Michael Entezami

Michael Entezami
Center for Prenatal Diagnosis and Human Genetics, Kudamm-199

About

159
Publications
13,509
Reads
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1,189
Citations
Citations since 2016
22 Research Items
435 Citations
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080

Publications

Publications (159)
Article
Objectives: To measure choroid plexus (CP) size in comparison to head size in normal fetuses and to compare this in fetuses with open spina bifida (OSB) and quantify the subjective sign of a 'dry brain'. Methods: This was a retrospective study of ultrasound images obtained during first-trimester screening between 11 and 13 weeks of gestation in...
Article
Objective To evaluate the detection rate of severe fetal anomalies at the first-trimester screening (FTS) and, vice versa, to evaluate the follow-up of pathological results at FTS at the time of mid-trimester screening (MTS) and throughout pregnancy and delivery in a partially selected population of low-risk pregnancies. Methods We conducted a pro...
Article
Introduction Doppler sonography of the uterine artery (UA) is done to monitor pregnancies, because the detected flow patterns are useful to draw inferences about possible disorders of trophoblast invasion. Increased resistance in the UA is associated with an increased risk of preeclampsia and/or intrauterine growth restriction (IUGR) and perinatal...
Article
Full-text available
Objective: To determine if intrauterine intraumbilical supplementation with amino acids (AA) and glucose can improve neonatal outcome of severe growth restricted human fetuses (IUGR). Methods: Prospective pilot study of intrauterine treatment of severe IUGR fetuses [n=14, 27 weeks of gestation (range 23-31)] with cerebroplacental ratio <1, with...
Article
The use of non-steroidal anti-inflammatory drugs like diclofenac in the third trimester of pregnancy can cause severe side effects, in particular oligohydramnios, premature closure of ductus arteriosus, and fetal kidney damage. However, the treatment with non-steroidal anti-inflammatory drugs until gestational week 28 is accepted as relatively safe...
Article
Purpose: To assess the prevalence and value of a suspicious prenasal skin thickness-to-nasal bone length ratio (PT/NB ratio) in comparison to other established markers in a large population of Down syndrome (DS) fetuses. Materials and Methods: This was a retrospective study of 139 DS fetuses and 530 normal fetuses scanned after 14 + 0 weeks of gest...
Article
Purpose To evaluate the potential of routine assessment of intracranial translucency (IT) and other posterior brain parameters in the early detection of open spina bifida during the 11 – 14 weeks screening examination. Materials and Methods This prospective, multicenter longitudinal study was conducted with the participation of 20 certified DEGUM I...
Article
Introduction: The efficacy of a therapy with certoparin; also in combination with aspirin and prednisolone; in high-risk pregnancies has been examined prospectively. Method: Data of 616 pregnancies have been analyzed. 238 patients injected Mono Embolex 3000; 239 patients Mono Embolex 8000 only. 62 patients injected Mono Embolex 8000 and took aspiri...
Article
To validate the diagnostic accuracy of a non-invasive prenatal test for detecting trisomies 13, 18 and 21 for a population in Germany and Switzerland. Random massively parallel sequencing (MPS) was applied using Illumina sequencing platform HiSeq2000. Fetal aneuploidies were identified using a Median Absolute Deviation based z-score equation. A bio...
Article
During the last few years, there has been a rapid development in prenatal diagnosis. Due to the improvements in sonographic examinations and the introduction of first-trimester screening, the number of invasive prenatal diagnostic procedures has dropped by more than 50 %. Recently, noninvasive prenatal diagnostic tests with cell-free fetal DNA from...
Article
Fragestellung: Iatrogene Verletzung der amnialen Membran bleibt weiterhin ein ungelostes Problem der Fetalchirurgie, das fur die Fruhgeburt u.a. mitverantwortlich ist. Verbesserung des neonatalen Outcomes durch Nutzen eines ultradunnen Fetoskops zur Laser-Koagulation beim feto-fetalen Transfusionssyndrom. Methode: Wir entwickelten einen Trokar fur...
Article
Fragestellung: Welchen Einfluss hat die Verwendung der atraumatischen 29G-Nadel auf den Verlauf der Schwangerschaften nach Amniozentese im 2. Trimester mit Chorion-Amnion-Dissoziation. Besteht bei nicht verschmolzenen Eihautblattern ein erhohtes Abortrisiko? Wenn ja, ist eine Punktionsverschiebung um 1 Woche gerechtfertigt? Methodik: Es wurden 378...
Conference Paper
Full-text available
Recent advances in non-invasive prenatal diagnosis show that massively parallel sequencing (MPS) of maternal plasma DNA allows accurate detection of common foetal aneuploidies. Here, we describe the results of a collaborative clinical study with the aim to validate the diagnostic accuracy of our non-invasive protocol based on MPS for detecting comm...
Article
Congenital diaphragmatic hernia (CDH) affects 1:2500-1:4000 newborns and shows additional malformations and chromosomal anomalies in 40%. Secondary lung hypoplasia is an important factor for the prognosis of the newborn. Survival rates of up to 100% published by single institutions are a selection of favourable cases. Population based studies show...
Article
Full-text available
To assess whether, at 11-13-week and mid-trimester ultrasound examinations, the biparietal diameter (BPD) in fetuses with open spina bifida is smaller than the reference range. In a multicenter retrospective analysis of data from 23 fetuses with open spina bifida diagnosed at 16-24 weeks, BPD at diagnosis was compared with that measured at 11-13 we...
Article
Here we describe the successful application of massively parallel sequencing for noninvasive prenatal detection of trisomy 21. In addition, for the detection of a broader spectrum of fetal aneuploidies, a target enrichment approach was successfully tested. The circulating cell-free DNA was prepared from 53 maternal blood samples and analysed using...
Article
Zusammenfassung In den letzten Jahrzehnten ist die Zahl an Mehrlingsschwangerschaften in Zusammenhang mit der zunehmenden Inanspruchnahme von Techniken der assistierten Reproduktion gestiegen. Aufgrund dessen werden auch in Deutschland pro Jahr mehrere hundert Paare im Rahmen einer Mehrlingsschwangerschaft vor die Frage des Fetozids an einem oder m...
Article
To improve neonatal outcome using ultrathin fetoscope for laser treatment of twin-to-twin transfusion syndrome. Retrospective cohort study of a series of 80 cases of twin-to-twin-transfusion syndrome prior to 26-weeks' gestation subjected to laser coagulation by means of a 1.0/1.2 mm fiber fetoscope with a sheath sectional area 2.65 mm(2)/3.34 mm(2...
Article
To evaluate the acceptance of noninvasive screening for trisomy 13, 18, 21 and the impact on invasive testing rates in women at an age≥35 years. In a retrospective analysis from 2003-2006 including 13 268 women≥35 years old with singleton pregnancies and 3133 invasive procedures, we evaluated the prenatal detection rate of aneuploidies in two cohor...
Article
Die Behandlung minderjähriger Patientinnen wirft besondere Fragestellungen und Probleme auf. Die Minderjährige kann selbst keinen wirksamen Behandlungsvertrag abschließen, was für die Behandlung von minderjährigen Privatpatientinnen bedeutsam ist. Sie kann aber sehr wohl bei Einsichtsfähigkeit in die Behandlung einwilligen, wobei eine Abstufung in...
Article
Fallvorstellung: Bei Hydrops fetalis und einem Nackenodem von 6mm Durchmesser wurde mit 12+2 Schwangerschaftswochen eine linksseitige Zwerchfellhernie aufgrund einer Dextropositio cordis und eines Enterothorax diagnostiziert (Abb. 1). Die Chorionzottenbiopsie ergab einen normalen Karyotyp. Mit 21+3 SSW zeigte sich linksseitig eine grosse echogene L...
Article
Fragestellung: die Zwerchfellhernie ist eine wichtige pranatale Diagnose, weil sie haufig von weiteren Fehlbildungen begleitet wird. Die Prognose hangt aber aufgrund des neonatalen Erstversorgung von der pranatalen Erkennung der Zwerchfellhernie ab. Wie haufig sind im pranatal diagnostizierten Kollektiv Begleitfehlbildungen und wie entscheiden die...
Article
Full-text available
Isolated fetal heart block is considered as an immunological disorder in the majority of cases. Mothers of affected fetuses often suffer from connective tissue disease (Sjögren syndrome or Lupus erythematodes). All of them test positive for anti-SS-A (anti Ro) and/or anti-SS-B (anti La) antibodies. Once established, third-degree congenital heart bl...
Article
Full-text available
Hydrops fetalis is the final common hemodynamic pathway for a variety of pathological states in the fetus, including high output states associated with fetal anemia or arterio-venous fistulas and abnormalities of both cardiac structure and rhythm. Hydrops fetalis secondary to cardiovascular decompensation is usually accompanied by elevations in fet...
Article
In 1:50 000 to 1:100 000 births, conjoined twins occur, caused by incomplete division of the embryonic disc more than 13 days after fertilisation. We present a case of cephalothoracopagus janiceps, a very rare form of conjoined twins, which was diagnosed at 13 weeks of gestation. Three-dimensional and colour Doppler ultrasound enabled precise prena...
Article
Problemstellung: Esophageal atresia (ET) is a malformation, which is difficult to diagnose at prenatal screening, especially in the 2nd trimester of pregnancy. Indicators of ET are an empty or almost empty fetal stomach and polyhydramnios. Visualization of the esophageal fluid filled pouch at the level of ET has been described in recent years, but...
Article
Problemstellung: Softmarkers as indicators of chromosomal abnormalities of the fetus are described for more than 15 years now. The main problems of softmarkers are, that they are usually published as sonographic phenomenon in high risk pregnancies prior to amniocentesis. So the positive predictive value is usually overestimated when applied to a sc...
Article
Problemstellung: Congenital high airway obstruction sequence (CHAOS) is a rare condition of obstruction of the trachea or larynx leading to fluid accumulation in the fetal lungs with enlargement of the lungs and as consequence fetal ascites, eventually fetal hydrops and fetal death. We present a case of CHAOS diagnosed at 21 weeks of gestation with...