Michael Taynnan Barros

Michael Taynnan Barros
University of Essex · School of Computer Science and Electronic Engineering

PhD
Assistant Professor in AI and Engineering in Medicine

About

100
Publications
24,039
Reads
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507
Citations
Introduction
Dr. Barros received his Ph.D. in Telecommunication Software at the Waterford Institute of Technology, Ireland (2016). His research interests are in molecular communications, bionano devices, biomedical engineering and 6G systems.
Additional affiliations
September 2019 - present
Tampere University
Position
  • Fellow
Description
  • European Union Marie Curie Research Fellow
April 2016 - August 2019
Waterford Institute of Technology
Position
  • PostDoc Position
Description
  • Irish research council postdoc fellow
April 2012 - April 2016
Waterford Institute of Technology
Position
  • Postgraduate Research/ PhD Student
Education
April 2012 - April 2016
Waterford Institute of Technology
Field of study
  • Molecular Communication, Internet of BioNanoThings, Nanomedicine
March 2011 - April 2012
Universidade Federal de Campina Grande (UFCG)
Field of study
  • Computer Networks, Computer Science
August 2007 - December 2010
Instituto Federal de Educação, Ciência e Tecnologia da Paraíba
Field of study
  • Telecommunications, Computer Science

Publications

Publications (100)
Article
Full-text available
This paper proposes the use of astrocytes to realize Boolean logic gates, through manipulation of the threshold of $$\hbox {Ca}^{2+}$$ Ca 2 + ion flows between the cells based on the input signals. Through wet-lab experiments that engineer the astrocytes cells with pcDNA3.1-hGPR17 genes as well as chemical compounds, we show that both AND and OR ga...
Article
Full-text available
High-frequency firing activity can be induced either naturally in a healthy brain as a result of the processing of sensory stimuli or as an uncontrolled synchronous activity characterizing epileptic seizures. As part of this work, we investigate how logic circuits that are engineered in neurons can be used to design spike filters, attenuating high-...
Article
Synaptic plasticity depends on the gliotransmitters' concentration in the synaptic channel. And, an abnormal concentration of gliotransmitters is linked to neurodegenerative diseases, including Alzheimer's, Parkinson's, and epilepsy. In this paper, a theoretical investigation of the cause of the abnormal concentration of gliotransmitters and how to...
Article
As the cellular networks continue to progress between generations, the expectations of 5G systems are planned towards high capacity communication links that can provide users access to numerous types of applications (e.g., augmented reality, holographic multimedia streaming). The demand for higher bandwidth has led the research community to investi...
Article
Full-text available
Calcium (Ca2+)-signaling-based molecular communication is a short-range communication process that diffuses and propagates ions between the cells of a tissue. The communication process is initiated via stimulation and amplification of the production of Ca2+ ions within a cell; these ions then diffuse through a physical connection between cells call...
Preprint
Full-text available
Glioblastoma Multiforme (GBM) is the most prolific and deadly brain cancer with a median survival time of around 15 months. Despite the many recent advances on its treatment, this brain tumor remains resistant to most therapeutic solutions available and ultimately recurs. Recurrence evolves from hypoxic foci of chemotherapy and radiotherapy resista...
Preprint
div> Wireless Neural Interfaces are minimally invasive untethered links between the brain tissue and silicon platforms. Even though these interfaces have been envisioned for many biomedical applications, it is unclear how the ultimate technology will be, due to the lack of studies that support spatially distributed networks. In this paper, we cont...
Preprint
Synaptic communication is studied by communication engineers for two main reasons. One is to enable novel neuroengineering applications that require interfacing with neurons. The other reason is to draw inspiration for the design of synthetic molecular communication systems. Both of these goals require understanding of how the chemical synaptic sig...
Preprint
Full-text available
Biocomputing technologies exploit biological communication mechanisms involving cell-cell signal propagation to perform computations. Researchers recently worked toward realising logic gates made by neurons to develop novel devices such as organic neuroprostheses or brain implants made by cells, herein termed as living implants. Several challenges...
Article
Full-text available
Demyelination of neurons can compromise the communication performance between the cells as the absence of myelin attenuates the action potential propagated through the axonal pathway. In this work, we propose a hybrid experimental and simulation model for analyzing the demyelination effects on neuron communication. The experiment involves locally i...
Article
Full-text available
Astrocytes and neurons respond to each other by releasing transmitters, such as γ-aminobutyric acid (GABA) and glutamate, that modulate the synaptic transmission and electrochemical behavior of both cell types. Astrocytes also maintain neuronal homeostasis by clearing neurotransmitters from the extracellular space. These astrocytic actions are alte...
Article
The COVID-19 pandemic in the last year has brought along numerous challenges on all fronts for humanity. Besides the high number of fatalities, economic and societal impact, the virus has also raised a question on the current approaches and methodologies for combatting pandemics. An important factor in this global fight against the pandemic, is the...
Preprint
Full-text available
The recent COVID-19 pandemic has driven researchers from different spectrum to develop novel solutions that can improve detection and understanding of SARS-CoV-2 virus. In this article we propose the use of Intelligent Reflector Surface (IRS) emitting terahertz signals to detect airborne respiratory aerosol cloud that are secreted from people. Our...
Article
While metasurface-based intelligent reflecting surfaces (IRS) are an important emerging technology for future generations of wireless connectivity in its own right, plans for the mass deployment of these surfaces motivate the question of their integration with other new and emerging technologies that would require such widespread deployment. This q...
Article
Full-text available
This paper presents the first comprehensive tutorial on a promising research field located at the frontier of two well-established domains, neurosciences and wireless communications, motivated by the ongoing efforts to define the (). In particular, this tutorial first provides a novel integrative approach that bridges the gap between these two seem...
Article
Progress in bioengineering and nanotechnology has led to advances in implantable nanoscale devices. Providing synthetic molecular communication among these devices is an ongoing unsolved challenge. Biological systems inspire promising approaches for engineering data communication in molecular communication, but noises from dynamic tissue signaling...
Article
Molecular communications (MC) broadly defines information exchange using (bio-)chemical signals over multiple scales. The research in this area addresses various fields where MC plays an important role. Notable examples include 1) the modeling of living systems, which aims to gain new insights into biological systems; 2) their interface with the ou...
Preprint
Full-text available
Biocomputing systems based on engineered bacteria can lead to novel tools for environmental monitoring and detection of metabolic diseases. In this paper, we propose a Bacterial Molecular Computing on a Chip (BMCoC) using microfluidic and electrochemical sensing technologies. The computing can be flexibly integrated into the chip, but we focus on e...
Article
Full-text available
Hundreds of millions of people worldwide are affected by viral infections each year, and yet, several of them neither have vaccines nor effective treatment during and post-infection. This challenge has been highlighted by the COVID-19 pandemic, showing how viruses can quickly spread and impact society as a whole. Novel interdisciplinary techniques...
Preprint
Full-text available
The COVID-19 pandemic has shaken the world unprecedentedly, where it has affected the vast global population both socially and economically. The pandemic has also opened our eyes to the many threats that novel virus infections can pose for humanity. While numerous unknowns are being investigated in terms of the distributed damage that the virus can...
Preprint
Full-text available
The recent COVID-19 pandemic has resulted in high fatality rates, especially for patients who suffer from underlying health issues. One of the more serious symptoms exhibited from patients suffering from an acute COVID-19 infection is breathing difficulties and shortness of breath, which is largely due to the excessive fluid (cellular leakage and c...
Conference Paper
Full-text available
Glioblastoma Multiform (GBM) is known as one of the most malignant tumours in the brain, and challenges remain in developing effective therapeutic solutions. This paper addresses an open-loop control molecular communication system using an adaptive algorithm that controls engineered induced Neural Stem Cells (iNSCs) to release therapeutic exosomes...
Article
Full-text available
a prominent glial cell type in the brain – form networks that tightly interact with the brain’s neuronal circuits. Thus, it is essential to study the modes of such interaction if we aim to understand how neural circuits process information. Thereby, calcium elevations, the primary signal in astrocytes, propagate to the adjacent neighboring cells an...
Article
Brain-Computer Interfaces (BCIs) have significantly improved the patientsfi quality of life by restoring damaged hearing, sight, and movement capabilities. After evolving their application scenarios, the current trend of BCI is to enable new innovative brain-to-brain and brain-to-the-Internet communication paradigms. This technological advancement...
Conference Paper
Full-text available
Abordagens promissoras para a engenharia da comunicação de dados para nanorredes são inspiradas nos sistemas biológicos, porém as comunicações moleculares possuem baixo desempenho devido à propagação estocástica dos dados e ao excesso de ruído no ambiente. A presença de ruído gera comunicações propensas a erros e comprometem o desempenho da rede. D...
Article
Full-text available
This paper presents the first comprehensive tutorial on a promising research field located at the frontier of two well-established domains: Neurosciences and wireless communications , motivated by the ongoing efforts to define how the sixth generation of mobile networks (6G) will be. In particular, this tutorial first provides a novel integrative a...
Preprint
Full-text available
Hundreds of millions of people worldwide are affected by viral infections each year, and yet, several of them neither have vaccines nor effective treatment during and post-infection. This challenge has been highlighted by the COVID-19 pandemic, showing how viruses can quickly spread and how they can impact society as a whole. Novel techniques that...
Preprint
Full-text available
While metasurface based intelligent reflecting surfaces (IRS) are an important emerging technology for future generations of wireless connectivity in its own right, the plans for the mass deployment of these surfaces motivate the question of their integration with other new and emerging technologies that would require mass proliferation. This quest...
Article
Full-text available
Brain-Computer Interfaces (BCI) arose as systems that merge computing systems with the human brain to facilitate recording, stimulation, and inhibition of neural activity. Over the years, the development of BCI technologies has shifted towards miniaturization of devices that can be seamlessly embedded into the brain and can target single neuron or...
Preprint
Full-text available
Brain-Computer Interfaces (BCI) arose as systems that merge computing systems with the human brain to facilitate recording, stimulation, and inhibition of neural activity. Over the years, the development of BCI technologies has shifted towards miniaturization of devices that can be seamlessly embedded into the brain and can target single neuron or...
Preprint
Full-text available
This paper proposes the use of Eukaryotic cells, namely astrocytes, to develop logic gates. The logic gates are achieved by manipulating the threshold of Ca$^{2+}$ ion flows between the cells, based on the input signals. Through wet-lab experiments that engineer the astrocytes cells with pcDNA3.1-hGPR17 genes, we show that both AND and OR gates can...
Article
Full-text available
The performance demands from data-intensive applications, such as multimedia streaming, as well as the growing number of devices connecting to the Internet, will increase the need for higher capacity wireless communication links. The research community has recently explored regions of the spectrum, including the Terahertz band (0.1 THz to 10 THz),...
Article
Full-text available
A novel implantable and externally controllable stem-cell-based platform for the treatment of Glioblastoma brain cancer has been proposed to bring hope to patients who suffer from this devastating cancer type. Induced Neural Stem Cells (iNSCs), known to have potent therapeutic effects through exosomes-based molecular communication, play a pivotal r...
Preprint
Full-text available
This paper presents the first comprehensive tutorial on a promising research field located at the frontier of two well-established domains: Neurosciences and wireless communications, motivated by the ongoing efforts to define how the sixth generation of mobile networks (6G) will be. In particular, this tutorial first provides a novel integrative ap...
Preprint
Full-text available
Classification of biological neuron types and networks poses challenges to the full understanding of the brain's organisation and functioning. In this paper, we develop a novel objective classification model of biological neuronal types and networks based on the communication metrics of neurons. This presents advantages against the existing approac...
Article
Full-text available
The 5G promise for ubiquitous communications is expected to be a key enabler for transportation efficiency. However, the consequent increase of both data payload and number of users derived from new Intelligent Transport Systems makes network management even more challenging; an ideal network management will need to be capable of self‐managing fast...
Article
With the advancement of synthetic biology, several new tools have been conceptualized over the years as alternative treatments for current medical procedures. This work we investigate how synthetically engineered neurons can operate as digital logic gates that can be used towards bio-computing inside the brain and its impact on epileptic seizure-li...
Conference Paper
This paper presents a preliminary analysis of how the body temperature conditions, such as hypothermia and hyperthermia, influences the response time of the maturation process of Th2 cells to B lymphocytes while receiving IL-4 molecules from transmitting basophil cells.
Conference Paper
Novel implantable and externally controllable bio-nanomachines-based treatment strategies for Glioblastoma brain cancer have been proposed recently to bring hope to patients who suffer from this devastating cancer type. The main challenges in developing such strategies lie in both crossing the stringent Blood-Brain Barrier and maximizing the drug c...
Article
Full-text available
This letter presents a topology inference technique for neuronal networks of the cortex of the human brain based on network tomography theory. We envision that this technique will be used for high-resolution and high-precision brain tissue tomography and imaging using principles of the Internet of Bio-Nano Things. Our network tomography solution re...
Preprint
Full-text available
With the advancement of synthetic biology, several new tools have been conceptualized over the years as alternative treatments for current medical procedures. Most of those applications are applied to various chronic diseases. This work investigates how synthetically engineered neurons can operate as digital logic gates that can be used towards bio...
Conference Paper
Full-text available
Os avanços em bioengenharia e nanotecnologia proporcionaram o surgimento de dispositivos de dimensões nanométricas, ex. a nanomáquina sintética, as nanoantenas e os nanoinjetores, capazes de detectar e agir sobre seu ambiente. Entretanto, apesar de necessário, é um grande desafio prover a comunicação entre eles. A comunicação eletromagnética conven...
Preprint
Full-text available
BCIs have significantly improved the patients' quality of life by restoring damaged hearing, sight and movement capabilities. After evolving their application scenarios, from medicine to entertainment, the trend of these interfaces is breaking new frontiers enabling new innovative brain-to-brain and brain-to-the-Internet communication paradigms. Th...
Article
Full-text available
Synthetic logic circuits have been proposed as potential solutions for theranostics of biotechnological problems. One proposed model is the engineering of bacteria cells to create logic gates, and the communication between the bacteria populations will enable the circuit operation. In this paper, we analyse the quality of bacteria-based synthetic l...
Article
Significant efforts have been made and are still being made on short-term traffic prediction methods, specially for highway traffic based on punctual measurements. Literature on predicting the spatial distribution of the traffic in urban intersections is, however, very limited. This work presents a novel data-driven prediction algorithm based on Ra...
Conference Paper
Full-text available
The field of Neuroengineering aims to investigate ways to proposed synthetic and controllable Boolean computing inside the brain using neuronal cells based on the existing neuronal computation abilities of the Brain. In this work, we propose the design of AND and OR logic gates using a mul-ticellular Boolean logic operation by engineering the molec...
Article
Full-text available
The Internet of Bio-Nano-Things is a new paradigm that can bring novel remotely controlled actuation and sensing techniques inside the human body. Towards precise bionano sensing techniques in the brain, we investigate the challenges of modelling spatial distribution of astrocyte networks by developing a mathematical framework that lays the groundw...
Preprint
Full-text available
The Internet of Bio-Nano-Things is a new paradigm that can bring novel remotely controlled actuation and sensing techniques inside the human body. Towards precise bionano sensing techniques in the brain, we investigate the challenges of modelling spatial distribution of astrocyte networks in developing a mathematical framework that lay the groundwo...
Conference Paper
The high level of connections and hierarchy in the cortical microcircuits communication channel characterises a complex system that yet neuroscientists cannot understand it fully. The quantification of the communication channel capacity of cortical microcircuits enables a further understanding of information transfer inside that microscale of the b...
Conference Paper
Full-text available
A major challenge in neuronal molecular communications lies in modulating signals through the neuronal network of the cortex that will minimize interference with the natural signalling. In this paper, we propose the use of Electroencephalogram (EEG) signals as a sensing mechanism to determine spiking interval gaps that can be used to stimulate arti...
Article
Full-text available
Studies have recently shown that the bacteria survivability within biofilms is responsible for the emergence of superbugs. The combat of bacterial infections, without enhancing its resistance to antibiotics, includes the use of nanoparticles to quench the quorum sensing of these biofilm-forming bacteria. Several sequential and parallel multi-stage...
Article
Full-text available
The outbreak of Ebola virus in recent years has resulted in numerous research initiatives to seek new solutions to contain the virus. A number of approaches that have been investigated include new vaccines to boost the immune system. An alternative post-exposure treatment is presented in this paper. The proposed approach for clearing Ebola virus ca...
Article
Full-text available
Synapses plasticity depends on the gliotransmit-ters' concentration in the synaptic channel. And, an abnormal concentration of gliotransmitters is linked to neurodegenerative diseases, including Alzheimer's, Parkinson's, and Epilepsy. In this paper, a theoretical investigation of the cause of the abnormal concentration of gliotransmitters and how t...