Mesut Tez

Mesut Tez
Ankara Numune Training and Research Hospital · Department of General Surgery

Doctor of Medicine
To create a new vitalist hypothesis about carcinogenesis

About

327
Publications
81,341
Reads
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2,446
Citations
Citations since 2017
164 Research Items
1318 Citations
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Introduction
Heat the curiosity in a large pan. Add the dogma free knowledge and to leave simmer for years, please add plenty of tolerance, eat with humility spoon, may be you can get the taste of science. M.T
Skills and Expertise
Additional affiliations
August 2002 - September 2014
Ankara Numune Training and Research Hospital
Position
  • Surgical Oncologist

Publications

Publications (327)
Article
Full-text available
Purpose This study is aimed at investigating the role of preoperative procollagen type 1 N-terminal peptide (P1NP) and collagen type 1 C-telopeptide (CTx) levels in predicting the development of postoperative hypocalcemia in primary hyperparathyroidism (PHPT). Methods In this prospective observational study, preoperative complaints of patients wit...
Article
Over the last thirty years, a new actor in the area of ecology and evolution has emerged: niche construction theory (NCT). The fundamental premise of NCT is that organisms may actively influence evolutionary processes by modifying their circumstances1⁠. According to Trappes et al., the concept of niche construction should only be applied to specie...
Preprint
Full-text available
Conrad Hal Waddington (1905-1975) was the first to discover that development was dependent on previously unknown gene activity, and he required an appropriate model organism. The epigenetic landscape is maybe his most well-known concept: a ball glides down a complicated valley, selecting path choices. The rolling ball reflects the evolution of a ce...
Article
The microbial dysbiosis is linked with inflammatory bowel diseases, hypertension, atherosclerosis, hepatitis, neuropsychiatric disorders, diabetes, obesity, asthma, and development of cancer. Despite the substantial developments in oncology, cancer is still not in the category of curative diseases. However, significant steps are being taken in this...
Article
Background/aim: Obesity is a risk factor for hyperuricemia. Bariatric surgery is an effective treatment method in metabolic control. The aim of our study was to evaluate the correlation of the preoperative and postoperative serum uric acid levels with body mass index, body weight, and excess weight loss in patients that underwent sleeve gastrectomy...
Article
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Abstract: In the search of theoretical models describing cancer, one of promising directions is chaos. It is connected to ideas of “genome chaos” and “life on the edge of chaos”, but they profoundly differ in the meaning of the term “chaos”. To build any coherent models, notions used by both ideas should be firstly brought closer. The hypothesis “l...
Preprint
Full-text available
Evolution from the perspective of a cancer surgeon
Preprint
Cancer is one of humanity's most pressing health issues today. There is currently no viable hypothesis about carcinogenesis. This is due to the reductionist/cartesian mindset that pervades all sciences. The gene-centric approach to biology exemplifies this point of view.
Article
Background The Ranson score has 11 parameters that are complex and laborious to implement. In this study, we aimed to create a revised Ranson score by modifying the parameters in Ranson. Methods A total of 938 patients diagnosed with acute pancreatitis (AP) between 2014 and 2021 were included in the study. The parameters of the Ranson score were i...
Article
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CITATIONS 0 READS 129 60 authors, including: Some of the authors of this publication are also working on these related projects: SafeConsume View project O perfil epidemiológico e demográfico dos pacientes com tumor da cabeça e pescoço HPV16+ numa instituição oncológica em Portugal View project
Poster
Full-text available
Preprint
No idea in science has been more threatening to humans' conceptions about themselves than Darwin's theory of evolution; it arguably has been the most controversial idea in the history of science[1]. The main mechanism of Darwinian evolution is Natural Selection. Neo-Darwinism is a synthesis of three areas: it combines Darwin's theory of evolution b...
Presentation
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4open, its Editorial Board, scientists, and the network of the Theodor-Billroth-Academy and its International Consortium of Research Excellence (INCORE) are aware of the current dire situation for Ukrainian scientists and students. After the unprovoked attack on Ukraine on February 24, 2022, our colleagues in Ukraine are now in fear for their fam...
Article
Full-text available
4open, its Editorial Board, scientists, and the network of the Theodor-Billroth-Academy and its International Consortium of Research Excellence (INCORE) are aware of the current dire situation for Ukrainian scientists and students. After the unprovoked attack on Ukraine on February 24, 2022, our colleagues in Ukraine are now in fear for their famil...
Article
Full-text available
Background: Textbook outcome has been proposed as a tool for the assessment of oncological surgical care. However, an international assessment in patients undergoing oesophagectomy for oesophageal cancer has not been reported. This study aimed to assess textbook outcome in an international setting. Methods: Patients undergoing curative resection f...
Article
br> Aim: Gastric cancer is a highly prevalent public health problem with high morbidity and mortality. İts primary treatment is surgery. Recently, studies involving biological parameters and genetics in gastric cancer have been emerging but with many blind spots. Our study aims to investigate the clinicopathological and prognostic significance of h...
Article
Full-text available
Background: The optimal anastomotic techniques in esophagectomy to minimize rates of anastomotic leakage and conduit necrosis are not known. The aim of this study was to assess whether the anastomotic technique was associated with anas-tomotic failure after esophagectomy in the international Oesophago-Gastric Anas-tomosis Audit cohort.
Article
Objective: This study aimed to characterize rates and management of anastomotic leak (AL) and conduit necrosis (CN) after esophagectomy in an international cohort. Background: Outcomes in patients with anastomotic complications of esophagectomy are currently uncertain. Optimum strategies to manage AL/CN are unknown, and have not been assessed in a...
Article
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Background: The complexity of oesophageal surgery and the significant risk of morbidity necessitates that oesophagectomy is predominantly performed by a consultant surgeon, or a senior trainee under their supervision. The aim of this study was to determine the impact of trainee involvement in oesophagectomy on postoperative outcomes in an internati...
Article
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In this study, we present a case of aneurysmal bone cyst presenting as pathologic fracture of the left proximal femur. The patient, who had history of multiple surgeries, was referred to us with a giant mass. The patient was found to develop osteosarcoma without radiation exposure. External hemipelvectomy was performed. Appropriate surgical managem...
Article
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https://www.frontiersin.org/articles/10.3389/fonc.2021.775723/full
Article
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Signet ring cell carcinoma (SRCC) is a poorly cohesive subtype of gastric cancer. It is more aggressive than other types of gastric cancer. There is no special method for its treatment, but gastrectomy and lymphadenectomy is the standard approach. The aim of this study is to investigate postoperative outcomes of D1 lymphadenectomy and D1(+)lymphade...
Preprint
Full-text available
Cancer is among the most important public health problems. Despite advancements in medical technology, there is no significant reduction in cancer deaths. The most important reason for this is that there is no valid theory about carcinogenesis. Currently, studies on cancer are based on somatic mutation theory. However, many studies have shown that...
Article
Full-text available
Introduction It is difficult to diagnose the symptoms of acute appendicitis in pregnant women due to its similarities with pregnancy physiology. In this study, we examined the diagnostic value of laboratory parameters in the diagnosis of acute appendicitis in pregnant women. Material and methods Forty-two patients who underwent appendectomy during...
Poster
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Comprassion of Somatic Mutation Theory(SMT), Tissue Organ-ization Field Theory (TOFT) and Chaotic Adaptation Theory(CAT): new version
Article
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Pandemics generally begin in small areas and subsequently spread widely. In order to detect an outbreak in its early stage, observation of the data for small regions is important. (control group) were retrospectively analyzed. A total of 1,432 chest CT images in the study group and 1,443 chest CT images in the control group were evaluated for COVID...
Article
Full-text available
Abstract Pandemics generally begin in small areas and subsequently spread widely. In order to detect an outbreak in its early stage, observation of the data for small regions is important. The aim of this study to investigate the presence of COVID-19-like pneumonia findings in computed tomography (CT) taken before the COVID-19 pandemic in Turkey. T...
Article
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Background No evidence currently exists characterising global outcomes following major cancer surgery, including esophageal cancer. Therefore, this study aimed to characterise impact of high income countries (HIC) versus low and middle income countries (LMIC) on the outcomes following esophagectomy for esophageal cancer. Method This international...
Poster
Full-text available
Illustrated comparison of SMT, TOFT and CAT
Preprint
Full-text available
Cancer is among the most important public health problems. Despite advancements in medical technology, there is no significant reduction in cancer deaths. The most important reason for this is that there is no valid theory about carcinogenesis. Currently, studies on cancer are based on somatic mutation theory. However, many studies have shown that...
Article
Full-text available
Background The delta neutrophil index has been accepted as an inflammatory marker, especially in sepsis. This study aimed to evaluate the effectiveness of the delta neutrophil index in predicting acute and complicated appendicitis. Methods Patients aged 18 years and over who underwent appendectomy were reviewed. The demographic features, pathology...
Preprint
New tools are required to obtain a better understanding of the biology of l cancer development, progression, and molecular heterogeneity. Fractal-based analyses are versatile and sensitive tools that have many potential applications in cancer research
Article
Abstract Background/ aim: Despite the use of ultrasound guidance, a significant part of thyroid biopsies are nondiagnostic (ND). We aimed to investigate the utility of the preoperative modified systemic inflammation score (mSIS) to predict malignancies in patients with persistent ND thyroid nodules (TNs). Materials and methods: Records of 924 pati...
Article
Background Although pilonidal sinus disease is common, development of associated malignancy is very rare. After surgical treatment, most surgeons send the excision material for a histopathological examination. The aim of this study was to examine whether it is necessary to routinely send the pilonidal sinus surgical excision material for this exami...
Article
Background: The Oesophago-Gastric Anastomosis Audit (OGAA) is an international collaborative group set up to study anastomotic leak outcomes after oesophagectomy for cancer. This Delphi study aimed to prioritize future research areas of unmet clinical need in RCTs to reduce anastomotic leaks. Methods: A modified Delphi process was overseen by the...
Article
Background: The Oesophago-Gastric Anastomosis Audit (OGAA) is an international collaborative group set up to study anastomotic leak outcomes after oesophagectomy for cancer. This Delphi study aimed to prioritize future research areas of unmet clinical need in RCTs to reduce anastomotic leaks. Methods: A modified Delphi process was overseen by the...
Article
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Preprint
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I try to explain adenoma carcinoma sequence in colorectal cancer with CAT(Chaotic Adaptation Theory)
Article
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Objective: To compare the differences in the clinical course of acute appendicitis between early elderly (60-79 years) and late elderly patients (≥80 years). Method: The sample consisted of 177 patients aged over 60 that underwent surgery at the emergency service with the diagnosis of acute appendicitis between January 2010 and May 2018. Patients’...
Article
Objective: This study aims to determine the frequency of incidental parathyroidectomy (IP), to reveal the risk factors and to present the clinical importance of IP through the experiences of our clinic. Materials and Methods: Patients undergoing thyroid surgery between June-2016 and May-2019 were reviewed retrospectively. Along with demographic da...
Article
Abstract Background: Approximately 20% of the thyroid biopsies render an indeterminate cytology.We evaluated the diagnostic value of preoperative modified systemic inflammation score(mSIS) in predicting the malignancy of indeterminate (ID) thyroid nodules (TNs).Methods: Data of 162 patients with indeterminate TNs were examined retrospectively. Them...
Article
Background: In acute appendicitis, the treatment approach may vary depending on the age and comorbidities of the patient and whether the appendix is complicated. In this study, we validated the appendistatTM score including the logistic regression model of complicated appendicitis and compared the efficacy of this scoring with C-reactive protein in...
Article
Background Approximately 20% of the thyroid biopsies render an indeterminate (ID) cytology. We evaluated the diagnostic value of preoperative modified systemic inflammation score (mSIS) in predicting the malignancy of ID thyroid nodules (TNs). Methods Data of 162 patients with indeterminate TNs were examined retrospectively. The mSIS was calculate...
Data
Cited in @WHO report An awesome #Teamwork by 35 #scientists from 15 #countries #Australia #Austria #Brazil #Ecuador #Germany #Guatemala #Iran #Israel #Italy #Philippines #Poland #Portugal #Spain #Turkey & #USA #Openaccess article “COVID-19: Pandemic surgery guidance” has been cited in @WHO report https://bit.ly/3mtd6ri Check out interview ht...
Article
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Aim: To investigate possible protective effects of Ankaferd Blood Stopper® (ABS) in an experimental liver ischemia reperfusion injury (IRI) model. Methods: The study was carried out on 30 female rats separated into 3 groups as sham, control (IRI), and treatment (IRI + ABS) groups. In the IRI + ABS group, 0.5 ml/day ABS was given for 7 days before s...
Article
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Context. Minimally invasive parathyroidectomy (MIP) procedure has become a widely accepted alternative to the standard four-gland exploration nowadays. Objective. The aim of this study was to evaluate patients with primary hyperparathyroidism (PHPT), who had been treated with thyroidectomy and bilateral neck exploration (BNE), rather than MIP alone...
Article
Full-text available
Based on high quality surgery and scientific data, scientists and surgeons are committed to protecting patients as well as healthcare staff and hereby provide this Guidance to address the special issues circumstances related to the exponential spread of the Coronavirus disease 2019 (COVID-19) during this pandemic. As a basis, the authors used the B...
Article
Full-text available
Based on high quality surgery and scientific data, scientists and surgeons are committed to protecting patients as well as healthcare staff and hereby provide this Guidance to address the special issues circumstances related to the exponential spread of the Coronavirus disease 2019 (COVID-19) during this pandemic. As a basis, the authors used the B...
Article
Full-text available
Abstract Despite the high quality of science and surgery, scientists and surgeons are committed to protecting patients as well as healthcare staff and hereby provide this Guidance to address the special issues related to the exponential spread of the Coronavirus disease 2019 (COVID-19) during this pandemic. As a basis, surgeons and scientists used...
Preprint
Full-text available
Despite the high quality of science and surgery, scientists and surgeons are committed to protecting patients as well as healthcare staff and hereby provide this Guidance to address the special issues related to the exponential spread of the Coronavirus disease 2019 (COVID-19) during this pandemic. As a basis, surgeons and scientists used the Briti...
Article
Full-text available
The frequency, pattern, and predictive factors for skip LN metastasis in patients with papillary thyroid carcinoma (PTC) remain controversial. In this study, we evaluated predictive factors of skip LN metastasis in these patients. We reviewed the medical records of 68 PTC patients who underwent total thyroidectomy, central neck dissection, and late...
Article
Full-text available
Background: Although cholecystectomy is the standard treatment modality, it has been shown that perioperative mortality is approaching 19% in critical and elderly patients. Percutaneous cholecystostomy (PC) can be considered as a safer option with a significantly lower complication rate in these patients. Aim: To assess the clinical course of ac...
Article
BACKGROUND Although cholecystectomy is the standard treatment modality, it has been shown that perioperative mortality is approaching 19% in critical and elderly patients. Percutaneous cholecystostomy (PC) can be considered as a safer option with a significantly lower complication rate in these patients. AIM To assess the clinical course of acute c...
Article
Full-text available
BACKGROUND: Acute appendicitis (AA) is one of the major causes of acute abdomen pain. Various laboratory markers have been studied for diagnosis of AA, but none of them have shown superiority to physical examination or imaging. GCP-2/CXCL6 is a chemokine expressed by macrophages and epithelial and mesenchymal cells during inflammation. The present...
Conference Paper
Background and Aim Circulating tumor cells (CTCs) in the blood are cells that have separated from the primary tumor and infiltrated into the lymphatic and / or circulatory system. Determining the presence or amount of free-circulating tumor cells in the blood is of great importance in determining the cancer cell metastasis potential, treatment proc...
Article
Full-text available
Background: We tried to examine association between the prognostic intensive care unit (ICU) scores and red cell distribution width (RDW) for prediction of mortality in a cohort of ICU patients at a single centre in Turkey. Methods: This is a retrospective cohort study conducted in a 9-bed mixed ICU of a tertiary hospital from January to December 2...
Article
Full-text available
Background Urinary system resections are performed during the cytoreductive surgery with hypertermic intraperitoneal chemotherapy (CRS-HIPEC). However, isolated ureter resection and reconstruction results are uncertain. The aim of this study was to evaluate the postoperative outcomes of isolated ureteral resection and reconstructions in patients wh...
Article
Full-text available
Background: Acute appendicitis (AA) is one of the major causes of acute abdomen pain. Various laboratory markers have been studied for diagnosis AA, but none of them have shown superiority to physical examination or imaging. GCP-2/CXCL6 is a chemokine expressed by macrophages and epithelial and mesenchymal cells during inflammation. The aim of this...
Preprint
Full-text available
Cancer, a disease of multicellular organisms, probably developed almost immediately following the transition from unicellular to metazoan life, about one billion years ago. Great efforts have been made to understand the carcinogenesis for many years. In this paper, We tried to explain the cancer based on "chaos", "adaptation" and "information" with...
Article
Full-text available
Aim: We aimed to evaluate the scoring systems in predicting severity and mortality in patients with Fournier gangrene. Material and Methods: Demographic, clinical and laboratory data of 76 patients included in the study were retrospectively analyzed. Demographic characteristics, clinical and laboratory parameters including FGSI, UFGSI and NFS score...
Article
Full-text available
Background: Despite advances in surgical approaches, emergency colorectal surgery has high mortality and morbidity. Objective: We aimed to create a simple and distinctive scoring system, for predicting mortality among patients undergoing emergency colorectal surgery. Design and setting: Prediction model development study based on retrospective...
Article
This article aims to compare available treatment options for type III liver hydatid cysts, including surgery and percutaneous techniques. Hydatid disease is a helminthic infection caused by Echinococcus granulosus and is a serious public health problem in endemic regions of the world. Hydatid cyst of the liver is the most common clinical presentati...
Preprint
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We try to summarize "Chaotic Adaptation Theory"
Preprint
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Tinbergen's four question: Explanation of behavior of the cancer cell with chaotic adaptation theory (CAT) Tinbergen's four questions fit within the levels of analysis previously described by Mayr. Mayr identified functional and evolutionary biology as overlapping, but differentiated fields of biology. The former is concerned with proximate causes...
Preprint
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Main theme of carcinogenesis is ADAPTATION/COHERENCE

Questions