Meral Yüksel

Meral Yüksel
Marmara University · Department of Medical Laboratory- Biochemistry

Professor

About

196
Publications
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Publications

Publications (196)
Article
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We aimed to evaluate the impact of hormone replacement, melatonin, or exercise alone or their combination on oxidative damage and functional status of heart, brain, and aorta of ovariectomized (OVX) rats and to determine whether the signaling pathway is dependent on sirtuin-1 (SIRT1). Ovariectomized Sprague Dawley rats were orally given either a ho...
Book
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Bu kitap farklı disiplinlerden uzmanların beslenme ve diyetetik konularına bakışından örnekler sunar. Kitapta beslenme nörobiyokimyasından psikonöroimmunolojiye, nöroinflamasyondan nörogastronomiye, beslenme hastalıklarından sürdürülebilir beslenmeye, nutrigenetikten nutrasötiklere, yeme bozukluklarından yeme bağımlılıklarına, farklı diyetlerin bil...
Article
Aims: We aimed to investigate putative neuroprotective effects of nesfatin-1 on oxidative brain injury and memory dysfunction induced by a single epileptic seizure and to compare these effects with those of antiepileptic phenytoin. Main methods: Wistar albino rats were randomly divided into a control group and pentylenetetrazole (PTZ)-seizure gr...
Article
Full-text available
Plasminogen activator inhibitor-1 (PAI-1) antagonists are known for their neuroprotective effects. In this study, it was aimed to investigate the possible protective effects of PAI-1 antagonists in a rat mild traumatic brain injury (TBI) model. Sprague-Dawley male rats were grouped as sham (n = 7), TBI (n = 9), and TBI + PAI-1 antagonist (5 and 10...
Preprint
Full-text available
Increased incidence of inflammatory bowel disease (IBD) is associated with the consumption of westernized diet (WD). In male Wistar albino rats induced with colitis by oral intake of dextran-sulfate sodium (DSS) for 10 days, we investigated how colitis-induced oxidative damage is affected by WD consumption started 3 weeks before DSS intake. Secondl...
Article
Aim: The aim of this study was to investigate the possible neuroprotective effects of Cinnamaldehyde (CA) on the secondary brain injury seen after traumatic brain injury (TBI) in a rat model. Methods: Rats were randomly divided into 4 groups: control (n=9), TBI (n=9), vehicle (0.1% Tween 80; n=8), and CA (100 mg/kg) (n=9). TBI was induced by the...
Article
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Background/aims: Gastrointestinal motility changes contribute to development and maintenance of obesity. Nesfatin-1 (NES-1) is involved in central appetite control. The aim is to elucidate effects of NES-1 and high-fat diet (HFD) on gastrointestinal motility and to explore myenteric neuron expressions of tyrosine hydroxylase (TH), vasoactive intes...
Preprint
Full-text available
Background: Plasminogen activator inhibitor-1 (PAI-1) antagonists are known for their neuroprotective effects. In this study, it was aimed to investigate the possible protective effects of PAI-1 antagonists in a rat mild traumatic brain injury (TBI) model. Method: Sprague Dawley male rats were grouped as sham (n=7), TBI (n=9), TBI + PAI-1 antagonis...
Article
Full-text available
How to cite: Gürler EB, Özbeyli D, Buzcu H, Çam ME, Yüksel M. Astaxanthin and Coenzyme Q10 are not synergistic against oxidative damage in cerulein-induced acute pancreatitis.
Article
Aims Acetaminophen-induced hepatorenal toxicity varies among sexes with controversial results among species. The aim was to compare the impact of sex and ovarian hormones on hepatorenal toxicity and to elucidate protective effects of estrogen and estrogen receptor (ER) agonists. Main methods Under anesthesia, female rats underwent ovariectomy (OVX...
Article
This study aimed to show the possible protective effects of high intensity interval training (HIIT) in PTSD-induced rats and probable underlying mechanisms. Female rats (n = 44) were separated as; Sedentary (SED), moderate intensity continuous training (MICT), HIIT groups. Then the groups were divided into subgroups according to PTSD induction (n =...
Article
Full-text available
Amaç: Bu çalışmada, Beta glukan, fukoksantin ve kombinasyonlarının serulein kaynaklı akut pankreatit (AP) sıçan modelindeki etkileri araştırıldı. Gereç ve yöntem: Sıçanlar kontrol ve AP gruplarına ayrıldı. AP bir saat arayla dört kez serulein (20 ug/kg/ip) enjeksiyonuyla oluşturuldu. Serulein enjeksiyonundan 3 gün önce AP gruplarına günde 1 kez taş...
Article
Full-text available
Background/aims: Astaxanthin (ATX) is a naturally occurring carotenoid and a potent antioxidant. Various anti-inflammatory effects of ATX have been examined. We aimed to investigate the protective effect of ATX and its mechanism in a cerulein-induced acute pancreatitis rat model. Materials and methods: The rats were randomized into 2 main groups...
Article
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In this study, the aim was to examine the potential protective effects of Myrtus communis subsp. communis leaf ethanol extract (MC) treatment against acute pancreatitis (AP) in rats. Thirty‐two rats were grouped as the saline‐pretreated control (C), MC‐pretreated control (MC), saline‐pretreated AP (AP), and MC‐pretreated AP (MC + AP) groups. To ind...
Article
Nesfatin-1, a recently discovered peptide, was shown to have anti-inflammatory effects. Acute pancreatitis (AP) is a life-threatening condition caused by various reasons. Although the etiology of AP is well-known, its pathogenesis is not clear. The aim of this study is to investigate the possible anti-inflammatory role of nesfatin-1 and its probabl...
Article
Background: 1,25 Dihydroxyvitamin D3 (1,25(OH)2D3) modulates inflammation and immune responses. Deficiency of 1,25(OH)2D3 was found to be associated with the risk of cancer, cardiovascular disease, osteoarthritis, infections, and autoimmune diseases. This study evaluated the effect of 1,25 dihydroxyvitamin D3 1,25(OH)2D3 on thioacetamide (TAA)-ind...
Article
INTRODUCTION: Obstructive sleep apnea syndrome (OSAS) is commonly associated with obesity, insulin resistance, metabolic syndrome, hypertension, and coronary artery disease. Irisin is a newly identified myokine and its serum concentration was found to be correlated with cardiac troponin and creatin kinase- MB in acute myocardial infarction patients...
Article
New findings: • What is the central question of this study? Could different hormonally active substances, including oestrogen receptor (ER) agonists, protect against oxidative brain damage and memory impairment induced by a single epileptic seizure in rats? If so, which signalling mechanisms are involved in their anti-inflammatory effects? • What...
Article
BACKGROUND: 1,25 Dihydroxyvitamin D3 (1,25(OH)2D3) modulates inflammation and immune responses. Deficiency of 1,25(OH)2D3 was found to be associated with the risk of cancer, cardiovascular disease, osteoarthritis, infections, and autoimmune diseases. This study evaluated the effect of 1,25 dihydroxyvitamin D3 1,25(OH)2D3 on thioacetamide (TAA)-indu...
Article
Objective: Traumatic brain injury (TBI) is one of the most common preventable causes of mortality and morbidity. Inflammation, apoptosis, oxidative stress, and ischemia are some of the important pathophysiological mechanisms underlying neuronal loss after TBI. Mildronate is demonstrated to be beneficial in various experimental models of ischemic d...
Article
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High-fat diet (HFD) consumption leads to metabolic disorders, gastrointestinal dysfunction and intestinal dysbiosis. Antibiotics also disrupt the composition of intestinal microbiota. The aim of the study was to investigate the impact of a short-term feeding with HFD on oxidative status, enteric microbiota, intestinal motility and the effects of an...
Article
Aims The purpose of the present study was to investigate the potential antioxidant, anti-apoptotic and sperm function-preserving effects of estrogen, estrogen receptor (ER)α and ERβ agonists in a rat model of testis torsion-detorsion (T/D). Main methods Under anesthesia, 6–8-week-old male Sprague-Dawley rats underwent sham-operation or testicular...
Article
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Aim: This study aimed to investigate the effects of gilaburu (Viburnum opulus L.,GB) fruit extract in a rat model of acetic acid (AA)-induced ulcerative colitis. Methods: Forty Sprague-Dawley rats of both sexes were used in this study. Starting immediately after or 1 week before the colitis induction, the rats were treated with GB (100 mg/kg/d;p.o....
Article
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Aim: This study aimed to investigate the effects of gilaburu (Viburnum opulus L.,GB) fruit extract on burn-induced remote organ injury in rats. Methods: Under ether anesthesia, rats were exposed to 90oC (burn) or 25oC (control) water-bath for 10s to induce burn and treated either with saline (1 ml;p.o.) or GB (100 mg/kg/d;p.o.) immediately and at 2...
Article
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Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is often associated with erectile dysfunction (ED). However, the underlying pathophysiological mechanisms of ED occurrence are still unclear in patients with CP/CPPS. The aim of the study was to investigate superoxide anion (O2•−) and total reactive oxygen species (ROS) production in semen...
Conference Paper
Full-text available
Serulein ile oluşturulan sıçan akut pankreatit modelinde antioksidan astaksantin ve koenzim Q10 tedavisinin olası sinerjistik iyileştirici etkisinin incelenmesi Dilek ÖZBEYLİ1*, Esra Bihter GÜRLER2, Hülya BUZCU3, Özlem Tuğçe ÇİLİNGİR-KAYA4, Muhammet Emin ÇAM5, Burcin ALEV6, Meral YÜKSEL7, Özgür Kasımay ÇAKIR3, Berrak Çağlayan YEĞEN3 1Marmara Üniver...
Conference Paper
Full-text available
Aim: We investigated astaxanthin (ATX)’s thereupatic effects and underlying antiinflammatory mechanisms in a cerulein-induced acute pancreatitis rat model. Methods: After ethical approval (76.2017mar), female Wistar rats (n=18) were injected twice with cerulein (50 μg/kg/hr intraperitonally), with an hour in between (Acute pancreatitis; AP); while...
Article
Full-text available
Purpose To investigate the pathophysiological role of superoxide anion and total reactive oxygen species (ROS) production by the spermatozoa of men with varicocele and its relationship with varicocele grade and semen parameters. Materials and Methods This prospective study included 34 men with grade II–III varicocele, regardless of their fertility...
Article
Background/aim: This study was designed to examine the effect of tadalafil, a phosphodiesterase (PDE)5 inhibitor, on the severity of joint and muscle damage in rats with adjuvant-induced arthritis (AA). Materials and methods: AA was induced by intradermal inoculation into right hind paw of male Sprague Dawley rats (300-450g) with complete Freund's...
Article
Riboflavin (RF) has been found to be a promising antioxidant and/or anti-inflammatory agent in several studies. However, the effect of RF against acetic acid (AA)-induced colonic injury is currently unknown. This study aimed to investigate the potential antioxidant and protective effects of RF in a rat model of ulcerative colitis. Starting immediat...
Article
OBJECTIVE: Nerium oleander (Apocynaceae) and Aloe vera (Liliaceae) are among the widely used herbal remedies for treating skin diseases and possess numerous activities such as antibacterial, antiviral, antifungal, and antioxidant. The aim of this study was to investigate the possible wound healing effect of Aloev era-based extract of the N. oleande...
Article
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Objectives: This study aimed to examine the anti-inflammatory potential of orally-administered minocycline, a semi-synthetic second-generation tetracycline, on burn-induced liver and kidney damage in rats. Materials and Methods: Female Sprague-Dawley rats (250- 300 g; n=7-8/group) were used. Burn and sham groups were exposed to 90 ºC and 25 ºC wate...
Article
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Background The aim of this study is to evaluate the anti-inflammatory and anti-fibrotic effects of halofuginone in caustic esophageal burn injury in rats. Materials and methodsCorrosive esophageal injury (CEI) was produced in male Wistar albino rats by instilling NaOH solution (1 ml, 37.5%) into the distal esophagus. Rats were decapitated on the 3r...
Article
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In order to elucidate the contribution of cycloxygenase (COX) enzymes in the anti-oxidant and anti-inflammatory mechanisms of nesfatin-1, which improves the healing process of chronic gastric ulcers, either acetic acid (80%; ulcer groups; n = 40) or saline (control groups; n = 40) was applied to the serosal surface of male Sprague Dawley rats' stom...
Article
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Formaldehyde (FA) is an organic chemical which is widely used all over the world and has hazardous effects for the environment. FA can react with many biomolecules in the biological systems and lead to toxic effects on humans. Melatonin (MEL), a neurohormone produced by pineal gland, has been shown to be an effective antioxi-dant with free radical...
Article
Our aim was to investigate the probable protective effects of aerobic, resistance and combined exercise methods on ovariectomy and d-galactose induced Alzheimer's Disease (AD)-like model. d-galactose (100mg/kg) or saline were administered intraperitoneally for 6 weeks to ovariectomized or sham-operated rats (n=8/group). Aerobic (AE), resistance (RE...
Article
Full-text available
Objectives: To investigate the impact of exercise on ulcerogenesis. Materials and Methods: Gastric ulcer was induced in Wistar albino rats that were either kept sedentary or had swimming exercise for 6 weeks. Under anesthesia, ulcer was induced by applying acetic acid on the stomach serosa, while control rats had sham-operation. On 3rd or 10th day...
Article
The role of second hand smoke [SHS] exposure on ulcerative colitis is not known. Our aim was to examine the effects of α-lipoic acid (ALA), chronic aerobic [AE] or resistance exercise [RE] on SHS exposed rats with colitis. Sprague-Dawley male rats [150-200g, n=54] were occupied for colitis induction. Among the colitis groups, one group was exposed...
Article
Introduction: Caffeine is an adrenergic antagonist that enhances neuronal activity. Psychological stress depresses cognitive function. Aim: To investigate the effects of acute and chronic low dose caffeine on anxiety-like behavior and cognitive functions of acute or chronic psychological stressed rats. Material-method: Acute or chronic caffein...
Article
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The aim of this study was to evaluate the possible protective effects of halofuginone on burn-induced oxidative injury of the liver and kidney. For the induction of burn, backs of Wistar albino rats were shaved and exposed for 10 seconds to water bath at 90°C, whereas rats in the control group were exposed for 10 seconds at 25°C. Rats were then adm...
Article
The aim of this study was to evaluate the effect of ethanol extract from leaves of Myrtus communis subsp. communis (MC) on acetic acid (AA)-induced ulcerative colitis in rats. On the fourth day of colitis induction, all rats were decapitated. Colitis was assessed by macroscopic and microscopic scores and by measuring malondialdehyde (MDA) and gluta...
Article
Full-text available
Öz Objectives: This study aimed to elucidate the possible protective effect of simvastatin (SIM) pretreatment on stress-induced gastric ulcer in rats. Materials and Methods: Gastric ulcer was produced in Sprague-Dawley rats (250-300 g) by cold-restraint stress. SIM (10 mg/kg/day; per oral) or saline was administered for 21 days prior to stress. On...
Article
Full-text available
Mucosal balance impairment, bacterial over-proliferation, cytokines, inflammatory mediators are known as responsible for inflammatory bowel disease. Besides known anorexigenic, neuroprotective, and anti-apoptotic effects, the major effect of nesfatin-1 on colitis is unknown. Our aim was to investigate the possible anti-inflammatory effects of nesfa...