Michael Feichtinger

Wunschbaby Institut Feichtinger

Background Although cancer in general affects an aged population, a significant number of women develop cancer at childbearing age. Long-term survival rates after gynecological cancer, especially in young patients are increasing and all quality-of-life aspects, including preservation of fertility have become of major relevance. Outcomes Surgical t...

[This corrects the article DOI: 10.1371/journal.pone.0128317.].

In 2003, human amniotic fluid has been shown to contain stem cells expressing Oct-4, a marker for pluripotency. This finding initiated a rapidly growing and very promising new stem cell research field. Since then, amniotic fluid stem (AFS) cells have been demonstrated to harbour the potential to differentiate into any of the three germ layers and t...

Even though luteal phase support is a standard method in fertility treatment the ideal time to start supplementation is still unknown. Therefore we evaluated different (early and late) initiation points of luteal phase support in a prospective randomized trial. 1111 Women undergoing an IVF/ICSI treatment in a private IVF clinic have been randomized...

Polycystic ovarian syndrome represents the most common endocrine disease of women of reproductive age. Symptoms include metabolic, gynecologic and cosmetic features. Genetic factors seem to contribute to the disease, affecting not only women but also male relatives of patients with similar symptoms. Besides, lifestyle factors play a central role im...

PurposeTo assess early embryonic developmental potential of embryos affected by maternally inherited meiotic aneuploidies.Methods This observational, descriptive study includes 930 oocytes from 151 patients which were retrospectively analyzed by combining the morphological assessment with the genetic results from polar body diagnosis.ResultsOf 930...

Bariatric surgery confers potential advantages for obese patients, but also risks for pregnancy. Perinatal outcomes may be varying between surgical procedures. This topic was recently addressed by a systematic review in BMC Pregnancy and Childbirth . This commentary will discuss the scientific background and implications for future research.

Recently, 2 branches of the wide area of synthetic biology-in vitro gametogenesis and synthetic embryo development-have gained considerable attention. Rodent induced pluripotent stem cells derived via reprogramming of somatic cells can in vitro be differentiated into gametes to produce fertile offspring. And even synthetic embryos with organ progen...

Due to the limited accessibility of the in vivo situation, the scarcity of the human tissue, legal constraints, and ethical considerations, the underlying molecular mechanisms of disorders, such as preeclampsia, the pathological consequences of fetomaternal microchimerism, or infertility, are still not fully understood. And although substantial pro...

BACKGROUND PGT-A using polar body (PB) biopsy derives a clinical benefit by reducing the number of embryo transfers and miscarriage rates but is currently not cost-efficient. Nanopore sequencing technology opens possibilities by providing cost-efficient, fast sequencing results with uncomplicated sample preparation workflows. METHODS In this compa...

Since the presence of cell free DNA (cfDNA) was reported in blastocoel fluid and spent culture medium the possibility to introduce a non-invasive preimplantation genetic testing (niPGT) as a new tool in assisted reproductive technology (ART) has been investigated by different groups.A variety of different approaches have been used until now to coll...

Objective To provide a video tutorial on vaginal transisthmic myomectomy in women with large submucosal fibroids. Design Stepwise demonstration of the technique, with a narrated video footage. Setting Submucosal fibroids protrude into the uterine cavity and can cause numerous symptoms, including abnormal uterine bleeding, dysmenorrhea, subfertili...

Study question Is long-read nanopore sequencing feasible and reproducible as routine technique for aneuploidy detection, potentially allowing fresh embryo transfer PGT-A cycles? Summary answer Pre-clinical analysis of euploid and aneuploid DNA and single cells using long-read nanopore sequencing resulted in high concordance and reproducible result...

Introduction: Previous studies demonstrated a continues decline in fetal growth throughout singleton pregnancy after bariatric surgery. However, intrauterine growth in twin pregnancy is subjected to further underlying processes. This study was to investigate the longitudinal assessment of fetal biometry and abdominal fat thickness of twin pregnanc...

This new edition provides a much-needed reference book to accommodate emerging and expanding knowledge in fertility preservation, the rapidly growing field of reproductive medicine associated with advances in oncology. Written by a team of world-leading experts in the field and comprehensive in its scope, the book covers the full range of technique...

Research question : Full-length 16S rRNA gene sequencing using nanopore technology is a fast alternative to conventional short-read 16S rRNA gene sequencing with low initial investment costs that has been used for various microbiome studies but has not yet been investigated as an alternative approach for endometrial microbiome analysis. Is in-situ...

Aims Dyslipidemia in pregnancy is associated with adverse pregnancy outcomes as elevated triglycerides might be considered as a risk factor for hyperglycemia and gestational diabetes. As only a few studies have addressed the association between maternal triglycerides and glucose metabolism, we aimed to explore the pathophysiologic associations of m...

Background: To investigate insulin sensitivity and glucose metabolism in pregnant lean and overweight polycystic ovary syndrome (PCOS) patients vs. lean and overweight controls without PCOS. Methods: Prospective cohort study on 67 pregnant women (31 with PCOS and 36 controls, subdivided into overweight or obese and normal weight). All women unde...

Aims: This study is aimed at assessing the association of previously developed indices of glucose homeostasis derived from principal component analysis (PCA) with parameters of insulin action, secretion, and beta cell function during pregnancy. Methods: In this prospective longitudinal study, an oral glucose tolerance test was performed in sixty...

Purpose Recent studies showed that women after surgery are at higher risk of delivering small-for-gestational infants. Thus, this study aims to investigate longitudinal changes of fetal subcutaneous adipose tissue thickness (FSCTT) of fetuses conceived after gastric bypass surgery as compared to BMI-matched controls. Methods Retrospective cohort s...

(Abstracted from J Assist Reprod Genet 2019;36:1649–1656) Although endometriosis affects approximately 10% of women of reproductive age and 40% of infertile women, the physiological mechanism of how this chronic inflammatory disease affects fertility remains unclear. There is little consensus in the literature that IVF/ICSI outcomes are impacted by...

Background: An early identification of the risk groups might be beneficial in reducing morbidities in patients with gestational diabetes mellitus (GDM). Therefore, this study aimed to assess the biochemical predictors of glycemic conditions, in addition to fasting indices of glucose disposal, to predict the development of GDM in later stage and th...

Purpose To investigate the impact of symptomatic and surgically confirmed endometriosis on ovarian sensitivity index (OSI) and cumulative live-birth rates (LBR) using predominantly single embryo transfer (SET). Methods Cross-sectional case-control study in a University-based ART program. Women with symptomatic and surgically confirmed endometriosi...

In this case report, we present a case of false positive CA 19-9 and CA 125 levels in a patient with suspected endometriotic cysts. The patient is a 34-year-old nulliparous woman with heavy black tea consumption and elevated CA 19-9 and CA 125 levels. After discontinuation of black tea intake and careful exploration of other possible factors, CA 19...

Bariatric surgery (BS) is regarded to be the most effective treatment of obesity with long lasting beneficial effects including weight loss and improvement of metabolic disorders. A considerable number of women undergoing BS are at childbearing age. Although the surgery mediated weight loss has a positive effect on pregnancy outcome, the procedures...

Bariatric surgery is recommended when other weight loss interventions, such as lifestyle modification or medications, have failed. A considerable number of women undergoing bariatric surgery are of childbearing age; hence, it is necessary to be aware of the effects of bariatric surgery on pregnancy for managing these patients. Although bariatric su...

Purpose To investigate intrauterine fetal growth development and birth anthropometry of fetuses conceived after maternal gastric bypass surgery. Materials and Methods Longitudinal cohort study describing longitudinal growth estimated by ultrasound on 43 singleton pregnancies after gastric bypass compared to 43 BMI-matched controls. Results In fetus...

Purpose: The aim of the study was to assess cytogenetic and embryoscopic characteristics in subsequent miscarriages of spontaneous pregnancy losses (SPL) and recurrent pregnancy losses (RPL). Methods: A retrospective cohort of 75 women was affected by repeated pregnancy loss. Of those, 34 had SPL, 24 primary RPL, and 17 secondary RPL. Ploidy sta...

McArdle disease or glycogen storage disease (GSD) type V is a rare autosomal recessive inherited disorder in skeletal muscle metabolism leading to exercise intolerance, muscle cramps and in some cases to rhabdomyolysis and acute renal failure due to elevated serum myoglobin levels. Albeit the uterine smooth muscle is not affected, pregnancy and del...

Hand anomalies observed in embryos with trisomy 15. The upper panel shows a cleft hand and the lower panel shows polydactyly, DOI: 10.1002/pd.5230. From Philipp et al., in this issue.

Objective: The morphologic features of embryos with full trisomy 15 are described. Method: 1195 pregnancy losses were examined embryoscopically and cytogenetically. Results: Of 1173 successfully karyotyped specimens, full trisomy 15 was diagnosed cytogenetically in 59 cases (5 %). All 59 trisomy 15 embryos were diagnosed cytogenetically in the...

Purpose: Allogeneic ovarian transplantation may be an alternative in the future to oocyte donation in women with premature ovarian failure. The objectives of this study were to (a) evaluate allotransplantation feasibility for restoration of ovarian function and (b) assess efficacy of synthetic preimplantation factor (PIF) monotherapy as sole immun...

Introduction: Scheduling of ovum pickups (OPU) only on weekdays may result in cases of apparently suboptimal timing for human chorionic gonadotropin (hCG) and OPU. This study aimed to assess whether live-birth rates were reduced in women with a potentially suboptimal day for hCG and OPU to avoid week-end work, according to ultrasonographic data on...

The aim of this pilot study was to assess if array comparative genomic hybridization (aCGH), non-invasive preimplantation genetic screening (PGS) on blastocyst culture media is feasible. Therefore, aCGH analysis was carried out on 22 spent blastocyst culture media samples after polar body PGS because of advanced maternal age. All oocytes were ferti...

Aims/hypothesisA history of gastric bypass surgery can influence the results of the OGTT recommended during pregnancy. Therefore, we compared OGTT glucose kinetics and pregnancy outcome between pregnant gastric bypass patients and BMI-matched, lean and obese controls. Methods Medical records were used to collect data on glucose measurements during...

Objective: To assess the cytogenetic and embryoscopic characteristics of primary and secondary recurrent pregnancy loss. Design: Clinical prospective descriptive study. Setting: Tertiary care center. Patient(s): Nine hundred and eighty-four women affected by first-trimester pregnancy loss; 145 patients with recurrent pregnancy loss (RPL) and...

The aim of this retrospective cohort study was to assess differences in infertility-related baseline characteristics and IVF outcome between European and Middle Eastern/North African (MENA) patients. Of 2703 patients undergoing their first IVF cycle, 2485 were Caucasian of European descent and 218 originated from the MENA region. MENA patients were...

Aims: There are emerging data indicating an association between PCOS (polycystic ovary syndrome) and metabolic derangements with potential impact on its clinical presentation. This study aims to evaluate the pathophysiological processes beyond PCOS with particular focus on carbohydrate metabolism, ectopic lipids and their possible interaction. Dif...

Objective: There are emerging data indicating an association between PCOS (polycystic ovary syndrome) and metabolic derangements with potential impact on its clinical presentation. Therefore, this study aims to assess carbohydrate metabolism, ectopic lipids and their possible interaction in women with PCOS. Moreover, differences between the two est...

[This corrects the article DOI: 10.1371/journal.pone.0128317.].

Fragestellung: Ziel dieser Studie war die Bestimmung der Serumkonzentrationen von angiogenetischem Faktor VEGF und anti-inflammatorischem Zytokin IL1RA im Nabelschnurblut (NS) von Muttern mit Gestationsdiabetes (GDM) im Vergleich zu einer stoffwechselgesunden Kontrollgruppe. GDM ist durch veranderte fetoplazentare Angiogenese und endothelialer Dysf...

Introduction Postponement of parenthood is a trend occurring across in the world as a result of social, cultural and family structure transitions. When women before 40 are not able to combine work and career with children, or when women are forming a new family after the age of 40, not only biology but often society is not supportive of their reque...