Michael Gasik

Aalto University Foundation · Chemical and Metallurgical Engineering, School of Chemical Engineering

The performance of current biomedical titanium alloys is limited by inflammatory and severe inflammatory conditions after implantation. In this study, a novel Ti–Nb–Zr–Si (TNZS) alloy was developed and compared with commercially pure titanium, and Ti–6Al–4V alloy. Electrochemical parameters of specimens were monitored during 1 h and 12 h immersion...

Laser surface texturing (LST) is a powerful technique for creating high quality micro-textured patterns with different shapes and sizes on metallic biomaterials. Textured surfaces may improve the interaction between bone and implant by increasing the surface contact area and thus promoting bone regeneration. The goal of this study was to explore Nd...

A home-made 3D Multi-Material Laser Powder Bed Fusion (3DMMLPBF) technology was exploited to manufacture novel multi-material Ti6Al4V–CoCrMo parts. This multi-material concept aims to bring to life a new and disruptive material's design concept for the acetabular cup. Only using a layer-by-layer approach it is possible to manufacture an acetabular...

The aim of this work was the development, production and characterisation of a multi-functional surface, consisting of a 420 stainless steel surface textured by laser and subsequently filled with pure copper by hot pressing, for plastic injection moulds. The influence of pure copper on the physical, chemical, surface, mechanical and thermal propert...

A home-made 3D multi-material laser powder bed fusion (3DMMLPBF) system was used to produce novel multi-material Inconel 718 (IN718)–copper (Cu) parts with potential to be applied in rocket engines. This innovative approach combines IN718 high strength and Cu high thermal conductivity in a single part, fabricated at once. The main goal of this stud...

This review provides a critical overview of the influence of the laser powder bed fusion (LPBF) processing parameters on the final properties of the three steels used in the plastic injection mould industry (420 stainless steel, H13, and P20 steels). The main objective is to provide an engineering overview concerning the response of the parts made...

Ti6Al4V alloy is an ideal lightweight structural metal for a huge variety of engineering applications due to its distinguishing combination of high specific mechanical properties, excellent corrosion resistance and biocompatibility. In this review, the mechanical properties of selective laser-melted Ti6Al4V parts are addressed in detail, as well as...

A novel multi-material design concept to be applied in plastic injection moulds is proposed combining the mechanical resistance of the 420 stainless steel alloy and the high thermal conductivity of copper, in a single component, fabricated in just one event by means of homemade 3D Multi-Material Laser Powder Bed Fusion equipment. The processing str...

In this study, samples of 420 stainless steel were obtained by hot pressing from powder at temperatures from 1,100 to 1,200°C. The aim was to explore the influence of the processing temperature on their grain size, microstructure, densification and mechanical properties. The results showed that it is possible to produce dense samples at these sinte...

In this study, Selective Laser Melting (SLM) was used to produce mono-material Ti64Al4V- and NiTi-cubic cellular structures with an open-cell size and wall thickness of 500 μm and 100 μm, respectively. Bioactive beta-tricalcium phosphate (βTCP) and polymer poly-ether-ether ketone (PEEK) were used to fill the produced structures open-cells, thus cre...

Since the last few decades, the development of smart hydrogels, which can respond to stimuli and adapt their responses based on external cues from their environments, has become a thriving research frontier in the biomedical engineering field. Nowadays, drug delivery systems have received great attention and smart hydrogels can be potentially used...

The surface of an annealed 420 stainless steel plate was textured using a fibre laser in this work. Four hundred textures were produced from eighty different combinations of processing parameters (laser power, scan speed, line spacing and number of passes). The most promising textures (fourteen combinations of the processing parameters) were obtain...

The in silico platform for the initial prediction of safety and efficacy of (bio-)material based on in vitro tests is elaborated. The set of bio-kinetic (in vitro) models serves as a tool, which is developed to facilitate follow-up steps for in vitro-in vivo extrapolation and prediction of biomaterial risk for the human organism. The service is des...

Alzheimer's disease (AD) is a neurodegenerative condition with enormous social and economic impact at a global scale. Given the inefficacy of the pharmacological treatments developed so far in decelerating/blocking AD pathology, the study and development of so-called alternative (i.e., nonpharmacological) and non-invasive therapies has become one o...

The study highlights the corrosion behavior of untreated and treated tantalum with addition of trimanganese tetraoxide (Mn3O4) nanoparticles in simulated inflammatory media. The anodic layer was produced on pure tantalum by anodization in electrolytes composed of ammonium fluoride, ethylene glycol, and water. Nanoparticles were deposited uniformly...

Modern 3D printing of implantable devices provides an important opportunity for the development of personalised implants with good anatomical fit. Nevertheless, 3D printing of silicone has been challenging and the recent advances in technology are provided by the systems which can print medical grade silicone via extrusion. However, the potential i...

Dental implants’ success comprises their proper stability and adherence to different oral tissues (integration). The implant is exposed to different mechanical stresses from swallowing, mastication and parafunctions for a normal tooth, leading to the simultaneous mechanical movement and deformation of the whole structure. The knowledge of the mecha...

Orthopaedic implants for load-bearing applications are usually composed of titanium-based materials. Aiming to propose a strategy able to improve the bone-implant interface on these implants, commercially pure titanium and Ti6Al4V alloy were subjected to anodic oxidation, hydrothermal treatment and to anodic oxidation followed by hydrothermal treat...

(1) It is estimated that 10% of the world’s population will need a dental implant in their lifetime. Despite all the advances in the comprehension of dental implant designs, materials and techniques, traditional implants still have many limitations. Customized root-analogue implants are, therefore, gaining increased interest in dental rehabilitatio...

Prevention of bacterial inflammation around dental implants (peri-implantitis) is one of the keys to success of the implantation and can be achieved by securing the gingival tissue-abutment interface preventing penetration of bacteria. Modern dental practice has adopted zirconia abutments in place of titanium, but the adhesion of gingival tissue to...

Nanofibrous substrates and scaffolds are widely being studied as matrices for 3D cell cultures, and disease models as well as for analytics and diagnostic purposes. These scaffolds usually comprise randomly oriented fibers. Much less common are nanofibrous scaffolds made of stiff inorganic materials such as alumina. Well-aligned matrices are a prom...

The number of patients undergoing joint replacement surgery has progressively increased worldwide due to world population ageing. In the Unites States, for example, the prevalence of hip and knee replacements has increased more than 6 and 10 times, respectively, since 1980. Despite advances in orthopaedic implant research, including the development...

Here we report a novel strategy to consolidate layered alumina demonstrating the directional electrical and thermal conductivity. The material was produced via incorporation of alumina nanofibers (20±2 nm in diameter) decorated by several layers of graphene wrapped around longitudinal axes of the fibers. The graphenated fibers, obtained with the he...

Biomaterials along with engineered tissues and implants are an essential part of any operations for tissue repair and regenerations. Besides chemical, mechanical, and rheology properties of templates and engineered products are very important—unfortunately, many different methods of biomechanical testing give rather different outcomes so it is not...

Background: Gingival tissue attachment is known to be important for long term prognosis of implants. This in vitro study evaluated the gingival attachment to zirconia implants and zirconia implants modified with sol-gel derived TiO2 coatings. Materials and methods: Zirconia endodontic posts (n = 23) were used to function as implants that were in...

SLM accuracy for fabricating porous materials is a noteworthy hindrance when aiming to obtain biomaterial cellular structures owing precise geometry, porosity, open-cells dimension and mechanical properties as outcomes. This study provides a comprehensive characterization of seventeen biomaterial Ti6Al4V-based structures in which experimental and n...

Orthopedic metallic devices are often related with devasting complications due to acute prosthetic joint infections. Gallium (Ga) antibacterial activity has been demonstrated by the evidence that Ga in solution ionize in a Ga³⁺ trivalent form that replace Fe³⁺ thus arresting metabolism. However, it is not clear whether such effect is restricted onl...

Load-bearing implants success is strongly dependent on several physical and chemical properties that are known to drive cellular response. In this work, multi-material β-TCP-Ti6Al4V cellular structures were designed to combine Ti6Al4V mechanical properties and β-Tricalcium Phosphate bioactivity, in order to promote bone ingrowth as the bioactive ma...

Selective Laser Melting (SLM) is an extremely versatile technology especially suited for the manufacturing of thin-walled parts. Micro-sized parts are highly influenced and dependent on the SLM processing parameters; thus being indispensable to assess the influence of processing parameters on SLM fabrication, as isolated parameters but also their i...

Scaffolds for articular cartilage repair have to be optimally biodegradable with simultaneous promotion of hyaline cartilage formation under rather complex biomechanical and physiological conditions. It has been generally accepted that scaffold structure and composition would be the best when it mimics the structure of native cartilage. However, a...

Amorphous calcium phosphate (ACP) is essential in formation of mineralized bone and using as a bone substitute. This study presents new aspects of carbonated ACP crystallization during heat treatment. Initially synthesis end pH and drying method (80 °C or freeze-drying) of ACP were varied. Thermal behaviour and structure of differently obtained ACP...

Conversely to natural teeth, where periodontal ligament (PDL) and pulp works as a damper reducing the effect of the stress on surrounding structures, when natural teeth is lost and replaced or restored the biting forces are directly transmitted to the bone or affect the integrity of the adjacent bottom layers. In this study, damping capacity and dy...

Ti6Al4V-alloy is commonly used in dental and orthopedic applications where tribochemical reactions occur at material/bone interface. These reactions are one of the main concerns regarding Ti6Al4V implants due to the generation of wear particles, linked to the release of metallic ions in toxic concentration which occurs when TiO2 passive film is des...

Multi-material Ti6Al4V cellular structures impregnated with 45S5 bioactive glass were designed and produced using Selective Laser Melting (SLM), an additive manufacturing technique, combined with Press and Sintering focusing on load bearing components like hip implants. These structures were designed to combine Ti6Al4V mechanical properties and pro...

One of the most important complications for implanted biomaterials is the attachment of bacteria on their surface and eventual biofilm formation which can result in significant patient discomfort and may require revision surgeries. In this chapter, the sequence, the underlying causes an consequences of bacterial attachment to biomaterial surfaces w...

A challenge in regenerative medicine is governed by the need to have control over the fate of stem cells that is regulated by the physical and chemical microenvironment in vitro and in vivo. The differentiation of the stem cells into specific lineages is commonly guided by use of specific culture media. For the first time, we demonstrate that human...

Three-dimensional (3D) customized scaffolds are anticipated in providing new frontiers in cells manipulation and advanced therapy methods. Here we demonstrate the application of hybrid 3D porous scaffolds, representing networks of highly aligned self-assembled ceramic nano-fibers, for culturing four types of cancer cells. Ultra-high aspect ratio (~...

The development of p-type transparent semiconductors with large optical bandgaps and high electrical conductivity is needed for a wide range of applications in optoelectronics and solar cell technologies. The experimental techniques currently used are limited to complex procedures and time consuming processing. In this work, we propose a versatile,...

A new, faster and more reliable analytical methodology for S(IV) species analysis at low pH solutions by bichromatometry is proposed. For decades the state of the art methodology has been iodometry that is still well justified method for neutral solutions, thus at low pH media possess various side reactions increasing inaccuracy. In contrast, the n...

Fitting of the models on the iodometry data from Fig 2 from the manuscript. (PDF)

Fitting of the models on the bichromatometry data from Fig 2 from the manuscript. (PDF)

The Ni-W binary system was assessed using critically evaluated experimental data with assistance from first principles analysis and the CALPHAD method. The solution phases (liquid, fcc-A1 and bcc-A2) were modeled using the substitutional regular solution model. The recently discovered Ni8W metastable phase was evaluated as Fe16C2- like martensite w...

Objectives: Thermal cycling is widely used to simulate the aging of restorative materials corresponding to the changes of temperature in the oral cavity. However, test parameters present in literature vary considerably, which prevents comparison between different reports. The aim of this work is to assess the influence of the specimens' geometry a...

One of the greatest challenges in the development of new medical products and devices remains in providing maximal patient safety, efficacy and suitability for the purpose. A 'good quality' of the tissue-implant interface is one of the most critical factors for the success of the implant integration. In this paper this challenge is being discussed...

Along with biocompatibility, bioinductivity and appropriate biodegradation, mechanical properties are also of crucial importance for tissue engineering scaffolds. Hydrogels, such as gellan gum, are usually soft materials, which may benefit from the incorporation of inorganic particles, e.g. bioactive glass, not only due to the acquired bioactivity,...

A quantum kinetic equation is obtained for an inhomogeneous solid having arbitrary gradient concentration and chemical potential. We find, starting from nonequilibrium statistical operator, a new equation to describe atom migration in solid states. In continuous approximation, this equation turns into a non-linear diffusion equation. We derive cond...

In this paper, the performance of a robust SO2 depolarized electrolyser (SDE) stack that involves neither Pt catalyst nor carbon compounds at ambient conditions is demonstrated. In particular, the effect of different anolyte flow configurations to the overall H2 production rate and SO2 carry-over phenomenon is presented. These results indicate that...

http://www.bjjprocs.boneandjoint.org.uk/cgi/content/abstract/99-B/SUPP_2/39

http://www.bjjprocs.boneandjoint.org.uk/cgi/content/abstract/99-B/SUPP_1/79

Nanostructured bone replacement materials are of high importance. Calcium phosphates (CaP) are one of them because of their outstanding response to living tissue. Aim was to develop new synthesis route to prepare amorphous CaP (ACP) nanoparticles with high specific surface area (SSA) and to study their structural and thermal properties. Current app...

Three-dimensional (3D) customized scaffolds capable to mimic a native extracellular matrix open new frontiers in cells manipulation and advanced therapy. The major challenge is in a proper substrate for in vitro models on engineered scaffolds, capable to modulate cells differentiation. Here for the first time we demonstrate novel design and functio...

SO2-depolarized electrolysis (SDE) is considered as one of the most efficient hydrogen production methods. To maximize H2 production in SDE, the phenomena occurring in the cell need to be understood and controlled. In this work, electrochemically driven SO2 carry-over and elemental sulphur formation in cathode space are analysed by various methods:...

Orthopedic applications commonly require the administration of systemic antibiotics. Gentamicin is one of the most commonly used aminoglycosides in the treatment and prophylaxis of infections associated with orthopedic applications, but gentamicin has a short half-life. However, silica nanoparticles (SiO2 NPs) can be used as elegant carriers for an...

One of the largest obstacles for SO2 depolarized electrolyser (SDE) commercialization is the material stability in rough operating conditions. In this work stainless steel bipolar plates have been coated with thin Au layer having bifunctional role: providing electrocatalytic surface for both electrode reactions and simultaneously improves the stain...

Abstract Lightweight metal-matrix composites (MMC) are being applied in many fields such as aerospace and automotive, where detailed knowledge about their elastic and inelastic properties is required to make optimal design of the component. In this study the high-temperature damping capacity and dynamic Young’s modulus of hot-pressed AlSi-based hyb...

The performance of dental restorations has been a concern of dentists and engineers. One of the topics that have concentrated most effort has been the study of the properties of the interface between the veneering porcelain to metallic or ceramic substrates, namely on the improvement of the adhesion between the two materials and its behaviour under...

The research of mechanical properties of poro-visco-elastic biomaterials is an important task, especially for tailoring the best conditions for in-growth and healing of implants. In this work we analysed the behaviour of biomaterials under different static and dynamic loading regimes, in "dry" and "wet" conditions. Retrieved data revealed nonlinear...

Evaluation of internal energy in a crystal lattice requires precise calculation of lattice sums. Such evaluation is a problem in the case of small (nano) particles because the traditional methods are usually effective only for infinite lattices and are adapted to certain specific potentials. In this work, a new method has been developed for calcula...

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Titanium-based implants are widely used in modern clinical practice, but their "optimal" properties in terms of porosity and topology, roughness and hydrophilic parameters are being a subject of intensive discussions. Recent in vitro results have shown a possibility to optimize the surface of an implant with maximal repelling of bacteria (Staphyloc...

The relation between the activation energy and the preexponential factor in the Arrhenius equation that describes the viscosity and electrical conductivity of oxide (slag) melts is systematically analyzed over wide composition and temperature ranges for the first time. When deriving this relation, we do not use any model concepts and assumptions co...