Mercè Alemany-Chavarria

Autonomous University of Barcelona | UAB · Department of Chemistry

Graphical analysis of the molecular structure of proteins can be very complex. Full-atom representations retain most geometric information but are generally crowded, and key structural patterns can be challenging to identify. Non-full atom representations could be more instructive on physicochemical aspects but be insufficiently detailed regarding...

Epithelial/Mesenchymal (E/M) plasticity plays a fundamental role both in embryogenesis and during tumorigenesis. The receptor for advanced glycation end products (RAGE) is a driver of cell plasticity in fibrotic diseases; however, its role and molecular mechanism in triple-negative breast cancer (TNBC) remains unclear. Here, we demonstrate that RAG...

Graphical analysis of the molecular structure of proteins can be very complex. Full atom representations retain most of the geometric information but are generally crowded and key structural patterns can be difficult to catch. Non-full atom representations could be more instructive on physicochemical aspects but be insufficiently detailed regarding...

Despite the revolution of immunotherapy in cancer treatment, patients eventually progress due to the emergence of resistance. In this scenario, the selection of the tumor antigen can be decisive in the success of the clinical response. T cell bispecific antibodies (TCBs) are engineered molecules that include binding sites to the T cell receptor and...

The interaction of two bis-chelated VIVO²⁺ complexes, formed by pipemidic (Hpip) and 8-hydroxyquinoline-5-sulfonic acids (Hhqs), with two small proteins, ubiquitin (Ub) and lysozyme (Lyz) was studied by EPR, ESI-MS, docking and DFT methods. The two complexes differ by electric charge (at neutral pH it is +2 and -2 for the species formed by Hpip and...