Melle J.W. van der Molen

Melle J.W. van der Molen
Leiden University | LEI · Institute of Psychology

Ph.D.

About

42
Publications
5,791
Reads
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834
Citations
Citations since 2016
28 Research Items
717 Citations
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2016201720182019202020212022020406080100120140
Introduction
I am an assistant professor in Clinical Neurodevelopmental Psychology at Leiden University. My work lies at the intersection between developmental cognitive neuroscience and clinical psychology. A key denominator of my work is employing a multimethod approach - combining behavioral and neuroimaging assessments, as well as advanced statistical methods. I aim at discovering reliable transdiagnostic markers that will aid in understanding the etiology of psychological disorders.
Additional affiliations
January 2013 - present
Leiden University
Position
  • Professor (Assistant)
September 2007 - July 2011
University of Amsterdam
Position
  • PhD Student
September 2007 - July 2011
University of Amsterdam
Position
  • PhD Student

Publications

Publications (42)
Article
Full-text available
Monitoring social threat is essential for maintaining healthy social relationships, and recent studies suggest a neural alarm system that governs our response to social rejection. Frontal-midline theta (4-8 Hz) oscillatory power might act as a neural correlate of this system by being sensitive to unexpected social rejection. Here, we examined wheth...
Article
Social anxiety disorder (SAD) is characterized by information processing biases, however, their underlying neural mechanisms remain poorly understood. The goal of this review was to give a comprehensive overview of the most frequently studied EEG spectral and event-related potential (ERP) measures in social anxiety during rest, anticipation, stimul...
Article
This study examined whether attention deficits in fragile X syndrome (FXS) can be traced back to abnormalities in basic information processing. Sixteen males with FXS and 22 age-matched control participants (mean age 29 years) performed a standard oddball task to examine selective attention in both auditory and visual modalities. Five FXS males wer...
Article
The current study examined neural and behavioral responses to social-evaluative feedback processing in social anxiety. Twenty-two non-socially and 17 socially anxious females (mean age = 19.57 years) participated in a Social Judgment Paradigm in which they received peer acceptance/rejection feedback that was either congruent or incongruent with the...
Article
Full-text available
We performed an EEG graph analysis on data from 31 typical readers (22.27 ± 2.53 y/o) and 24 dyslexics (22.99 ± 2.29 y/o), recorded while they were engaged in an audiovisual task and during resting-state. The task simulates reading acquisition as participants learned new letter-sound mappings via feedback. EEG data was filtered for the delta (0.5-4...
Article
Full-text available
Pursuing dating relationships is important for many people's well-being, because it helps them fulfill the need for stable social relationships. However, the neural underpinnings of decision-making processes during the pursuit of dating interactions are unclear. In the present study, we used a novel online speed dating paradigm where participants (...
Article
Full-text available
Adolescence is a developmental period characterized by substantial biological, neural, behavioral, and social changes. Learning to navigate the complex social world requires adaptive skills. Although anticipation of social situations can serve an adaptive function, providing opportunity to adjust behavior, socially anxious individuals may engage in...
Preprint
Frontal midline (FM) theta (4–8 Hz) reactivity to unexpected social rejection seems to be an important correlate of a neural threat-detection system. Neurovisceral integration theory proposes that the functioning of such systems is indexed by heart rate variability (HRV). Here, we tested this by examining whether baseline HRV predicts FM-theta reac...
Article
Recent studies suggest that individuals with dyslexia may be impaired in probability learning and performance monitoring. These observations are consistent with findings indicating atypical neural activations in frontostriatal circuits in the brain, which are important for associative learning. The current study further examined probability learnin...
Article
Full-text available
Developmental dyslexia may involve deficits in functional connectivity across widespread brain networks that enable fluent reading. We investigated the large-scale organization of EEG functional networks at rest in 28 dyslexics and 36 typically reading adults. For each frequency band, we assessed functional connectivity strength with the phase lag...
Article
Background: Social anxiety disorder (SAD) is the extreme fear and avoidance of one or more social situations. The goal of the current study was to investigate whether heart rate variability (HRV) during resting state and a social performance task (SPT) is a candidate endophenotype of SAD. Methods: In this two-generation family study, patients wi...
Article
Full-text available
Cross-frequency coupling (CFC) between frontal delta (1–4 Hz) and beta (14–30 Hz) oscillations has been suggested as a candidate neural correlate of social anxiety disorder, a disorder characterized by fear and avoidance of social and performance situations. Prior studies have used amplitude-amplitude correlation (AAC) as a CFC measure and hypothes...
Article
Full-text available
Objectives: Social anxiety disorder (SAD) is a serious and prevalent psychiatric condition, with a heritable component. However, little is known about the characteristics that are associated with the genetic component of SAD, the so-called ‘endophenotypes’. These endophenotypes could advance our insight in the genetic susceptibility to SAD, as they...
Article
Full-text available
Social anxiety disorder is an invalidating psychiatric disorder characterized by extreme fear and avoidance of one or more social situations in which patients might experience scrutiny by others. The goal of this two-generation family study was to delineate behavioral and electrocortical endophenotypes of social anxiety disorder related to social e...
Article
Background: Social anxiety disorder (SAD) is characterized by an extreme and intense fear and avoidance of social situations. In this two-generation family study we examined delta-beta correlation during a social performance task as candidate endophenotype of SAD. Methods: Nine families with a target participant (diagnosed with SAD), their spous...
Article
Full-text available
The goal of the present study was to examine whether frontal alpha asymmetry and delta–beta cross-frequency correlation during resting state, anticipation, and recovery are electroencephalographic (EEG) measures of social anxiety. For the first time, we jointly examined frontal alpha asymmetry and delta–beta correlation during resting state and dur...
Article
Full-text available
Objective: Neuroimaging research suggested a mixed pattern of functional connectivity abnormalities in developmental dyslexia. We examined differences in the topological properties of functional networks between 29 dyslexics and 15 typically reading controls in 3rd grade using graph analysis. Graph metrics characterize brain networks in terms of i...
Article
Full-text available
The effects of neuroticism and depressive symptoms on psychophysiological responses in a social judgment task were examined in a sample of 101 healthy young adults. Participants performed a social judgment task in which they had to predict whether or not a virtual peer presented on a computer screen liked them. After the prediction, the actual judg...
Article
Introduction: Disruptions in functional connectivity and dysfunctional brain networks are considered to be a neurological hallmark of neurodevelopmental disorders. Despite the vast literature on functional brain connectivity in typical brain development, surprisingly few attempts have been made to investigate brain network integrity in fragile X sy...
Poster
Full-text available
Graph Analysis of EEG Resting State Functional Networks in Dyslexic and Typically Reading Children
Article
Full-text available
This study provides a joint analysis of the cardiac and electro-cortical—early and late P3 and feedback-related negativity (FRN)—responses to social acceptance and rejection feedback. Twenty-five female participants performed on a social- and age-judgment control task, in which they received feedback with respect to their liking and age judgments,...
Conference Paper
Fragile X syndrome (FXS) is the most common inherited type of intellectual disability and is caused by an abnormal expansion of trinucleotide (CGG) repeats in the FMR1-gene located on the X chromosome. Both FXS humans and animals (e.g., FMR1 KO rodents) display hypersensitivity to sensory stimulation in most sensory modalities. Here we characterize...
Article
Full-text available
Disruptions in functional connectivity and dysfunctional brain networks are considered to be a neurological hallmark of neurodevelopmental disorders. Despite the vast literature on functional brain connectivity in typical brain development, surprisingly few attempts have been made to characterize brain network integrity in neurodevelopmental disord...
Article
Full-text available
Cognitive models posit that the fear of negative evaluation (FNE) is a hallmark feature of social anxiety. As such, individuals with high FNE may show biased information processing when faced with social evaluation. The aim of the current study was to examine the neural underpinnings of anticipating and processing social-evaluative feedback, and it...
Article
This study characterizes the resting-state EEG in males with fragile X syndrome to reveal abnormalities in oscillatory brain dynamics. Analyses of the eyes-closed EEG epochs showed that the resting-state EEG in FXS can be characterized by elevated relative theta power (4-8Hz) and reduced relative upper-alpha power (10-12Hz). Although preliminary, t...
Article
The ability to flexibly adapt to the changing demands of the environment is often reported as a core deficit in fragile X syndrome (FXS). However, the cognitive processes that determine this attentional set-shifting deficit remain elusive. The present study investigated attentional set-shifting ability in fragile X syndrome males with the well-vali...
Article
The present study investigated involuntary change detection in a two-tone pre-attentive auditory discrimination paradigm in order to better understand the information processing mechanisms underlying attention deficits in fragile X syndrome (FXS) males. Sixteen males with the FXS full mutation and 20 age-matched control participants (mean age 29 ye...
Article
The present study examined the cognitive profile in Fragile X Syndrome (FXS) males, and investigated whether cognitive profiles are similar for FXS males at different levels of intellectual functioning. Cognitive abilities in non-verbal, verbal, memory and executive functioning domains were contrasted to both a non-verbal and verbal mental age refe...
Article
Full-text available
Fragiele-X-syndroom, de meest voorkomende erfelijke oorzaak van verstandelijke handicap, gaat gepaard met beperkingen in het cognitief functioneren en het gedrag. Melle van der Molen onderzocht welke beperkingen in het cognitief functioneren specifiek zijn voor mannen met het fragiele-X-syndroom . Ook bekeek hij of deze beperkingen kunnen worden ve...

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Projects

Projects (2)
Project
EEG frontal-midline theta reflects a neural mechanism involved in the processing of social feedback, as well as learning from feedback in uncertain situations. We assume that aberrations of this mechanism are critical in the development and maintenance of social anxiety. We will use an innovative classification approach to uncover factors that are likely to influence this neural mechanism (e.g., personality and environment characteristics) during adolescent development. Our findings will provide a deeper understanding of the critical factors implicated in social anxiety, and will help us to predict who is at risk of developing social anxiety disorder later in life.
Project
Aim: delineating the topology of functional brain networks in dyslexic children and adults during resting-state and task-related conditions. Collaborative project: the Universiteit van Amsterdam (UvA) brings its expertise in cognitive psychophysiology of development and dyslexia. The Vrije Universiteit (VU) contributes with its expertise in advanced brain network analyses in clinical populations. Project led by prof. dr. Maurits van der Molen. Awarded with the ABMP grant. [http://www.abmp.eu]