Michael P Manns

Michael P Manns
Hannover Medical School | MHH · Department of Gastroenterology, Hepatology and Endocrinology

MD and Professor

About

2,968
Publications
163,874
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112,170
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Publications

Publications (2,968)
Article
In 2014, an analysis was conducted to evaluate the hepatitis C virus (HCV) epidemiology and disease burden in Germany. Since then, there have been considerable developments in HCV management like the implementation of direct acting antivirals. The aim of this analysis was to assess the recent data available for Germany, establish an updated 2020 HC...
Article
Full-text available
Based on the hypothesis that autoimmunological factors coregulate the pathomechanism in biliary atresia (BA), adjuvant therapy with steroids has become routine, although its efficacy has never been proven. In 2010, a study on the advantages of budesonide compared to prednisolone in autoimmune hepatitis gave rise to experimental therapy using budeso...
Article
Full-text available
Incomplete histological remission of autoimmune hepatitis (AIH) is associated with a reduced long-term survival and an increased relapse rate even during biochemical remission (BR). The aim of this international multicenter study was to explore the diagnostic fidelity of cytokeratin-18 cell death markers to noninvasively detect incomplete histologi...
Article
Full-text available
Autoimmune liver diseases (AILD), namely autoimmune hepatitis (AIH), primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), are rare diseases. These days, patients with PBC almost never require liver transplantation. When treated early with ursodeoxycholic acid patients have a normal life expectancy if the disease is diagnosed...
Article
Full-text available
Filoviruses infect a wide range of cell types with the exception of lymphocytes. The intracellular proteins cathepsin B and L, two-pore channel 1 and 2, and bona fide receptor Niemann–Pick Disease C1 (NPC1) are essential for the endosomal phase of cell entry. However, earlier steps of filoviral infection remain poorly characterized. Numerous plasma...
Article
Stopping long-term nucleos(t)ide analogue therapy increases HBsAg loss rates in HBeAg-negative patients. Viral rebound may induce immune responses facilitating functional cure. We analyzed which factors are associated with timing of virological relapse in 220 Asian HBeAg-negative patients from the prospective ABX203 vaccine study. Unexpectedly, onl...
Article
e15625 Background: Chemosaturation with percutaneous hepatic perfusion (CS-PHP; Hepatic CHEMOSAT Delivery System; Delcath Systems Inc, USA) is a novel medical device, which delivers high doses of melphalan directly to the liver in patients with primary and secondary liver tumours while limiting systemic toxicity through hemofiltration of the hepati...
Article
Background: Treatment of chronic hepatitis C genotype 3 (GT3) is more challenging compared with other genotypes. Since 2014, several new treatment regimens have been approved but sometimes based on limited data. Aim: To validate the use, effectiveness and safety of anti-viral treatment in chronic hepatitis C genotype 3 infection under real-word...
Article
Background: Leading causative factors of peptic ulcer disease (PUD) in the general population are infection with Helicobacter pylori (HP) and exposure to non-steroidal anti-inflammatory drugs (NSAID). We hypothesized that this may be different in transplant recipients given increased exposure of immunosuppressive and anti-microbial drugs. Methods...
Article
Background and Aims: Very potent direct acting antivirals for the treatment of chronic hepatitis C virus infection were recently introduced into daily clinical practice. Currently, treatment uptake is hampered by their high costs, eliciting prioritization of treatment. We aimed to evaluate the direct medical costs during interferon (IFN)-based anti...
Article
Background Persistent infection with the hepatitis C virus (HCV) causes profound alterations of the cytokine and chemokine milieu in peripheral blood. However, it is unknown to what extend these alterations affect the progression of liver disease and whether HCV clearance normalizes soluble inflammatory mediators. Methods We performed multianalyte...
Conference Paper
Einleitung: Die primär sklerosierende Cholangitis (PSC) ist eine chronische, destruierende Gallengangserkrankung, die mit einem deutlich erhöhten Risiko für das Cholangiokarzinom (CCA) einhergeht. Bei vielen PSC Patienten findet sich eine zusätzliche chronisch entzündliche Darmerkrankung (CED) und/oder eine autoimmune Hepatitis (AIH) Komponente, so...
Article
Background: Gastrointestinal bleeding (GIB) is one of the most common emergencies in gastroenterology. The aim of this study was to investigate the association between the incidence of GIB and seasonal, circadian and meteorological patterns in the emergency department (ED) of a tertiary hospital. Patients and methods: From January 2007 until Dec...
Article
Infections with hepatitis B-, C- and D- viruses have a significant health burden. In Germany, the seroprevalence of HBs-Ag is calculated with 0.6 % and of HCV-antibodies with 0.3 %. However, most patients are not diagnosed. Sequelae are liver-cirrhosis and hepatocellular carcinoma. Several S3-guidelines for the diagnosis and treatment of viral hepa...
Article
Background: The use of interferon-free antiviral therapy in patients with chronic HCV infection is associated with high rate of sustained virological response (SVR). The aim of this study was to evaluate changes of liver stiffness (LS) using Acoustic Radiation Force Impulse Imaging (ARFI) elastography and transient elastography (TE) during antivira...
Article
Background: Hepatitis delta is the most severe form of viral hepatitis. Pegylated interferon alpha (PEG-IFNa) is effective in only 25 – 30% of patients and associated with frequent side effects. The aim of this study was to analyze the outcome of hepatitis delta according to different management strategies (no treatment, nucleos(t)ide therapies, in...
Article
Hintergrund: Weltweit ist das Hepatitis E Virus (HEV) der haufigste Ausloser akuter viraler Hepatitiden. Bis vor kurzen war die Hepatitis E vor allem als reiseassoziierte Erkrankung in Deutschland bekannt. In den letzten 10 Jahren ist die Anzahl an gemeldeten akuten HEV Infektionen in Deutschland um das 30fache angestiegen. Dabei handelt es sich vo...
Article
Einleitung: Es gibt bisher wenig Daten zur Ätiologie der gastroduodenalen Ulkuskrankheit (PUD) bei Patienten nach Organtransplantation (Tx-Patienten). Die wichtigsten bekannten Risikofaktoren für eine PUD sind die Infektion mit H. Pylori (HP) sowie die langfristige Einnahme nichtsteroidaler Antirheumatika (NSAR). Ziele: Primäres Ziel war die Kläru...
Article
Background: Early treatment of acute hepatitis C virus (HCV) infection with interferon alfa monotherapy for 12 – 24 weeks is highly effective but is associated with frequent unfavorable side effects. There is no fully published study yet exploring the safety, efficacy and required treatment duration of interferon-free treatment of acute hepatitis C...
Article
Hintergrund: Das hepatozellulare Karzinom (HCC) gehort zu den haufigsten und lethalsten Tumoren weltweit. Fur Patienten mit HCC stehen stadiengemas lokale und systemische Therapiemodalitaten zur Verfugung. Entsprechend des Stage Migration-Konzepts wird mit Tumorprogress eine Verschiebung der Therapiemodalitat fur ein weiter fortgeschrittenes Tumors...
Article
Background Hepatocellular carcinoma (HCC) represents an increasing health problem with limited therapeutic options. In patients with intermediate disease stage, transarterial chemoembolisation (TACE) is widely applied. Treatment response is routinely assessed by imaging techniques according to the international response evaluation criteria in solid...