Michael Ochse

Michael Ochse

Dr. rer. nat.

About

65
Publications
9,399
Reads
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610
Citations
Citations since 2017
18 Research Items
220 Citations
2017201820192020202120222023010203040
2017201820192020202120222023010203040
2017201820192020202120222023010203040
2017201820192020202120222023010203040
Education
October 1990 - June 1999
University of Wuerzburg
Field of study
  • Chemistry

Publications

Publications (65)
Article
Full-text available
The systematic position of a large and strikingly coloured reddish-black moth, Cartaletis dargei Herbulot, 2003 (Geometridae: Sterrhinae) from Tanzania, has remained questionable since its description. Here we present molecular and morphological evidence showing that Cartaletis dargei only superficially resembles true Cartaletis Warren, 1894 (the r...
Article
Full-text available
Die tropisch-afrikanische Gattung Mesothisa (Geometridae: Ennominae) umfasst bisher 16 beschriebene Arten und wird hier um die neuen Taxa Mesothisa truschi sp. nov., Mesothisa truschi kibala subsp. nov., Mesothisa knudlarseni sp. nov., Mesothisa baaka sp. nov., Mesothisa sebastiani sp. nov. und Mesothisa nimba sp. nov. erweitert. Description of new...
Article
Full-text available
Digitale Zusammenführung heterogener Dokumente in eine harmonisierte Datenbank der Grundstücke der Pollichia mit Statistiken und Karten. In: POLLICHIA-KURIER 36(4)-2020, 7-10, Link: https://www.pollichia.de/images/Pollichia_Kurier_2020_04_tn.pdf
Article
Full-text available
Current studies have shown a severe general decline in insect species diversity, their abundance, and a biomass reduction of flying insects. Most of previous studies have been performed at single sites, or were spatially restricted at the landscape level. In this study, we analyse trends of species richness and shifts in species composition of butt...
Article
Herein we report the discovery of a novel series of phosphodiesterase 10A inhibitors. Optimization of a HTS hit (17) resulted in potent, selective, and brain penetrant 23 and 26; both exhibited much lower clearance in vivo and decreased volume of distribution (rat PK) and have thus the potential to inhibit the PDE10A target in vivo at a lower effic...
Article
Full-text available
Michael Ochse, 48, Chemiker, Falterexperte, Biospharenreservat Pfalzerwald-Nordvogesen: "Im Sommer fahre ich zweimal pro Woche in den Wald, um eine Lichtfalle aufzustellen und Nachtfalter zu beobachten. Faszinierend, was die Natur hervorgebracht hat: all die Farben, Muster und Formen! Schmetterlingsforschung ist seit 30 Jahren meine private Leiden...
Article
Full-text available
From Uganda Euchromia manfredi nov.sp. and from Tanzania Euchromia deprinsi nov.sp. are described. The male holotype, paratypes, the male genital structure, the habitat of E. manfredi nov.sp. and the morphological most similar species Euchromia hampsoni Seitz, 1926 are illustrated. Es werden aus Uganda Euchromia manfredi nov.sp. sowie aus Tansania...
Article
The glycine transporter 1 (GlyT1) has emerged as a key novel target for the treatment of schizophrenia. Herein, we report the synthesis and biological evaluation of aminotetralines and aminochromanes as novel classes of competitive GlyT1 inhibitors. Starting from a high-throughput screening hit, structure-activity relationship studies led first to...
Article
Full-text available
Development in faunistic research and bibliography on butterflies and moths of Pfalz , Rheinhessen, and the lower Nahetal (Rheinland-Pfalz). - Research on butterflies and moths in Pfalz, Rheinhessen, and the lower Nahetal has changed during the past two and a half decades. Up to the 1990s, a comparatively small number of lepidopterologists collect...
Article
Full-text available
Abstract. The results of field work conducted during the second Afrotropical Workshop (2014) on Lepidoptera in Kibale National Park and Mpanga Forest (Mpigi District) in Uganda are published.The aim was to establish a species inventory for these locations. Following a description of the investigated sites a comprehensive annotated species lists for...
Article
Full-text available
Faunistic information for 38 species of Thyretina (Erebidae, Arctiinae) in the West African countries Cameroon, Ghana, Guinea and Liberia is given. Based on the collecting localities the affinity to rain forest habitats in the nowadays highly degraded landscapes is given. The following seven new species and a taxonomic change are produced: Balacra...
Article
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The genus Tervurenia gen. nov. is designated as new and its single species T. eloumdeni spec. nov. is described from western and central Africa (Afrotropical region). The genus is separable from its closely related genera by the simultaneous occurrence in males of pectinate antenna, extremely reduced, lobate hindwings, and the tuft of elongate scal...
Conference Paper
Full-text available
Background: Schizophrenia is prevalent in about 1% of the population worldwide. Approved antipsychotic drugs primarily affect positive symptoms such as delusions and hallucinations by modulation of dopaminergic function. In contrast, cognitive and negative symptoms, such as anhedonia, are poorly medicated and represent a large unmet medical need. A...
Patent
The invention relates to fused heterocyclic compounds with affinity to S1P receptors, pharmaceutical compositions comprising such compounds, the use of such compounds in the treatment, alleviation or prevention of diseases and conditions in which an SIP receptor is involved or in which modulation of the endogenous SIP signaling system via an S1P re...
Conference Paper
Elizabeth L VAN DER KAM1, Sean C TURNER1, Michael OCHSE1, Jeroen VAN BERGEIJK1, Reinhold MUELLER1, Mario MEZLER1, Katja HEMPEL1, Adrian HOBSON2, Christopher M HARRIS2, Alfred HAHN1, Anton BESPALOV1, Beatrice RENDENBACH-MUELLER1 1AbbVie Deutschland GmbH & CO KG, 2AbbVie Bioresearch Center Objective: Sphingosine-1-phosphate (S1P) plays an importan...
Patent
The present invention relates to tetrahydroisoquinoline of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such tetrahydroisoquinolines, and the use of such tetrahydroisoquinolines for therapeutic purposes. The tetrahydroisoquinolines are GlyT1 inhibitors.
Patent
The present invention relates to tetraline and indane derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such tetraline and indane derivatives, and the use of such tetraline and indane derivatives for therapeutic purposes. The tetraline and indane derivatives...
Patent
The present invention relates to phenalkylamine derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such phenalkylamine derivatives, and the use of such phenalkylamine derivatives for therapeutic purposes. The phenalkylamine derivatives are GlyT1 inhibitors.
Patent
The present invention relates to aminoindane derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such aminoindane derivatives, and the use of such aminoindane derivatives for therapeutic purposes. The aminoindane derivatives are GlyT1 inhibitors.
Patent
Full-text available
The invention relates to compounds of general formula (I), corresponding enantiomeric, diastereomeric and/or tautomeric forms thereof as well as pharmaceutically acceptable salts thereof and the prodrugs of said compounds. The invention also relates to the use of said compounds as binding partners for 5-HT5 receptors for treating diseases that are...
Article
Full-text available
The historical and actual distribution of Distoleon tetragrammicus (Fabricius, 1798) in Southern Germany is described. In Rheinland-Pfalz, Saarland, Hessen, Bayern and Baden-Württemberg the species lives in many cases in light deciduous and coniferous forests. It is found mainly from the end of June until the middle of August.
Patent
The present invention relates to heterocyclic compounds of the formula (I) or a physiologically tolerated salt thereof. The present invention also relates to pharmaceutical compositions comprising such heterocyclic compounds, and the use of such heterocyclic compounds for therapeutic purposes.
Article
Full-text available
Results of the 14th „GEO day of biodiversity“ in the transboundary biosphere reserve Palatinate Forest - Northern Vosges As part of the GEO Biodiversity Day, on 16 June 2012 an assessment of the flora and fauna in the cross-border Palatinate Forest-North Vosges Biosphere Reserve was undertaken. The Rhineland-Palatinate Nature and Environment Founda...
Article
Full-text available
Abstract. A report on a workshop held in 2011 covering Afrotropical Lepidoptera research organised by the Butterfly Conservation Society, Ghana (BCGHANA) is given. The post-event field trip in various localities in southern Ghana revealed many interesting Lepidoptera records, including 33 species of Sphingidae, 31 species of Lasiocampidae, 23 speci...
Article
Full-text available
Abstract. We describe the identification of polliniaria of the orchid genus Epidendrum Linnaeus on the proboscis of the sphingid moth Adhemarius sexoculata Grote, 1867. Species designation of the plants revealed that the plant species is Epidendrum nocturnum Jacquin, 1760. The potential of ecological pollinatorplant pairings is discussed as a museu...
Patent
Full-text available
The present invention relates to guanidine compounds of the general formula I corresponding enantiomeric, diastereomeric and/or tautomeric forms thereof as well as pharmaceutically acceptable salts thereof. The present compound further relates to the use of guanidine compounds as binding partners for 5-HT5 receptors for the treatment of diseases w...
Patent
Full-text available
The present invention relates to 4-benzylaminoquinolines of the formula (I) or physiologically tolerated salts thereof. The invention relates to pharmaceutical compositions comprising such quinolines, and the use of such quinolines for therapeutic purposes. The quinolines are GIyTI inhibitors.
Article
In the forebrain, synaptic glycine concentrations are regulated through the glycine transporter GlyT1. Because glycine is a coagonist of the N-methyl-D-aspartate (NMDA) receptor (NMDAR), which has been implicated in schizophrenia, inhibition of GlyT1 is thought to provide an option for the treatment of schizophrenia. In support of this hypothesis,...
Article
Full-text available
The holo-mediterranean owlet moth Luperina dumerilii (DuroNCHEL, 1826) has been found in Germany exclusively in warmer areas of the southern regions, namely in the Markgrafler Rheinebene, the Kaiserstuhl, the Rheingau, the Nahetal, and in Mainfranken. In the latter, a caterpillar was found in nature for the first time. The habitat of the species is...
Article
The iridoid alkaloid gardenamide A (3) was isolated from the phytochemically uninvestigated East African Rubiaceae species Rothmannia urcelliformis (Hiern) Bullock. Its absolute stereostructure was determined by quantum chemical CD calculations, which constitutes the first application of this useful chiroptical tool within the class of iridoids. An...
Article
The biaryl axis is the joint central structural element of a broad variety of structurally (in particular stereochemically) and biosynthetically interesting as well as pharmacologically promising natural products. The increasing importance of this challenging class of secondary metabolites, its widespread occurrence, its pharmacological implication...
Article
The isolation of 6-hydroxyluteolin-7-O-(1"-alpha-rhamnoside) from the Central American epiphyte Vriesea sanguinolenta Cogn. and Marchal (Bromeliaceae) is described here. Its stereostructure was established by spectroscopic methods and an X-ray structure analysis of its hepta-O-acetyl derivative. This flavonoid glycoside had previously been reported...
Article
The stereoselective total synthesis of the antimalarial korupensamines A (1a) and B (1b) by application of the "lactone method" is described. Key steps of this first atropo-selective access to 5,8'-coupled naphthylisoquinoline alkaloids were the regioselective intramolecular coupling of ester 8 to give the configurationally labile lactone-bridged b...
Article
The total synthesis of the N-quaternary isoquinoline alkaloid gentrymine B (1) and of its unnatural enantiomer as well as its oxidative degradation is described. A further proof of stereostructure and hints at the biosynthetic origin of the unusual S,S-configuration in gentrymine B (1) were obtained by an additional biomimetic synthesis of 1 from t...
Article
Configurationally unstable biaryl lactones of type (M)-1 (P)-1 and ring-opened 2-acyl-2‘-hydroxy biaryl compounds of type (M)-4 (P)-4 are versatile precursors for the atroposelective preparation of axially chiral biaryls. The activation barriers of their atropisomerization process, which constitutes a fundamental precondition for the dynamic kineti...
Data
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and...
Article
Full-text available
C14H15BrO2, monoclinic, P121/c1 (No. 14), a = 9.655(1) Å, b = 14.337(2) Å, c = 9.692(2) Å, β = 108.07(1)°, V = 1275.4 Å3, Z = 4, Rgt(F) = 0.057, wR(F) = 0.052, T = 293 K.
Article
The first isolation of 4-oxonicotinamide-1-(1′-β-d-ribofuranoside) from a nonmammalian source, the West African plant Rothmannia longiflora Salisb. (Rubiaceae), is described. Its stereostructure was established by spectroscopic methods and an X-ray structure analysis of its tri-O-acetyl derivative. This N-glycoside had previously been isolated only...
Article
Full-text available
From the leaves of Burchellia bubalina (Rubiaceae) pure P- and a-gardiol have been isolated, the latter in crystalline form for the first time. X-ray analysis of P-gardiol establishes its relative configuration. Treatment of the tosyl derivative of P-gardiol with base affords a crystalline elimination product amenable to X-ray analysis. Evidence is...
Article
The regio- and stereoselective total synthesis of the antimalarial naphthylisoquinoline alkaloid and michellamine-'half', korupensamine B (1b), is described. The synthesis involves the ester-type prefixation of its protected isoquinoline moiety 3 with a monocyclic benzoic acid 2, the intramolecular coupling to give a lactone-bridged biaryl intermed...
Article
The first synthesis of an N-quaternary salt of a naphthylisoquinoline alkaloid, N,N-dimethyldioncophyllinium A iodide, is described. For this potential natural product, a degradative procedure for the unambiguous stereoanalysis of the stereogenic centers has been elaborated. It shows enhanced anti-plasmodial activity in vitro towards Plasmodium fal...
Article
Full-text available
The naphthylisoquinoline alkaloids, only found in the two families Ancistrocladaceae and Dioncophyllaceae, show numerous promising pharmacological properties, e.g. anti-malarial and anti-HIV activities. Using a broad diversity of methods including various coupling techniques like LC-NMR and LC-MS, the isolation and structural elucidation of nearly...

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