Michael Reiser

Michael Reiser
DRK Blutspendedienst

Dr. hum. biol.

About

16
Publications
2,248
Reads
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332
Citations
Introduction
Additional affiliations
September 2007 - March 2012
Ulm University
Position
  • PhD Student

Publications

Publications (16)
Article
Full-text available
Clinical development of chimeric antigen receptor (CAR)-T-cell therapy has been enabled by advances in synthetic biology, genetic engineering, clinical-grade manufacturing, and complex logistics to distribute the drug product to treatment sites. A key ambition of the CARAMBA project is to provide clinical proof-of-concept for virus-free CAR gene tr...
Article
Full-text available
Vaccines have played a pivotal role in improving public health, however, many infectious diseases lack an effective vaccine. Controlling the spread of infectious diseases requires continuing studies to develop new and improved vaccines. Our laboratory has been investigating the immune enhancing mechanisms of Toll-like receptor (TLR) ligand-based ad...
Article
Full-text available
Vaccines are arguably one of the greatest advancements in modern medicine. Subunit vaccines comprise the majority of current preparations and consist of two main components—antigen and adjuvant. The antigen is a small molecule against which the vaccine induces an immune response to provide protection via the immunostimulatory ability of the adjuvan...
Preprint
Widespread treatment of human diseases with gene therapies necessitates the development of gene transfer vectors that integrate genetic information effectively, safely and economically. Accordingly, significant efforts have been devoted to engineer novel tools that i) achieve high-level stable gene transfer at low toxicity to the host cell; ii) ind...
Article
Full-text available
TOLL-like receptor (TLR) ligands activate both innate and adaptive immune cells, while modulating the cellular immune response. The outer membrane protein (OMP) from Neisseria meninigitidis, PorB, is a naturally occurring TLR2 ligand and functions as an adjuvant. Here, we demonstrate that PorB increases the level of OVA in the endo-/lysosomal cellu...
Article
Full-text available
Vaccines are critical in the fight against infectious diseases, and immune-stimulating adjuvants are essential for enhancing vaccine efficacy. However, the precise mechanisms of action of most adjuvants are unknown. There is an urgent need for customized and adjuvant formulated vaccines against immune evading pathogens that remain a risk today. Und...
Article
Background Vaccines are a powerful tool for preventing the transmission of diseases, however very few take advantage of specific mechanistic knowledge. In order for newer and better vaccines to be developed, a greater understanding of adjuvant mechanism and immune system priming needs to be achieved. Our laboratory has focused on the natural adjuva...
Article
Membrane wrapped nanoparticles represent a versatile platform for utilizing specific lipid-receptor interactions, such as siallyllactose-mediated binding of the ganglioside GM3 to Siglec1 (CD169), for targeting purposes. The membrane wrap around the nanoparticles does not only serve as a matrix to incorporate GM3 as targeting moiety for antigen pre...
Article
Full-text available
The use of DNA vaccines requires pharmaceutical grade DNA that causes the immunization on the basis of a nucleic acid sequence that encodes the protein to be vaccinated against. This nucleic acid sequence can be a circular or linear plasmid, preferably a double stranded one and should not contain any other and especially not any "toxic" sequences....
Article
Little is known about whether presentation of endogenous and exogenous HBV surface antigens on APCs targeted by vaccination and/or virus-harbouring hepatocytes influences de novo priming of CD8(+) T cells. We showed that surface antigen-expressing transfectants exclusively display a K(b) /S190 epitope, whereas cells pulsed with recombinant surface...
Article
Vaccines are vital in the fight against infectious diseases. Many vaccines are successful because of adjuvants added to their formulations or in the case of live attenuated vaccine because the adjuvant is inherent, however they have been used with little understanding of their mechanisms. PorB, a TLR2 agonist, is the major outer membrane protein of...
Article
MicroRNAs (miRs) are small non-coding RNAs that are involved in post-translational modulation of gene expression. Not much is known about the role of miRs in vaccine adjuvant activity. In this study, we investigated miRs elicited by PorB, a TLR2 dependent adjuvant from N. meningitidis, in vivo and in vitro. Mice (WT) were immunized 3 times, 2 weeks...
Article
Full-text available
Immunodominance hierarchies operating in immune responses to viral Ags limit the diversity of the elicited CD8 T cell responses. We evaluated in I-A(b+)/A2-HHD-II and HLA-DR1(+)/A2-DR1 mice the HLA-A*0201-restricted, multispecific CD8 T cell responses to the human CMV tegument phosphoprotein pp65 (pp65) Ag. Vaccination of mice with pp65-encoding DN...
Article
Full-text available
RIP-B7.1 mice express the costimulator molecule B7.1 (CD80) on pancreatic beta cells and are a well-established model for studying de novo induction of diabetogenic CD8 T cells. Immunization of RIP-B7.1 mice with preproinsulin (ppins)-encoding plasmid DNA efficiently induces experimental autoimmune diabetes (EAD). EAD is associated with an influx o...

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