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May 2006 - present
Publications
Publications (13)
Low‐affinity immunoglobulin gamma Fc region receptor III‐B (FcγRIIIB) deficiency is present in ˜0·05% of the general population. Among our patients, FcγRIIIB deficiency was less frequent in those with immune‐system disorders (one of 1815 patients, 0·05%) than in those with blood disorders (nine of 2147 patients, 0·42%, P = 0·023): mainly primary im...
Improved therapies in multiple myeloma (MM) have forced a constant risk stratification update, first Durie-Salmon, then international scoring systems (ISS), next revised-ISS (RISS) including high-risk cytogenetic abnormalities (HRCAs) such as del(17p) and t(4;14), and now R2-ISS including 1q21 gain has been proposed. Predictive value of 1q21 gain b...
Standard risk stratification (sRisk) guides clinical management in monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM) and multiple myeloma (MM). Nonetheless, clinical results are considerably heterogeneous among patients with similar risk status. Blood and bone marrow samples from 276 MGUS, 56 SMM and 242 M...
Proliferation and apoptosis of neoplastic cells are prognostic biomarkers in plasma cell neoplasms (PCNs). The prognostic capacity of proliferation to apoptosis ratio (Ratio-PA) in the era of immunomodulatory treatments is re-evaluated in 316 gammopathy of undetermined significance (MGUS), 57 smoldering multiple myeloma (SMM), and 266 multiple myel...
Resumen
Introducción
Las anemias hemolíticas (AH), son un grupo heterogéneo de enfermedades que se caracterizan por destrucción precoz de los hematíes (hemólisis).
Patogenia. Manifestaciones clínicas
Las AH pueden ser congénitas o adquiridas. Las AH congénitas son consecuencia de alteraciones genéticas que determinan defectos en la membrana del h...
Resumen
Introducción
Las anemias hemolíticas (AH) engloban un grupo muy heterogéneo de anemias que tienen en común la destrucción precoz de los hematíes, proceso conocido como hemólisis. En consecuencia, existen ciertos datos de laboratorio comunes a todas ellas, como la anemia con aumento de reticulocitos, la elevación de la bilirrubina indirecta...
PCH is a rare autoimmune hemolytic anemia (AIHA) but is one of the most common causes of AIAH in children. For the diagnosis, it is important to perform the appropriate methods of serological investigation and show the typical biphasic reaction. This is a case report of a child who presented with features of haemolysis and was diagnosed with PCH of...
La neutrofilia se define como una cifra absoluta de neutrófilos mayor de 7.500 células/μl. En función del tiempo de evolución, se puede dividir en aguda (horas, días) o crónica (semanas, meses), dependiendo habitualmente de la prolongación en el tiempo del evento causal. Puesto que la mayoría de las neutrofilias son secundarias a una causa subyacen...