
Mete Bora TüzünerBoğaziçi University Life Sciences and Technologies Application and Research Center
Mete Bora Tüzüner
Ph.D.
About
42
Publications
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Introduction
Mete Bora Tüzüner does research in Molecular Mechanisms of Diseases, Oncology, Molecular Biology and Cancer. '
Additional affiliations
February 2010 - June 2010
September 2006 - September 2008
Publications
Publications (42)
The relationship between steroid hormones and breast cancer has been known for decades. Steroid hormones play an active role in cellular proliferation in this cancer type and show their mitogenic effects by binding to estrogen, progesterone, and androgen receptors. Reducing the concentrations of active hormones in the systemic circulation may be in...
Background:
Alzheimer's disease is a progressive neurodegenerative disorder characterized by memory loss and cognitive impairment. The diagnosis of Alzheimer's disease according to symptomatic events is still a puzzling task. Developing a biomarker-based, low-cost, and high-throughput test, readily applicable in clinical laboratories, dramatically...
Breast cancer (BC) has a high incidence rate among women worldwide, and the mechanisms and etiology of this disease are not yet fully understood. The peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear hormone receptor that plays important roles in energy metabolism and cellular differentiation, is also suggested to be effective...
Background:
Expression of kallikrein-11 (KLK11) has been found to be related to the prognosis of various human cancer types but its physiological functions in the steps of breast cancer (BC) progression are still unknown.
Materials and methods:
BC and adjacent normal breast tissue samples were collected from 28 patients. KLK11 expression levels...
Background and aims:
It is becoming evident that local estrogen exposure is important in postmenopausal breast cancer patients. The microenvironment is established by breast stromal cells based on communication with tumor cells that is essential to cancer development, invasion, and metastasis. Here we investigated aromatase activity levels in both...
COVID-19 or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appeared throughout the World and currently affected more than 9 million people and caused the death of around 470,000 patients. The novel strain of the coronavirus disease is transmittable at a devastating rate with a high rate of severe hospitalization even more so for the e...
Background and aims:
It is becoming evident that local estrogen exposure is important in postmenopausal breast cancer patients. The microenvironment is established by breast stromal cells based on communication with tumor cells that is essential to cancer development, invasion, and metastasis. Here we investigated aromatase activity levels in both...
COVID-19 or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appeared throughout the World and currently affected more than 3.6 million people and caused the death of around 252,000 people. The novel strain of the coronavirus disease is transmittable at a devastating rate with a high rate of severe hospitalization even more so for the e...
Steroid hormonlar ve meme kanseri arasındaki ilişki on yıllardan beri bilinmektedir.
Çalışmamız meme kanseri hastalarından alınan taze tümör ve çevre doku örneklerindeki
steroid seviyelerinin ve bu steroidlerin sentezlenmesinde rol alan enzimlerin ekspresyonunun çalışılmasını hedeflemektedir. Lokal steroid sentez yolağının klinik parametrelerle bir...
Flavonoids, secondary metabolites of plants, have bioactive effects such as antioxidant, antibacterial, antifungal, antiviral and anticancer. They can affect many cellular pathways and selectively lead cancer cells to death using the apoptosis pathway.
Cancer patients are encouraged to have a diet, rich in flavonoid content, in order to eliminate...
It was aimed to underline the importance and explain the meaning of genetic testing in warfarin dosing and investigate and evaluate the contributions of the CYP2C9, VKORC1, and CYP4F2 variants in a Turkish population. Two hundred patients were genotyped for CYP2C9 (rs1799853, rs1057910 and rs56165452), VKORC1 (rs9934438, rs8050894, rs9923231, rs729...
AMAÇ: En sık rastlanan meme kanseri tipi olan invaziv duktal karsinomların etkili tedavisi için ilgili moleküler mekanizmaların anlaşılması önemlidir. Oldukça heterojen bir yapıya sahip olan meme kanserinde sadece tümör hücrelerinin değil mikroçevrenin de kanser gelişiminde etkisi olduğu bilinmektedir. Çalışmamızda tümör dokusunda ve mikroçevrede a...
Background and Objective: Antimycin A (AntA) is a potent Electron Transport System (ETS) inhibitor exerting its effect through inhibiting the transfer of the electrons by binding to the quinone reduction site of the cytochrome bc1 complex (Complex III), which is known to be impaired in Huntington’s Disease (HD). The current studies were undertaken...
Multiple sclerosis (MS) often starts in the form of clinically isolated syndrome (CIS) and only some of the CIS patients progress to relapsing-remitting MS (RRMS). Biomarkers to predict conversion from CIS to MS are thus greatly needed for making correct treatment decisions. To identify a predictive cerebrospinal fluid (CSF) protein, we analyzed th...
Network of co-regulated proteins in cortex, hippocampus and cerebellum is shown in relation with inflammation pathway. (Purple: Inflammation related proteins, Green: Downregulated proteins, Red: Upregulated proteins)
Differential expression analysis of protein abundances in 5XFAD and LM brains. List of proteins with significantly altered protein abundances (> 1.5-fold change; p < 0.05) in AD versus LM brain is provided with peptide counts, confidence scores, p values and maximum fold changes. Differentially expressed proteins in the cortex, hippocampus, and cer...
Top upstream regulators of co-regulated proteins in cortex, hippocampus and, cerebellum.
Alzheimer’s disease (AD) is a progressive disorder characterized by a variety of molecular pathologies causing cortical dementia with a prominent memory deficit. Formation of the pathology, which begins decades before the diagnosis of the disease, is highly correlated with the clinical symptoms. Several proteomics studies were performed using anima...
In recent years, an increasing number of research papers revealed that the compositional and volumetric alterations in the extracellular matrix are the consequences of aging and may be related to Alzheimer’s disease (AD). In this study, we aimed to demonstrate the alterations in hippocampal extracellular fluid proteins in vivo using the 5XFAD mouse...
Leukocyte diapedesis is an important process in breast cancer etiopathogenesis. Therefore, Junctional adhesion molecule-A (JAM- A) and lymphocyte function-associated antigen-1 (LFA-1) genes are among potential candidate genes involved in breast cancer development. In the present study, JAM-A rs790056 (T>C), LFA-1 rs8058823 (A>G) and LFA-1 rs2230433...
halen meme kanseri mikroçevresindeki intrakrin mekanizmaları anlamamıza yardımcı olacak bazı sorular yanıt beklemektedir. Bundan dolayı çalışmamızda kanser ve sağlıklı insan meme dokularındaki Aromataz ekspresyonunu ve enzim aktivitesini araştırdık. GEREÇ-YÖNTEM: Her hastadan (n=20) bir tümör (T) ve tümöre yakın bir çevre meme adipoz doku örneği (P...
There is growing attention focused on local estrogen production in the breast tissue and its possible role in breast cancer initiation and progression. Understanding the underlying mechanisms for estrogen synthesis and the microenvironment consisting of tumor and its surrounding adipose tissue might open new avenues in breast cancer prevention, pro...
miRNA involvement has been observed in almost every type of cancer, including breast cancer. The etiology of abnormal expression of miRNAs in cancer is still not clearly understood. In order to obtain insight into miRNA deregulation in breast cancer, we analyzed expression levels of five breast cancer-related miRNAs, miRNA21, miRNA155, miRNA19a, mi...
Abstract We described the serological prevalence of West Nile Virus (WNV) antibodies among the human population in a historical and strategic region of Turkey. A serologic survey was conducted based on suspected cases in April, 2009, in the Mesopotamia region of Turkey, in the villages that were located alongside the Zergan River. All the sera were...
AMAÇ: Acinetobacter enfeksiyonları, ülkemizde yoğun bakım ünitelerinde önemli bir sorundur ve hastane enfeksiyonları etkenleri arasında önde gelmektedir. A.baumannii, hastane ortamında uzun süre canlılığını koruyabilme özelliğine sahip bir bakteri olduğundan, enfeksiyon kontrol önlemlerinin alınması ve çevresel kontaminasyonun bulaşma dinamiklerini...
Breast cancer (BC), is more prevalent in subjects who have had prolonged exposure to heterocyclic amines, aromatic amines and high levels of oestradiol. Cytochrome P450 1B1 (CYP1B1) and N-acetyltransferase2 (NAT2) have complementary role in metabolism of xenobiotics such as arylamines and heterocyclic amines, CYP1B1 also hyroxylates 17-beta oestrad...
Genetically modified organisms (GMO) are products which have acquired a feature without its own inherent by alterations in its genetic sequence or gene transfer. These products are also transgenic products, this technology is also called recombinant DNA technology. At first GMO technology applications started for increasing the profit margin in the...
Breast cancer is the commonest cancer among women in industrialized countries. Most sporadic breast carcinomas are likely to be caused by low-penetrance genes. Genes encoding enzymes involved in estrogen and carcinogen metabolism are among these low-penetrance genes. In this study, for the first time the T/C (A1/A2) polymorphism at the 5' untransla...
The human body has a number of endogenous free-radical scavenging systems. Paraoxonase1 (PON1) is one of the enzymes involved in such systems. The purpose of this study was to investigate the relationship between bladder cancer and the polymorphism of PON1 which results in Q/R substitution at codon 192. This is the first report of this polymorphism...