About
19
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Introduction
Michael Mamoun, M.D. is a neuroscientist and physician specializing in psychiatry, neuroimaging, and brain stimulation. He is actively involved in clinical practice as well as research. He is board-certified in Psychiatry and Addiction Medicine by the American Board of Psychiatry and Neurology, and is a member of the Clinical TMS Society, and American Society for Functional Neuroradiology. He has experience in PET, MRI, functional MRI, DTI, and ASL neuroimaging modalities.
Current institution
CNS Health
Current position
- Medical Doctor
Additional affiliations
July 2005 - June 2009
July 2009 - present
Education
August 2001 - May 2005
Publications
Publications (19)
Two service members were diagnosed with PTSD due to military trauma exposure. One presented with the classical manifestation; the other presented with the dissociative subtype. A statistical map revealed anterior localization of insula connectivity in the classical PTSD patient and posterior localization in the dissociative PTSD patient. These diff...
Background:
This study sought to validate the clinical utility of multimodal magnetic resonance imaging (MRI) techniques in the assessment of neurodegenerative disorders. We intended to demonstrate that advanced neuroimaging techniques commonly used in research can effectively be employed in clinical practice to accurately differentiate heathy agi...
The present study investigates a potential method to optimize effective functional localization strategies for both language regions and the dorsolateral prefrontal cortex (dlPFC) while in a scanner. This functional task combines elements of creative problem solving, executive decision making based on an internal rule set, and working memory. Retro...
A 29-year-old woman presented with head and neck dystonia, as well as functional seizures. The patient was an active military service member with a history of combat-related trauma. Resting blood oxygen level dependent (BOLD) functional MRI (fMRI) scans of the brain demonstrated an increased anterior cingulate component of the salience network and...
Introduction: Preclinical studies support investigation of focused ultrasound for breakdown of cerebral pathologies in neurodegenerative conditions including Alzheimer’s disease (AD) and Parkinson’s disease (PD).
Methods: A focused transcranial Doppler device with probes (2 MHz, 520 mW/cm2) affixed bilaterally was used to target the hippocampus (AD...
Preclinical studies support investigation of focused ultrasound for breakdown of cerebral pathologies in neurodegenerative conditions including Alzheimer’s disease (AD) and Parkinson’s disease (PD). A focused transcranial doppler (TCD) device with probes (2 MHz, 520 mW/cm2) affixed bilaterally was used to target the hippocampus (AD) or substantia n...
This corrects the article DOI: 10.1038/npp.2017.48.
In the brain, microglia continuously scan the surrounding extracellular space, in order to respond to damage or infection by becoming activated and participating in neuroinflammation. When activated, microglia increase the expression of the translocator protein (TSPO) 18 kDa, thereby making TSPO expression a marker for neuroinflammation. We used th...
Rationale
Upregulation of α4β2* nicotinic acetylcholine receptors (nAChRs) is one of the most well-established effects of chronic cigarette smoking on the brain. Prior research by our group gave a preliminary indication that cigarette smokers with concomitant use of caffeine or marijuana have altered nAChR availability.
Objective
We sought to deter...
For the past 30 years, research examining predictors of successful smoking cessation treatment response has focused primarily on clinical variables, such as levels of tobacco dependence, craving, and self-efficacy. However, recent research has begun to determine biomarkers (such as genotype, nicotine and metabolite levels, and brain imaging finding...
Introduction:
When microglia become activated (an integral part of neuroinflammation), cellular morphology changes and expression of translocator protein (TSPO) 18 kDa is increased. Over the past several years, [(11)C]DAA1106 has emerged as a reliable radiotracer for labeling TSPO with high affinity during positron emission tomography (PET) scanni...
Importance:
Cigarette smoking leads to upregulation of nicotinic acetylcholine receptors (nAChRs) in the human brain, including the common α4β2* nAChR subtype. While subjective aspects of tobacco dependence have been extensively examined as predictors of quitting smoking with treatment, no studies to our knowledge have yet reported the relationshi...
Cigarette smoking leads to up-regulation of brain nicotinic acetylcholine receptors (nAChRs), including the common α4β2* nAChR subtype. While a substantial percentage of smokers receive treatment for tobacco dependence with counseling and/or medication, the effect of a standard course of these treatments on nAChR up-regulation has not yet been repo...
One-third of smokers primarily use menthol cigarettes and usage of these cigarettes leads to elevated serum nicotine levels and more difficulty quitting in standard treatment programmes. Previous brain imaging studies demonstrate that smoking (without regard to cigarette type) leads to up-regulation of β2*-containing nicotinic acetylcholine recepto...
