Michael G. Tyshenko

Michael G. Tyshenko
University of Ottawa · Institute of Population Health

PhD, MPA

About

153
Publications
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Introduction
Michael G. Tyshenko specialises in interdisciplinary studies combining science, health policy, communication, risk management and impacts on society. Research areas include: emerging health risk issues, eHealth-mHealth development, bioinformatics, medical nanotechnology, zoonotic diseases, and pandemic sequalae-management.

Publications

Publications (153)
Article
A recent approach for bioterrorism risk management calls for stricter regulations over biotechnology as a way to control subversion of technology that may be used to create a man-made pandemic. This approach is largely unworkable given the increasing pervasiveness of molecular techniques and tools throughout society. Emerging technology has provide...
Article
Following the detection of bovine spongiform encephalopathy (BSE) in Canada, and subsequently in the United States, confidence in the safety of beef products remained high. Consumers actually increased their consumption of beef slightly after the news of an increased risk from mad cow disease, which has been interpreted as public support for beef f...
Article
Full-text available
Background Kuwait had its first COVID-19 in late February, and until October 6, 2020 it recorded 108,268 cases and 632 deaths. Despite implementing one of the strictest control measures-including a three-week complete lockdown, there was no sign of a declining epidemic curve. The objective of the current analyses is to determine, hypothetically, th...
Article
Full-text available
Risk management decisions in public health require consideration of a number of complex, often conflicting factors. The aim of this review was to propose a set of 10 fundamental principles to guide risk decision-making. Although each of these principles is sound in its own right, the guidance provided by different principles might lead the decision...
Article
Full-text available
Chronic wasting disease (CWD) is a spongiform encephalopathy disease caused by the transmission of infectious prion agents. CWD is a fatal disease that affects wild and farmed cervids in North America with few cases reported overseas. Social interaction of cervids, feeding practices by wildlife keepers and climate effects on the environmental carry...
Article
Full-text available
Background Anticipating an initial shortage of vaccines for COVID-19, the Centers for Disease Control (CDC) in the United States developed priority vaccine allocations for specific demographic groups in the population. This study evaluates the performance of the CDC vaccine allocation strategy with respect to multiple potentially competing vaccinat...
Article
Full-text available
Externality exists in healthcare when an individual benefits from others being healthy as it reduces the probability of getting sick from illness. Healthy workers are considered to be the more productive labourers leading to a country’s positive economic growth over time. Several research studies have modelled disease transmission and its economic...
Poster
Full-text available
Anticipating an initial shortage of vaccines for COVID-19, the Centers for Disease Control (CDC) in the United States developed priority vaccine allocations for specific demographic groups in the population. In this poster, I present our recent study that evaluates the performance of the CDC vaccine allocation strategy with respect to multiple pote...
Preprint
Full-text available
Background: Anticipating an initial shortage of vaccines for COVID-19, the Centers for Disease Control (CDC) in the United States developed priority vaccine allocations for specific demographic groups in the population. This study evaluates the performance of the CDC vaccine allocation strategy with respect to multiple potentially competing vaccina...
Article
Full-text available
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a World Health Organization designated pandemic that can result in severe symptoms and death that disproportionately affects older patients or those with comorbidities. Kuwait reported its first imported cases of COVID-19 on February 24, 2020. Analysis of data from the first three mont...
Chapter
Full-text available
The recent COVID-19 pandemic has caused significant societal impacts. Besides loss of life there were large additional costs incurred by every country including the treatment of patients and costs to implement response plans. The pandemic resulted in major economic disruptions and stalled growth worldwide due to travel bans, lockdowns, social dista...
Article
Full-text available
The application, timing, and duration of lockdown strategies during a pandemic remain poorly quantified with regards to expected public health outcomes. Previous projection models have reached conflicting conclusions about the effect of complete lockdowns on COVID-19 outcomes. We developed a stochastic continuous-time Markov chain (CTMC) model with...
Preprint
Full-text available
Background: Kuwait had its first COVID-19 in late February, and until October 6, 2020 it recorded 108,268 cases and 632 deaths. Despite implementing one of the strictest control measures-including a three-week complete lockdown, there was no sign of a declining epidemic curve. The objective of the current analyses is to determine, hypothetically, t...
Preprint
Full-text available
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a World Health Organization designated pandemic that can result in severe symptoms and death that disproportionately affects older patients or those with comorbidities. Kuwait reported its first imported cases of COVID-19 on February 24, 2020. Analysis of data from the first three mont...
Article
Full-text available
Background: Anticipating an initial shortage of vaccines for COVID-19, the Centers for Disease Control (CDC) in the United States developed priority vaccine allocations for specific demographic groups in the population. This study evaluates the performance of the CDC vaccine allocation strategy with respect to multiple potentially competing vaccina...
Preprint
Full-text available
The application, timing, and duration of lockdown strategies during a pandemic remain poorly quantified with regards to expected public health outcomes. Previous projection models have reached conflicting conclusions about the effect of complete lockdowns on COVID-19 outcomes. We developed a stochastic continuous-time Markov chain (CTMC) model with...
Article
Full-text available
Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging zoonotic coronavirus that has a tendency to cause significant healthcare outbreaks among patients with serious comorbidities. We analyzed hospital data from the MERS-CoV outbreak in King Abdulaziz Medical Center, Riyadh, Saudi Arabia, June–August 2015 using the susceptible-expos...
Article
Full-text available
Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing based on expanded application of high-throughput in vitro screening and in silico methods to assess potential health risks of environmental agents. This review examines progress on the vision for toxicity testing elaborated by the US National Research Coun...
Article
Full-text available
The detection of prion protein in widely used urine-derived fertility drugs has raised the possibility that prions from urine donors with (asymptomatic) prion disease could be present in these drugs. A high level of uncertainty exists regarding this issue. An international expert panel provided judgments related to prion disease transmission throug...
Presentation
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SARS in Canada lecture
Article
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This article summarises efforts at disease surveillance and risk management of chronic wasting disease (CWD). CWD is a fatal neurodegenerative disease of cervids and is considered to be one of the most contagious of the transmissible spongiform encephalopathies (TSEs). Evidence has demonstrated a strong species barrier to CWD for both human and far...
Article
“Prion Research in Perspective IV” is PrioNet Canada’s fourth open paper call and maintains its mandate allowing PrioNet Canada researchers, the Alberta Prion Research Institute, and other partner organizations a venue to publish their latest research.
Article
A high degree of uncertainty exists for chronic wasting disease (CWD) transmission factors in farmed and wild cervids. Evaluating the factors is important as it helps to inform future risk management strategies. Expert opinion is often used to assist decision making in a number of health, science, and technology domains where data may be sparse or...
Article
ABSTARCT Chronic wasting disease (CWD) is a neurodegenerative, protein misfolding disease affecting cervids in North America in epidemic proportions. While the existence of CWD has been known for more than 40 years, risk management efforts to date have not been able to curtail the spread of this condition. An expert elicitation exercise was carried...
Chapter
Full-text available
Nepal, like many other low-income countries, is facing an increasing burden of disease and deaths from Noncommunicable Diseases (NCDs). The main NCDs causing some of the highest mortality in Nepal are cardiovascular diseases (CVD), cancers, chronic obstructive pulmonary disorder (COPD) and chronic respiratory diseases and diabetes. When compared, t...
Chapter
Full-text available
The rapid commercialization of nanotechnology over the past decade has caught many regulatory agencies off guard without sufficient capacity to oversee nanomaterials or the means to assess the potential toxicity of different nanomaterials. One of the most difficult decisions in public health practice is determining when evidence is sufficient for a...
Presentation
Full-text available
Globally, millions of lives (and billions of dollars) are lost each year because of communicable diseases. In Canada influenza in 2014-2015 alone totalled 7,719 hospitalizations and 591 deaths. All infectious and parasitic diseases rank 10th in Canada causing ~4,300 annual deaths (all ages male and female). The basic component of every communicable...
Presentation
Full-text available
Listeriosis outbreak in Ready to Eat meats in Canada 2008 and the Government policy revisions 2011 response.
Presentation
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A review of pharmacogenomics and Adverse Drug Reactions (ADRs) in a Canadian context. Two examples (Codeine and Warfarin) are reviewed and the rise of high-throughput sequencing (new pyrosequencing methods) for personalized medicine is explored to mitigate ADRs. Finally, ethical concerns over personalized medicine are discussed (equity, informed co...
Chapter
Full-text available
Bovine spongiform encephalopathy (BSE) belongs to a group of transmissible spongiform encephalopathies (TSEs). These fatal diseases (listed in Table 1) are caused by proteinaceous agents that have many unusual properties, including a relatively high degree of resistance to standard methods of inactivation and degradation.
Article
News media remains one of the foremost communication portals for information regarding the risks and benefits of new technologies. News media content provides information which helps to shape public attitudes toward emerging technologies. An analysis of national news media content from May 2008 to May 2012 was conducted for nanotechnology content i...
Article
The establishment of nanotechnology across commercial markets, technology sectors, and policy arenas has been accompanied by the spread of nanotechnology-related activities in many countries, far beyond the institutional and cultural context from which it originated. This special issue examines this international dimension of nanotechnology by focu...
Book
Full-text available
Preface: There are a myriad number of different types of risks that, as individuals, we face every day that impact human health. Exposure to hazards can result from the natural and build environments with modulation of this exposure due to other factors such as our biology (eg. genetics, age, gender and comorbid conditions) and social interactions...
Article
Full-text available
Much uncertainty surrounds transmission of transmissible spongiform encephalopathies (TSEs) through blood and blood derived products. A first expert elicitation with 14 experts was conducted in March 2008, and a second re-elicitation involving 11 experts was held a year later in March 2009. Both expert groups were calibrated using a series of seed...
Book
Full-text available
In late September 2004 I met Cathy Paterson, a good friend I hadn’t seen in several years, by chance in a small Kingston, Ontario restaurant. It was an auspicious event that led to this book about risk communication of pandemic disease, and a detailed treatment of risk communication during the Severe Acute Respiratory Syndrome (SARS) outbreak in Ca...
Article
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There is a high level of uncertainty surrounding the potential for iatrogenic prion transmission through transplantation, medical instrument reuse, blood transfusion, and blood product use due to a lack of evidence-based research on this important risk issue. A group of specialists was enlisted to evaluate some of the knowledge gaps in this area us...
Article
Full-text available
Before the first domestic case of bovine spongiform encephalopathy (BSE) was identified in May 2003, Canada was the world's third largest exporter of cattle behind the USA and Australia. After the detection of BSE, over 30 countries imposed an immediate ban on imported Canadian beef and cattle products, including the USA. The interdependence of the...
Article
Full-text available
This paper reviews the history of the risk management challenges faced by many countries and regions of the world which have had cases of bovine spongiform encephalopathy (BSE) from 1986 to the present. The paper first summarises the nature of prion diseases from a scientific perspective, and then presents an overview of the findings of an extensiv...
Article
Full-text available
Globally, Canada is only a minor beef producing country, and yet ranks fourth among countries exporting beef products. That fact alone shows considerable market vulnerability. When coupled with dependence on corporate-owned slaughter capacity and heavy reliance on only one export market (the USA), that vulnerability is magnified. Economic losses fr...
Article
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The World Organisation for Animal Health (formerly the Office of International Epizootics, or OIE) provides inter-governmental guidance on animal health issues. The OIE Terrestrial Animal Health Code contains standards and recommendations to prevent import of infectious pathogens during trade of animal products. The OIE designed recommendations for...
Article
Full-text available
Bovine spongiform encephalopathy (BSE) emerged in the UK in the mid-1980s, and eventually spread to other countries, ultimately becoming a disease of global concern. Each BSE-affected country detected its first domestic case at different points in time, faced different internal and external challenge levels, and responded with different risk manage...
Article
Full-text available
Imports of animal feeds containing contaminated meat and bone meal (MBM) from the UK and other countries in the late 1980s and early 1990s was identified as the major risk factor for an increased risk of bovine spongiform encephalopathy (BSE) entering into the Netherlands. The first BSE case was confirmed in March 1997. Early preventive measures, s...
Article
Full-text available
Following the outbreak of BSE in the UK in the mid-1980s, Israel banned the importation of live cattle and meat and bone meal from the UK. The appearance of its first and only domestic case in 2002 prompted the implementation of several additional protective measures, including improvements to the active surveillance system and the removal of high...
Article
Full-text available
In 1990, Switzerland became the first country in mainland Europe to report a native case of bovine spongiform encephalopathy (BSE), despite a low level of live bovine and meat and bone meal (MBM) imports from the UK, the country generally recognised as the origin of the epidemic. Although an MBM to ruminant feed ban was immediately put into effect,...
Article
Full-text available
Regardless of the increased spread of bovine spongiform encephalopathy (BSE) to several European countries during the late 1990s Japan considered the occurrence of domestic BSE a remote possibility. However, Japan was the first country outside of Europe to report a domestic case of BSE. The public vehemently rejected beef and its increased risk to...
Article
Full-text available
India is unique in its management of bovine spongiform encephalopathy (BSE) due to its distinct system of socio-religious beliefs with respect to cows and beef consumption. Hindus, who comprise the great majority (over 80%) of India's population, revere the cow as a symbol of life, a practice that has evolved over the centuries according to Hindu t...
Article
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Bovine spongiform encephalopathy (BSE) has never been reported in South America. As BSE began to be detected in other parts of the world, Argentina and Brazil were able to gain a larger share of the global demand for beef, with these two countries currently controlling one-third of the world export beef market. In both countries, the practice of pa...
Article
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The prevalence of bovine spongiform encephalopathy (BSE) in Nordic countries is low. To date, there have been 14 BSE cases in domestic cattle in Denmark, three cases in Danish cattle exported to other countries, one case in Finland, one in Sweden, and no cases in Norway. As of April 2008, no cases of variant Creutzfeldt-Jakob disease (vCJD) have be...
Article
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During the late 1970s, the People's Republic of China (PRC) launched a series of far-reaching economic reforms in rural areas of the country in order to develop a market economy; after three decades, these nationwide reforms have achieved enormous success. The country witnessed phenomenal growth in its economic development and became the second lar...
Article
Full-text available
Italy experienced two imported cases of bovine spongiform encephalopathy (BSE) in 1994 and viewed the disease as a 'foreign' problem. Early, precautionary actions including: a 1989 ban on UK meat and bone meal (MBM), 1990 ban on UK beef, 1994 domestic ban on mammalian MBM to ruminants, and 1996 ban on UK live cattle, protected Italy from a much lar...
Article
Full-text available
Large imports of cattle and meat and bone meal from countries potentially affected by bovine spongiform encephalopathy (BSE) may have led to the BSE agent entering Belgium, and the occurrence of domestic BSE cases. The first case was confirmed in 1997. The ability to avoid amplification of incoming infectivity, as well as to reduce already circulat...
Article
Full-text available
Geographic proximity and a long history of integration between US and Canadian cattle industries have resulted in similar management of BSE risk factors. Both countries have had a single imported case of BSE followed by multiple endemic cases of the bovine disease. Comparable risk management strategies have been put in place, such as a ban on the f...
Article
Full-text available
Portugal was one of the first countries outside of the UK to detect indigenous bovine spongiform encephalopathy (BSE) cases. However, initial low compliance with control measures contributed to the occurrence of increasing numbers of cases. This resulted in Portugal being the only other country to be designated at a higher risk level (GBR IV) by th...
Article
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The UK was the first country to detect bovine spongiform encephalopathy (BSE) in 1986, and has reported the vast majority (over 97%) of the world's BSE cases. BSE resulted in large economic losses, disbanding of the lead government agency responsible for managing the outbreak and a loss of public trust in government. Despite a World Organization fo...
Article
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To date, Russia has not reported any cases of bovine spongiform encephalopathy (BSE) or variant Creutzfeldt-Jakob disease (vCJD) in its own territory. Qualitative self risk assessment indicated that if BSE occurred in the Russian Federation, the economic consequences would be devastating for its agriculture and economy. Preventive measures taken by...
Article
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The experience of bovine spongiform encephalopathy (BSE) risk assessment and management in France was somewhat unique among BSE affected countries. Due to its proximity to the UK, the French meat and bone meal industry was challenged with particularly high amounts of infectivity from imported contaminated feed and infected cattle. Although France a...
Article
Full-text available
Between 1962 and 1966, Australia and New Zealand ceased importing rendered animal protein from any country other than each other; as a result, both were protected against bovine spongiform encephalopathy (BSE) contaminated meat and bone meal (MBM), which was being exported from the UK during the 1980s. More recently, global trade considerations hav...
Article
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Costa Rica is a representative Latin American country with significant regional cattle production for its size. The country experienced an exceedingly low challenge for bovine spongiform encephalopathy (BSE) as evidenced by no direct meat and bone meal imports from the UK, few imported cattle, no specified risk materials imports from high risk coun...