Merve Erginer Hasköylüİstanbul University-Cerrahpaşa
Merve Erginer Hasköylü
Ph.D
Assistant Professor at Istanbul University Cerrahpaşa Institute of Nanotechnology and Biotechnology
About
27
Publications
3,105
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
206
Citations
Citations since 2017
Introduction
Merve Erginer Hasköylü currently works at the Department of Bio-Engineering, Marmara University. Merve does research in Biomaterials, Tissue Engineering, Anticoagulant Systems, Cosmeceuticals, Cell Biology, Genetics and Molecular Biology.
Additional affiliations
January 2014 - January 2019
February 2012 - May 2012
June 2011 - June 2011
Education
January 2014 - January 2018
July 2012 - December 2014
January 2011 - July 2011
Publications
Publications (27)
Considering the need for systematic studies on levan based hydrogels to widen their use in drug delivery systems and biomedical applications, this study is mainly focused on the synthesis and comprehensive characterization as well as drug release properties of hydrogels based on Halomonas levan (HL) and its chemical derivatives. For this, hydrolyze...
Considering the significant advances in nanostructured systems in various biomedical applications and the escalating need for levan-based nanoparticles as delivery systems, this study aimed to fabricate levan nanoparticles by the electrohydrodynamic atomization (EHDA) technique. The hydrolyzed derivative of levan polysaccharide from Halomonas smyrn...
Several exopolymers with different chemical composition and correspondingly variety in their physico-chemical properties from halophilic microorganisms have still been described, however, with a low production yield. Chromohalobacter canadensis 28 isolated from Pomorie saltern synthesized an unusual exopolymer (EP) containing 72% γ-polyglutamic aci...
Sponge-derived natural bioactive glass microspheres with self-assembled surface channel arrays opening into a hollow core for bone tissue and controlled drug release applications, Chemical Engineering Journal (2020), doi: https://doi. ABSTRACT Porous, bioactive microspheres have always been a dream material to biomedical scientists for bone regener...
Unusual composition of an exopolymer (EP) from an obligate halophilic bacterium Chromohalobacter canadensis 28 has triggered an interest in development of an effective bioreactor process for its production. Its synthesis was investigated in 2‐L bioreactor at agitation speeds at interval 600‐1000 rpm, at a constant air flow rate of 0.5 vvm; aeration...
Pseudomonas aeruginosa is an opportunistic pathogen that causes high morbidity and mortality rates due to its biofilm form. Biofilm formation is regulated via quorum sensing (QS) mechanism and provides up to 1000 times more resistance against conventional antibiotics. QS related genes are expressed according to bacterial population density via sign...
Hydrogels from Halomonas levan polysaccharide were prepared at different crosslinking densities. Swelling results demonstrated pH dependent rather than temperature dependent swelling of the hydrogel and the highest swelling value was achieved at basic conditions with a swelling ratio of 9.1 ± 0.1 which is the highest reported for levan based hydrog...
Bone health and regeneration is crucial to human survival. With the advancement in the bone research area, bone implants have been under scrutiny to find a better material that could help in bone regeneration and growth. A wide range of material has been studied and examined to find the ideal combination. In this paper, a new blend of Tri-calcium p...
Electrospraying assures many advantages such as economical manufacturing and less time-consuming when
compared with other conventional particle production methods. In this research, we investigated the encapsulation of
melatonin (MEL) hormone in polycaprolactone (PCL) microparticles by using electrospraying method. Scanning
electron microscopy (SEM...
In the last decade, nerve tissue engineering has attracted much attention due to the incapability of self-regeneration. Nerve tissue regeneration is mainly based on scaffold induced nanofibrous structures using both bio and synthetic polymers. The produced nanofibrous scaffolds have to be similar to the natural extracellular matrix and should provi...
Combinatorial Matrix-Assisted Pulsed Laser Evaporation (C-MAPLE) was recently introduced to the fast generation of compositional libraries of two biopolymers in a single-step process, for tissue engineering and regenerative medicine applications.
Synchronized laser irradiation of two distinct cryogenic targets, one consisting of Sulfated Halomonas...
Natural and functional food ingredients as dietary fibers gained escalating popularity due to increasing number of conscious consumers [1]. These indigestible functional ingredients not only improves product quality but also have many features like shelf life extension, reducing product deterioration and waste prevention in industrial perspective....
HL and its chemical derivatives are being developed as new biomaterials. Hydrolyzed, phosphonated and sulphated HL derivatives are used to form hydrogels and nanofibers for their use as adhesive patches for wound healing or drug delivery purposes. Natural and chemically modified derivatives of HL could open new fields in biomaterial applications.
Study is aimed to investigate HL and its oligofructan derivatives as a functional food ingredient in bread and effects on dough rheology
Halomonas levan temelli fonksyionel gıda bileşenlerinin geliştirilmesi
Optimized electrospinning conditions were applied to produce single and multilayered (ML) scaffolds composed of polycaprolactone, collagen and elastin. The ML scaffold was cross-linked with glutaraldehyde to increase the stability. Morphological and structural characteristics of the scaffolds were measured by SEM and FTIR analyses. Results revealed...
Heparin Mimetic Activity of Sulfated Halomonas Levan is searched
Chemical derivatives of levan from Halomonas smyrnensis AAD6T with low, medium and high levels of sulfation were synthesized and characterized by FTIR and 2D-NMR. Sulfated levan samples were found to exhibit anticoagulation activity via the intrinsic pathway like heparin in a dose-dependent manner. Exceptionally high heparin equivalent activity of...
Chemically sulfated derivative of levan polysaccharide is tested for its bioactivity
Heparin mimetic activity of chemically sulfated derivative of Halomonas levan polysaccharide is investigated
There is increased interest in smart bioactive materials to control tissue regeneration for the engineering of cell instructive scaffolds. We introduced combinatorial matrix-assisted pulsed laser evaporation (C-MAPLE) as a new method for the fabrication of organic thin films with a compositional gradient. Synchronized C-MAPLE of levan and oxidized...
Projects
Projects (3)
A main objective of the project is the investigation of the suitability of EP synthesized by Chromohalobacter canadensis 28 for use in cosmetic industry by a development of a laboratory technology for its production followed by study of its biocompatibility, moisturizing, antiaging, anti-irritant and lifespan enhancer activities.
Functional foods have gained escalating importance on both scientific and commercial platforms due to the increasing demand of the health-conscious consumers. In food industry, fructans have the largest market share among the natural functional food additives. Especially inulin and inulin-type fructans stand out as the best known and widely used natural fructan additives due to their well established prebiotic, anticancer, antioxidant, antipathogenic and immunostimulatory activities. On the other hand, levan-type fructans are being consumed as functional food in various cultures and are mainly associated with high value food applications such as increasing the shelf life of food, bread quality and dough rheology, as edible food packaging and antipathogenic sweetener. In particular, several recent reports point to the superiority of levan-type fructans when compared to inulin-type fructans and hence there has been an elevated interest in developing levan-based functional food additives.
