Melissa Ruffin

CEA · Laboratoire de Biologie Médicale

Introduction La pandémie de COVID 19 bouleverse le monde depuis plus d’un an. En l’absence de traitement efficace pour endiguer cette dernière, l’accent doit être mis sur les moyens de prévention : gestes barrières, dépistage, signalement et enfin vaccination. Le Service de Maladies Infectieuses comprenant l’activité Centre de Vaccination (CDV), pe...

Introduction L’immunodépression est associée à des complications infectieuses et néoplasiques évitables. Malgré l’augmentation du nombre de patients immunodéprimés, les mesures de prévention recommandées (hygiène, vaccination, dépistage des foyers chroniques et des lésions néoplasiques) restent insuffisamment appliquées. Matériels et méthodes Notr...

Purpose: To assess occupational exposure from uranium bioassay results which are low and impacted by dietary intakes. Material and methods: First, the bioassay results of a group of workers exposed to UO2 were compiled along with results of a control group. A Bayesian approach was developed to account for dietary intakes in the calculation of th...

Interpretation of data collected during individual monitoring of uranium dioxyde exposure: collective dose assessment. Uranium is naturally present in the diet, at highly variable levels, leading to detectable activity in excreta, independently of occupational exposure to uranium. The interpretation of bioassay data from individual routine monitori...

Vasovagal syncope (VVS) is an alarming yet benign condition that may present postoperatively for the first time in otherwise healthy patients. Although VVS is associated anecdotally with nasal manipulation, no data have been found to quantify this incidence with otolaryngology surgeries. We present a case of profound, recurrent syncope and document...

The regenerative medicine market offers phenomenal opportunities for growth in the next few decades. However, there are still major issues to be addressed to enable this nascent industry to truly flourish, especially with regard to investment and the attitudes of regulatory agencies and reimbursement bodies in an area which is relatively new to the...

In France, the Clinical Biochemistry Laboratories (CBL) are in charge of the monitoring of nuclear workers. These laboratories must be accredited and have ministerial certification. The accreditation of radiobioassay analyses requires notably Proficiency Testing (PT) between laboratories. One of the most important PT providers, in this field, is th...

Special education teachers working with secondary level English language learners (ELLs) with learning disabilities (LD) are often faced with the question of how to provide reading comprehension instruction that meets the needs of this unique group. If a learner has the dual diagnosis of ELL and LD, how does one provide effective instruction? This...

The aim of this study is to model plutonium (Pu) excretion from the analysis of a well-documented Pu wound case involving repeated diethylene-triamine-penta-acetic acid (DTPA) perfusions up to 390 d and monitoring up to 3109 d. Three modelling approaches were simultaneously applied involving: (1) release of soluble Pu from the wound, estimated with...

implication of the occupational physician and of the expert in the management and the dosimetry of an accidental contamination. This case concerns a wound contaminated by plutonium. In managing the consequences of such an incident, the occupational physician of a nuclear installation has to solve various questions in the field of dosimetry, communi...

The move toward more efficient and clinically effective organizations is made possible by healthcare data warehouses that are feasible, practical, and up-and-running.

Advances in information technology are helping clinicians to realize the promise of evidence-based medicine, which includes benchmarking, outcomes monitoring, predictive modeling, and clinical pathways. By integrating individual clinical expertise and the best available research, physicians can apply the disciplines and techniques of clinical resea...

In the United States, coronary heart disease (CHD) is the leading cause of death in women. The incidence of CHD rises dramatically in women following menopause, which can be partially attributed to a more atherogenic lipoprotein profile. For years, observational and epidemiological data have suggested that estrogen and progesterone therapy reduced...

To evaluate the current use of bone densitometry and agents to prevent bone loss among long-term corticosteroid users. A telephone survey of patients receiving long-term oral corticosteroid treatment. One hundred forty-seven patients receiving a mean prednisone dose of 10 mg per day for an average of 1-2 years were surveyed. Twenty-nine percent rep...

As drilling in directional and extended-reach wells continues to gain popularity, high torque and drag become increasingly important issues. This is particularly true for water-based muds (WBM), which generally give rise to high coefficients of friction (COF) between the drillstring and the wellbore and, therefore, high torque and drag. In addition...

Nonadherence is a significant medical problem in the United States, leading to excessive morbidity, mortality, and medical costs. In the conclusion to this two-part article, the authors describe a pilot study involving 311 patients taking an angiotensin-converting enzyme inhibitor that evaluates the principal factors for nonadherence to pharmaceuti...

Nonadherence is a significant medical problem in the United States, leading to excessive morbidity, mortality, and medical costs. In this first installment of a two-part article, the authors review the literature and discuss the effects of the problem, with particular reference to patients with congestive heart failure.

The pharmacy practicum is a six semester consecutive course sequence that was implemented as part of our four-year professional degree program. Each semester features the same overall design whereby groups of 10-12 students are assigned to a faculty mentor for three years. These students are engaged in a variety of experiential activities, with a s...

The paper presents Alcatel's Notification Service which has been designed in the context of TINA. It has been partly developed in the framework of the TINA auxiliary ACTS projects: ReTINA (AC048) and VITAL (AC003). A first prototype was issued in mid 1996. Based on the users' feedback, a second version has been designed and will be delivered by the...

Developing models of pharmaceutical care (PC) for educating students and practitioners represents a fundamental role for schools of pharmacy. Virginia Commonwealth University has sought to facilitate the implementation of PC in the community by hiring faculty to practice in this setting. The mission of the faculty is to implement PC in a community...

Congress passed The Health Insurance Portability and Accountability Act of 1996 in the doldrums of last Summer, and promptly charged the National Committee on Vital and Health Statistics to begin working on the regulations that will help providers, payers, and all members of the public adhere to the spirit of the law. What does this legislation por...

Why is medical informatics important to health care leaders? As an emerging science, informatics focuses on applying computing and communication technology to decision making for clinicians and managers. It enhances the understanding of how information and communication systems can impact the work health care managers must accomplish. As the cost o...

Listed here are some medical management and health care related Web sites on the Internet worth visiting, as well as favorite search engines and how to use them. From health care systems and hospitals, to health plans and insurers, the industry is using Web technology to promote programs and outcomes, and to provide information on health and wellne...

Who would have guessed that managed care would dominate the health care industry in the final two decades of the millennium? That physicians would be joining labor unions? Or that they would be going back to school to become Fellows of the American College of Physician Executives? To find out what may be in store for health care in America five to...

Technology continues to accelerate at an amazing pace. Where have we been, where are we going, and what do these technology enhancements mean to the health care industry? We are entering the era of the personal computer becoming the window to the multimedia digital world of cyberspace. Microprocessors will continue to improve from one generation to...

Objective To determine whether providing cholesterol results during a patient-physician office encounter would affect the process-of-care in patients with hypercholesterolemia. Methods We used a randomized, parallel-group, control design to conduct the study. Thirty-five participants had a lipoprotein analysis performed using the L.D.X. cholestero...

How can you get the news that you want, when you want it, no matter where you are? The idea of customized news is indeed new. Instead of sitting passively in front of the TV or turning the pages of your newspaper, you can program your computer to search for the news that is of interest to you from myriad sources. The idea of getting the news as you...

As the popularity of the Internet's World Wide Web exploded in 1994 and 1995, corporations began adopting the browser software called Mosaic (and its derivatives) for their networks. Why? That same software can be used to "surf" the Internet. Since Intranets are easier to maintain and less expensive, they are replacing the more expensive "groupware...

The following points were agreed on by participants during the conference: The high incidence of prostate cancer makes it an important target for cancer control measures. Increased use of PSA testing has led to a doubling of identified early stage prostate cancer cases since 1989. Both African-American men and men with a family history of prostate...

The era of the networked society--and medical care depending on networked intelligence--is dawning. Physicians need to plan for office practice information systems in common, with an eye to conveying data electronically between all the locations of care and all the providers involved in caring for defined populations of people. The shared database...

Five years ago, a few zealots in Switzerland, at the CERN Laboratory, were contemplating using the Internet for hypertext and for transfer of still images, recorded sounds, and compressed video files. Five years later, the World Wide Web defines a set of standards for packaging and routing information over the Internet that involve millions of peop...

In this second part of a two-part column, Dr. Ruffin provides greater detail on seven key factors that he believes will govern the operations of integrated systems. Successful systems, he says, will be those that attract and retain physicians, have disciplined governance, integrate care through sharing of information among system elements, conserve...

This paper describes the compaction techniques and problems and compares them to those of garbage collection. By studying how certain garbage collection problems are solved in the context of log compaction, it tries to suggest new paths of research for garbage collection in the domains of distribution, parallelisation and fault-tolerance

Consultants are usually well-meaning people who enjoy the variety of organizations and problems they face in their work. Most do not like to get bogged down in fruitless and wasteful consulting engagement any more than managers of health care organizations like to supervise them, but at least the consultants are paid for their time. The health care...

The key to survival in managed care is management of financial risk. You need to know what is in your contract and what you are obligated to do for which population during which period. Information systems can be an enormous help in managing managed care contracts and the financial risks they entail, but poorly selected and configured information s...

In contrast to assertions that investor-owned (I-O) hospitals are more efficient than voluntary hospitals, this study finds no significant difference between I-Os and voluntaries where the efficiency measure is length of hospitalization (LOH). The data base used is a national probability sample of hospitals and patients. The analysis accounts for v...

Thesis (Ph. D.)--South Dakota State University, 1980. Includes bibliographical references (leaves 169-173). Photocopy.