Michael Lelah

Michael Lelah
NutriScience Innovations

PhD

About

29
Publications
485
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
894
Citations
Citations since 2016
0 Research Items
156 Citations
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080

Publications

Publications (29)
Article
Adulteration of herbal supplements is an increasing problem throughout the industry. There have been a multitude of FDA recorded recalls of herbal supplements found to contain adulterated materials, all resulting from deliberate adulteration. A rapid technique was developed to screen raw materials used to manufacture men's virility, sports nutritio...
Article
Effective integration of synthetic fiber scaffold materials into connective tissues depends to a great degree on tissue attachment and ingrowth into the material. The authors have developed an experimental model that utilizes rat tendon explants to test the rates of cell colony formation on different types of synthetic fibers that are used as tendo...
Article
Complement activation by Cuprophan hemodialysis membranes has been linked to a variety of pathological sequelae (neutropenia and various cardiopulmonary manifestations) seen in the clinical setting. The modification of reactive surface hydroxyl groups on regenerated cellulose with various dicarboxylic-acid anhydrides has been found to significantly...
Article
Recurrent traumatic damage by mechanical action is a major cause of catheter exit site problems in CAPD patients. The purpose of this study was to determine the efficacy of a new external immobilization device (Immobilizer) on wound healing characteristics at the catheter exit site. Sixteen Tenckhoff catheters were surgically implanted in four Yuca...
Article
Despite the use of polyurethanes in a number of blood-contacting applications, little is known about the contributing effects of the various polyurethane components in thrombogenesis. In order to investigate blood-polyurethane interactions, a number of different polyurethanes were examined in an acute canine ex vivo series shunt experiment. Multipr...
Chapter
Segmented polyurethanes are widely used in commercial and experimental blood-contacting applications which include vascular prostheses, blood filters, catheters, insulation for pacemaker leads, heart valves, cardiac assist devices, and chambers for artificial hearts. The use of this family of polymers for such applications is due to the physiologic...
Article
Circular tubings are used extensively in biomedical implants and devices. It is desirable to determine contact angles on the inner or outer surfaces of such tubing in its final fabricated form. In this study, a technique for the measurement of contact angles on tubing surfaces in an aqueous environment is reported. This has particular applications...
Article
Full-text available
An acute ex vivo canine series shunt technique, together with in vitro blood contact experiments, were used to study the blood compatibility of poly(styrene-b-butadiene-b-4-vinylpyridine) triblock polymers. The ABC type triblock polymers were solvent cast from different solvents, and were chemically modified by quaternization of the pyridine block,...
Article
The effect of incorporation of ions into polyurethanes on their interfacial interaction with blood is of interest because of the relative blood compatibility of polyurethanes, and the effect of ionic domains on surface properties and thus blood response. A series of uncharged, anionic, cationic, and zwitterionic polyetherurethanes was coated on tub...
Article
A new acute canine ex vivo femoral A-V series shunt experiment is described. Platelet and fibrinogen deposition on a series of up to ten different polymers may be tested in the same nonanticoagulated animal. The method reduces the time and expense associated with animal testing, and also allows for the simultaneous monitoring of platelet and fibrin...
Article
The initial adherence and activation of platelets on a surface may be a major determinant of the thrombogenicity of that surface. The response of platelets to four polymers: polyethylene (PE), polyvinyl chloride (PVC), silicone rubber (SIL), and oxidized polyethylene (OX-PE) was studied in vitro with scanning electron microscopy. Platelets from mon...
Chapter
The contact of blood with a polymer surface results in the initial deposition of proteins, platelets, and other formed elements. Proteins deposit during the first moments of blood contact1, while platelets start to adhere after about one minute of blood contact, when the protein layer is about 200 Å thick2. The polymerization of fibrinogen to fibri...
Article
An acute canine ex-vivo femoral A-V shunt technique was used to study thrombus formation and embolization on a number of porous and non-porous polymer surfaces over a one-hour blood contact period. The technique allows for simultaneous exposure of all the surfaces under similar physiological and hematological conditions. This makes comparisons betw...
Article
Solution grade and extruded grade Biomer (SB and EB, respectively) are polyurethanes that have been suggested for use in biomedical applications. The bulk materials were examined by elemental analysis, differential scanning calorimetry, thermomechanical testing, and stress-strain testing. The extruded grade material has a lower soft segment molecul...
Article
An investigation of the spreading behavior of drops of a number of aqueous anionic, cationic and non-ionic surfactant solutions has demonstrated, for the first-time, spreading to a maximum solid-solution contact area, and then contraction to a smaller final size. The nature and kinetics of the spreading and contraction are shown to be dependent on...
Article
The spreading kinetics of drops on glass was experimentally studied. The liquids used were triply distilled water, aqueous electrolytic solutions of various pH's, low alcohols, glycerine, and squalane. A wide range of parameters was covered, including temperature, humidity, volume, viscosity, surface tension, and pH. A power law dependence of the c...
Article
The properties of solution grade and extrusion grade Biomer have been investigated and compared. In vivo blood compatibility studies using arteriovenous (AV) shunts of the cast and extruded materials show that extruded Biomer is more thromboresistant than solution cast Biomer. This has important implications for long-term implantation studies, sinc...
Article
The effects of the most commonly recommended cleaning procedures on the wettability of soda-lime glass surfaces were investigated. Changes in wettability were evaluated by measuring the contact angle of a water drop and, in cases in which the contact angle approached zero, by determining the spreading rate. Three cleaning procedures - with EDTA sol...
Article
Typescript. Thesis (Ph. D.)--University of Wisconsin--Madison, 1984. Vita. Includes bibliographical references (leaves 210-223).

Network

Cited By