Michael O. Harris-Love

Michael O. Harris-Love
University of Colorado | UCD · Department of Physical Medicine and Rehabilitation

About

76
Publications
17,961
Reads
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2,784
Citations
Citations since 2017
28 Research Items
1741 Citations
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20172018201920202021202220230100200300400
20172018201920202021202220230100200300400
Additional affiliations
August 2019 - present
University of Colorado
Position
  • Professor
August 2019 - present
VA Eastern Colorado Health Care System
Position
  • Faculty Member
January 2014 - July 2019
George Washington University
Position
  • Professor (Associate)

Publications

Publications (76)
Article
Full-text available
A growing body of scientific literature suggests that not only changes in skeletal muscle mass, but also other factors underpinning muscle quality, play a role in the decline in skeletal muscle function and impaired mobility associated with aging. A symposium on muscle quality and the need for standardized assessment was held on April 28, 2016 at t...
Article
Full-text available
Estimates of muscle tissue composition may have greater prognostic value than lean body mass levels regarding health-related outcomes. Ultrasound provides a relatively low cost, safe, and accessible mode of imaging to assess muscle morphology. The purpose of this study was to determine the construct validity of muscle echogenicity as a surrogate me...
Article
Full-text available
The goals of this narrative review are to provide a brief overview of the muscle and tendon adaptations to eccentric resistance exercise and address the applications of this form of training to aid rehabilitative interventions and enhance sports performance. This work is centered on the author contributions to the Special Issue entitled "Eccentric...
Article
Full-text available
Purpose To train and test a machine learning model to automatically measure mid-thigh muscle cross-sectional area (CSA) to provide rapid estimation of appendicular lean mass (ALM) and predict knee extensor torque of obese adults. Methods Obese adults [body mass index (BMI) = 30–40 kg/m ² , age = 30–50 years] were enrolled for this study. Participa...
Article
Background: The combination of neuromuscular impairments plus psychosocial aspects of chronic kidney disease (CKD) may predispose these patients to greater risk for experiencing increased levels of fatigability. There has been extensive clinical and scientific interest in the problem of fatigue in CKD and end-stage kidney disease (ESKD) patients,...
Article
Objective To compare muscle ultrasound (MUS) parameters in patients with juvenile dermatomyositis (JDM) and healthy controls, and examine their association with JDM disease activity measures and magnetic resonance imaging (MRI). Methods MUS of the right mid-rectus femoris was performed in 21 patients with JDM meeting probable or definite Bohan and...
Article
Full-text available
Introduction: The primary aims of the present study were to assess the relationships of early (0–50 ms) and late (100–200 ms) knee extensor rate of force development (RFD) with maximal voluntary force (MVF) and sit-to-stand (STS) performance in participants with chronic kidney disease (CKD) not requiring dialysis. Methods: Thirteen men with CKD (eG...
Article
Full-text available
Background: The single-leg heel raise test is a common clinical assessment; however, little is known about its validity in people with multiple sclerosis (MS). This study investigated the validity of the single-leg heel raise test in a group of people with MS and a healthy control group (CTL). Materials and Methods: Twenty-one people with MS (49 ±...
Article
Full-text available
The purpose of this preliminary study was to describe changes in physical function and torque capacity in adults with chronic kidney disease (CKD) in response to a novel progressive eccentric-overload resistance exercise (ERE) regime. Participants included men (n = 4) diagnosed with CKD according to estimated glomerular filtration rate (eGFR) betwe...
Article
Full-text available
Skeletal muscle fat infiltration (known as myosteatosis) is an ectopic fat depot that increases with aging and is recognized to negatively correlate with muscle mass, strength, and mobility and disrupt metabolism (insulin resistance, diabetes). An interdisciplinary workshop convened by the National Institute on Aging Division of Geriatrics and Clin...
Article
Full-text available
We are glad to introduce the Third Journal Club of Volume five, the third issue. This edition is focused on relevant studies published in the last years in the field of PhysioMechanics of Human Locomotion, chosen by our Editorial Board members and their colleagues. We hope to stimulate your curiosity in this field and to share with you the passion...
Chapter
Resistance activities, which include weight machines, free weights and resistance tubing or bands, and body-weight activities, provide a stimulus to the neuromuscular system promoting health and functional adaptations. As the aging population continues to grow, the ability to maintain or slow the decline in neuromuscular health is essential for the...
Preprint
Full-text available
Background Physical function is severely compromised in people with chronic kidney disease (CKD) and worsens with continued decreases in kidney function. Neuromuscular force capacity is a key determinant of physical function in healthy older adults, though its importance in persons with CKD is less understood. Methods This study aimed to determine...
Poster
Full-text available
Chronic kidney disease (CKD) is associated with skeletal muscle loss and neuromuscular dysfunction, resulting in reduced physical performance. Inertial flywheel resistance exercise (RE) has been shown to be an effective training option for improving neuromuscular outcomes in healthy adults. However, evidence supporting its application in patients w...
Article
Full-text available
Objectives: The aim of this study was to analyze the effects of virtual dance exercise on skeletal muscle architecture and function in community-dwelling older women. Methods: Forty-two moderately active older women participated in this study and chose to join either the control group (CG; n=20; 70.3 ± 5.6 years) or exercise group (EG; n=22; 69....
Article
Objectives Assessing aging muscle through estimates of muscle heterogeneity may overcome some of the limitations of grayscale analyses. The objectives of this study included determining statistical model parameters that characterize muscle echogenicity and are associated with strength in younger and older participants. Methods Thirty‐three communi...
Article
Full-text available
Full text: https://www.mdpi.com/2411-5142/3/4/53/htm | Journal of Functional Morphology and Kinesiology (ISSN 2411-5142) | The optimal management of sarcopenia requires appropriate endpoint measures to determine intervention efficacy. While hand grip strength is a predictor of morbidity and mortality, lower extremity strength may be better associ...
Article
Full-text available
Skeletal muscle wasting has gained interest as a primary consequence of chronic kidney disease (CKD) due to the relationship between skeletal muscle mass, mortality and major adverse cardiovascular events in this population. The combination of reductions in physical function, skeletal muscle performance and skeletal muscle mass places individuals w...
Article
Full-text available
Chronic kidney disease (CKD) is a progressive condition that may negatively affect musculoskeletal health. These comorbidities may include malnutrition, osteoporosis, and decreased lean body mass. Secondary sarcopenia due to CKD may be associated with mobility limitations and elevated fall risk. Physical therapists are well-positioned among the hea...
Article
Full-text available
Full text: https://archivesphysiotherapy.biomedcentral.com/articles/10.1186/s40945-017-0033-9; Motion capture virtual reality-based rehabilitation has become more common. However, therapists face challenges to the implementation of virtual reality (VR) in clinical settings. Use of motion capture technology such as the Xbox Kinect may provide a use...
Article
Objective: To investigate in a pilot study the safety and efficacy of infliximab in patients with refractory dermatomyositis (DM) and polymyositis (PM). Methods: A randomized, double-blind, placebo-controlled trial including subjects with active DM or PM. Participants had stable doses of immunosuppressive medication and prednisone (≤0.5mg/kg/day...
Article
The CDC recently recognized sarcopenia as a reportable medical condition necessitating better screening and diagnosis of this geriatric syndrome. The purpose of this work is to inform practitioners how sarcopenia screening is aided by the new ICD-10-CM code and briefly review recent VA initiatives for proactive care. Additional objectives include i...
Technical Report
Full-text available
The CDC recently recognized sarcopenia as a reportable medical condition necessitating better screening and diagnosis of this geriatric syndrome. The purpose of this work is to inform practitioners how sarcopenia screening is aided by the new ICD-10-CM code and briefly review recent VA initiatives for proactive care. Additional objectives include i...
Article
Knee osteoarthritis (OA) is a complex condition involving articular cartilage, connective tissue, and skeletal muscle. Diagnostic ultrasound (US) has been proposed as an approach to characterize muscle changes in those with chronic conditions. The purpose of this study was to determine if quantitative US muscle morphology and morphometry measures a...
Article
Knee osteoarthritis (OA) is a chronic disease characterized by articular cartilage damage, pain, and weakness. Ambulating stairs is a leading source of pain in people with OA, and disease progression may be marked by asymmetrical gait abnormalities. The purpose of this study was to assess relative peak knee extension torque and Step-Up-and-Over (SU...
Article
Full-text available
The applied use of eccentric muscle actions for physical rehabilitation may utilize the framework of periodization. This approach may facilitate the safe introduction of eccentric exercise and appropriate management of the workload progression. The purpose of this data-driven Hypothesis and Theory paper is to present a periodization model for isoki...
Article
Full-text available
Background. Quantitative ultrasound measures are influenced by multiple external factors including examiner scanning force. Force feedback may foster the acquisition of reliable morphometry measures under a variety of scanning conditions. The purpose of this study was to determine the reliability of force-feedback image acquisition and morphometry...
Poster
Background: Knee osteoarthritis (OA) is a chronic disease characterized by articular cartilage damage, pain, and muscle weakness. Ambulating stairs is a leading source of pain in people with OA, and disease progression may be marked by asymmetrical gait abnormalities. The primary objective of this study was to determine the relationship between kne...
Article
Full-text available
Full text: https://doi.org/10.7717/peerj.1721 Background: Quantitative diagnostic ultrasound imaging has been proposed as a method of estimating muscle quality using measures of echogenicity. The Rectangular Marquee Tool (RMT) and the Free Hand Tool (FHT) are two types of editing features used in Photoshop and ImageJ for determining a region of in...
Article
Full-text available
Full text: http://journal.frontiersin.org/article/10.3389/fphys.2015.00302/full ..... Introduction: Age-related changes in muscle mass and muscle tissue composition contribute to diminished strength in older adults. The objectives of this study are to examine if an assessment method using mobile diagnostic ultrasound augments well-known determina...
Article
Full-text available
The patient was a 58-year-old African-American male with radiographic evidence of bilateral knee osteoarthritis (OA). He participated in a standardized 12-week eccentric strengthening program within a Veterans Affairs (VA) medical center. The use of an eccentric training paradigm may prove to be beneficial for older adults with knee OA since eccent...
Conference Paper
Full-text available
Background: Diagnostic musculoskeletal ultrasound has been shown to elicit a hyperechoic response in intramuscular adipose tissue. Skeletal muscle characterized by excessive intramuscular adipose tissue is marked by diminished peak force generation in older adults. Previous study findings also suggest that poor muscle tissue quality, as estimated w...
Conference Paper
Full-text available
Background: Ultrasound has been proposed as inexpensive method to assess age related changes in muscle tissue composition and lean body mass without the use of ionizing radiation. However, the reliability of the method may be affected by examiner technique and experience. Augmented ultrasound feedback may aid measurement consistency among multiple...
Article
Full-text available
Objective: To determine the relationship between peak isometric muscle force and temporal characteristics of gait in individuals with sporadic inclusion body myositis (s-IBM). Patients and Methods: An observational study of 42 individuals with s-IBM (12 female; age: 61.6 ±7.3 years [mean ±standard deviation]; disease duration 8.9 ±4.3 years) was co...
Article
Full-text available
Objective The Adult Myopathy Assessment Tool (AMAT) is a 13-item performance-based battery developed to assess functional status and muscle endurance. The purpose of this study was to determine the intrarater and interrater reliability of the AMAT in adults with myositis.Methods Nineteen raters (13 physical therapists and 6 physicians) scored video...
Article
Full-text available
Diagnostic musculoskeletal ultrasound has potential clinical utility in characterizing pathological muscle tissue. Sonography has been long proposed as method of assessing muscle damage due to neuromuscular diseases such as muscular dystrophy, and more recently, changes in body and tissue composition associated with muscle wasting disorders such as...
Article
Full-text available
Sarcopenia is characterized by an age-related loss of muscle mass associated with diminished strength and physical functioning. This syndrome is not currently screened within the Veterans Health Administration (VHA) healthcare system or systematically documented within the electronic medical record, primarily due to a lack of agreement regarding th...
Article
Full-text available
Purpose. The adult myopathy assessment tool (AMAT) is a performance-based battery comprised of functional and endurance subscales that can be completed in approximately 30 minutes without the use of specialized equipment. The purpose of this study was to determine the construct validity and internal consistency of the AMAT with a sample of adults w...
Article
Purpose: To determine the validity of the single limb heel raise (SLHR) test as a potential screening tool to detect lower extremity disability in patients with sporadic inclusion body myositis (sIBM). Methods: We compared gait speed and fall history between subjects with sIBM who either could complete one SLHR (SLHR group) or could not complete...
Article
Objective: To identify the clinical and laboratory predictors of clinical improvement in a cohort of myositis patients treated with rituximab. Methods: We analyzed data for 195 patients with myositis (75 with adult polymyositis [PM], 72 with adult dermatomyositis [DM], and 48 with juvenile DM) in the Rituximab in Myositis trial. Clinical improve...
Article
Full-text available
Background Repeated heel raises have been proposed as a method of ankle plantar flexor strength testing that circumvents the limitations of manual muscle testing (MMT). Objective To examine the relationship among ankle plantar flexor isometric maximum voluntary contraction (MVC), repeated single-limb heel raises (SLHR), and MMT in participants with...
Article
Full-text available
Objective: To assess the safety and efficacy of rituximab in a randomized, double-blind, placebo-phase trial in adult and pediatric myositis patients. Methods: Adults with refractory polymyositis (PM) and adults and children with refractory dermatomyositis (DM) were enrolled. Entry criteria included muscle weakness and ≥2 additional abnormal val...
Article
Spinal and bulbar muscular atrophy (SBMA) is caused by polyglutamine expansion in the androgen receptor, which results in ligand-dependent toxicity. Animal models have a neuromuscular deficit that is mitigated by androgen-reducing treatment. We aimed to assess the efficacy and safety of the 5α-reductase inhibitor dutasteride in patients with SBMA,...
Article
Full-text available
Spinal and bulbar muscular atrophy is an X-linked motor neuron disease caused by a CAG repeat expansion in the androgen receptor gene. To characterize the natural history and define outcome measures for clinical trials, we assessed the clinical history, laboratory findings and muscle strength and function in 57 patients with genetically confirmed d...
Article
Full-text available
Spinal and bulbar muscular atrophy is an X-linked motor neuron disease caused by a CAG repeat expansion in the androgen receptor gene. To characterize the natural history and define outcome measures for clinical trials, we assessed the clinical history, laboratory findings and muscle strength and function in 57 patients with genetically confirmed d...
Article
Full-text available
Resident's case problem. Kaposi's sarcoma (KS) is the most common form of cancer in patients with human immunodeficiency virus (HIV) infection. Although KS is often initially asymptomatic, this neoplasm may progress to affect multiple organ systems, including structures of the musculoskeletal system, which can produce symptoms similar to those asso...
Article
The purpose of this study was to describe gait parameters in children and adolescents with a diagnosis of Friedreich ataxia (FA) and examine the relationship between disease severity, measured by the Friedreich Ataxia Rating Scale (FARS) and gait parameters. The study examined whether FARS scores can discriminate between those who walk independentl...
Article
Full-text available
Sporadic inclusion-body myositis (sIBM) is the most common disabling, adult-onset, inflammatory myopathy histologically characterized by intense inflammation and vacuolar degeneration. In spite of T cell-mediated cytotoxicity and persistent, clonally expanded and antigen-driven endomysial T cells, the disease is resistant to immunotherapies. Alemtu...
Article
Full-text available
To describe the distribution and severity of muscle weakness using manual muscle testing (MMT) in 172 patients with PM, DM and juvenile DM (JDM). The secondary objectives included characterizing individual muscle group weakness and determining associations of weakness with functional status and myositis characteristics in this large cohort of patie...
Article
The purpose of this study was to investigate the acute effects of 3 types of stretching-static, dynamic, and proprioceptive neuromuscular facilitation (PNF)-on peak muscle power output in women. Concentric knee extension power was measured isokinetically at 60 degrees x s(-1) and 180 degrees x s(-1) in 12 healthy and recreationally active women (me...
Article
Full-text available
Hereditary Inclusion Body Myopathy (HIBM) is an autosomal recessive, adult onset, non-inflammatory neuromuscular disorder with no effective treatment. The causative gene, GNE, codes for UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, which catalyzes the first two reactions in the synthesis of sialic acid. Reduced sialylation of musc...
Data
Isoelectric focusing of serum transferrin and Apo C-III. A. Normal sialylation of transferrin (N-linked glycoprotein) in all four patients before IVIG (Pre), after IVIG loading (Mid), and after the treatment period (Post). Samples of patients 3 and 4 were electrophoresed on a gel different from the gel for samples 1 and 2. Transferrin sialo-isoform...
Article
Children with juvenile idiopathic inflammatory myopathies (JIIM) present with muscle inflammation and decreased strength that may affect their functional abilities. The purpose of this study was to determine the intra-rater and inter-rater reliability of the 0 to 10-point manual muscle testing method for children with JIIM. For the intra-rater and...
Chapter
Polymyositis (pm) is een ondercategorie van idiopathische inflammatoire myo­pathie (iim), die vaak samengaat met proximale spierzwakte en diverse stoor­nissen van het auto-immuunsysteem en het bindweefsel.
Article
Polymyositis (PM) is a subset of idiopathic inflammatory myopathy (IIM), often associated with proximal muscle weakness and various autoimmune and connective tissue disorders. Histopathologic findings in PM include endomysial infiltration of CD8+ lymphocytes affecting muscle fibers with major histocompatibility complex class I (MHC1) expression. Th...
Article
Objective. The Adult Myopathy Assessment Tool (AMAT) is a 13-item performance-based battery developed to assess functional status and muscle endurance. The purpose of this study was to determine the intrarater and interrater reliability of the AMAT in adults with myositis. Methods. Nineteen raters (13 physical therapists and 6 physicians) scored vi...
Article
Full-text available
Kaposi's sarcoma is the most common form of cancer in patients with human immunodeficiency virus (HIV) infection. Although Kaposi sarcoma lesions may contribute to significant physical impairments, there is a lack of scientific literature detailing the role of physiotherapy in the treatment of HIV-associated Kaposi's sarcoma. The present Case Repor...
Article
Full-text available
We describe the rehabilitation management during a 12-month period of a 14-year-old female with Friedreich ataxia. Interventions included task-oriented bimanual reaching activities, functional strengthening, and gait training using a walker featuring tension-controlled wheels and a reverse-braking system. Her physical status was assessed with the N...
Article
The sequelae associated with idiopathic inflammatory myopathy (IIM) often result in disability and decreased quality of life. Our understanding of how exercise mitigates disability may be facilitated through the use of a conceptual model. This review describes the enablement-disablement model applied to myositis and explores the role of physical ac...
Article
The lack of consensus regarding outcome measures and trial design issues in the idiopathic inflammatory myopathies (IIM) is inhibiting the conduct and interpretation of clinical trials. To begin to address these problems, a multispecialty group of over 70 adult and pediatric neurologists, rheumatologists, rehabilitation medicine physicians, statist...
Article
The purpose of this project was to determine the reliability of commonly used indices of anaerobic fatigue. Eight normal subjects with an average age of 38 (SD, 9.4) years participated in this study. Six trials of maximal elbow flexion were performed over 2 sessions using a dynamometer with the elbow in 60 degrees of flexion and the forearm in supi...
Article
Repeated measures of 14 temporal factors of gait obtained with a multimemory stopwatch from a variety of subjects with locomotor impairments. To estimate the intratester and intertester reliability of 14 temporal factors of gait by using a multimemory stopwatch; to compare novice and expert clinicians at mastery of making these temporal measurement...

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