Michael A Nitsche

Michael A Nitsche
Leibniz Research Center for Working Enviroment and Human Factors | IFADO · Psychology and Neurosciences

Prof., MD

About

624
Publications
186,404
Reads
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58,378
Citations
Introduction
Michael A. Nitsche is Director of the Dept. Psychology and Neurosciences at the Leibniz Research Centre for Working Environment and Human Factors in Dortmund, and holds a position as scientific staff member at the Dept. Neurology of the University Medical Center Bergmannsheil, Bochum, Germany. He is a leading expert in plasticity research in humans, including non-invasive brain stimulation, neuropsychopharmacology, and cognition.
Additional affiliations
May 2015 - present
Leibniz Research Center for Working Enviroment and Human Factors
Position
  • Managing Director
January 1999 - April 2015
University Medical Center, Georg-August-University, Goettingen
Position
  • Consultant, Group Leader

Publications

Publications (624)
Article
In paragraph 3.5 of their article, the authors provide some information about the nonmotor properties of tongue motor cortex. As a complement to the interesting work of Bono et al. (2022), in this commentary we focus on this aspect by addressing the link of the tongue motor cortex to the reward system, and its relevance for emotion processing, soci...
Article
Full-text available
Earlier research suggested that after 210 practice trials, the supplementary motor area (SMA) is involved in executing all responses of familiar 6-key sequences in a discrete sequence production (DSP) task (Verwey, Lammens, and van Honk, 2002). This was indicated by slowing of each response 20 and 25 min after the SMA had been stimulated for 20 min...
Article
The purpose of this single subject study was to investigate whether transcranial direct current stimulation (tDCS) applied to both hemispheres combined with speech therapy can improve language learning in a pair of 5-year-old twins with corpus callosum dysgenesis (CCD). The treatment protocol included anodal tDCS with simultaneous speech therapy in...
Article
Circadian rhythms have received increasing attention within the context of mental disorders. Evening chronotype has been associated with enhanced risk to develop anxiety and post-traumatic stress disorder (PTSD). The classical fear conditioning paradigm is a powerful tool to reveal key mechanisms of anxiety and PTSD. We used this paradigm to study...
Article
Full-text available
Attempts to enhance human memory and learning ability have a long tradition in science. This topic has recently gained substantial attention because of the increasing percentage of older individuals worldwide and the predicted rise of age-associated cognitive decline in brain functions. Transcranial brain stimulation methods, such as transcranial m...
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Background With increasing obese populations worldwide, developing interventions to modulate food-related brain processes and functions is particularly important. Evidence suggests that transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) may modulate the reward–control balance towards facilitation of cogni...
Article
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Implicit motor learning and memory involve complex cortical and subcortical networks. The induction of plasticity in these network components via non-invasive brain stimulation, including transcranial direct current stimulation (tDCS), has shown to improve motor learning. However, studies showing these effects are mostly restricted to stimulation o...
Article
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Background Stuttering is a disorder that begins in childhood and can persist into adulthood. In the present study, it was hypothesized that the combined intervention of transcranial direct current stimulation (tDCS) and Delayed Auditory Feedback (DAF) would cause greater improvement in speech fluency in comparison to the intervention with DAF alone...
Article
Phonological awareness (PA) training is a core intervention in dyslexia. Recently, transcranial direct current stimulation (tDCS) has been probed as a complementary intervention for increasing reading ability in dyslexia, but not for enhancing the efficacy of PA. The aim of the current study was thus to examine whether tDCS combined with a PA inter...
Article
Introduction: Over the last century, a variety of theories have been proposed to explain the etiology of stuttering, but the exact cause and neurological origin of it are still uncertain. The aim of the present study is to investigate the correlation between stuttering severity and ERP measures. Methods: 36 adults were recruited in this study. Thi...
Article
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Dopamine is a key neuromodulator of neuroplasticity and an important neuronal substrate of learning, and memory formation, which critically involves glutamatergic N-methyl-D-aspartate (NMDA) receptors. Dopamine modulates NMDA receptor activity via dopamine D1 and D2 receptor subtypes. It is hypothesized that dopamine focuses on long-term potentiati...
Article
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Low-intensity transcranial electrical stimulation (tES), including alternating or direct current stimulation, applies weak electrical stimulation to modulate the activity of brain circuits. Integration of tES with concurrent functional MRI (fMRI) allows for the mapping of neural activity during neuromodulation, supporting causal studies of both bra...
Article
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Background Neuromodulatory effects of transcranial direct current stimulation (tDCS) in older humans have shown heterogeneous results, possibly due to sub-optimal stimulation protocols associated with limited knowledge about optimized stimulation parameters in this age group. We systematically explored the association between the stimulation dosage...
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Stimulation of the vagus nerve, a parasympathetic nerve that controls the neuro-digestive, vascular, and immune systems, induces pain relief, particularly in clinical conditions such as headache and rheumatoid arthritis. Transmission through vagal afferents towards the nucleus of the solitary tract (NST), the central relay nucleus of the vagus nerv...
Article
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Non-invasive direct current stimulation (DCS) of the human brain induces neuronal plasticity and alters plasticity-related cognition and behavior. Numerous basic animal research studies focusing on molecular and cellular targets of DCS have been published. In vivo, ex vivo, and in vitro models enhanced knowledge about mechanistic foundations of DCS...
Article
Objective Performance accuracy and reaction time in cognitive tasks are routinely used to evaluate the efficacy of tDCS to affect cognitive task performance. tDCS alters the excitability of targeted brain areas and thereby alters performance of cognitive tasks. The drift diffusion model (DDM) provides some additional measures to explore information...
Article
Noninvasive brain stimulation techniques (NiBS) have gathered substantial interest in the study of dementia, considered their possible role in help defining diagnostic biomarkers of altered neural activity for early disease detection and monitoring of its pathophysiological course, as well as for their therapeutic potential of boosting residual cog...
Article
Full-text available
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation procedure to modulate cortical excitability and related brain functions. tDCS can effectively alter multiple brain functions in healthy humans and is suggested as a therapeutic tool in several neurological and psychiatric diseases. However, variability of results is...
Chapter
The original version of chapter 15, page 283, and chapter 35, page 667, had wrongly attributed author affiliation to "University of Sao Paulo, Institute of Psychiatry, Sao Paulo, Brazil, Department of Psychiatry University of British Columbia, Vancouver, Canada, Department of Experimental Psychology, University of Oxford, Oxford, UK, Department of...
Article
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Network-level synchronization of theta oscillations in the cerebral cortex is linked to many vital cognitive functions across daily life, such as executive functions or regulation of arousal and consciousness. However, while neuroimaging has uncovered the ubiquitous functional relevance of theta rhythms in cognition, there remains a limited set of...
Article
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Combining non-invasive brain stimulation (NIBS) with resting-state functional magnetic resonance imaging (rs-fMRI) is a promising approach to characterize and potentially optimize the brain networks subtending cognition that changes as a function of age. However, whether multifocal NIBS approaches are able to modulate rs-fMRI brain dynamics in aged...
Preprint
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BACKGROUND Previous research revealed a number of biological and environmental factors modulating cognitive functioning over a human’s lifespan. However, the relationships and interactions between biological factors, such as genetic polymorphisms, immunological parameters, metabolic products or infectious diseases, and environmental factors, like l...
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Background: Previous research revealed several biological and environmental factors modulating cognitive functioning over a human's lifespan. However, the relationships and interactions between biological factors (eg, genetic polymorphisms, immunological parameters, metabolic products, or infectious diseases) and environmental factors (eg, lifesty...
Article
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Over the last decades, interest in transcranial electrical stimulation (tES) has grown, as it might allow for causal investigations of the associations between cortical activity and cognition as well as to directly influence cognitive performance. The main objectives of the present work were to assess whether tES can enhance the acquisition and app...
Article
Background and purpose of the study: Individuals with general anxiety disorder (GAD) have deficits in emotional and cognitive processing, including cognitive bias, which plays a causal role in anxiety. Hyperactivity of the ventromedial prefrontal cortex (vmPFC) and dorsolateral prefrontal cortex (dlPFC) is assumed to be involved in cognitive bias....
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The accurate recognition of others’ facial expressions is a core skill for social interactions. The left Dorsolateral Prefrontal Cortex (L-DLPFC) represents a key node in the network for facial emotion recognition. However, its specific role is still under debate. As such, the aim of the current neuromodulation study was to assess the causal role o...
Article
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The present study aimed to investigate the effect of transcranial alternating current stimulation (tACS) on the primary motor cortex (M1) during action observation, and subsequent action execution, on motor cortex excitability. The participants received tACS at 10 Hz or 20 Hz, or a sham stimulation over the left M1 for 10 min while they observed a...
Article
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Mouse models of non-alcoholic fatty liver disease (NAFLD) are required to define therapeutic targets, but detailed time-resolved studies to establish a sequence of events are lacking. Here, we fed male C57Bl/6N mice a Western or standard diet over 48 weeks. Multiscale time-resolved characterization was performed using RNA-seq, histopathology, immun...
Chapter
Non-invasive brain stimulation with weak electrical currents (transcranial electrical stimulation, tES), including direct (transcranial direct current stimulation, tDCS) or alternating current stimulation (transcranial alternating current stimulation, tACS), has been developed in neuroscience research in the last decades and since then has become a...
Chapter
TDCS is a promising method for altering cortical excitability with clinical implications. It has been increasingly used in children and adolescents especially in recent years. Yet, its potential target populations, developmental aspects, and efficacy parameters still require further investigation. In this chapter, we discuss the physiological mecha...
Chapter
The most common adverse effects of tDCS are erythema (skin redness), burning, tingling, itching, headache, and discomfort on the site of stimulation. These side effects occur in up to one-third of patients and are generally mild, short lived, and well tolerated. Skin burning is an uncommon side effect that is often associated with repeated tDCS ses...
Chapter
Transcranial direct current stimulation (tDCS) noninvasively induces cortical excitability alterations via application of continuous, weak direct current through the scalp and has been adopted in clinical settings, particularly in psychiatry, as adjunctive treatment option. This chapter discusses the interaction between tDCS and application of phar...
Article
Full-text available
Targeted memory reactivation (TMR) and transcranial direct current stimulation (tDCS) can enhance memory consolidation. It is currently unknown whether TMR reinforced by simultaneous tDCS has superior efficacy. In this study, we investigated the complementary effect of TMR and bilateral tDCS on the consolidation of emotionally neutral and negative...
Article
Full-text available
Circadian rhythms have natural relative variations among humans known as chronotype. Chronotype or being a morning or evening person, has a specific physiological, behavioural, and also genetic manifestation. Whether and how chronotype modulates human brain physiology and cognition is, however, not well understood. Here we examine how cortical exci...
Article
The COVID-19 pandemic has imposed extraordinary and unpredictable changes on our lifestyle for an unknown duration. Consequently, core aspects of wellbeing including behavior, emotion, cognition, and social interactions are negatively affected. Sleep and circadian rhythms, with an extensive impact on physiology, behavior, emotion, and cognition are...
Article
Introduction: 1) During tES, increasing intracellular Ca2+ levels beyond those needed for inducing LTP may collapse aftereffects. 2) State-dependent plastic aftereffects are reduced when applied during muscle activation as compared to rest. 3) Cortical surround inhibition by antagonistic muscle activation inhibits the center-innervated agonist. O...
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Background Gait problems are an important symptom in Parkinson’s disease (PD), a progressive neurodegenerative disease. Transcranial direct current stimulation (tDCS) is a neuromodulatory intervention that can modulate cortical excitability of the gait-related regions. Despite an increasing number of gait-related tDCS studies in PD, the efficacy of...
Article
Full-text available
Background: Persistence of post-detoxification problems in drug addiction is one of the disadvantages of the ultra-rapid opioid detoxification (UROD) method. Transcranial direct current stimulation (tDCS) has been introduced in experimental addiction treatment for some years. Results of pilot studies suggest that it might be a promising method for...
Article
Full-text available
Background Social Anxiety Disorder (SAD) is the most common anxiety disorder while remains largely untreated. Disturbed amygdala-frontal network functions are central to the pathophysiology of SAD, marked by hypoactivity of the lateral prefrontal cortex (PFC), and hypersensitivity of the medial PFC and the amygdala. The objective of this study was...
Article
Full-text available
Although research provides a rich literature about the influence of emotional states on temporal cognition, evidence about the influence of the style of emotion processing, as a personality trait, on temporal cognition is extremely limited. We provide a novel contribution to the field by exploring the relationship between difficulties of identifyin...
Preprint
Full-text available
Background: Social Anxiety Disorder (SAD) is the most common anxiety disorder while remains largely untreated. Disturbed amygdala-frontal network functions are central to the pathophysiology of SAD, marked by hypoactivity of the lateral prefrontal cortex (PFC), and hypersensitivity of the medial PFC and amygdala. The objective of this study was to...
Article
Full-text available
Background The serotonergic system has an important impact on basic physiological and higher brain functions. Acute and chronic enhancement of serotonin levels via selective serotonin reuptake inhibitor (SSRI) administration impacts neuroplasticity in humans, as shown by its effects on cortical excitability alterations induced by non-invasive brain...
Preprint
Full-text available
Circadian rhythms have natural relative variations among humans known as chronotype. Chronotype or being a morning or evening person, has a specific physiological, behavioural, and also genetic manifestation. Whether and how chronotype modulates human brain physiology and cognition is, however, not well understood. Here we examined how chronotype a...
Preprint
Full-text available
Although research provides a rich literature about the influence of emotional states on temporal cognition, evidence about the influence of the style of emotion processing, as a personality trait, on temporal cognition is extremely limited. We provide a novel contribution to the field by exploring the relationship between difficulties of identifyin...
Article
Full-text available
Since the addition of fluoride to drinking water in the 1940s, there have been frequent and sometimes heated discussions regarding its benefits and risks. In a recently published review, we addressed the question if current exposure levels in Europe represent a risk to human health. This review was discussed in an editorial asking why we did not ca...
Presentation
Full-text available
Best paper prize 2021 - International Neuroethics Society
Article
Transcranial direct stimulation, a non-invasive neurostimulation technique for modulating cortical excitability, and yoga have both respectively been shown to positively affect cognition. While preliminary research has shown that combined transcranial direct stimulation and meditation may have synergistic effects on mood and cognition, this was...
Article
[SEE comments for the full-text] Abstract: Theory of mind (ToM) is the ability to attribute subjective mental states to oneself and others and is significantly impaired in autism spectrum disorder (ASD). A frontal-posterior network of regions including the ventromedial prefrontal cortex (vmPFC) and temporoparietal junction (TPJ) is involved in ToM....
Article
Full-text available
Dopamine is crucial for neuroplasticity, which is considered to be the neurophysiological foundation of learning and memory. The specific effect of dopamine on plasticity such as long-term potentiation (LTP) and long-term depression (LTD) is determined by receptor subtype specificity, concentration level, and the kind of plasticity induction techni...
Article
The present study aimed to assess the impact of transcranial direct current stimulation (tDCS) on different domains of inhibitory control in children with mild or severe ADHD symptoms. Twenty- four children with ADHD, in two groups with severe and mild symptoms, received anodal or sham tDCS over the right dlPFC during performing inhibitory control...
Preprint
Full-text available
Sleep and cognition are strongly linked via their impact on synaptic strength. Whether and how sleep deprivation modulates human brain physiology and cognition is, however, not well understood. Here we examined how cortical excitability, inducibility of LTP- and-LTD-like plasticity, learning and memory formation and higher-order cognition are affec...
Preprint
Theory of Mind (ToM) is the ability to attribute subjective mental states to oneself and others and is significantly impaired in Autism Spectrum Disorder (ASD). A frontal-posterior network of regions including the ventromedial prefrontal cortex (vmPFC) and temporoparietal junction (TPJ) is involved in ToM. Previous studies show an underactivation o...
Article
Transcranial direct current stimulation (tDCS) applied over the prefrontal cortex has been shown to improve behavioral responsiveness in patients with disorders of consciousness following severe brain injury, especially those in minimally conscious state (MCS). However, one potential barrier of clinical response to tDCS is the timing of stimulation...
Article
Full-text available
Stroke patients frequently suffer from chronic limb pain, but well-suited treatment approaches have been not established so far. Transcranial direct current stimulation (tDCS) is a safe and non-invasive brain stimulation technique that alters cortical excitability, and it has been shown that motor cortex tDCS can reduce pain. Some data also suggest...
Preprint
Executive functions (EFs), or cognitive control, are higher-order cognitive functions needed for adaptive goal-directed behaviours and are significantly impaired in majority of neuropsychiatric disorders. Different models and approaches are proposed for describing how EFs are functionally organized in the brain. One popular and recently proposed or...
Article
Full-text available
Executive functions (EFs), or cognitive control, are higher-order cognitive functions needed for adaptive goal-directed behaviours and are significantly impaired in majority of neuropsychiatric disorders. Different models and approaches are proposed for describing how EFs are functionally organized in the brain. One popular and recently proposed or...
Article
Full-text available
Background Neural oscillations in the cerebral cortex are associated with a range of cognitive processes and neuropsychiatric disorders. However, non-invasively modulating oscillatory activity remains technically challenging, due to limited strength, duration, or non-synchronization of stimulation waveforms with endogenous rhythms. Objective /Hypo...
Article
Full-text available
Background: tDCS modulates cortical plasticity and has shown potential to improve cognitive/motor functions in healthy young humans. However, age-related alterations of brain structure and functions might require an adaptation of tDCS-parameters to achieve a targeted plasticity effect in older humans and conclusions obtained from young adults might...
Article
Anxiety disorders are among the most prevalent mental disorders. Present treatments such as cognitive behavior therapy and pharmacological treatments show only moderate success, which emphasizes the importance for the development of new treatment protocols. Non-invasive brain stimulation methods such as repetitive transcranial magnetic stimulation...
Article
Full-text available
Background Noradrenaline (NA) has an important role as a neuromodulator of the central nervous system. Noradrenergic enhancement was recently shown to enhance glutamate-dependent cortical facilitation, and long term potentiation-like plasticity. As cortical excitability and plasticity are closely linked to various cognitive processes, here we aimed...
Article
Full-text available
Background The dorsal premotor cortex (PMd) is a key region in bimanual coordination. However, causal evidence linking PMd functionality during motor planning and execution to movement quality is lacking. Objective We investigated how left (PMdL) and right PMd (PMdR) are causally involved in planning and executing bimanual movements, using short-t...