Michael B Bonsall

Michael B Bonsall
University of Oxford | OX · Department of Biology

PhD (London) Insect Population Dynamics (1997)

About

329
Publications
56,561
Reads
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8,567
Citations
Citations since 2017
124 Research Items
4886 Citations
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20172018201920202021202220230200400600800
20172018201920202021202220230200400600800
Introduction
Additional affiliations
April 2005 - present
University of Oxford
January 1997 - March 2005
Imperial College London
Education
January 1994 - December 1996
Imperial College London
Field of study
  • Biology
October 1990 - June 1993
Imperial College London
Field of study
  • Biology

Publications

Publications (329)
Article
Full-text available
Microbial colonisation is paramount to the normal development of the immune system, particularly at mucosal sites. However, the relationships between the microbiome and the adaptive immune repertoire have mostly been explored in rodents and humans. Here, we report a high-throughput sequencing analysis of the chicken TCRβ repertoire and the influenc...
Article
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Coral reef sessile organisms inhabiting cryptic spaces and cavities of the reef matrix perform vital and varied functional roles but are often understudied in comparison to those on exposed surfaces. Here, we assess the composition of cryptobenthic taxa from three remote tropical reef sites (Central Indian Ocean) alongside a suite of in situ enviro...
Article
Full-text available
CRISPR/Cas gene drives can bias transgene inheritance through different mechanisms. Homing drives are designed to replace a wild-type allele with a copy of a drive element on the homologous chromosome. In Aedes aegypti, the sex-determining locus is closely linked to the white gene, which was previously used as a target for a homing drive element (w...
Article
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Discrete-time random walks (RWs) have proven to be a powerful modelling tool in ecology, particularly utilised for the study of animal movement at an individual level. There are several descriptors for the analysis of movement paths, but ecologists routinely use two simple metrics: the mean squared displacement and the sinuosity index (which measur...
Article
Full-text available
Positive mood amplification is a hallmark of the bipolar disorder spectrum (BPDS). We need better understanding of cognitive mechanisms contributing to such elevated mood. Generation of vivid, emotionally compelling mental imagery is proposed to act as an ‘emotional amplifier’ in BPDS. We used a positive mental imagery generation paradigm to manipu...
Preprint
Full-text available
Intensive care unit (ICU) staff continue to face recurrent work-related traumatic events throughout the COVID-19 pandemic. Intrusive memories (IMs) of such traumatic events comprise sensory image-based memories. Harnessing research on preventing IMs with a novel behavioural intervention on the day of trauma, here we take critical next steps in deve...
Article
Campylobacter jejuni ( C.jejuni) is the most common causative agent of bacterial food poisoning worldwide and is known to be genetically highly diverse. C. jejuni is increasingly resistant to fluoroquinolone antibiotics, but very few studies have investigated variant-specific patterns of resistance across time. Here we use statistical modelling and...
Article
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The introgression of genetic traits through gene drive may serve as a powerful and widely applicable method of biological control. However, for many applications, a self-perpetuating gene drive that can spread beyond the specific target population may be undesirable and preclude use. Daisy-chain gene drives have been proposed as a means of tuning t...
Article
Parental care has been gained and lost evolutionarily multiple times. While many studies have focused on the origin of care, few have explored the evolutionary loss of care. Understanding the loss of parental care is important as the conditions that favour its loss will not necessarily be the opposite of those that favour the evolution of care. Evo...
Article
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Trophic interaction modifications occur in food webs when the direct or indirect interaction between two species is affected by a third species. These behavioral modification effects are often referred to as associational effects. Changes in focal resource availability and consumption by a generalist herbivore can affect a range of outcomes from re...
Article
Although Pavlovian threat conditioning has proven to be a useful translational model for the development of anxiety disorders, it remains unknown if this procedure can generate intrusive memories – a symptom of many anxiety-related disorders, and whether intrusions persist over time. Social support has been related to better adjustment after trauma...
Article
Background The mosquito Aedes polynesiensis inhabits Pacific islands and territories and transmits arboviruses and parasites. In the context of rapid environmental change, understanding the effects of environmental heterogeneity on mosquitoes is crucial. Methods First, empirical field data and remote sensing data were combined to model spatial het...
Article
Intelligent life has emerged late in Earth’s habitable lifetime, and required a preceding series of key evolutionary transitions. A simple model (the Carter model) explains the late arrival of intelligent life by positing these evolutionary transitions were exceptionally unlikely ‘critical steps’. An alternative model (the neocatastrophism hypothes...
Article
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Commercial poultry flocks frequently harbor the dangerous bacterial pathogen Campylobacter. As exclusion efforts frequently fail, there is interest in potential ecologically informed solutions. A long‐term study of Campylobacter sequence types was used to investigate the competitive framework of the Campylobacter metacommunity and understand how mu...
Article
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Making discrete and precise genetic changes to wild populations has been proposed as a means of addressing some of the world’s most pressing ecological and public health challenges caused by insect pests. Technologies that would allow this, such as synthetic gene drives, have been under development for many decades. Recently, a new generation of pr...
Article
Full-text available
Iteroparous parents face a trade-off between allocating current resources to reproduction versus maximizing survival to produce further offspring. Parental allocation varies across age and follows a hump-shaped pattern across diverse taxa, including mammals, birds and invertebrates. This nonlinear allocation pattern lacks a general theoretical expl...
Article
When vaccinating a large population in response to an invading pathogen, it is often necessary to prioritize some individuals to be vaccinated first. One way to do this is to choose individuals to vaccinate based on their location. Methods for this prioritization include strategies that target those regions most at risk of importing the pathogen, a...
Article
Full-text available
The ability to engineer gene drives (genetic elements that bias their own inheritance) has sparked enthusiasm and concerns. Engineered gene drives could potentially be used to address long-standing challenges in the control of insect disease vectors, agricultural pests and invasive species, or help to rescue endangered species. However, risk concer...
Article
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The success of public health interventions is highly dependent on the compliance of the general population. State authorities often implement policies without consulting representatives of faith-based communities, thereby overlooking potential implications of public health measures for these parts of society. Although ubiquitous, these challenges a...
Article
Many insects rely on intracellular bacterial symbionts to supplement their specialized diets with micronutrients. Using data from diverse and well-studied insect systems, we propose three lines of evidence suggesting that hosts have tight control over the density of their obligate, intracellular bacterial partners. First, empirical studies have dem...
Article
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Objectives The COVID-19 pandemic has underscored the need for rapid novel diagnostic strategies. Metagenomic Next-Generation Sequencing (mNGS) may allow for the detection of pathogens that can be missed in targeted assays. The goal of this study was to assess the performance of nanopore-based Sequence-Independent Single Primer Amplification (SISPA)...
Article
Parental care, mating dynamics, and life history co‐evolve. Understanding the diversity of reproductive patterns found in nature is a major focus of evolutionary ecology research. Previous research suggests that the origin of parental care of eggs will be favored when egg and adult death rates and juvenile survival are relatively high. However, the...
Article
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Background To mitigate the spread of the COVID-19 coronavirus, some countries have adopted more stringent non-pharmaceutical interventions in contrast to those widely used. In addition to standard practices such as enforcing curfews, social distancing, and closure of non-essential service industries, other non-conventional policies also have been i...
Article
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Many organisms show signs of deterioration with age in terms of survival and reproduction. We tested whether intraspecific variation in such senescence patterns can be driven by resource availability or reproductive history. We did this by manipulating nutritional stress and age at first reproduction and measuring age‐dependent reproductive output...
Preprint
Full-text available
When vaccinating a large population in response to an invading pathogen, it is often necessary to prioritise some individuals to be vaccinated first. One way to do this is to choose individuals to vaccinate based on their location. Methods for this prioritisation include strategies which target those regions most at risk of importing the pathogen,...
Article
Risk assessors, risk managers, developers, potential applicants, and other stakeholders at many levels discuss the need for new or further risk assessment guidance for deliberate environmental releases of gene drive-modified organisms. However, preparing useful and practical guidance entails challenges, to which we offer recommendations based on ou...
Article
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Countries around the world have observed reduced infections from the SARS-CoV-2 virus, that causes COVID-19 illness, primarily due to non-pharmaceutical interventions (NPIs) such as lockdowns and social distancing measures designed to limit physical proximity between people. However, economies and societal interactions require restarting, and so lo...
Article
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Using data on rearing and welfare metrics of multiple commercial broiler flocks, we investigate how welfare measures such as hock burn, mortality, and pododermatitis, among others, impact the likelihood of a flock becoming colonized by Campylobacter. Using both logistic regression and Bayesian networks, we show that, while some welfare metrics were...
Article
Full-text available
Potential future application of engineered gene drives (GDs), which bias their own inheritance and can spread genetic modifications in wild target populations, has sparked both enthusiasm and concern. Engineered GDs in insects could potentially be used to address long-standing challenges in control of disease vectors, agricultural pests and invasiv...
Article
Heterogeneity has been observed in the responses of Arctic shrubs to climate variability over recent decades, which may reflect landscape‐scale variability in belowground resources. At a northern fringe of tall shrub expansion (Yuribei, Yamal Peninsula, Russia), we sought to determine the mechanisms relating nitrogen (N) limitation to shrub growth...
Article
Aedes aegypti is the dominant vector of dengue, a potentially fatal virus whose incidence has increased eightfold in the last two decades. As dengue has no widely available vaccine, vector control is key to reducing the global public health burden. A promising method is the release of self-limiting Ae. aegypti, which mate with wild Ae. aegypti and...
Preprint
A long-term study of Campylobacter sequence types was used to investigate the competitive framework of the Campylobacter metacommunity, and understand how multiple sequence types simultaneously co-occur in a flock of chickens. A combination of matrix and patch-occupancy models were used to estimate parameters describing the competition, transmissio...
Preprint
Full-text available
Using data on rearing and welfare metrics of multiple commercial broiler flocks from the last ten years, we investigate how welfare measures such as hock burn, mortality, weight, and pododermatitis, among others, impact the likelihood of a flock becoming colonized by Campylobacter. Using both logistic regression and Bayesian networks, we show that,...
Article
Full-text available
COVID-19 is causing a significant burden on medical and healthcare resources globally due to high numbers of hospitalisations and deaths recorded as the pandemic continues. This research aims to assess the effects of climate factors (i.e., daily average temperature and average relative humidity) on effective reproductive number of COVID-19 outbreak...
Preprint
Full-text available
By January 2020, the COVID-19 illness has caused over two million deaths. Countries have restricted disease spread through non-pharmaceutical interventions (e.g., social distancing). More severe 'lockdowns' have also been required. Although lockdowns keep people safer from the virus, they substantially disrupt economies and individual well-being. F...
Chapter
Accurate models are crucial for predicting the spread of vector-borne diseases, and for developing appropriate control policies. Simple models often ignore finer details of vector biology, commonly due to lack of pertinent field data. However, for tsetse ( Glossina spp), vectors of the parasites causing debilitating human and livestock trypanosomia...
Article
Population Biology of Vector-Borne Diseases is the first comprehensive survey of this rapidly developing field. The chapter topics provide an up-to-date presentation of classical concepts, reviews of emerging trends, synthesis of existing knowledge, and a prospective agenda for future research. The contributions offer authoritative and internationa...
Preprint
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RNA guided CRISPR gene drives have shown the capability of biasing transgene inheritance in multiple species. Among these, homing endonuclease drives are the most developed. In this study, we report the functioning of sds3 , bgcn , and nup50 expressed Cas9 in an Aedes aegypti homing split drive system targeting the white gene. We report their inher...
Article
Reinforcing the high-dose/refuge strategy with releases of transgenic insects has been suggested as a method for simultaneously managing agricultural pest populations and resistance to transgenic crops. Theoretical and empirical studies have shown that these approaches can work when deployed against closed populations and the assumptions of the HDR...
Article
It is unknown how abundant extraterrestrial life is, or whether such life might be complex or intelligent. On Earth, the emergence of complex intelligent life required a preceding series of evolutionary transitions such as abiogenesis, eukaryogenesis, and the evolution of sexual reproduction, multicellularity, and intelligence itself. Some of these...
Technical Report
Full-text available
The European Food Safety Authority (EFSA) carried out an online public consultation to receive input from interested parties/persons on the draft scientific opinion on the adequacy and sufficiency evaluation of existing guidelines for the molecular characterisation (MC), environmental risk assessment (ERA) and post-market environmental monitoring (...
Article
Full-text available
Advances in molecular and synthetic biology are enabling the engineering of gene drives in insects for disease vector/pest control. Engineered gene drives (that bias their own inheritance) can be designed either to suppress interbreeding target populations or modify them with a new genotype. Depending on the engineered gene drive system, theoretica...
Article
Full-text available
Despite continued efforts to improve biosecurity protocols, Campylobacter continues to be detected in the majority of commercial chicken flocks across Europe. Using an extensive data set of Campylobacter prevalence within a chicken breeder flock for over a year, multiple Bayesian models are presented to explore the dynamics of the spread of Campylo...
Article
Full-text available
Understanding the ecological and evolutionary factors that influence species rarity has important theoretical and applied implications, yet the reasons why some species are rare while others are common remain unresolved. As a novel exploration of scientific knowledge, we used network analysis conceptually to visualize the foci of a comprehensive ba...
Article
Full-text available
Every host is colonized by a variety of microbes, some of which can protect their hosts from pathogen infection. However, pathogen presence naturally varies over time in nature, such as in the case of seasonal epidemics. We experimentally coevolved populations of Caenorhabditis elegans worm hosts with bacteria possessing protective traits (Enteroco...
Article
Full-text available
Countries around the world are in a state of lockdown to help limit the spread of SARS-CoV-2. However, as the number of new daily confirmed cases begins to decrease, governments must decide how to release their populations from quarantine as efficiently as possible without overwhelming their health services. We applied an optimal control framework...
Preprint
Full-text available
Despite continued efforts into improving biosecurity protocol, Campylobacter continues to be detected in the majority of commercial chicken flocks across Europe. Using an extensive data set of Campylobacter prevalence within a chicken breeder flock for over a year, multiple Bayesian models are presented to explore the dynamics of the spread of Camp...
Article
1. Density dependence is the effect of density on population growth. Density dependence is an aggregate term for a suite of complex interactions between animals and their environment. 2. Mechanistic studies of density dependence in mosquito ecology are sparse, and the role of environmental factors is poorly understood. 3. Two empirical study design...
Preprint
Full-text available
Mosquito-borne diseases cause significant social and economic damage across much of the globe. New biotechnologies that utilise manipulations of the mosquito genome have been developed to combat disease. The successful implementation of genetic mosquito control technologies may depend upon ecological, evolutionary and environmental factors, as well...
Preprint
Full-text available
Countries around the world are in a state of lockdown to help limit the spread of SARS-CoV-2. However, as the number of new daily confirmed cases begins to decrease, governments must decide how to release their populations from quarantine as efficiently as possible without overwhelming their health services. We applied an optimal control framework...
Article
Full-text available
Dengue is a debilitating and devastating viral infection spread by mosquito vectors, and over half the world’s population currently live at risk of dengue (and other flavivirus) infections. Here, we use an integrated epidemiological and vector ecology framework to predict optimal approaches for tackling dengue. Our aim is to investigate how vector...
Article
Full-text available
Study objectives Intrusive memories of psychological trauma are a core clinical feature of posttraumatic stress disorder (PTSD), and in the early period post-trauma may be a potential target for early intervention. Disrupted sleep in the weeks post-trauma is associated with later PTSD. The impact of sleep and intrusive memories immediately post-tra...
Article
Full-text available
Natural enemies of plants have the potential to influence the dynamics of plant populations and the structure of plant communities. In diverse tropical forests, research on the effects of plant enemies has largely focused on the diversity-enhancing effects of highly specialized enemies, while the community-level effects of enemies with broader diet...
Article
Full-text available
Many biological, psychological and economic experiments have been designed where an organism or individual must choose between two options that have the same expected reward but differ in the variance of reward received. In this way, designed empirical approaches have been developed for evaluating risk preferences. Here, however, we show that if th...
Article
Ecosystem dynamics are driven by both biotic and abiotic processes, and perturbations can push ecosystems into novel dynamical regimes. Plant-plant, plant-soil and mycorrhizal associations all affect plant ecosystem dynamics; however, the direction and magnitude of these effects vary by context and their contribution to ecosystem resilience over lo...
Article
Full-text available
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Article
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Climate change challenges societal functioning, likely requiring considerable adaptation to cope with future altered weather patterns. Machine learning (ML) algorithms have advanced dramatically, triggering breakthroughs in other research sectors, and recently suggested as aiding climate analysis (Reichstein et al 2019 Nature 566 195-204, Schneider...
Article
Full-text available
Trophic interaction modifications, where a consumer‐resource link is affected by additional species, are widespread and significant causes of non‐trophic effects in ecological networks. The sheer number of potential interaction modifications in ecological systems poses a considerable challenge, making prioritisation for empirical study essential. H...
Article
Understanding evolutionary patterns of parental investment and care has been a long-standing focus in studies of evolutionary and behavioural ecology. Indeed, patterns of investment and care are highly diverse, and fully understanding such diversity has been challenging. Recently, several studies have highlighted the need to consider coevolutionary...
Article
Full-text available
Globally, the bacterial genus Campylobacter is one of the leading causes of human gastroenteritis, with its primary route of infection being through poultry meat. The application of biosecurity measures is currently limited by a lack of understanding of the transmission dynamics within a flock. Our work is the first to undertake a mathematical mode...
Article
The immune system is a robust and often untapped accomplice of many standard cancer therapies. A majority of tumors exist in a state of immune tolerance where the patient's immune system has become insensitive to the cancer cells. Because of its lymphodepleting effects, chemotherapy has the potential to break this tolerance. To investigate this, we...
Article
Full-text available
Allocation of resources to competing processes of growth, maintenance, or reproduction is arguably a key process driving the physiology of life history trade‐offs and has been shown to affect immune defenses, the evolution of aging, and the evolutionary ecology of offspring quality. Here, we develop a framework to investigate the evolutionary conse...
Article
Full-text available
We evaluate the total probability of human extinction from naturally occurring processes. Such processes include risks that are well characterized such as asteroid impacts and supervolcanic eruptions, as well as risks that remain unknown. Using only the information that Homo sapiens has existed at least 200,000 years, we conclude that the probabili...
Article
Full-text available
Vector ecology is integral to understanding the transmission of vector-borne diseases, with processes such as reproduction and competition pivotal in determining vector presence and abundance. The arbovirus vectors Aedes aegypti and Aedes albopictus compete as larvae, but this mechanism is insufficient to explain patterns of coexistence and exclusi...
Article
Full-text available
1.Considerable emphasis has been placed recently on the importance of incorporating non-trophic effects in to our understanding of ecological networks. Interaction modifications are well established as generating strong non-trophic impacts by modulating the strength of inter-specific interactions. 2.For simplicity and comparison with direct intera...
Article
Full-text available
Vector-borne diseases are a major public health concern inflicting high levels of disease morbidity and mortality. Vector control is one of the principal methods available to manage infectious disease burden. One approach, releasing modified vectors (such as sterile or GM mosquitoes) Into the wild population has been suggested as an effective metho...
Article
Full-text available
Clonal hematopoiesis of indeterminate potential (CHIP) is a recently identified process where older patients accumulate distinct subclones defined by recurring somatic mutations in hematopoietic stem cells. CHIP’s implications for stem cell transplantation have been harder to identify due to the high degree of mutational heterogeneity that is prese...
Data
LSK-SLAM populations in our cohort of old and young mice. LSK-SLAM cells displayed significantly more variability than LSK cells in a cohort of 3 month old (n = 5) and 11 month old (n = 6) mice. The difference is not significant at p = 0.12 based on a 2-tailed T test. The sample sizes of our cohorts here is the primary limitation in preventing us f...
Data
Analysis of stem cell values at stability. A key question we examined in our model was to determine the steady-state relationship between the healthy and mutant hematopoietic stem cell populations, H1 and H2, respectively. Our analysis found an expression for the homeostatic ratio of stem cell populations dependent on ecological parameters. (PDF)
Article
Full-text available
Parental care is a key life-history trait that increases offspring fitness. When one thinks of parental care, nurturing behaviors such as guarding, provisioning, and grooming typically come to mind. However, such conventional forms of care often co-occur with offspring abandonment or filial cannibalism (the consumption of one's offspring). Offsprin...
Preprint
Full-text available
Vector ecology is integral to understanding the transmission of vector-borne diseases, with processes such as reproduction and competition pivotal in determining vector presence and abundance. The arbovirus vectors Aedes aegypti and Aedes albopictus compete as larvae, but this mechanism is insufficient to explain patterns of coexistence and exclusi...
Preprint
Full-text available
Globally, the bacterial genus Campylobacter is one of the leading causes of human gastroenteritis, with its primary route of infection being through poultry meat. Despite decades of study we appear to be no closer to preventing outbreaks within commercial chicken flocks, and the application of biosecurity measures is limited by a lack of understand...