Merel Hamer

Merel Hamer
Erasmus MC | Erasmus MC · Department of Dermatology

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23
Publications
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628
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Publications

Publications (23)
Article
面部衰老的特征是几种皮肤的变化,但目前还不清楚这些变化是如何相互联系的,以及这些变化是如何与不同类型的面部衰老联系在一起的。 来自荷兰、中国和英国的研究人员参与了这项研究,旨在确定哪些面部变化与不同类型的衰老最相关。 作者测量了七个不同的个体特征,这些特征可以用肉眼来识别。这些是普遍性(全面性)皱纹、他人印象中的年龄、评估光损伤的指标(Griffiths 分级)、色素斑点(暗斑)、毛细血管扩张(蜘蛛状扩张的血管)、光化性角化病(癌前病变的皮肤斑块),以及存在一种称为角质形成细胞癌的皮肤癌,如鳞状细胞癌。 他们用来识别这些个体面部变化的分组的方法被称为“主成分分析”,这种方法可以最好地用来识别出皮肤的老化。这是一种统计方法,用于比较和识别复杂数据中的相似性。 研究团队的检查手段包括面部照片,但...
Article
Facial ageing is characterised by several skin changes, but it is not currently clear how these changes are related to each other, and how these are linked to the different types of facial ageing. This study, involving investigators from the Netherlands, China and the U.K., was designed to identify which facial changes are best associated with diff...
Article
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The skin's tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and rep...
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Hair color is one of the most recognizable visual traits in European populations and is under strong genetic control. Here we report the results of a genome-wide association study meta-analysis of almost 300,000 participants of European descent. We identified 123 autosomal and one X-chromosome loci significantly associated with hair color; all but...
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Background: Little is known about the effects of different dietary patterns on facial wrinkling. Objective: We aimed to investigate the association between diet and facial wrinkles in a population-based cohort of 2,753 elderly participants of the Rotterdam Study. Methods: Wrinkles were digitally quantified as the area in facial photographs the...
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Shape variation of human head hair shows striking variation within and between human populations, while its genetic basis is far from being understood. We performed a series of genome-wide association studies (GWASs) and replication studies in a total of 28,964 subjects from 9 cohorts from multiple geographic origins. A meta-analysis of three Europ...
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Data from in-vitro experiments suggest vitamin D reduces the rate of skin aging whereas population studies suggest the opposite, most likely due to confounding by UV-exposure. We investigated whether there are causal associations between 25-hydroxyvitamin D concentrations and features of skin aging in a bidirectional Mendelian Randomization Study....
Article
Facial wrinkling is one of the most notable signs of skin aging. Men and women show different wrinkling patterns yet the lifestyle and physiological factors underlying these sex-specific patterns are relatively unknown. Here, we investigated sex-specific determinants for facial wrinkles. Wrinkle area was quantified digitally using facial photograph...
Article
The prevalence of several skin diseases increases with age, in part due to age-related physio-pathological alterations.1 The global burden of disease project (GBD) 2,3 presented a comprehensive overview of the burden due to skin diseases across different age groups. However, the point prevalences of many common skin diseases, especially in elderly...
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Looking young for one's age has been a desire since time immemorial. This desire is attributable to the belief that appearance reflects health and fecundity. Indeed, perceived age predicts survival [1] and associates with molecular markers of aging such as telomere length [2]. Understanding the underlying molecular biology of perceived age is vital...
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The global demand for products that effectively prevent the development of male-pattern baldness (MPB) has drastically increased. However, there is currently no established genetic model for the estimation of MPB risk. We conducted a prediction analysis using single-nucleotide polymorphisms (SNPs) identified from previous GWASs of MPB in a total of...
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Skin aging can be divided into 4 different subtypes: wrinkles, pigmented spots, telangiectasia and sagging. This prospective population-based study examined 2731 participants aged 51-98 years old, in order to discover risk factors for facial wrinkles. Known risk factors, such as smoking, excessive UV-exposure and low BMI, were confirmed. Besides th...
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Full-text available
Facial pigmented spots are a common skin aging feature, but genetic predisposition has yet to be thoroughly investigated. We conducted a genome-wide association study (GWAS) for pigmented spots in 2844 Dutch Europeans from the Rotterdam Study (mean age: 66.9±8.0; 47% male). Using semi-automated image analysis of high resolution digital facial photo...
Article
Background Accurate measurement of the extent skin has aged is crucial for skin aging research. Image analysis offers a quick and consistent approach for quantifying skin aging features from photographs, but is prone to technical bias and requires proper validation.Methods Facial photographs of 75 male and 75 female North-European participants, ran...

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