to clinically evaluate the results obtained with this treatment method. We treated 10 women aged 42 to 62, suffering from skin aging. After carrying out the hydration and sebometry skin tests i...

In this study, the application of a recently introduced device based on electromagnetic energy transfer by microwaves for fat reduction, permitted to study specifically the modifications of thick fibrous collagen interlobular septa in the subcutaneous adipose tissue, related to the formation of large clusters of adipocytes. The use of Picrosirius R...

Introduction: Melasma is an acquired circumscribed hyperpigmented disorder seen mainly on the malar area of face and other parts of body. We evaluated the safety and efficacy of two different creams for melasma. Methods: 60 volunteers with melasma were evaluated in this study, divided in 3 groups: A, B and C. Patients in group A and B were treat...

In this study we report our multicentric experience of synthetic medical certified polyamide hair implants in male androgenetic and female menopausal and chronic alopecia. Biofibre hair implantation was performed by means of a standardized, mini‐invasive technique followed by regular post‐operative care along 3 years. From May 2015, 278 patients we...

This book provides a guide to the diagnosis and management of pigmentary disorders. Each chapter explores a different clinical case to give the reader an interdisciplinary understanding of treatment options. Particular attention is given to the treatment of hypopigmentation, hypomelanosis and discoloration with cases highlighting the effects of dru...

BACKGROUND: Recently, some new methods for sexing of chicken eggs by fluorescence and Raman spectroscopy through the shell membrane have been proposed. On the other hand, in another investigation, a new virus medical imaging has been suggested. AIM: In this research, summing over these considerations, a new technique for sexing of chicken eggs by...

The P.N.E.I. (Psycho-Neuro-Endocrine-Immunology) approach is represented by the interdisciplinary concept of bidirectional cross-talk between the psycho-neuro-endocrine and immune systems, which can influence the immune response. The well-known Gut-Brain Axis and the Gut-Skin Axis can be merged in a bigger network-the Gut-Brain-Skin Axis, with comp...

The main surgical treatment for melanoma consists in wide surgical excision of the primary lesion and the sentinel node but in recent times management of melanoma is rapidly evolving with the introduction of new systemic therapies, like BRAF inhibitors, MEK inhibitors and antibodies anti-PD-1 that show good results in controlling even advanced stag...

The eyes are an important component of facial aesthetics. They are in the center of an anatomical area of the face very important for rejuvenation procedures, the so-called "periorbital region." The appearance of the eyes therefore decisively influences the perception of the aesthetics and aging of the entire face. In juvenile age, the skin of the...

To recover chick embryos damaged the brain, two methods are presented. In both of them, somatic cells of an embryo introduced into an egg cell and an embryo have emerged. In one method, injured a part of the brain in the head of an embryo is replaced with a healthy part of the brain. In the second method, the heart of brain embryo dead is transplan...

Recently, some scientists from NASA have claimed that there may be a black hole like structure at the centre of the earth. We show that the existence of life on the earth may be a reason that this black hole like object is a black brane that has been formed from biological materials like DNA. Size of this DNA black brane is 109 times longer than th...

Increasing incidence and poor outcome of chronic non-communicable diseases in western population would require a paradigm shift in the treatments. Guidelines-based medical approaches continue to be the standard rule in clinical practice, although only less than 15% of them are based on high-quality research. For each person who benefits from the 10...

Subcutaneous adipose tissue was defined as the “perfect filler” as is soft and malleable and is usually enough present in the body for correcting volume defects and small remodelling purposes. The first attempts to implant autologous adipose tissue dates back to the end of the twentieth century, and with the refinement of harvesting, processing and...

A week‐long World Vitiligo Day campaign culminates efforts of numerous activists around the world to bring this once forgotten skin disease to the attention of general public, healthcare system and biopharma industry. The campaign international headquarters moves across the globe each year, this year coming to Hanoi, Vietnam. Support for the event...

T The P.N.E.I. (Psycho-Neuro-Endocrine-Immunology) approach is represented by the interdisciplinary concept of bidirectional cross-talk between the psycho-neuro-endocrine and immune systems, which can influence the immune response. The well-known Gut-Brain Axis and the Gut-Skin Axis can be merged in a bigger network- the Gut-Brain-Skin Axis, with...

BACKGROUND: Pseudo-ainhum is defined as any case of auto‐amputation not associated with the classic spontaneous ainhum seen in Africans with unknown etiology. CASE PRESENTATION: A severely ill 58-year-old male patient presented with a painless constricting circular band on his left second toe. His medical history was remarkable for severe alcoholi...

BACKGROUND: The concept of immunocompromised districts of skin has been developed by Ruocco and helps to explain certain aspects of the macromorphology of skin diseases. This concept unites the isomorphic response of Koebner and the isotopic response of Wolf. CASE REPORTS: We present different cutaneous conditions which can lead to immunocompromise...

AIM: In this paper, inspiring Darwin’s theory, we propose a model which connects evolutions of neural circuits with evolutions of cosmos. In this model, in the beginning, there are some closed strings which decay into two groups of open strings. METHODS: First group couple to our universe from one side and produce matters like some genes of DNAs a...

Topical treatment is the cornerstone for the management of mild to moderate psoriasis. Despite efforts in drug development, patient's satisfaction with the available topical treatments is limited. A strategy to improve safety, efficacy and comfort of topical treatment provides the development of new drug delivery and drug carrier systems. This revi...

Botulinum toxin (BTX) is a neurotoxin protein derived from the Clostridium botulinum bacterium that inhibits the release of acetylcholine at the neuromuscular junction level whose effects has been used for many years to treat a variety of muscular/neuromuscular conditions and more recently also for cosmetic use. BTX has experimented in some dermat...

Botulinum toxin (BTX) is a neurotoxin derived from the Clostridium botulinum bacterium that inhibits the release of acetylcholine at the neuromuscular junction level whose effects has been used for many years to treat a variety of muscular/neuromuscular conditions and more recently also for cosmetic use. BTX has experimented in some dermatological...

There are numerous cases reports and studies confirming the enhanced incidence of melanoma among patients with mastocytosis, especially with systemic mastocytosis. These two diseases are arising from two different types of cells; melanoma arises from neural crest cells and mastocytosis from hematopoietic stem cells. But there are a lot of similarit...

Incidence of melanoma is increasing every year. A few years ago, we could not speak about long term survivors with melanoma. Chemotherapy did not give a good effect in the past. Metastasis occurred very rapidly, and the progression of melanoma was very fast. But now, with new forms of therapy, especially immunotherapy and target therapy, for the fi...

Insomnia means difficulty in falling asleep and/or stays asleep. Insomnia commonly leads to daytime sleepiness, lethargy, and a general feeling of being unwell. The most common treatment of insomnia includes GABAA receptor positive allosteric modulators or Melatonin agonists. Our study aimed to evaluate the efficacy of Magnesium-melatonin-vitamin B...

As indicated by the latest scientific evidence, the lines between different fields of medicine gradually blur and overlap more and more. Psychiatry and dermatology have seen this trend in the last decade as an ever-increasing number of studies suggest the strong connection of many dermatological syndromes and diseases with psychiatric conditions an...

Understanding the mechanisms of cancer immune-tolerance is one of the most important challenges. Several studies have demonstrated the potential anticarcinogenic effects of beta-blockers, in patients with prostate cancer, breast cancer, and melanoma. At the other side variety of dermatoses may be caused or aggravated by β-blockers-psoriasis, lichen...

BACKGROUND: Recently, it has been developed a new technology for the reduction of subcutaneous adipose tissue through a non-invasive treatment by microwaves. The main objective of the present study is to demonstrate the feasibility of utilising a non-invasive, localised microwaves (MW) device to induce thermal modifications into subcutaneous adipos...

Nutrigenomic DNA reprogramming in different chronic diseases and cancer has been assessed through the stimulation of gene expression and mRNA synthesis versus DNA silencing by CpG DNA modification (methylation); histone modification (acetylation, methylation) and expression of small noncoding RNAs, known as microRNAs (miRNAs). With regard to the sp...

BACKGROUND: Wells syndrome is a rare idiopathic dermatosis of the eosinophilic spectrum. Diagnostic criteria include cutaneous eruptions of variable morphology with eosinophilic infiltrates, peripheral blood eosinophilia, a relapsing, remitting course, and exclusion of systemic disease. Diagnosis is often delayed. CASE PRESENTATION: We present a 2...

BACKGROUND: Eccrine poroma is a benign tumour of eccrine duct epithelium. The usual clinical presentation is nodular. CASE REPORT: We present a 78-year-old man with a painful pendulating flesh-coloured malodorous plantar tumour. Differential diagnoses included telangiectatic granuloma, acrochordon, basal cell or squamous cell carcinoma, cylindroma,...

BACKGROUND Systemic corticosteroid is used to treat alopecia areata, but it is associated with side effects. Mini-pulse therapy is thought to be effective but able to reduce side effects. AIM The study aimed to evaluate the effectiveness of oral mini-pulse methylprednisolone in the treatment of alopecia areata. METHODS Patients received methylpre...

AIM To evaluate the effectiveness and safety of micro-needling therapy in atrophic acne scar treatment. METHOD A prospective, single centred study was implemented in a total of 31 patients suffering from atrophic acne scar grade 2 to 4 of Goodman and Baron scaring grading system was recruited. They were treated by microneedle derma roller every we...

BACKGROUND Up to now, surgical excision of apocrine glands still has been a method that yields high treatment results and low rate of odour recurrent for patients, but many people worry about some serious complications that have been observed postoperatively, such as hematoma and skin necrosis. These prolong wound healing, leading to unsightly scar...

BACKGROUND Keloid is an overactive condition of the skin tissue to early lesions characterised by proliferation of fibroblasts, excessive collagen production in the lesion. Treatment of keloids is a big challenge because of the poor response rate and high risk of recurrence after treatment. We found that bleomycin offers promise in the treatment of...

AIM: To examine the efficacy and safety of Narrowband ultraviolet B (NB-UVB) in Vietnamese vitiligo patients. METHODS: We recruited thirty-one patients (14 males, 17 females), aged from 7 to 67 years, with both segmental vitiligo (SV) and non-segmental vitiligo (NSV), treated three times weekly with NB-UVB. The starting dose for adults from 15 yea...

AIM Evaluation the effect of intralesional corticosteroid injection on keloid, at the National Hospital of Dermatology and Venereology from 1/2009 to 12/2009. METHODS A group of 65 patients with keloid were randomly assigned into three groups. In the studied group, 33 patients were intralesionally injected 7.5 mg/1 cm² of TCA. In the control group...

BACKGROUND: B-cell activating factor (BAFF) is considered to have a role in the pathogenesis of systemic sclerosis (SSc). AIM: We conducted a longitudinal study on early SSc patients to determine the change in BAFF serum level after treatment and its association with organ involvements. METHODS: A total of 46 patients (32 diffuse, 14 limited) wer...

BACKGROUND: Oral isotretinoin is an effective therapy for acne. However, isotretinoin can induce hyperhomocysteinemia and decreased serum folic acid level, which may be a risk for cardiovascular disease and thrombosis, as well as psychoses. Besides, many recent types of research emphasise the safety and effects of the low dose isotretinoin therapy....

BACKGROUND Molluscum contagiosum is a common viral disease primarily affecting children. AIM The objective is to compare the efficacy of 10% potassium hydroxide (KOH) solution versus 10% salicylic pomade in the treatment of molluscum contagiosum. METHODS Clinical trials on 70 patients were randomised into 2 groups: 39 patients treated with 10% KO...

BACKGROUND: Chronic urticaria, a mast cell-driven condition, is common, debilitating and hard to treat. H1-antihistamines are the first line treatment of chronic urticaria, but often patients do not get satisfactory relief with the recommended dose. European guidelines recommend increased antihistamine doses up to four-fold. AIM: We conducted this...

BACKGROUND The detection of pathogenic fungus is an important step and key to assessing the sensitivity of the antifungal drugs, and therefore choosing an effective treatment method. AIM To identify Malassezia species from scales of a patient with pityriasis versicolor. METHODS Three hundred patients with pityriasis versicolor who were positive w...

BACKGROUND Vitiligo is an acquired pigmentary disease, that causes progressive loss of melanocytes, resulting in hypopigmented skin patches. Current treatments aim at stopping the disease progression and achieving repigmentation of the amelanotic areas. Corticosteroids, surgery, topical immunomodulators, total depigmentation of normal pigmented ski...

AIM: Compare itraconazole alone, fluconazole combined with ketoconazole and ketoconazole in the treatment of patients with pityriasis versicolor. MATERIAL AND METHODS: A group of 240 pityriasis versicolor patients (confirmed with KOH and culture) were classified into 3 groups: Fluconazole 300 mg a week and 2% ketoconazole foam twice a week for 2 w...

OBJECTIVES: This study aims to evaluate the effectiveness of Alex Trivantage laser wavelength 755 nm (ATL) in the treatment of freckles at Hanoi Hospital of Dermatology and Venereology, Vietnam. PATIENTS AND METHODS: A group of 30 patients with freckles were treated by ATL (Alex Trivantage-Candela Co America) with spots size 3 mm, wavelength 755 m...

BACKGROUND The World Health Academy of Dermatology, the Vitiligo Research Foundation, the Military Medical Academy of Belgrade Serbia, the University of Parma-Italy and the University of Rome Guglielmo Marconi, Rome-Italy have successfully joined Vietnamese Dermatology Community in the ambitious project of positionìng Vietnam in the Dermatologic Ol...

AIM: To access the effectiveness, safety and tolerance of methotrexate (MTX) in psoriatic arthritis (PsA) treatment. METHODS: We recruit 37 patients, admitted at HCMC Hospital of Dermato-Venereology from 1/2016 to 3/2017, with MTX dosage ranging from 10 mg to 15 mg per week. RESULTS: Skin lesion response after 12 weeks improved PASI 50: 40.5%, PA...

BACKGROUND: Infected eczema is one of the most common complications of eczema. The progression and treatment of infected eczema have become more complex and difficulty due to the antibiotic resistance of bacteria and the abuse of antibiotics in treatment. AIM: Our research was conducted with the aim of investigating the severity of in vitro antibi...

We conducted a prospective, cross-sectional study at Ho Chi Minh City Hospital of Dermato Venereology from January 2016 to March 2017 in 40 psoriatic arthritis (PsA) patients to evaluate the disease progression and therapeutic burden about the HLA patterns. Based upon our results, PsA with HLA-B27 (+) had a threat of severe arthritis. PsA with HLA-...

AIM Evaluate the resistance of dermatophytes to systemic antifungal drugs in the Vietnamese population. METHODS We enrolled 101 patients with cutaneous dermatophytosis at the Dermato-Venereology hospital in HCMC from August 2016 to March 2017. All the specimens were subjected to direct examination (10% KOH mount) and culture on Sabouraud dextrose...

AIM: To compare the effectiveness of narrowband ultraviolet B (NBUVB) and oral methotrexate (MTX) to oral MTX alone in Vietnamese psoriasis patients, from May 2016 to May 2018. METHODS: We conducted a non-randomized trial on 70 patients with plaque-type psoriasis of moderate to severe. Thirty-five patients apply NBUVB once/day in 5 days/week for 4...

A cross-sectional study was performed on 48 psoriasis Vietnamese patients treated with metformin as an add-on for methotrexate and 48 psoriasis patients treated methotrexate alone. The mean PASI scores were 5.25 ± 5.72. Total QOL scores had a slight difference between patients treated metformin combined with methotrexate and methotrexate alone (62....

AIM: To investigate the efficacy of plastic surgery in the treatment of giant congenital melanocytic nevus (GCMN). METHODS: We enrolled 20 patients with 44 lesions and performed one of the following procedures: serial excision, skin grafting, tissue expansion, primary skin closure, distant flap, and adjacent flap. We assessed the outcome at 10 day...

BACKGROUND: Aging is an increasing concern of modern society, particularly facial ageing. In recent years, the microinjection technique has increasingly been emphasised as a skin rejuvenation strategy. Hyaluronic acid (HA) plays an important role in the hydration of the extracellular space and can thus improve skin hydration, firmness and viscoelas...

BACKGROUND: Atopic dermatitis (AD) is a common, chronic, relapsing, genetically determined inflammatory skin disorder. Staphylococcus aureus (S. aureus) plays an important role in the pathogenesis of AD. Atopic skin is susceptible to infection with S. aureus. AIM: This study was aimed to compare the skin S. aureus colonisation status and its secre...

BACKGROUND: Psoriasis, the prevalence of which ranges from 2% to 3% of the general population, has been recently recognised as not only a chronic inflammatory skin disorder but also an immunometabolic systemic disease. Dyslipidemia is one of the most important comorbidities of psoriasis. Statins, frequently used as anti-hyperlipidemic agents, may b...

AIM To evaluate the efficacy of imiquimod 5% in periungual wart treatment. MATERIAL AND METHODS A group of 40 patients were recruited to apply imiquimod 5 % cream once daily for 5 consecutive days per week in 8 weeks. They were classified into 3 levels: Mild (the total lesion area ≤ 25 mm²), moderate (25 mm² <total lesion area ≤ 50 mm²), severe (t...

AIM: This longitudinal study aims to evaluate the efficacy of oral itraconazole in the treatment of seborrheic dermatitis in Vietnamese patients. METHODS: Thirty patients were enrolled at National Hospital of Dermatology and Venereology, Hanoi, Vietnam and were treated with oral itraconazole (200 mg daily in 14 days followed by 200 mg weekly in 4...