Michael B Keogh

Michael B Keogh
RCSI-Bahrain · School of Medicine

PhD.

About

30
Publications
7,615
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493
Citations
Citations since 2016
16 Research Items
397 Citations
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080

Publications

Publications (30)
Article
Full-text available
Wound healing requires a tight orchestration of complex cellular events. Disruption in the cell-signaling events can severely impair healing. The application of biomaterial scaffolds has shown healing potential; however, the potential is insufficient for optimal wound maturation. This study explored the functional impact of a collagen-chondroitin s...
Article
Full-text available
The aim was to determine whether gum Arabic (GA) supplementation prevents cognitive decline in type 2 diabetes, through stimulation of mitochondrial function in the hippocampus. Type 2 diabetic rats and controls were assigned to following groups for 16 weeks: Control + Water; Control + GA 10% w/v; Diabetes + Water; Diabetes + GA 10% w/v. Latency in...
Article
Full-text available
Novel biomaterials can be used to provide a better environment for cross talk between vessel forming endothelial cells and wound healing instructor stem cells for tissue regeneration. This study seeks to investigate if a collagen scaffold containing a proangiogenic gene encoding for the chemokine stromal-derived factor-1 alpha (SDF-1α GAS) could be...
Article
Full-text available
Non-healing diabetic foot ulcers (DFUs) can lead to leg amputation in diabetic patients. Autologous stem cell therapy holds some potential to solve this problem; however, diabetic stem cells are relatively dysfunctional and restrictive in their wound healing abilities. This study sought to explore if a novel collagen–chondroitin sulfate (coll–CS) s...
Article
Full-text available
Skin wounds can lead to serious morbidity complications in diabetic patients due to the reduced healing potential of autologous stem cells. One reason for the low functional potency of stem cells from diabetic patients (diabetic stem cells) is attributed to their senescent-like nature. Here, we investigated if an anti-ageing protein, β-klotho, coul...
Article
Enhancing angiogenesis is the prime target of current biomaterial‐based wound healing strategies. However, these approaches largely overlook the angiogenic role of the cells of the nervous system. Therefore, we explored the role of a collagen‐chondroitin sulfate scaffold functionalized with a proangiogenic gene stromal‐derived factor‐1α (SDF‐1α)—an...
Preprint
Full-text available
Background: Diabetic foot ulcer is one of the leading causes of leg amputation and mortality in diabetic patients. Autologous stem cell therapy holds some potential to be a solution to this problem, however diabetic stem cells are relatively dysfunctional and restrictive in their wound healing abilities. This study sought to explore if a novel coll...
Preprint
Full-text available
Background Diabetic foot ulcer is one of the leading causes of leg amputation and mortality in diabetic patients. Autologous stem cell therapy holds some potential to be a solution to this problem, however diabetic stem cells are relatively dysfunctional and restrictive in their wound healing abilities. This study sought to explore if a novel colla...
Article
Full-text available
Background Breast cancer is the most common malignancy in women worldwide. About 5%–10% are due to hereditary predisposition. The contribution of BRCA1/2 mutations to familial breast cancer in Bahrain has not been explored. The objective of this study was to investigate the spectrum of BRCA1/2 genetic variants and estimate their frequencies in fami...
Article
Full-text available
Background There is a strong association between cardiometabolic risk and adipose tissue dysfunction with great consequences on type 2 diabetic patients. Visceral Adiposity Index (VAI) is an indirect clinical marker of adipose tissue dysfunction. Gum Arabic (GA) is a safe dietary fiber, an exudate of Acacia Senegal. Gum Arabic had shown lipid lower...
Article
Ensuring an adequate angiogenic response during wound healing is a prevailing clinical challenge in biomaterials science. To address this, we aimed to develop a pro-angiogenic gene-activated scaffold (GAS) that could activate MSCs to produce paracrine factors and influence angiogenesis and wound repair. A non-viral polyethyleneimine (PEI) nanoparti...
Article
Full-text available
Solar Disinfection of water (SODIS) is a treatment method that traditionally exposes low turbidity water filled in clear bottles to direct sunlight up to 6 h. Typically, water should have turbidity lower than 30 NTU before solar exposure; however turbidities of water sources in communities vary and can reach higher than 200 NTU. In order to reduce...
Article
Full-text available
The rise in lower extremity amputations (LEAs) due to non-healing of foot ulcers in diabetic patients calls for rapid improvement in effective treatment regimens. Administration of growth factors (GFs) are thought to offer an off-the-shelf treatment however, the dose- and time-dependent efficacy of the GFs together with the hostile environment of d...
Article
Full-text available
Background:Gum Arabic (GA) is a water-soluble dietary fiber, indigestible to both humans and animals. While GAcurrently does not have any therapeutic potential, ithas nutritional value andsome effects on metabolism of glucose and lipids. Thus, theaim of this study is to assess the effect of GA on serum level of glucose, lipids,and the BMI in type 2...
Article
Full-text available
http://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-016-3535-6 Background Communities living in developing countries as well as populations affected by natural or man-made disasters can be left at great risk from water related diseases, especially those spread through the faecal-oral route. Conventional water treatments such as boilin...
Poster
Full-text available
GA decreases risk of diabetes mellitus complications by controlling of metabolic elements in patients with type 2 diabetes mellitus, this is a two-arm randomised, placebo controlled, double-blind trial was conducted in a total number of 91 patients with T2DM.
Article
Full-text available
Objective: To evaluate the efficacy of SODIS treatment in inactivating E-coli and Enterococcus faecalis in 1.5 L transparent PET (polyethylene terephthalate) plastic bottles and 19 L carbamide water dispensers. Design: A Laboratory-Based Scientific Study. Setting: Microbiology Unit, RCSI-MUB. Method: 1.5 L transparent PET plastic bottles and 19 L...
Article
Full-text available
Background: The partnership between hospital policy and staff procedures needs to be coordinated. In the case of neonatal care, failures of this partnership can result into complications. Objective: To evaluate staff awareness, hospital policy and current procedures relating to total parenteral nutrition (TPN) in Neonatal Intensive Care Units in Ba...
Article
Full-text available
The small treated volume (typically ∼2 L) associated with polyethylene terephthalate (PET) bottles that are most frequently used in solar water disinfection (SODIS), is a major obstacle to uptake of this water treatment technology in resource-poor environments. In order to address this problem we have conducted a series of experiments in Spain, Bah...
Article
Full-text available
Introduction Flow perfusion bioreactors may be used to provide mechanostimulatory effects to cells and to improve cell distribution within a biomaterial. This study assessed the use of a flow perfusion bioreactor to improve cell distribution and osteogenesis within a collagen glycosaminoglycan (CG) scaffold. Materials and Methods CG scaffolds were...
Poster
Adipose derived stem cells are more easily obtained than mesenchymal stem cells and they possess excellent differentiation capabilities for tissue engineering. This research focused on establishment of a protocol to isolate human adipose derived stem cells from liposuction aspirates. We then explored their potential to be used in tissue engineering...
Article
Full-text available
In tissue engineering, bioreactors can be used to aid in the in vitro development of new tissue by providing biochemical and physical regulatory signals to cells and encouraging them to undergo differentiation and/or to produce extracellular matrix prior to in vivo implantation. This study examined the effect of short term flow perfusion bioreactor...
Article
Full-text available
Anchorage-dependent cells respond to the mechanical and physical properties of biomaterials. One such cue is the mechanical stiffness of a material. We compared the osteogenic potential of collagen-glycosaminoglycan (CG) scaffolds with varying stiffness for up to 6 weeks in culture. The mechanical stiffness of CG scaffolds were varied by cross-link...
Article
Full-text available
Collagen glycosaminoglycan (CG) scaffolds have been clinically approved as an application for skin regeneration. The goal of this study has been to examine whether a CG scaffold is a suitable biomaterial for generating human bone tissue. Specifically, we have asked the following questions: (1) can the scaffold support human osteoblast growth and di...

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Projects (2)
Project
Examine the effects of dietary supplementation with Gum Arabic on learning and memory, as well as neurodegeneration in the hippocampus, of type 2 diabetic rats.