Michael Tvilling Madsen

Michael Tvilling Madsen
Zealand University Hospital · Department of Surgery

M.D. Ph.D.

About

29
Publications
2,127
Reads
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626
Citations
Citations since 2017
16 Research Items
544 Citations
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Introduction
Michael Tvilling Madsen currently works at the Department of Surgery, Zealand University Hospital. Michael does research in Sleep Medicine and Surgery. Their current project is 'The Effect of MElatonin on Depression, Anxiety, CIrcadian and Sleep Disturbances in Patients After Acute Myocardial Syndrome (MEDACIS)'.
Additional affiliations
August 2018 - present
University of Copenhagen, Køge Sygehus
Position
  • Senior Researcher
Description
  • Senior researcher: Clinical trial design Meta analyses Cancer rehabilitation Sleep and circadian pattern
August 2015 - July 2018
Zealand University Hospital
Position
  • PhD Student
Description
  • Research group under Professor Ismail Gögenur
January 2015 - August 2018
Zealand University Hospital
Position
  • PhD Student
Description
  • Center for surgical science

Publications

Publications (29)
Article
Full-text available
Neoadjuvant chemoradiotherapy (NCRT) is indicated in locally advanced rectal cancer (LARC) to downstage tumors before surgery. Watchful waiting may be a treatment option to avoid surgery in patients, obtaining a complete clinical response. However, biomarkers predictive of treatment response and long-term prognosis are lacking. Here we investigated...
Article
Full-text available
Objective The objective of the current study was to quantitatively explore aspects of external validity, both researcher's choices (eligibility) and patient's choices (consent), of a recently conducted clinical trial. Methods A cohesive comparison between the MEDACIS trial (NCT02451293) database and a national quality and research database was con...
Article
Background Sleep and circadian disturbances play a major role in recovery after critical illness. Ample research has shown sleep to be disturbed during the stay at the intensive care unit (ICU); however, the trajectory of sleep after ICU discharge is sparsely described. The current study aimed to describe the development of the sleep‐wake rhythm in...
Article
Importance: Tumour-infiltrating lymphocytes (TILs) have previously been found to influence patient prognosis in other gastrointestinal cancers, for instance in colorectal cancer. An immunosuppressive phenotype often characterizes pancreatic cancer with a low degree of immune cell infiltration. Cytotoxic CD8+ T cell infiltration in tumours is found...
Article
Full-text available
The surgical stress response can accelerate clinical metastasis formation. Perioperative glucocorticoids might modulate this response and the metastatic process. We aimed to describe associations between perioperative glucocorticoids and long-term outcomes after cancer surgery. We searched four databases for eligible trials and performed meta-analy...
Poster
Full-text available
Background Pancreatic cancer (PC) contributes to over 7 % of all cancer related deaths worldwide with a relative 5-year survival of less than 8 %. High levels of tumor-infiltrating lymphocytes (TILs) are associated with improved survival in many cancer types. Examining the impact of TILs on survival in PC could provide better prognostication and he...
Article
Background/Objective Anastomotic leakage (AL) is one of the most severe complications following colorectal cancer surgery and is associated with increased short and long term mortality. The literature is conflicting regarding increased risk of recurrence after AL. The aim of this study was to systematically review the impact of anastomotic leakage...
Article
Depression and depressive symptoms are prevalent in patients with cancer. Depression is underdiagnosed and therefore, patients often receive inadequate treatment for depression. We have assessed the evidence of primary prophylactic treatment for depression in patients with cancer. The systematic review was prospectively registered at PROSPERO and w...
Article
Background: Depression following acute coronary syndrome is prevalent and associated with increased mortality and morbidity. Melatonin may function as a primary prophylactic antidepressant substance and alleviate depressive symptoms. The study was undertaken to determine if melatonin administered following an acute coronary syndrome (ACS) could pr...
Article
Full-text available
Objectives This study performed a contemporary systematic review and meta-analysis of exercise-based cardiac rehabilitation (ExCR) for heart failure (HF). Background There is an increasing call for trials of models of ExCR for patients with HF that provide alternatives to conventional center-based provision and recruitment of patients that reflect...
Article
Full-text available
Endothelial dysfunction (ED) precedes acute coronary syndrome. Oxidative stress results in ED but is reversible. Melatonin is aside from being a circadian hormone also an antioxidant. The aim of this study was to investigate if 25 mg melatonin administered for twelve weeks following acute coronary syndrome (ACS) could improve ED. In this placebo‐co...
Article
Study objectives: Investigation into sleep and coronary heart disease (CHD) has predominantly been focused on sleep disturbances as a risk factor for developing CHD. Objectively measured and self-reported sleep at a patient level has only been sparsely and not systematically reported. Therefore, we set out to review the literature for studies usin...
Article
Circadian disturbances in relation to surgery have been extensively researched through the latest couple of decades. Surgery has been shown to affect melatonin rhythm, core body temperature, cortisol rhythm, activity rhythm and sleep in the perioperative period. The changes translate into both subjective patients' discomfort, prolonging convalescen...
Article
Many countries have implemented cancer pathways with strict time limits dictating the pace of diagnostic testing and treatment. There are concerns that prehabilitation may worsen long-term oncological outcomes if surgery is delayed. We aimed to systematically review the literature investigating the association between increased time between diagnos...
Article
Major depressive disorder is significantly increased in patients following acute coronary syndrome resulting in twofold increased mortality compared with patients without depression. The depression diagnosis is often missed leading to considerable undertreatment. This systematic review assesses the current evidence of primary prophylactic treatment...
Article
Full-text available
Background Depression following acute coronary syndrome (ACS) constitutes a serious and debilitating problem. Approximately one in five patients will develop significant depression following ACS and less severe depressive symptoms are even more frequent. Furthermore, anxiety symptoms and sleep-wake disturbances are frequent. The objective of the ME...
Article
Full-text available
Study objectives: To investigate whether administration of an oral dose of 6 mg melatonin before bedtime perioperatively in breast cancer surgery could change sleep outcomes measured by actigraphy. Methods: This paper reports secondary outcomes from a double-blind, placebo-controlled, randomized clinical trial where patients received 6 mg melato...
Article
During oncological treatment patients often suffer from fatigue, insomnia, and daytime inactivity. This cluster of symptoms and overall survival are linked with circadian rhythm disruptions in rest-activity, which can be objectively characterized using actigraphy. We systematically reviewed the body of literature using actigraphy to characterize th...
Article
Full-text available
Objective: We set out to investigate whether administration of an oral dose of 5 mg melatonin in the evenings after laparoscopic cholecystectomy could reduce sleep disturbances measured by actigraphy. Methods: We performed a double-blinded, placebo-control, randomised clinical trial where 54 patients received 5 mg melatonin or placebo approximately...
Article
Background: Sleep disturbances after surgery are frequent and a valid tool to quantify these is warranted. We set out to make an epoch by epoch validation of actigraphy against polysomnography (PSG) for detection of sleep and wake in women undergoing surgery for breast cancer. Methods: Twelve patients, 30-70 years, undergoing a lumpectomy were inc...
Article
Full-text available
Background. Sleep disturbances and cognitive dysfunction are common in patients with breast cancer. Disturbed sleep leads to poor cognitive performance and exogenous melatonin may improve sleep and attenuate cognitive dysfunction. We hypothesized that melatonin would improve sleep and cognitive function after surgery. Methods. This study reports se...
Article
Sleep disturbances are a prevalent and disabling problem for patients with cancer. Sleep disturbances are present throughout the cancer trajectory and especially prominent during oncological treatment. Previously sleep disturbances have primarily been quantified with subjective ratings scales. Actigraphy is an easy to use, non-invasive method for o...
Article
Depression, anxiety and sleep disturbances are known problems in patients with breast cancer. The effect of melatonin as an antidepressant in humans with cancer has not been investigated. We investigated whether melatonin could lower the risk of depressive symptoms in women with breast cancer in a three-month period after surgery and assessed the e...
Article
Sleep disturbances and changes in self-reported discomfort and melatonin secretion are common in the post-operative period. We aimed to study the distribution of sleep stages in the perioperative period and evaluate changes in secretion of the melatonin metabolite aMT6s and subjective parameters of sleepiness, pain, general well-being and fatigue i...
Article
Full-text available
Patients undergoing surgery have severe sleep and sleep-wake rhythm disturbances resulting in increased morbidity. Actigraphy is a tool that can be used to quantify these disturbances. The aim of this manuscript was to present the literature where actigraphy has been used to measure sleep and sleep-wake rhythms in relation to surgery. A systematic...
Article
Surgery is accompanied by a surgical stress response, which results in increased morbidity and mortality. Oxidative stress is a part of the surgical stress response. Minimally invasive laparoscopic surgery may result in reduced oxidative stress compared with open surgery. Nineteen patients scheduled for sigmoid resection were randomly allocated to...
Article
Full-text available
Introduction Breast cancer represents about one-third of all cancer diagnoses and accounts for about 15% of cancer deaths in women. Many of these patients experience depression, anxiety, sleep disturbances and cognitive dysfunction. This may adversely affect quality of life and also contribute to morbidity and mortality. Melatonin is a regulatory c...

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Project (1)
Project
he objective of the study is to investigate whether prophylactic treatment with melatonin has an effect on depressive symptoms. Secondarily melatonin's effect on anxiety, sleep and circadian disturbances will be investigated. The MEDACIS trial is a randomised, placebo-controlled, double-blinded multicenter trial investigating the effect of 25 mg exogenous melatonin (intervention group) against placebo (control group) and the study is designed as a parallel group superiority trial. https://clinicaltrials.gov/ct2/show/NCT02451293?term=medacis&rank=1