
Mehmet Murat KislaAnkara University · Department of Pharmaceutical Chemistry
Mehmet Murat Kisla
Master of Science
About
11
Publications
2,554
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Citations
Introduction
He currently works at Ankara University Faculty of Pharmacy as a research assistant. His work mainly includes syntheses, purification processes, qualitative/quantitative analyses and computational analyses of potentially active anti-cancer and anti-bacterial compounds with phenothiazine, indole and benzimidazole scaffolds.
Additional affiliations
January 2018 - January 2020
Education
September 2012 - January 2018
Publications
Publications (11)
Several 5-((5-substituted-1H-indole-3-yl)methylene)-3-(2-oxo-2-(3/4-substituted-phenylethyl)-thiazolidine-2,4-dione derivatives (9–24) were designed and synthesized as CDK6 inhibitors, and their anticancer activity was probed on the MCF-7 breast cancer cell line and their effects on gene expression profiles were elucidated. According to biological...
Background
Benzimidazoles are widely used scaffolds against various types of cancer including breast cancer. To this end, anticancer agents must be developed using the knowledge of the specific targets of BC
Objective
In this study, we aim to review the compounds used against some of the biomolecular targets of breast cancer. To this end, we prese...
The approach of utilizing protecting groups (PGs) in organic chemistry has led to the successful syntheses of an array of useful organic compounds. This strategy has also addressed some of the complexities associated with many organic reactions. These PGs find useful applications in simple and complex reactions that involve the synthesis of large o...
Several 5-(alkylsulfonyl)-1-substituted-2-(1H-pyrrol-2-yl)-1H-benzo[d]imidazole derivatives were synthesized and their antioxidant activities were investigated using lipid peroxidation (LPO) and 7-ethoxyresorufin O-deethylase (EROD) assays. Docking analysis with Human NAD[P]H-Quinone oxidoreductase 1 (NQO1) was also performed to gather thorough inf...
Cancer poses a world-wide healthcare problem, demanding selective and effective therapy protocols. To address that, a vast amount of therapeutic candidates are being investigated in the field of medicinal chemistry. Accordingly, indole-benzimidazole structures have recently gained considerable interest because of their anticancer properties and est...
Indole-benzimidazoles have recently gained attention due to their antiproliferative and antiestrogenic effects. However, their structural similarities and molecular mechanisms shared with selective estrogen receptor modulators (SERMs) have not yet been investigated. In this study, we synthesized novel ethylsulfonyl indole-benzimidazole derivatives...
Background
Finding efficient therapy against hospital-acquired MRSA infections has become rather important in the last decade. To this end, inhibition of the enzyme pyruvate kinase (PK) is being investigated for antibacterial activity, since this enzyme controls energy generation and metabolic flux distribution. Our main scaffold consists of benzim...
Objective: Methicillin- resistant S. aureus (MRSA) is a type of bacteria which is resistant to various types of antibiotics and causes mortality in hospital environment and community. To further investigate the inhibition activity of previously synthesized retinoidal compounds against MRSA, docking studies of these compounds with MRSA pyruvate kina...
Objective: Drug candidate compounds that are going to be synthesized have to reach body tissues and show minimum toxic effects within the body. Partition coefficient (log P), which is a physicochemical parameter of Quantitative Structure- Activity Relationship subject, effects the pharmacokinetical characteristic of the compound. In this context, r...
INTRODUCTION: Hepatocellular carcinoma (HCC), is one of the deadliest cancer types, where the treatment options are limited. Therefore, it is important to design and test compounds in HCC cells with effects against cancer growth and metastasis. We have synthesized and identified several promising phenothiazines with anticancer properties in HCC. In...
Questions
Question (1)
When i try to dock ligands containing chlorine, bromine, Selenium etc. (elements containing lower case letters), the resulting atom gets converted from Cl to CL and the interactions change accordingly. When hydrogen bond interactions become essential, this causes a serious problem. Does anybody know probable solution to this error?