Mehmet Ozansoy

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Verified

Mehmet verified their affiliation via an institutional email.

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• PhD
• Professor (Assistant) at Istanbul Medipol University

Neurodegenerative diseases are the progressive loss of structure and function of neurons, including neuronal death. Such diseases can be affected positively or negatively by many materials in the body. One of these materials is TNF-α. TNF-α is a cytokine involved in systemic inflammation. It plays a decisive role in the continuation of the cell's l...

Chronic stress is a significant factor in cancer progression, affecting both tumor growth and metastasis. While most studies focus on adrenergic receptor-mediated effects, the role of glucocorticoids in this process remains underexplored. This study investigates the impact of chronic stress-induced glucocorticoids on colorectal (HCT116) and lung ca...

Background/Objectives: The role of the gut microbiome in the development and progression of many diseases has received increased attention in recent years. Boron, a trace mineral found in dietary sources, has attracted interest due to its unique electron depletion and coordination characteristics in chemistry, as well as its potential role in modul...

Burkitt lymphoma (BL) is a rapidly growing type of B-cell lymphoma that affects both children and adults. Its development involves abnormal activity of the MYC gene and the presence of the Epstein-Barr virus (EBV). Rituximab is a chimeric monoclonal antibody (mAb) which targets the CD20 receptor on the B-cell surface and was the first antibody to b...

Introduction: Glioma constitutes 60% of adult brain tumors and is characterized by a poor prognosis. Rituximab is an FDA-approved anti-CD20 monoclonal antibody used in the treatment of autoimmune diseases and non-Hodgkin lymphomas. Its cytotoxicity is known to increase through cell cycle arrest, apoptosis induction, and upregulation of reactive oxy...

Lung cancer and Burkitt’s lymphoma present significant challenges in cancer treatment due to their aggressive nature and limited therapeutic options. Gemcitabine, known for its DNA-disrupting effects, and hydrocortisone, with potential MYC inhibition, were investigated for their combined anti-cancer effects. However, contrary to expectations, their...

Pharmacological and phytochemical investigations have unveiled the remarkable medicinal and nutritional properties of ingredients derived from Plantago L. Among these, iridoid glycosides stand out for their potent anti-tumor effects, mediated via the STAT (signal converter and activator of transcription) signaling pathway. The suppression of STAT3...

Neuroscience, Molecular biology, cell viability, Photobiomodulation, TNF-Alpha

Glioma is a type of tumor with a poor prognosis, accounting for 60% of adult brain tumors. Temozolomide is an FDA-approved oral alkylating drug for the first-line therapy of glioma, with the postulated mechanism of action based on the capacity of its metabolites to deposit methyl groups on DNA guanine bases. Gemcitabine is a chemotherapy drug used...

The protooncogene MYC is translocated and dysregulated in Burkitt lymphoma (BL), a very aggressive type of B-cell non-Hodgkin lymphoma. One of the first malignancies for which chemotherapy alone provided a cure was BL because of its quick development and strong sensitivity to the drug. A critical trace element for both people and animals, boron is...

Boron, an important trace element for humans and animals, is a dynamic nutrient of essential importance to animal and human biology. It is not found in the elemental form in nature but present as a component of Sodium Pentaborate Tetrahydrate(SPT), Boric Acid(BA), and Sodium tetraborate decahydrate(SBD). Three methods were used: MTT to measure cell...

The brain-network correlates of personality traits in major depressive disorder (MDD) have not yet been investigated. Furthermore, it is still unclear whether personality traits relate to the depressive episode. This study assessed network properties, depression severity, and personality traits in patients with MDD (n=25) compared with age- and sex...

Exosomes are potent mediators of physiological and pathological processes. In Alzheimer's disease and inflammatory disorders, due to exosomes' distinctive ability to cross the blood-brain barrier, a bidirectional communication between the periphery and the central nervous system exists. Since exosomes can carry various biochemical molecules, this r...

zet: Gemsitabin varlığında FBM yöntemiyle uyarılacak farklı kanser hücre hatlarının canlılık ve metastaz tepkilerinin incelenmesi neticesinde kanser tedavisine yönelik uygun uyarım kombinasyonu parametrelerinin belirlenmiştir. Giriş/Objective:Laser fotobiyomodülasyon (FBM) yöntemi, belirli parametrelerde lazer ışımasına maruz kalan hücrelerin canlı...

We published the abovementioned article about probiotic mixture VSL#3 on October 6, 2021. Since the product was named VSL#3 in our purchasing process in early 2016, it is referred to as VSL#3 in our article. In addition, the product currently known as VSL#3 is not the same as De Simone Formulation. De Simone Formulation is now available as Visbiome...

Pharmacological and phytochemical studies have shown that ingredients derived from Plantago L. provide many medical and nutritional benefits, including immunomodulatory, anti-oxidant and anti-tumor effects. Iridoid glycosides are secondary metabolites with anti-tumor effects. The anti-tumor effects of iridoid glycosides are mediated by the STAT (si...

Triazines are in great interest for their potential to mimic nucleoside analog compounds. Three different isomers exist including 1,2,3‐triazine, 1,3,5‐triazine (s‐triazine) and 1,2,4‐triazine. All of these skeletons were investigated. Among them, 5,6‐diaryltriazines were previously tested on MCF7 and other tumor cell lines. In this study, we have...

Inflammatory bowel disease (IBD) is a progressive chronic inflammatory disease affecting the gastrointestinal tract with a chronic relapsing and remitting disease course. While there are a number of therapeutic strategies available to treat IBD, a definitive treatment still hasn’t been defined, leading to alternative treatment options including nut...

Objective: Treatment of inflammatory bowel disease (IBD) usually involves medical therapy. For this reason, it is recommended to seek alternative treatment methods such as nutritional therapy. The aim of the study is to evaluate the effects of probiotics and omega-3 fatty acids on total oxidant and total antioxidant levels in an experimental coliti...

Boron is a naturally occurring trace element found in organic and inorganic complexes. Boron-containing compounds are required for living organisms for diverse metabolic functions, including nitrogen fixation in microorganisms, cell wall stability in plants, and bone and carbohydrate metabolism in animals. The number of studies about the effect of...

Background: Recent studies have been revealed that oxidative damage is the main cause of aging and age-related neurodegenerative diseases like Alzheimer's disease (AD). Melatonin is secreted from the pineal gland and its secretion has been found to be altered in AD. In the last decade the role of exosomes in spreading toxic proteins and inducing t...

Aim: The neuroprotective eff ects of clopidogrel have already been shown in various experimental models. Taking into account the fact that clopidogrel is well tolerated and approved for use in various clinical settings, it can be an attractive candidate for further clinical investigations, especially when the anti-oedema eff ect appears to be a rea...

Aim: Neurodegeneration caused by the axonal injury is a widely seen phenomenon in spinal cord and traumatic brain injuries. Due to the disintegration of the synaptic connection neurotrophic factors could not be transported retrogradely towards the cell body and the deprivation of the trophic factors lead to the degeneration and death of the injured...

Background and Aim Recent data have shown that olfactory dysfunction is strongly related to Alzheimer’s Disease (AD) that is often preceded by olfactory deficits suggesting that olfactory dysfunction might represent an early indicator of future cognitive in prediabetes. Methods We have applied to a group of normal (n=15), prediabetic (n=16) and ty...

The clinical use of cisplatin, which is a first-line anticancer agent, is highly restricted due to its adverse effects on kidneys that lead to nephrotoxicity. Therefore, some potential reno-protective substances have been used in combination with cisplatin to cope with nephrotoxicity. Due to its high antitumor activity and oxygen-carrying capacity,...

Objective: Besides its hematopoietic function, erythropoietin (EPO) may protect tissues from degenerative disorders. As such, EPO and its receptors were revealed in nonhematopoietic cells, including stromal and endometrial epithelial cells. However, the role of EPO in endometrial disorders is still unknown. Here, we aimed to examine the role of EPO...

Background Antibiotic therapies targeting multiple regenerative mechanisms have the potential for neuroprotective effects, but the diversity of experimental strategies and analyses of non-standardised therapeutic trials are challenging. In this respect, there are no cases of successful clinical application of such candidate molecules when it comes...

Huntington Hastalığı(HH), HTT geninde bulunan CAG tekrarlarının artmasıyla oluşan ve otozomal dominant kalıtılan nörodejeneratif bir hastalıktır. Önceki çalışmalarda hastalığın mekanizması genetik araştırmalarla aydınlatılmıştır. Proteomik alanda yapılan çalışmaların sayısı az olmakla birlikte MALDI-MS görüntüleme tekniği kullanılarak HH mekanizmas...

Objective: To investigate the molecular mechanisms of colistimethate sodium-induced nephrotoxicity and the protective effect of N-acetylcysteine (NAC) against nephrotoxicity. Methods: Twenty-eight Wistar rats were divided into four groups comprised of control, colistin, NAC, and colistin–NAC co-treatment, respectively. Serum creatinine and urine N-...

Objective: Besides its hematopoietic function, the erythropoietin (EPO) may protect tissues from degenerative disorders. As such, EPO and its receptors were revealed in nonhematopoietic cells, including stromal and endometrial epithelial- cells. However, the role of EPO in endometrial disorders was still unknown. Here we aimed to examine the role...

Alzheimer’s disease (AD) is a progressive disorder characterized by a variety of molecular pathologies causing cortical dementia with a prominent memory deficit. Formation of the pathology, which begins decades before the diagnosis of the disease, is highly correlated with the clinical symptoms. Several proteomics studies were performed using anima...

Network of co-regulated proteins in cortex, hippocampus and cerebellum is shown in relation with inflammation pathway. (Purple: Inflammation related proteins, Green: Downregulated proteins, Red: Upregulated proteins)

Differential expression analysis of protein abundances in 5XFAD and LM brains. List of proteins with significantly altered protein abundances (> 1.5-fold change; p < 0.05) in AD versus LM brain is provided with peptide counts, confidence scores, p values and maximum fold changes. Differentially expressed proteins in the cortex, hippocampus, and cer...

Top upstream regulators of co-regulated proteins in cortex, hippocampus and, cerebellum.

In recent years, an increasing number of research papers revealed that the compositional and volumetric alterations in the extracellular matrix are the consequences of aging and may be related to Alzheimer’s disease (AD). In this study, we aimed to demonstrate the alterations in hippocampal extracellular fluid proteins in vivo using the 5XFAD mouse...

Rifampicin exerts significant brain protective functions in multiple experimental models. Here we summarized the underlying mechanisms of the neuroprotective and pro-cognitive effects of rifampicin that is mediated by its anti-inflammatory, anti-tau, anti-amyloid and cholinergic effects. Beyond suggesting that rifampicin shows strong brain protecti...

Background / Aim: Recent studies revealed that the brain extracellular matrix (ECM) molecules have several roles on the synaptic response and the stabilization of synaptic connectivity in Alzheimer’s Disease (AD). In order to investigate the role of ECM in the genesis and progression of the disease, we analyzed the proteome alterations in the hippo...

Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after modeling, male BALB/c mouse models of cold-induced traumatic brain injury were intraperitoneally administered 3 and 10 mg/kg e...

This paper proposes Gilbert Simondon’s ontogenetic theory of individuation as an overarching framework for multilevel semiosis. What renders this theory suitable for this role is the fact that it shares a significant part of its heritage with biosemiotics, which provides compatibility between them. Unlike many philosophers who have worked on indivi...

Background: Postoperative atrial fibrillation (POAF) is a potentially life-threatening complication after coronary artery bypass graft (CABG) surgery. The expression of the cardioprotective SIRT1 protein with its antioxidant activity is increased in cardiac tissue of patients suffering from POAF. So far, information is lacking about the relationsh...

Parkinson's disease (PD) is the second most common neurodegenerative disorder, defined by the presence of resting tremor, muscular rigidity, bradykinesia, and postural instability. PD is characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta of the midbrain. The neuropathological hallmark of the dise...

Mutations in ALS2 gene/alsin are associated with recessive forms of motor neuron disorders including Juvenile Amyotrophic Lateral Sclerosis (JALS), Infantile-onset Ascending Hereditary Spastic Paraplegia (IAHSP) and Juvenile Primary Lateral Sclerosis (JPLS). In this study, we show that alsin and another MND-linked protein, spartin are related to ea...

Mutations in Als2 gene cause several autosomal recessive forms of motor neuron diseases including Juvenile Amyotrophic Lateral Sclerosis (JALS), Juvenile Primary Lateral Sclerosis (PLSJ) and Infantile-onset Ascending Hereditary Spastic Paralysis (IAHSP). To find novel protein-protein interactions of Als2 protein we performed a yeast two hybrid scre...

Both prokaryotic and eukaryotic cells share the basic mechanisms of secretory protein synthesis. However, unlike prokaryotes, eukaryotic cells posses a system of compartments, the so-called endomembrane system, which are involved in the synthesis process. A comparison of the prokaryotic and eukaryotic protein synthesis processes and particularly th...

Mutations of the parkin gene on chromosome 6 cause early-onset parkinsonism. Myopathy has not been reported to be a feature of this condition. Here we report the muscle biopsy findings of a 53-year-old man with a novel parkin gene mutation (IVS-9-1 deletion). His symptoms were characterized by typical early-onset, dopa-responsive, and slowly progre...

Tauopathies: A Distinct Class of Neurodegenerative Diseases Neurodegenerative diseases are characterized by neuronal loss and intraneuronal accumulation of fibrillary materials, of which, neurofibrillary tangles (NFT) are the most common. Neurofibrillary tangles also occur in normal aging and contain the hyperphosphorylated microtubule-associated p...

Parkinson's Disease (PD) is a late-onset and progressive neurodegenerative disorder. The main pathological characteristics of familial and sporadic cases is degeneration of dopaminergic neurons in substantia nigra pars compacta and intracellular protein aggregates (Lewy bodies) in surviving neurons. Six different genes defined in familial cases and...

Progressive supranuclear palsy (PSP) is a tau deposition neurodegenerative disorder which usually occurs in sporadic form and is associated with a common variant of the tau gene. Rare familial forms of PSP have been described. Recently familial frontotemporal dementia linked to chromosome 17 (FTDP-17) has been shown to be due to mutations in tau an...

Frontotemporal dementia (FTD) is an important cause of neurodegenerative dementia, particularly in younger patients. TAU has been identified as the gene responsible for FTD linked to chromosome 17, but it is likely that there is pathological and genetic heterogeneity among families with FTD. To explore the genetic and pathological basis of familial...

SUMMARY Parkinson's disease is a late-onset and progressive neurodegenerative disorder. The main pathological characteristic of familial and sporadic PD, is the degeneration of dopaminergic neurons in substantia nigra pars compacta. The intracellular protein aggregates (Lewy bodies) found in surviving dopaminergic neurons is another important crite...