Michael NordineUniversity Hospital Frankfurt · Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy
Michael Nordine
Doctor of Medicine
R&D: smart bio-signal monitoring solutions. Human physiological research. Resident-Clinical Anesthesiology.
About
27
Publications
133,235
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Citations
Introduction
Medical Doctor/Medical Researcher. Areas of expertise: Artificial Gravity, Clinical Anesthesiology, Human Physiology, Non-invasive physiological monitoring, Time Series based Human physiological data analysis, Human physiology in extreme environments (Micro/Hyper-Gravity, Immersion, Surgery, Clinical).
Additional affiliations
March 2018 - December 2021
Position
- Medical Doctor
Description
- Medical research/development in non-invasive multi-dimensional hemodynamic monitoring solutions. Medical residency in clinical anesthesiology.
November 2016 - January 2018
MIAMED
Position
- Copywriter International
July 2015 - October 2016
Education
October 2011 - March 2018
January 2001 - May 2005
Publications
Publications (27)
BACKGROUND
Peri-operative and critically ill patients often experience mild to moderate hypovolaemic shock with preserved mean arterial pressure (MAP), heart rate (HR) and decreased stroke volume index (SVI).
OBJECTIVES
The aim of this study was to evaluate echocardiographic parameters during simulated mild to moderate central hypovolaemia.
DES...
Introduction: Orthostatic dysregulation occurs during exposure to an increased gravitational vector and is especially common upon re-entering standard Earth gravity (1 g) after an extended period in microgravity (0 g). External peripheral skin cooling (PSC) has recently been described as a potent countermeasure against orthostatic dysregulation dur...
Background
To implement a goal-directed fluid therapy (GDFT) protocol using crystalloids in hip revision arthroplasty surgery within a quality management project at a tertiary hospital using a monocentric, prospective observational study.
Methods
Adult patients scheduled for elective hip revision arthroplasty surgery were screened for inclusion in...
Abstract: Background: Non-invasive tracking of beat-to-beat pulse transit time (PTT) via piezoelectric/piezocapacitive sensors (PES/PCS) may expand perioperative hemodynamic monitoring. This study evaluated the ability for PTT via PES/PCS to correlate with systolic, diastolic, and mean invasive blood pressure (SBPIBP, DBPIBP, and MAPIBP, respective...
Background: Non-invasive acquistion of beat-to-beat pulse transit time (PTT) via piezoelectric/piezocapacitive sensors (PES/PCS) may expand perioperative hemodynamic monitoring. This study evaluated the ability for PTT via PES/PCS to correlate with systolic, diastolic, and mean invasive blood pressure (SBPIBP, DBPIBP, and MAPIBP) and to detect SBPI...
Objectives
The objective of the study was to compare the overall feasibility, respiratory and hemodynamic stability as well as process times of a Dexmedetomidine based sedative regime compared with general anesthesia amongst patients undergoing MitraClip procedures.
Design
Retrospective cohort study
Setting
Single tertiary university center
Part...
Introduction: The human dive reflex (HDR), an O2 conserving reflex, is characterised by an interplay of central parasympathetic and peripheral sympathetic reactions, which are presumed to operate independently of each other. The HDR is fully activated during apnoea with facial immersion in water and complete immersion in water is thought to increas...
Introduction: Rapid environmental changes, such as successive hypoxic-hypoxic orthostatic challenges (SHHOC) occur in the aerospace environment, and the ability to remain orthostatically resilient (OR) relies upon orchestration of physiological counter-responses. Counter-responses adjusting for hypoxia may conflict with orthostatic responses, and a...
Purpose
Myocardial opioid receptors were demonstrated in animals and humans and seem to colocalize with membranous and sarcolemmal calcium channels of the excitation–contraction coupling in the left ventricle (LV). Therefore, this study investigated whether blockade of the cardiac opioid system by naltrexone would affect cardiac function and neuroh...
(1) Background: To evaluate time-dependent right ventricular (RV) performance in patients with COVID-19-associated acute respiratory distress syndrome (ARDS) undergoing intensive care (ICU) treatment. (2) Methods: This prospective observational study included 21 ICU patients with COVID-19-associated ARDS in a university hospital in 2020 (first wave...
The number of high-risk patients undergoing surgery is growing. To maintain adequate hemodynamic functioning as well as oxygen delivery to the vital organs (DO2) amongst this patient population, a rapid assessment of cardiac functioning is essential for the anesthesiologist. Pinpointing any underlying cardiovascular pathophysiology can be decisive...
Background
The number of high-risk patients undergoing surgery is steadily increasing. In order to maintain and, if necessary, optimize perioperative hemodynamics as well as the oxygen supply to the organs (DO2) in this patient population, a timely assessment of cardiac function and the underlying pathophysiological causes of hemodynamic instabilit...
Objectives:
Transcatheter aortic valve replacement (TAVR) has become an alternative treatment for patients with symptomatic aortic stenosis not eligible for surgical valve replacement due to a high periprocedural risk or comorbidities. However, there are several areas of debate concerning the pre-, intra- and post-procedural management. The standa...
Orthostatic instability is one of the main consequences of weightlessness or gravity challenge and plays as well a crucial role in public health, being one of the most frequent disease of aging. Therefore, the assessment of effective countermeasures, or even the possibility to predict, and thus prevent orthostatic instability is of great importance...
Cardiovascular deconditioning occurs in astronauts during microgravity exposure, and may lead to post-flight orthostatic intolerance, which is more prevalent in women than men. Intermittent artificial gravity is a potential countermeasure, which can effectively train the cardiovascular mechanisms responsible for maintaining orthostatic integrity. S...
Introduction: The physiological adaptations encountered during changes in gravitational force (+Gz) are highly relevant for manned space exploration and countermeasure research and development. While changes in cardiovascular parameters during +Gz challenges have been observed and described in numerous papers, the influence of gender and anthropome...
Intro: Rapid changes in environmental conditions can occur during escape velocity, sub-orbital flight, and atmospheric re-entry. Such a scenario would inherently expose a crew to rapid onset hypoxia and hyper-gravity (+G), which could lead to crew incapacitation, and mission compromise. The likelihood of such a scenario occurring becomes more proba...
Continuous recordings of core body temperature (CBT) are a well-established approach in describing circadian rhythms. Given the discomfort of invasive CBT measurement techniques, the use of skin temperature recordings has been proposed as a surrogate. More recently, we proposed a heat-flux approach (the so-called Double Sensor) for monitoring CBT....
Purpose
We hypothesized that lower body microvessels are particularly challenged during exposure to gravity and hypergravity leading to failure of resistance vessels to withstand excessive transmural pressure during hypergravitation and gravitation-dependent microvascular blood pooling.
Methods
Using a short-arm human centrifuge (SAHC), 12 subjects...
Introduction: Exposure to hypoxic, hyper-gravitational, and combined hypoxic/hyper-gravity environments can occur during exploration of new and extreme environments. Exposure to these situations can lead to the stimulation of peripheral chemoreceptors via hypoxia, as well as baroreceptor stimulation via hyper-gravity, which trigger a compensatory a...
Introduction: The goal of this study was to determine which anthropometric factors measured via air displacement plethysmography (ADP) play a significant role in augmenting orthostatic stability during sustained acceleration G-force (+G) exposure in a short arm human centrifuge (SAHC). The authors hypothesized that test subjects with a greater norm...
Introduction The purpose of this investigation was to examine the endogenous physiological cardiovascular counter measures active during 2 rounds of alternating +Gz s in a short arm human centrifuge (SAHC). We hypothesized that the hemodynamic mechanisms at play during initial +Gz, such as increases in heart rate (HR) and total peripheral resistanc...
Introduction The aim of this study was to determine which anthropometric factors play a significant role in maintaining orthostatic stability prior to hyper gravity +Gz exposure in a short arm human centrifuge (SAHC). Methods 20 +Gz naive test subjects, were exposed to two rounds of +2Gz in a SAHC. The G force profile followed a plan of nine phases...
Background
Splenic contraction has been observed to occur in humans during exposition to adverse environmental conditions. This contraction of the spleen results in the expulsion of stored erythrocytes, in which tissue oxygenation is maintained . These splenic contractions are proposed to be an adaptation mechanism, which are primarily triggered du...
Questions
Questions (39)
Hello. I need to perform a logistics regression for a small sample size (n=20) to determine predictive factors for an event. The only problem is that a few data points skew the whole sample, leading me to receive a massive Odds Ratio of >200. This is not a realistic result, and am wondering how to best negate this. How does one properly perform a logistical regression with small sample sizes with high variance in certain variables? Anyone have any tips or tricks?
Thanks in advance
Does anyone have any objective criteria (either from publications or technical reports) detailing what typical +Gz loads and durations are for current manned space craft (Orion, Dragon, Starship for example) during take off and orbital re-entry? I am trying to determine an appropriate +Gz Cut-Off. For the Space-Shuttle, I have read it was about +2.5 Gz, but could not find an exact duration of this load. At minimal, I would need a source saying what the expected +Gz load would be for a manned crew for current space craft.
Thanks in advance.
I have a time series analysis, in which I have determined a mean per each phase. When I run an ANOVA Test with repeated measures comparing the phases, I receive a non significant result, despite a visible difference between means per phase. I would assume that this is due to high variability amongst the phases. If I run the same analysis, albeit with a T-Test, then I receive a significant difference between 2 phases. Question is, is this discrepancy due to variability, or another factor? Can one just use T-test on a phase per phase basis, or does a multiple phase analysis require an ANOVA test?
In reporting systemic vascular resistance measurements, one can use mmHg/min/L, dyn/sec/cm5, or pascals per second/cm2. Is there a general consensus from the field of applied physiology or medical physiology as to which one to use? There seems to be a varied use of SVR units used amongst different publications. Any suggestions would be greatly appreciated.
Thank you
Hello, I am looking to verify if a -20/-40 mmHg LBNP load is equivalent to +1/+2Gz stimulus in an SAHC in humans. I assume this is correct, however I am looking for any data which would validate this. Any info would be helpful. Also, bonus points would go to any paper which directly compares the 2 methods.
Thank you
There are a few papers that discuss what the Compensatory reserve index (CRI) is, and its relevance during simulated hemorrhage. These papers only elude that the CRI is calculated using a unique algorithm. How exactly then, is it calculated. i.e which parameters does one need to calculate (MAP, HR, SV, TRP, etc)? Also, can one calculate the CRI retrospectively?
It is my understanding that, regardless of the formula used, that RMR is 15% higher than BMR. So, theoretically, if one had BMR's from a large sample (humans), and just multiplied by 1.15, then one should have a reliable RMR for everyone, correct? Would anyone have any different advice or strategies for this?
I am attempting to track down reliable data concerning BMI/BSA (anthropometrics) of the German population. So far, my search has not revealed any optimal data. I would be interested in Data from the last 10 years ideally.
Thank you
Today marks the day in which the renewable resource of the planet have been exhausted, which creates a so-called Ecological Debt. I would like to know how statistics for this statement are compiled? How serious is this claim on scientific merit?
During my preparation for state boards in Germany, I have come across a trend particularly for viral infections. In complete blood count analysis during an acute infection, one often finds an increase in Lymphocytes as well as a decrease in Thrombocyte counts. Is the thrombocytopenia a reaction due to this lymphocytopenia (due to bone marrow proliferation and cytokine release), or are the thrombocytes being degraded as a result of the infection (increase in spleen size due to sequestration or increased turnover of thrombocytes)? Any insight on this would be valuable.
Thanx
