Metowogo Kossi

Metowogo Kossi
Université de Lomé · Departement of Pharmacology and physiology

Ph D, Dr, Assistante professor

About

48
Publications
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258
Citations

Publications

Publications (48)
Article
Full-text available
Objective: The medicinal plant Cochlospermum planchonii Hook.f. is used in the management of various ailments in Togolese pharmacopoeia. In this study, we aimed to evaluate the antioxidant and anti-inflammatory activities of roots and leaves of C. planchonii, and burn wound healing activity of its leaf hydroethanolic extracts in rodents. Materials...
Article
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Background: Aloe buettneri, Mitracarpus scaber and Hannoa undulata are three plants species used in the Togolese traditional medicine to cure dermatosis. This study aims at assessing their anti-oxidant and anti-microbial activities on acne-developing micro-organisms. Methods: Six micro-organisms including Cutibacterium acnes ATCC 6919, Pseudomonas...
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Full-text available
The snake bites victims’ proportion is not well known among the population and statistical values are not available to consider snake bites as a significant cause of death especially in rural Africa. In Togo, the rural population uses various plants for the treatment of snake bites. The objective of this work is to conduct two types of surveys, nam...
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Full-text available
Annona senegalensis and Securidaca longepedunculata are two plants traditionnaly used in inflammation and wounds infection treatment after snakebites. This study aims to investigate the in vitro anti-inflammatory and antimicrobial activities of the hydroalcoholic extracts of Annona senegalensis and Securidaca longepedunculata. Antimicrobial activit...
Article
Ethnopharmacological relevance: Cancer is a multistep disease and its management is exceedingly expensive. Nowadays medicinal plants are gaining more attention in drug discovery and approximately 70% of anticancer drugs were developed from natural products or plants. A strong candidate from medicinal plant with anticancer potential should have fou...
Article
Objectives In sub-Saharan Africa, the therapeutic use of medicinal plants is of arousing interest. Reproductive disorders are a public health problem like everywhere else in the world. The population, especially in rural areas, uses medicinal plants for their beneficial effects. In Africa, the population uses these medicinal plants for their health...
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Full-text available
Cochlospermum planchonii is a plant traditionally used in Togo to treat burn wounds. The present study aimed at evaluating the effect of the root hydroethanolic extract of Cochlospermum planchonii on the skin burn wounds. Burns were induced in ICR mice by applying on the skin of the dorsal region a metal stick (0.7 cm diameter) preheated at 100 °C...
Article
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Cochlospermum planchonii is traditionally used in Togo in treating several diseases, including burn wounds which achievement requires anti-infective and good cicatrisation processes. This study aims to evaluate the antimicrobial properties of hydroethanolic extracts from leaves and roots of C. planchonii and its phytochemical composition. Five (05)...
Article
Introduction: Bridelia ferruginea is a plant known for its antidiabetic properties. However, few studies on leaf extracts have induced anti-hyperglycemic activity on normal mice subjected to carbohydrate overload. The current study was designed to assess the effect of the leaf extracts’ fraction on fructose-induced diabetic mice. Methods: The in vi...
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Ethnopharmacological relevance Combretum micranthum G. Don (CM) is extensively used in traditional medicine throughout West Africa and commonly known as "long-life herbal tea" or "plant to heal". Further, traditional healers frequently use the title plant to mitigate of renal disorders. Aim of the study To explore the nephroprotective property of...
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Cancer is an emerging public health problem in sub-Saharan Africa. Several medicinal plants are used by traditional healers to treat tumors. In Togo, there are no recorded data for these plants but traditional healers claim to cure tumors with some success. So, information on medicinal plants used to cure human tumors and cancer could be of great i...
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Crataeva adansonii DC. ssp. adansonii is a medicinal plant belong to Capparidaceae family, used traditionally by Togolese to treat diabetes mellitus. The aim of this study was to evaluate the antihyperglycaemic and antioxidant activities of the plant leaves. The effect of hydroethanolic extract of C. adansonii ssp. adansonii leaves was assessed in...
Article
Full-text available
Background: Combretum micranthum (CM) (Combretaceae) is widely used in traditional medicine throughout West Africa for the treatment of diabetes, hypertension, inflammation, malaria and liver ailments. In our recent research we demonstrated that CM has nephroprotective potentials in diabetes mellitus, hypertension and renal disorders. However, to t...
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Nephrotoxicity is known to be a major complication during cisplatin chemotherapy in cancer patients. In the present study, the protective effect of a hydroalcoholic extract of Combretum micranthum (CM) against cisplatin (CP)-induced renal damage was evaluated using in-vitro human embryonic kidney (HEK)-293 cells and in-vivo experiments. Further, in...
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Management of chronic renal failure is exceedingly expensive. Despite of encouraging experimental outcomes, there is a lack of potent nephroprotective drugable molecules in a clinics or market. To develop a nephroprotective phytomedicine, the present study was designed to do a literature survey on reported phytochemical and biological analysis of C...
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Context and purpose: The roots of B. ferruginea are used in traditional Togo medicine in the treatment of diabetes. Studies have shown that leaves have a low antihyperglycemic effect. This study aims to improve the effect of leaves. Methods: The hydroalcoholic extract of the leaves underwent a fractionation (separation in cold alcohol) and an OGTT...
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Objective: This study aims to evaluate the fractions from whole extracts of roots and stem barks of Newbouldia laevis and their effect on sickling. Methods: Hydroethanolic extracts of stem barks and roots of Newbouldia laevis were fractionated by the technics of cold precipitation in ethanol. The fractions obtained after phytochemical screening wer...
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Background Spondias mombin L. (Anacardiaceae) leaves were used in Togolese folk to treat dystocia, expel placenta and manage post-partum hemorrhage during child birth. Objectives This study aimed to establish how the extract of S. mombin leaves increase uterine smooth muscle contractions relevant to its traditional use to facilitate child birth....
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Purpose: To investigate the effect of total hydroalcohol root extract of Plumeria alba (Apocynaceae) and its active fraction on diabetes in rats. Methods: The effect of total hydroalcohol extract at 250 mg/kg and different fractions was evaluated on oral glucose tolerance test (OGTT) in mice. The effect of the active fractions on OGTT was measured...
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Paullinia pinnata L. is a plant widely used in African traditional medicine especially in the treatment of erectile dysfunction. This study aims to evaluate the cardiotoxicity of 50% hydroalcoholic extract of the roots of P. pinnata. The result of the acute toxicity test has shown a LD50 greater than 5000 mg/kg. During the 28 days subchronic admini...
Article
The leaves of Acanthospermum hispidum (DC) are used traditionally by Togolese to treat various hepatic disorders. The aim of the present study was to evaluate the hepatoprotective effect and antioxidant activities of the hydroethanolic extract of A. hispidum on carbon tetrachloride (CCl4)-induced liver damage in Wistar rats. The extract was also st...
Article
Purpose: To evaluate the fetal toxicity and cytotoxicity of L. kerstingii in pregnant rats exposed in the organogenic period.Methods: Mated female rats were randomly assigned to three experimental groups of 8 animals each. Pregnant rats received orally 500 or 1000 mg/kg of 50 % hydroalcohol extract of L. kerstingii, daily from the 17th to the 20th...
Article
Postpartum hemorrhage remains health problem observed in maternity. In Sub-Saharan Africa, traditional phytotherapy propose plants reputed to manage postpartum bleeding. Spondias mombin is one of Togolese plant used by rural folk to stop hemorrhage at the time of complicated deliverances. The aim of this present work is to evaluate the effects this...
Article
Acacia nilotica is a medicinal plant used traditionally in Togo to treat various diseases including burn wounds. The aim of this study was to evaluate experimentally Acacia nilotica burn wound healing effect. Cutaneous burn wounds were symmetrically caused on depilated areas of rat skin through contact with an aluminum bar (r = 10 mm), preheated at...
Article
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The purposeof this study was to evaluate experimentally Acacia nilotica burn wound healing effect.Fourgroups of ratswere formed andeach batchconsisted oftwelverats. Burn wounds were assessed by planimetry and histological parameters of healing.Twelve days after burn wound induction, wound contraction in the uninfected groups was 19,9% for topical a...
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In Togo folk medicine, water infusion of Plumeria alba (Apocynaceae) root has a reputation for the local management and treatment for type 2 diabetes. The present study was investigated to evaluate the effect of Plumeria alba hydro alcoholic extract on some markers of metabolic syndrome in type 2 diabetes (hyperlipidemia, glucose intolerance, obesi...
Article
Sickle cell anemia is a genetic disease in which the final step leading to morbidity is the polymerization of deoxyhemoglobin S. Therefore, one of the recommended treatments for sickle cell disease is its inhibition. For this reason, the aim of this study was to evaluate the inhibitory properties of Morinda lucida semi-ethanolic extract on the poly...
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Plumeria alba Linn (Apocynaceae) is used in Togolese traditional medicine to treat diabetes mellitus and wounds. The present investigation was carried out to evaluate the toxicity of hydroalcoholic extract of Plumeria alba roots in Sprague Dawley rats. The acute toxicity test was conducted by administering orally dose of 5 g/Kg. General behavior an...
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The leaves of Spondias mombin Linn (Anacardiaceae) are used by traditional healers in some parts of Africa to treat dystocia and postpartum hemorrhage. All experiments are performed on albino wistar mature and immature rats. This study was undertaken to evaluate the effect of Spondias mombin Linn on rat parturition in order to determine its action...
Article
Calotropis procera leaves latex and root are commonly used in traditional Togolese medicine to treat various disease like gastric inflammation and ulcer. The anti-ulcerogenic potential of hydro-ethanolic extract of leaves (HELE) and root (HERE) were investigated using ethanol induced gastric lesion method in experimental Sprague Dawley rats (150 -...
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Hypertension and diabetes are traditional major common risk factors of ischemic heart diseases. Antidiabetic and anhypertensive property of Parkia biglobosa (PB) are well documented. In our previous study, we demonstrated that stem bark of PB possessed cardioprotective effects in rats. Fermented seeds of PB (African mustard) is a natural nutritiona...
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Vitex doniana is traditionally used in Togo to treat various diseases including wounds. The aim of this work was to evaluate the efficiency of Vitex doniana on cutaneous wound healing. Wounds were induced in ICR mice divided into four groups as following: Group I received carbopol 974P NF empty gel, Groups II and III were treated topically with car...
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Heliotropium indicum (Boraginaceae) is used in the traditional Ivory Coast pharmacopeia to treat asthma. In the present study, wound healing effect of n- butanol fractions was evaluated in H292- cells. Fractions which possessed better wound healing activity were fractionated on Sephadex LH20 column chromatography. Two compounds have been isolated w...
Article
Kigelia africana is traditionally used in Togo to control epileptic seizures. We undertook this study in order to evaluate its anticonvulsive properties. We pretreated Wistar albino rats of both sexes with the hydroethanolic extract (v: v) of the leaf of K. africana at 250 mg/kg and 500 mg/kg of body weight. This pretreatment was done one hour prio...
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Ixora coccinea L. (Rubiaceae) possess anti-inflammatory and antitussive properties. It is traditionally used for various respiratory ailments including catarrhal bronchitis cough and asthma. In the present study we investigated anti-asthmatic properties of an hydro alcoholic leaf extract of I. coccinea in an ovalbumin (OVA)-induced asthmatic rat mo...
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Aloe buettneri A. Berger is commonly used in traditional Togolese medicine to treat inflammatory and gastric ulcers. The present study examined the gastro-protection effect of the hydro-alcoholic extract of A. buettneri on mucus production and gastric pH. A gastric ulcer is induced by ethanol 95° alone (1 mL/kg body weight), after pre-treatment wit...
Article
Full-text available
Purpose: Aloe buettneri A. Berger is commonly used in Togolese folk medicine to treat inflammation and gastric ulcer. In this study we investigated the anti-oedema, analgesic, antipyretic and ulcer healing properties of the hydro-alcohol extract of their leaves. Methods: Rat oedema paw were induced by the injection of 0.1 ml of formaldehyde 1%, tai...

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Project (1)
Project
Most people in our developping countries use plant to treat various diseases. Incidence of most non transmissible pathology in our countries, like inflammation disease (asthma, gastric ulcer, wound, diabetes, cardiovascular pathology...) is increasing. The aim of our project is to valorize the use of plant compound.