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Publications (28)
Interstitial fluid (ISF) is considered an underutilized source of biomarkers for disease diagnosis and monitoring. However, biomacromolecular markers can not be enriched in ISF due to the restriction of capillary walls, which limits the wide use of ISF in biomarkers analysis. Here, an integrated micro-extracting system (MES) that includes a multimi...
We investigate the rheological properties of interpenetrating networks reconstituted from the main cytoskeletal components: filamentous actin, microtubules, and vimentin intermediate filaments. The elastic modulus is determined largely by actin, with little contribution from either microtubules or vimentin. However, vimentin dramatically impacts th...
Cancer is one of the leading causes of human death, despite enormous efforts to explore cancer biology and develop anticancer therapies. The main challenges in cancer research are establishing an efficient tumor microenvironment in vitro and exploring efficient means for screening anticancer drugs to reveal the nature of cancer and develop treatmen...
The Vernier effect magnifies optical sensitivity by the superposition of two spectra with slightly shifted frequencies from a sensing interferometer (SIM) and a reference interferometer (RIM). In this study, we demonstrate that the Vernier effect can be obtained through a single interferometer, which detects the changed signal and provides an artif...
In this paper, we proposed a two-state model to quantitatively illustrate the working mechanism of caveolae structure in the regulation of cell membrane stretch. First, we derived the free energy compositions of one caveola in an arbitrary state. This model predicts two local minima for the free energy of one caveola at the completely open and comp...
Biosensors have been extensively studied in the areas of biology, electronics, chemistry, biotechnology, medicine, and various engineering fields. The interdisciplinarity creates an ideal platform for scientists to analyze biological species and chemical materials in a direct, efficient, and sensitive manner; this is expected to revolutionize the l...
Conformance control during waterflooding in an oil reservoir is utilized to redistribute water and increase the sweep efficiency and hence oil production. Using preformed gel particles can effectively redirect the flow by blocking the high permeability zones and forcing water into low permeability zones where the oil is trapped. However, the size o...
Structural morphology is the key parameter for efficacy of nanomedicine. To date, lipid‐based nanomaterial has been the most widely used material in nanomedicine and many other biomedical applications. However, to the best of our knowledge, there has not been an in‐depth or systematic investigation of the structure–function relationship of lipid‐ba...
Micro-channel heat sink (MCHS) has been extensively used in various electronic cooling fields. Double-layered MCHS, or DL-MCHS, is regarded as one effective technique for high-heat-flux transfer and is expected to meet the ever-increasing heat load requirement of future electronic device generations. In order to improve the cooling capacity, two ne...
An ultrasensitive refractive index (RI) sensor based on enhanced Vernier effect is proposed, which consists of two cascaded fiber core-offset pairs. One pair functions as a Mach-Zehnder interferometer (MZI), the other with larger core offset as a low-finesse Fabry-Perot interferometer (FPI). In traditional Vernier-effect based sensors, an interfero...
The emerging single-cell technologies call for novel biological tools that can manipulate target cells in a massive and spatially-arranged manner. Here we report a nanophotonic platform, named WANTS (Waveguide-pair Array-based Nanophotonic Trapping System), for massive trapping and alignment of rod-shaped bacteria. This platform leverages silicon w...
In this paper we experimentally studied the instabilities of pre-stretched viscoelastic fluid in cross-slot devices. We first investigate the instability of the flow in a standard cross-slot at different Weissenberg numbers without pre-stretch. It is found the viscoelastic flow is transformed from the steady symmetric state to the instabilities sta...
Transient flow responses of viscoelastic fluids to different external body forces are studied. As a non-Newtonian fluid, the viscoelastic fluid exhibits significant elastic response which does not raise in Newtonian fluid. Here, we investigate the transient response of a viscoelastic Poiseuille flow in a two-dimensional channel driven by external b...
Fluid mixing plays an essential role in many microfluidic applications. Here, we compare the mixing in time pulsing flows for both a Newtonian fluid and a viscoelastic fluid at different pulsing frequencies. In general, the mixing degree in the viscoelastic fluid is higher than that in the Newtonian fluid. Particularly, the mixing in Newtonian flui...
The suppression of ship radiation noise is studied through a generalized Lorenz system. The system integrates a classical Lorentz system with a time-delay feedback control and an external acoustic excitation. The output of the system can be categorized into three different states: the quasi-periodic state, the periodic state and the chaotic state....
Fluid mixing plays an essential role in microscale flow systems. Here, we propose an active mixing approach which enhances the mixing of viscoelastic fluid flow in a simplified pore T-junction structure. Mixing is actively controlled by modulating the driving pressure with a sinusoidal signal at the two inlets of the T-junction. The mixing effect i...
Metamaterials interact with incident electromagnetic waves through their consisting subwavelength metamolecules. In this paper, we reported a reconfigurable metamaterial which tunes its THz response experimentally from a single mode resonance at 2.99 THz to a dual mode resonance at 2.94 THz and 2.99 THz. The reconfiguration is realized through a mi...
Polarization is an important property of electromagnetic (EM) wave and different polarization manipulations are required for varied optical applications. Here we report a reconfigurable metasurface which achieves both the polarization conversion and the polarization rotation in THz regime. The metasurface is reconfigured through the micro-electro-m...
In order to obtain a fluid with both drag reducing and heat transfer enhanced abilities, we use viscoelastic fluid for drag reducing and stimulate the elastic turbulence for the sake of heat transfer enhancement. To further enhance the heat transfer, carbon powder particles were added to the viscoelastic fluid where Polyacrylamide Ethylene Glycol s...
In order to choose the threshold of different fluid state and reveal the physical mechanism of the flow, the thermal convection of channel flow of viscous fluid is investigated by the chaos dynamics in this paper, in which the temperature at lower plate is slightly higher than the upper plate. Based on the Navies-Stokes equations of viscous fluids,...
A finite-volume method (FVM) is used to address combined heat transfer, natural convection, and volumetric radiation with an isotropic scattering medium, in a tilted shallow enclosure. Numerical simulations are performed in the in-house fluid flow software GTEA. All the results obtained by the present FVM agree very well with the numerical solution...
Based on the Burgers equation and Manley-Rowe equation, the derivation about nonlinear interaction of the acoustic waves has been done in this paper. After nonlinear interaction among the low-frequency weak waves and the pump wave, the analytical solutions of acoustic waves’ amplitude in the field are deduced. The relationship between normalized en...
With the application of supercavitation effect, a novel device named Rotational Supercavitating Evaporator (RSCE) has been designed for desalination. In order to study the effect of temperature on the performance of RSCE and then direct the experimental study on RSCE for the next step, numerical simulations are conducted on the supercavitating flow...
To determine the parameter combination for reducing the line spectrum energy value of Duffing system, based on a single degree of freedom vibration Duffing system, fourth-order Runge-Kutta method simulation was used to analyze the output characteristics of linear systems and nonlinear systems. The effects of damping and nonlinear parameters on syst...
According to the physical characteristics of the marine structure and acoustic wave propagation characteristics, in order to reduce underwater noise, a feedback control model of acoustic nonlinear interaction is established in this paper. The power spectrum and the acoustic energy changing characteristics of single-frequency acoustic wave, which ha...
For viscous acoustic computation at low Mach numbers, non-linear incompressible Navier-Stokes equations and acoustic perturbed equations are proposed. The derivation is based on non-linear compressible Navier-Stokes equations. On unstructured collocated grids the flow part and acoustic part are discretized using SIMPLEC method with a cell-centered...
A fast particle tracking algorithm based on unstructured grids is proposed. The cost of CPU time with this algorithm is compared with a recently developed one for a spray on a fixed chamber with different particle numbers. It shows a clear advantage of the present algorithm. Numerical simulation of gas-liquid two-phase reacting flows is performed i...
