Mehtap Yazicioglu

Mehtap Yazicioglu
Trakya University · Department of Pediatric Allergy

Full Professor

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70
Publications
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539
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Introduction
Skills and Expertise

Publications

Publications (70)
Article
Introduction: Although drug allergy workup for pediatric patients (skin and drug provocation tests [DPT]) is performed, the procedures are troublesome, painful, and time-consuming. The aim of this study was to assess parents' perception of and satisfaction with their child's drug allergy workup. Further, to evaluate parents' tendency to use the te...
Article
Introduction: The skin prick test (SPT) is a reliable method to confirm sensitization in IgE-mediated allergic diseases; however, it has been reported to be affected by several personal and environmental factors. Our objective was to determine the factors affecting the skin reactivity to histamine and allergens and investigate whether it differs a...
Article
Full-text available
Background The association between arginase I (ARG1) and arginase II (ARG2) genes and asthma has been reported in previous studies, but associations between polymorphisms in ARG genes and preschool wheezing (PSW) phenotypes are still unknown. Objective To examine the association between genetic variation in ARG1 and ARG2 genes and PSW phenotypes....
Article
Background: Anaphylaxis is not common in dentistry, but poor anaphylaxis management may lead to mortality. Objective: The aim of this study was to evaluate dentists’ knowledge and preparedness to manage anaphylaxis. Materials and Methods: The study was designed as an online survey. It included questions about anaphylaxis management practices and...
Article
Local allergic rhinitis (LAR) is a differentiated rhinitis phenotype defined by perennial or seasonal rhinitis symptoms without systemic atopy. The diagnosis can be made by a positive response to the nasal allergen challenge (NAC) (the gold standard for diagnosis) in the absence of skin prick test and/or serum allergenspecific immunoglobulin E. Cli...
Article
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Background: Previous studies revealed there are many gaps in the awareness and knowledge regarding the diagnosis and management of drug allergy (DA) among various health-care professionals. Objective: To assess the knowledge, attitudes, and practices towards DA among residents and interns of 3 university hospitals in the region of Trakya (Thrace...
Article
Parvovirus B19 has a wide spectrum of clinical manifestations. Erythema multiforme and vasculitis are rarely reported with parvovirus B19 infections. Reactions to insect stings can range from local swelling to life-threatening systemic reactions. There have been rare reports of unusual reactions, such as vasculitis, occurring in a temporal relation...
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Background: Atopic dermatitis (AD) is a common inflammatory skin disease with complex pathogenesis. Natural flavonoids exhibit strong anti-inflammatory and antioxidant properties in many human diseases. In this study, the potential bioactive effect of quercetin, a polyphenolic plant-derived flavonoid, on the AD model of human keratinocytes was eval...
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Objective: This study aimed to assess the regular use of long-term asthma-control medication and to determine inhaler techniques in asthmatic children. Methods: The study was conducted on asthmatic children aged 6-18 years. Information on rescue and controller medications was given and the proper inhalation technique was demonstrated. One month...
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Background: Fatty acid synthetase (Fas)/Fas ligand (FasL)-dependent apoptotic pathways have been reported as being involved in the pathogenesis of drug-induced maculopapular rashes. Objective: We investigated serum soluble FasL (sFasL) levels and peripheral blood lymphocyte subtypes to discriminate maculopapular drug eruptions (MPDE) from viral...
Article
Background: Type 3 von Willebrand disease (VWD) is a severe bleeding disorder with a prevalence of 1:1 million live births. There are several von Willebrand factor (VWF) replacement products used in the treatment of acute bleeding episodes or as prophylaxis. Patients who receive multiple transfusions have an increased risk of developing antibodies...
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Background: Food allergy is associated with stress, anxiety, and impairment in quality of life in both children and families. This study aimed to assess the anxiety of mothers in the case of suspected food allergy in their children and the influence of Internet usage on their levels of anxiety and food elimination. Methods: Ninety-two patients a...
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Having a penicillin allergy label associates with worse healthcare outcomes and increased costs. However, whether penicillin allergy testing is cost-saving remains unclear. Objective: We aimed to assess the practice and cost perceptions of penicillin allergy diagnostic tests and procedures through a survey of drug allergy experts. Methods: We deve...
Article
Background Environmental and dietary factors during pregnancy may affect development of infantile atopic dermatitis (AD). This study analyzed whether maternal consumption of selected Turkish fermented foods (FF) and other factors during pregnancy affect the development of AD during the first 2 years of life. Methods Eighty‐four children with physi...
Article
Aim: To investigate teachers’ knowledge and preparedness of schools about food allergy and anaphylaxis in elementary schools in Edirne city. Material and Methods: The study was performed as a cross sectional survey study. Questionnaires were answered by 560 teachers, all of them were working in 35 public elementary schools in Edirne. In addition to...
Article
Background Drug hypersensitivity reactions (DHRs) are important clinical problems in childhood. There have been only a limited number of studies conducted in Turkey on this subject. This study was performed to obtain knowledge about DHRs in pediatric patients. Therefore, this study assesses the properties of hypersensitivity reactions, culprit drug...
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Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis are two rare but life-threatening diseases characterized by detachment of epidermis, bullous skin lesions and mucous membrane erosions. Anti-epileptic drugs are highly suspected to be the causative agents. Although carbamazepine (CBZ) is the most associated anti-epileptic drug, oxcarbaze...
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Background: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. A complex interaction of both genetic and environmental factors is thought to contribute to the disease. Recently relations between single nucleotide polymorphisms (SNPs) of toll-like receptors (TLRs) and AD have been reported. Aims: The aim of the study was...
Conference Paper
Full-text available
Table of contents Oral Abstracts O1 Functionally distinct HMGB1 isoforms correlate with physiological processes in drug-induced SJS/TEN Daniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas Chaponda, Gospel Nwikue, Elena M. Cornejo Castro, Daniel J. Antoine, Munir Pirmohamed O2 Hypersensitivity reactions to beta-lactams, does the t cell recogni...
Conference Paper
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Table of contents A1 Role of fibrocytes in allergic rhinitis Marie-Ève Côté, Marie-Ève Boulay, Sophie Plante, Jamila Chakir, Louis-Philippe Boulet A2 Patterns of aeroallergens sensitization in Northern Alberta Hanan Ahmed, Maria-Beatriz Ospina, Kyriaki Sideri, Harissios Vliagoftis A3 Addressing acceptable risk for adolescents with Food-Induced Anap...
Article
Drug reactions (DR) are adverse or harmful effects of drugs. They constitute 6.5% of all hospital admissions. DR develops with a rate of 15% in patients who are treated by hospitalization. The possibility of DR should be considered in the differential diagnosis when any medical problem occurs in a person who uses medication. Detailed history and ph...
Article
RATIONALE: Currently available metered dose inhalers (MDIs) do not track the remaining number of doses. Therefore, we assume that asthmatic children use their controller MDIs regularly and we estimate the time that MDIs should be discarded is the discard point labeled on the canister and box to prevent the use of empty MDIs. However, we hypothesize...
Article
Food allergy is defined as type 1 hypersensitivity reaction of IgE antibodies against food proteins. As its frequency increases in the world, food allergy is becoming more common in our country. Infants, who have allergic rhinitis, bronchial asthma, atopic dermatitis and food allergy in their families, have a high risk of food allergy. Therefore de...
Article
Background: Acute asthma is one of the most common medical emergencies in children. Appropriate assessment/treatment and early identification of factors that predict hospitalization are critical for the effective utilization of emergency services. Objective: To identify risk factors that predict hospitalization and to compare the concordance of...
Article
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Background: The Childhood Asthma Control Test (C-ACT) has been proposed to be a simple, patient-based test that is able to reflect the multidimensional nature of asthma control. In this analysis, the aim was to evaluate the perceptions of physicians and caregivers concerning C-ACT and its predictive value for future asthma-related events. Method:...
Article
To cite this article: Yazicioglu M, Elmas R, Turgut B, Genchallac T. The association between DRESS and the diminished numbers of peripheral B lymphocytes and natural killer cells. Pediatr Allergy Immunol 2012: 23: 289–296. Drug reaction with eosinophilia and systemic symptoms (DRESS) is a drug-induced, severe multiorgan system reaction whose exact...
Article
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Chronic urticaria is defined as an urticaria type that consists of lesions that have continued every day or almost every day for at least for 6 weeks. These lesions last long and effect patient's standard of living; limited results of researches intended for etiology in most cases create difficulty for both patient and physician. When we eliminate...
Article
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The reliability and validity of Turkish version of Childhood Asthma Control Test (C-ACT). The management of asthma is an important as well as difficult issue of physician's daily practice particularly in busy clinical settings. C-ACT was created to identify asthma control levels in children aged 4-11 years. Our aim was to evaluate the reliability,...
Article
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Studies evaluating the role of indoor molds in the development of allergic or respiratory symptoms in schools are few in childhood. This study aimed to investigate relation between indoor molds and allergic diseases or respiratory symptoms in primary school's children in Edirne, Turkey. Ten public primary schools were included into the study. A tho...
Article
Successful management of childhood asthma requires a thorough idea of the economic impact of asthma and its determinants, as policy makers and physicians inevitably influence the outcome. The aim of this study was to define the cost of childhood asthma in Turkey and its determinants. In April 2006, a multi-center, national study was performed where...
Article
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Allergic diseases generally begin early during childhood, but a late diagnosis is common. This study aimed to evaluate the prevalence of asthma and asthma-related symptoms among kindergarten children in Edirne, Turkey. 873 subjects based on a modified ISAAC questionnaire were included. The prevalence of 'wheezing ever' and 'wheezing during the prev...
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The first asthma camp in Turkey was organized for one week in Iznik in September 1996. The camps were continued annually around the same time of the year in 1997, 1998, 2000, and in the consecutive years thereafter. The camp includes educational, sports and social activities. Children's knowledge about asthma and their attitudes towards physical an...
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This study was performed to determine hepatitis B and measles seroprevalence among the population under 30 years of age in Turkey. Blood samples of 2,683 subjects from eight provinces of Turkey were studied. Measles IgG was determined by hemagglutinin inhibition method, and hepatitits B surface antigen (HBsAg), anti-hepatitis B surface antibody (an...
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Asthma and allergic rhinitis are common problems in children and the causative pollen allergens vary according to the geographical area. The aim of this study was to investigate patterns of sensitization to common inhalant allergens, especially pollens, in Turkish children living in the Trakya region and to determine differences between rural and u...
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This study was conducted to determine the hepatitis A virus (HAV) seroprevalence in nine provinces representative of Turkey as a whole. These provinces are representative of the country's geographical location, and demographic, economic and social characteristics. In each province, sample sizes were determined using published data on HAV seropreval...
Article
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Chicken pox highly contagious and common throughout the world, is an infectious disease caused by varicella zoster virus (VZV). This study was conducted to determine the seroprevalence of VZV in a population under age 30 and to identify the relationship of VZV seroprevalence and several characteristics of the study subjects in nine provinces of Tur...
Article
The contribution of indoor fungal exposure to childhood asthma is not completely clear. To investigate airborne fungal flora within the homes of asthmatic and control children, and to assess the influence of housing characteristics regarding indoor fungi. Forty-seven atopic asthmatic and 23 nonatopic control children were studied. Allergen sensitiv...
Article
There is a perception that asthmatic symptoms may be worsoned by ingestion of certain foods. This study aimed to investigate whether ingestion of cow's milk or egg might induce respiratory symptoms in asthmatic children. Fifty asthmatic children aged 1.5 to 6 years old, with positive Immulite Food Panel FP5 test results were included in the study....
Article
Full-text available
Asthma and chronic bronchitis are diseases that may present similar symptoms. Because eosinophil granulocytes play an important role in the pathogenesis of asthma, the assessment of eosinophilic inflammation may be useful in making a differential diagnosis of these two diseases. This study investigated the serum and sputum eosinophil cationic prote...
Article
Background: With the aim of establishing the role of blunt trauma, a trauma without any fracture or obvious wound, as a risk factor in children who were admitted for community-acquired severe staphylococcal septicemia with various organ involvement, 63 patients were investigated during a seven-year study period. All children were previously health...
Article
Studies have shown that environmental factors contribute to the development of asthma. Hence, we investigated the relation between current asthma and indoor environmental factors such as exposure to pets, tobacco smoke, home dampness, number of people living in home, and stuffed toys in child's bedroom in a questionnaire based study in primary scho...
Article
In order to evaluate peripheral and nasal eosinophilia and serum total IgE levels in ascariasis, 30 children between two and 12 years of age whose fecal samples were found to contain Ascaris lumbricoides, and 30 children between 1.5 and 12 years of age who did not have ascaris in their fecal samples, were enrolled in the study. Peripheral eosinophi...
Article
The value of a new in vitro multiallergen IgE antibody test in the diagnosis of atopy in children was compared with that of skin-prick tests and total serum IgE level determination. Twenty children with clinical histories and symptoms of asthma, median age 5 years, and 20 healthy children, median age 5.5 years, were enrolled. Total serum IgE levels...
Article
The principal findings in newborn's hypoxic-ischemic encephalopathy are widespread brain edema, cortical, periventricular and basal ganglionic hypodensity and watershed infarcts. Recently, a different finding termed 'reversal sign' in grey matter-white matter density is defined according to CT findings of these cases. In this study we defined 'reve...
Article
In this study, a newborn infant with Sjogren-Larsson syndrome is presented with clinical, EEG and brain computed tomography findings, and congenital ichthyosiform dermatoses which progress with neurologic involvement, have been reviewed in differential diagnosis.

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Project (1)
Project
The aim of this reseach is to investigate the oral health and and oral microbiome of children with asthma