
M.H.W. HooiveldUniversity Medical Center Groningen, University of Groningen, The Netherlands · Research Institute BCN-BRAIN / Research School BCN / Cancer Research Center Groningen - Research Office
M.H.W. Hooiveld
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Publications (19)
[This corrects the article on p. 899 in vol. 55. doi: 10.1387/ijdb.113358ad].
Background:
In medical curricula, considerable effort is put into scientific education and research training. The output of these efforts, however, is not known.
Aim:
To assess the number of students who published at least one scientific paper during the course of their medical studies.
Methods:
Names and initials of all students who received the...
Hox collinearity is a spectacular phenomenon that has excited life scientists since its discovery in 1978. Two mechanisms have been proposed to explain the spatially sequential pattern of Hox gene expression in animal embryonic development: interactions among Hox genes, or the progressive opening of chromatin in the Hox clusters, from 3' to 5'. A r...
In medical curricula, considerable effort is put into scientific education and research training. The output of these efforts, however, is not known.
To assess the number of students who published at least one scientific paper during the course of their medical studies.
Names and initials of all students who received their medical degree in 2006 or...
De Junior Scientific Masterclass (JSM) biedt gemotiveerde studenten extra mogelijkheden om binnen de studie geneeskunde en
tandheelkunde wetenschappelijk onderzoek te doen. De JSM wil binnen het Universitair Medisch Centrum Groningen (UMCG) een
kweekvijver zijn voor (tand)artsen, die later patiëntenzorg willen combineren met wetenschappelijk onderz...
To establish whether the number of physicians interested in a career in academia (i.e. research) is declining.
Descriptive.
The researchers analysed the pre- and post-doctoral careers of PhD students at 3 university medical centres (VU Amsterdam, Nijmegen and Maastricht) in 4 separate reference years (1989, 1994, 1999 and 2003), using information f...
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Otx2, a vertebrate homologue of the Drosophila orthodenticle gene, coordinates two processes in early embryonic development. Not only does it specify cell fate in the anterior regions of the embryo, it also prevents the cells that express it from participating in the convergence extension movements that shape the rest of the body axis. Here we show...
Inductive interactions between different cell layers have an extremely important role in early embryogenesis. One of the most intensively studied and best characterised of these is the induction of neural tissue from ectodermal cells by the dorsal mesoderm. The competence of ectodermal cells to respond to neural induction varies according to dorsal...
We have characterised a short (30 base pair) element from the Xenopus Wnt-5a promoter which is nearly identical to one located in the human Wnt-5a promoter, and has the same position relative to the transcription start site. When placed in front of a LacZ gene, this element can reproduce the same expression pattern observed for Wnt-5a at the late g...
Understanding why metazoan Hox/HOM-C genes are expressed in spatiotemporal sequences showing colinearity with their genomic sequence is a central challenge in developmental biology. Here, we studied the consequences of ectopically expressing Hox genes to investigate whether Hox-Hox interactions might help to order gene expression during very early...
The purpose of this study was to make an explicit test of the idea that a retinoid could act as a morphogen, differentially activating genes and specifying anteroposterior (a-p) level in the developing vertebrate central nervous system (CNS). Our approach was to characterize the concentration-dependent effects of retinoic acid (RA) on the neural ex...
Peptides related to melanocortin (alpha MSH) and corticotropin (ACTH), collectively termed melanocortins, exert trophic effects on the outgrowth of neurites from peripheral and central nervous system in vitro. Here we study the neurite outgrowth promoting effect of alpha-MSH on corticospinal (CS) neurons in vitro. Corticospinal neurons were identif...
The muscle-myosin heavy-chain (mMHC) gene of Drosophila hydei has been sequenced completely (size 23.3 kb). The sequence comparison with the D. melanogaster mMHC gene revealed that the exon-intron pattern is identical. The protein coding regions show a high degree of conservation (97%). The alternatively spliced exons (3a-b, 7a-d, 9a-c, 11a-e, and...
The outgrowth of corticospinal tract axons in rat spinal cord primarily occurs during the first postnatal week. Axons originating from a group of layer V pyramidal cell bodies situated in the anterior part of the cerebral sensorimotor cortex project mainly to the cervical gray matter (Joosten et al., Dev. Brain Res., 36 (1987) 121-130). By co-cultu...