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Michael Mielewczik

Michael Mielewczik
Agroscope · Competitiveness and System Evaluation

Dr. sc. ETH

About

55
Publications
17,950
Reads
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1,403
Citations
Citations since 2016
27 Research Items
1131 Citations
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
Additional affiliations
October 2020 - present
Agroscope
Position
  • Research Associate
January 2018 - September 2020
Rothamsted Research
Position
  • Agroecosystems modeller
October 2014 - March 2018
Imperial College London
Position
  • Fellow

Publications

Publications (55)
Article
Full-text available
To investigate whether discrepancies in trials of use of bone marrow stem cells in patients with heart disease account for the variation in reported effect size in improvement of left ventricular function. Identification and counting of factual discrepancies in trial reports, and sample size weighted regression against therapeutic effect size. Meta...
Article
Full-text available
Most spectral data for the amphibian integument are limited to the visible spectrum of light and have been collected using point measurements with low spatial resolution. In the present study a dual camera setup consisting of two push broom hyperspectral imaging systems was employed, which produces reflectance images between 400 and 2500 nm with hi...
Article
Full-text available
We present a novel method for quantitative analysis of dicot leaf expansion at high temporal resolution. Image sequences of growing leaves were assessed using a marker tracking algorithm. An important feature of the method is the attachment of dark beads that serve as artificial landmarks to the leaf margin. The beads are mechanically constricted t...
Article
Background: Autologous bone marrow stem cell therapy is the greatest advance in the treatment of heart disease for a generation according to pioneering reports. In response to an unanswered letter regarding one of the largest and most promising trials, we attempted to summarise the findings from the most innovative and prolific laboratory. Method...
Article
Full-text available
Background: Photorespiratory carbon metabolism was long considered as an essentially closed and nonregulated pathway with little interaction to other metabolic routes except nitrogen metabolism and respiration. Most mutants of this pathway cannot survive in ambient air and require CO(2)-enriched air for normal growth. Several studies indicate that...
Preprint
Full-text available
ELLEN S. TUPPER was a 19th century expert bee-keeper who was most active during and shortly after the end of the American Civil War. A vigorous writer and apiarist, primarily focused on business interests and opportunities, she became the first female editor of an entomological journal in 1869. Joining the mid-western suffragettes, who at this time...
Article
Full-text available
ELLEN S. TUPPER war eine bekannte amerikanische Bienenzüchterin des 19. Jahrhunderts, die vor allem in der Zeit kurz nach dem amerikanischen Bürgerkrieg aktiv war. Sie arbeitete als Autorin und Imkerin, wobei ihr Fokus primär auf unternehmerische Interessen und sich ergebenden Gelegenheiten lag. Im Jahr 1869 wurde sie die erste Herausgeberin eines...
Preprint
Full-text available
In the era of high-throughput visual plant phenotyping, it is crucial to design fully automated and flexible workflows able to derive quantitative traits from plant images. Over the last years, several software supports the extraction of architectural features of shoot systems. Yet currently no end-to-end systems are able to extract both 3D shoot t...
Article
Full-text available
Abstract: The claim that spinach contains a lot of iron is one of the longest standing myths in science. In recent decades, this early error though has become widely known to the public and several theories were proclaimed, how this misconception was born. The most famous one, known in many varieties and reported in numerous books and scientific jo...
Article
Background: Symptomatic relief is the primary goal of percutaneous coronary intervention (PCI) in stable angina and is commonly observed clinically. However, there is no evidence from blinded, placebo-controlled randomised trials to show its efficacy. Methods: ORBITA is a blinded, multicentre randomised trial of PCI versus a placebo procedure fo...
Article
Full-text available
Approximately 150 years ago, the Augustinian monk GREGOR MENDEL first published his articles on the rules of heredity, which became the founding stone of genetics and are today known as Mendelian laws. However, MENDEL also intensively worked on numerous other scientific topics such as meteorology and entomology. Even though his interest in bees is...
Article
Present-day high-resolution leaf growth measurements provide exciting insights into diel (24-h) leaf growth rhythms and their control by the circadian clock, which match photosynthesis with oscillating environmental conditions. However, these methods are based on measurements of leaf area or elongation and neglect diel changes of leaf thickness. In...
Article
Full-text available
Current guidelines for measuring cardiac function by tissue Doppler recommend using multiple beats, but this has a time cost for human operators. We present an open-source, vendor-independent, drag-and-drop software capable of automating the measurement process. A database of ~8000 tissue Doppler beats (48 patients) from the septal and lateral annu...
Article
Full-text available
The ‘rediscovery’ of Mendel’s laws in 1900 was a turning point in modern research of heredity/genetics. According to the traditional view, adopted and fostered by many textbooks of genetics, Mendel’s principles were presented in the first half of 1900 simultaneously and independently by three biologists (H. de Vries, C. Correns, E. v. Tschermak-Sey...
Article
Background: Correctly selecting the end-diastolic and end-systolic frames on a 2D echocardiogram is important and challenging, for both human experts and automated algorithms. Manual selection is time-consuming and subject to uncertainty, and may affect the results obtained, especially for advanced measurements such as myocardial strain. Methods...
Article
Full-text available
Die " Wiederentdeckung " der Mendelschen Regeln im Jahr 1900 wird als Wendepunkt in der modernen Wissenschaft der Genetik angesehen. Während der ersten Hälfte des 20. Jahrhunderts wurde allgemein angenommen, dass die " Wiederentdeckung " mehrfach, unabhängig und parallel durch drei europäische Botaniker (Carl Correns, Hugo de Vries und Erich von Ts...
Article
Full-text available
Zusammenfassung Professor Dr. Erich von Tschermak-Seysenegg (1871–1962) trug in einem erheblichen Maße zur Entwicklung der modernen, experimentell begründeten Pflanzenzüchtung in der ersten Hälfte des 20. Jahrhundert bei. In der zeitge-nössischen scientific community spielte jedoch in erster Linie seine Stellung als einer der drei " Wiederentdecker...
Article
Full-text available
Zusammenfassung Folgt man der traditionellen Auffassung zur Bedeutung von Mendels Experimenten, so wurden seine Arbeiten zunächst verkannt und gerieten für Jahrzehnte in Vergessenheit, bevor sie " wiederentdeckt " und erstmals erneut abgedruckt wurden. Tatsächlich sind bislang nur eine Handvoll Verweise auf Mendels Hybridexperimente an Erb-sen aus...
Article
Plant phenotyping consists in the observation of physical and biochemical traits of plant genotypes in response to environmental conditions. Challenges , in particular in context of climate change and food security, are numerous. High-throughput platforms have been introduced to observe the dynamic growth of a large number of plants in different en...
Article
Objectives: To determine the optimal frame rate at which reliable heart walls velocities can be assessed by speckle tracking. Background: Assessing left ventricular function with speckle tracking is useful in patient diagnosis but requires a temporal resolution that can follow myocardial motion. In this study we investigated the effect of differ...
Article
Full-text available
The ‘rediscovery’ of the Mendelian laws in the year 1900 marks not only a watershed in the history of quantitative exact biology, but also laid the foundation for the success of genetics as an important part of the tradition in biological school education. Carried by the combinatory elegance of the Mendelian experiments, which also could be ideally...
Article
Full-text available
Objectives To compare the frequency of discrepancies in retracted reports of clinical trials with those in adjacent unretracted reports in the same journal. Design Blinded case-control study. Setting Journals in PubMed. Population 50 manuscripts, classified on PubMed as retracted clinical trials, paired with 50 adjacent unretracted manuscripts fro...
Article
Full-text available
Scientific literature can contain errors. Discrepancies, defined as two or more statements or results that cannot both be true, may be a signal of problems with a trial report. In this study, we report how many discrepancies are detected by a large panel of readers examining a trial report containing a large number of discrepancies. We approached a...
Article
We read with interest the recent C-CURE (Cardiopoietic stem Cell therapy in heart failURE) trial [(1)][1] of stem cells used for the treatment of heart failure. Completing such a multicenter trial is a great achievement, but applying its findings either to clinical care or future trial design might
Article
Full-text available
Summary: We tested a camera system which allows to roughly estimate the amount of refl ectance properties in the near infrared (NIR; ca. 700-1000 nm). The effectiveness of the system was studied by taking photos of 165 insect species including some subspecies from museum collections (105 Coleoptera, 11 Hemi ptera (Pentatomidae), 12 Hymenoptera, 10...
Article
Full-text available
Being intimately intertwined with (C3) photosynthesis, photorespiration is an incredibly high flux-bearing pathway. Traditionally, the photorespiratory cycle was viewed as closed pathway to refill the Calvin–Benson cycle with organic carbon. However, given the network nature of metabolism, it hence follows that photorespiration will interact with m...
Article
Full-text available
Reduction of flux through photorespiration has been viewed as a major way to improve crop carbon fixation and yield since the energy-consuming reactions associ-ated with this pathway were discovered. This view has been supported by the biomas-ses increases observed in model species that expressed artificial bypass reactions to photorespiration. Her...
Data
Phenotypes before and after transition from high CO2 to ambient air (long days, 16/8 h). Plants were grown exactly as described in the legend to Figure S1 but with a 16/8 h photoperiod and only for 6 weeks since developmental stage 5.1 was reached earlier in long days. The display format also corresponds to Figure S1. (TIF)
Data
Metabolic response of Arabidopsis wild type after transition to ambient air. (XLSX)
Data
Phenotypes before and after transition from high CO2 to ambient air (short days, 10/14 h). Plants were grown in high CO2 (1%) with a 10/14 h day/night cycle. After reaching developmental stadium 5.1 (about 8 weeks), CO2 concentration was reduced to air levels and plants monitored. Individual panels show two representative plants from each line (hpr...
Data
PSII fluorescence imaging before and after transition to ambient air. Plants were grown exactly as described in the legend to Figure S1. At the indicated times after transition to ambient CO2, plants were dark-adapted for 10 min and fluorescence images collected. Images are normalized to the Fv/Fm color bar at the bottom at the figure. Shown is one...
Data
Metabolic response of hpr1 after transition to ambient air. (XLSX)
Data
Metabolic response of pglp1 after transition to ambient air. (XLSX)
Article
Full-text available
A series of reticulated Arabidopsis thaliana mutants were previously described. All mutants show a reticulate leaf pattern, namely green veins on a pale leaf lamina. They have an aberrant mesophyll structure but an intact layer of bundle sheath cells around the veins. Here, we unravel the function of the previously described reticulated EMS-mutant...
Article
Full-text available
We tested a camera system which allows to roughly estimate the amount of reflectance properties in the near infrared (NIR; ca. 700-1000 nm). The effectiveness of the system was studied by taking photos of 165 insect species including some subspecies from museum collections (105 Coleoptera, 11 Hemiptera (Pentatomidae), 12 Hymenoptera, 10 Lepidoptera...
Poster
Full-text available
Oxygenic photosynthesis essentially requires photorespiration. Mutants of core cycle enzymes are characterized by inability to thrive in normal air but its recovery in elevated CO2 concentrations. This feature was described as the `photorespiratory phenotype` and a general feature of pathway deletions. However, during the last years different phen...
Article
Full-text available
Diel (24 h) leaf growth patterns were differently affected by temperature variations and the circadian clock in several plant species. In the monocotyledon Zea mays, leaf elongation rate closely followed changes in temperature. In the dicotyledons Nicotiana tabacum, Ricinus communis, and Flaveria bidentis, the effect of temperature regimes was less...
Article
Histomonas meleagridis is a 10-20 microm-sized flagellated protozoan, causing histomoniasis in gallinaceous birds. Different strains of H. meleagridis from different origins were used to establish clonal cultures, which can be traced back to a single cell. Cells from these clonal cultures were examined by transmission electron microscopy. Results g...
Article
Full-text available
ABSTRACT X-ray analysis (ESMA) of the (exo)chorion of the eggs of the stick insect Pharnacia westwoodi showed the presence of calcium. Spot analyses of fracture planes revealed a rather homogeneous distribution in the three layers identified in histological sections and by scanning electron microscopy. This was true also for the micropylar plate; s...
Book
Linux hat sich längst zu einem Multimedia-Betriebssystem entwickelt. Für fast jede Hardwarekomponente existieren längst die passenden Treiber und Softwareapplikationen. Ganz gleich, ob Sie nun Ihren CD-Brenner, Ihren Scanner oder Ihre Digitalkamera unter Linux einsetzen möchten - all dies stellt in den meisten Fällen längst kein Problem mehr dar. L...

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Projects

Projects (6)
Project
Agricultural activities influence the environment and continuously adapt to a wide variety of drivers, such as economic incentives, scientific and technological developments, socio-political conditions, climate change, etc. The conservation of biodiversity in agricultural landscapes is not at the forefront of agricultural decision-making, but is essential for their functionality and adaptability. At the same time, hardly any methods are known to define what the necessary biodiversity infrastructure is, nor how it could be preserved. SALBES investigates this question and takes a landscape perspective, focusing on the agricultural system, in order to secure the ecological infrastructure, as well as the associated agricultural biodiversity and its functions (ESS) under the current and future framework conditions and drivers of agricultural use.
Archived project