Michael Opoku-Darko

Michael Opoku-Darko
Mayo Clinic - Rochester · Department of Neurosurgery

MD.,MSc.FRCSC.FAANS

About

17
Publications
836
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125
Citations
Citations since 2016
15 Research Items
121 Citations
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2016201720182019202020212022010203040

Publications

Publications (17)
Article
Objective: The objective of this study was to determine the frequency with which brain biopsy for presumed CNS relapse of systemic hematological malignancies yields new, actionable diagnostic information. Hematological malignancies represent a disparate group of genetic and histopathological disorders. Proclivity for brain involvement is dependent...
Article
Full-text available
Pediatric glioblastoma multiforme (GBM) involving the spine is an aggressive tumor with a poor quality of life for patients. Despite this, there is only a limited number of reports describing the outcomes of pediatric spinal GBMs, both as primary spinal GBMs and metastases from an intracranial tumor. Here, we performed an individual patient meta-an...
Article
INTRODUCTION Evidence suggests that cytoreduction is associated with improved survival in glioblastoma (GBM) and that maximal, or gross total resection of the tumor offers the best chance for prolonged survival. We developed a novel surgical technique for removal of GBM called Circumferential resection during which we identify the interface between...
Article
BACKGROUND Glioblastoma (GBM) occurs commonly in individuals above 65 years of age. Most clinical trials that guide recommendations for treatment of GBM tend to exclude patients above the age of 65 years. In this study, we evaluated a cohort of elderly patients treated at a single institution in order to identify factors that impact overall surviva...
Article
BACKGROUND Incidentally discovered diffusely infiltrating gliomas (iDIGs) are lesions found on brain imaging for a reason not attributable to the lesion. Patients are usually asymptomatic at time of discovery. Incidentally DIGs can harbor different genetic abnormalities and vary widely in size at diagnosis. We hypothesized that tumor size at the ti...
Article
Full-text available
Background Traumatic atlantoaxial rotatory subluxation (TAARS) in adults is rare. We present an uncommon case of traumatic atlantoaxial rotatory subluxation with an associated type II odontoid fracture in a neurologically intact patient and describe a novel technique used for a successful closed reduction. Case description A 20-year-old female pre...
Article
Background: Evidence suggests a survival benefit for patients with glioblastoma who undergo maximal safe surgical resection. Not all glioblastomas are amenable to surgical resection and anatomical location is one potentially limiting factor. Glioblastomas that invade the corpus callosum and cross midline to the contralateral hemisphere, butterfly...
Article
OBJECTIVE Occasionally, diffusely infiltrating low-grade gliomas (LGGs) are identified as incidental findings in patients who have no signs or symptoms that can be ascribed to the tumors. The diagnosis of incidental, asymptomatic LGGs has become more frequent due to the vast increase in access to medical imaging technology. While management of thes...
Article
Full-text available
Background: Spondylodiscitis is commonly caused by Staphylococcus aureus. Anaerobic organisms are the causative agents in only 3–4% of cases. Diagnosis of anaerobic spondylodiscitis can be challenging due to their low virulence nature. Case description: We describe a rare case of spondylodiscitis caused by Prevotella intermedia managed with antibio...
Article
Background: Occasionally low grade gliomas (LGGs) are identified incidentally while asymptomatic. The diagnosis of incidental LGGs has become more frequent due to increase in access to medical imaging. While management of these lesions remains controversial, early surgery has been suggested to improve outcome. Methods: All LGGs treated between 2004...
Article
Background Patients with diffuse glioma are known to have impaired cognitive functions pre-operatively. However, the mechanism of these cognitive deficits remains unclear. Resting state functional connectivity in the fronto-parietal network (FPN) is associated with cognitive performance in healthy subjects. For this reason, it was hypothesized that...
Article
Objective: Brain tumor patients are known to have deficits in cognitive, motor, and emotional domains. Comprehensive evaluation of the brain tumor patient includes taking into account all these domains at baseline and throughout treatment. However, standard neuropsychological assessment methods are lengthy, expensive, and are often variable. The a...
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INTRODUCTION Uncommonly, diffusely infiltrating gliomas (DIGs) are identified incidentally while asymptomatic. Early surgical management of these tumors has been suggested to improve outcome. We set out to identify and review the characteristics and outcomes of patients with incidental, asymptomatic DIGs. METHODS All DIGs surgically treated by the...
Article
Tumor vasculature is known to express high levels of the longest splice variant of tumor endothelial marker 8 (TEM8). Little is known about its expression by tumor cells. Five of eight cell breast cancer cell lines tested expressed significant levels of the longest TEM8 splice variant (TEM8.1), and to a lesser extent, the shortest splice variant (T...

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