Mehmet Haligur

• Assoc.Prof. Dr
• Professor at Cukurova University

Background: Canine parvoviral enteritis is a highly contagious infection in the intestines caused great morbidity and mortality in untreated dogs younger than 6 months. Matrix metalloproteinases consist of zinc-and calcium-dependent extracellular matrix-degrading endopeptidases that are tightly controlled by endogenous metalloproteinase tissue inhi...

The beak structure changes according to the feeding patterns of birds. Further, the morphological and histological structures of their tongues vary. Therefore, the current study aimed to perform macroanatomical and histological examinations and scanning electron microscopy of the barn owl's (Tylo alba) tongue. Two dead barn owls were brought to the...

Neoplastik hastalıklar tarih içinde oldukça önemli yer tutan bir hastalık grubu olarak insan ve hayvanlarda önemli bir ölüm sebebidir. Sunulan çalışmada materyal olarak, 2016-2018 yılları arasında Adana Çukurova Üniversitesi Ceyhan Veteriner Fakültesi Patoloji Anabilim Dalı’na özel veteriner kliniklerinden gönderilen evcil hayvanlara ait biyopsi ma...

BACKGROUND: This study aimed to reveal the morphological aspects of the tongue and investigate the histologic and scanning electron microscopic (SEM) findings of the papillae on the tongue of the European badger. MATERIALS AND METHODS: Two adult European badgers were used as material. The tongues of the European badgers were removed via the dissect...

Objective: Pentoxifylline (PTX) has immunomodulatory properties and is known to reduce sepsis-associated infant mortality. We aimed to evaluate maternal oral and intra-amniotic administration of PTX for the prevention of fetal inflammation and injury in a caprine model. Materials and Methods: Inflammation-mediated fetal injury was induced with mate...

In this case report, a 5 year old, female cat that died during the perianesthetic period and diagnosed with lung adenocarcinoma was described pathologically. The cat was brought to a private veterinary clinic for shaving and anesthetized. It experienced restlessness, vomiting, respiratory distress and died after a while of anesthetic administration...

In this study, Rift Valley Fever Virus (RVFV) infection was searched serologically and pathologically in cattle (178 Holstein), sheep (160 native), goats (66 ordinary goats, 98 Honamli goats, 16 Saanen goats) with an abortion history and in unborn cattle (8), sheep (24) and goat (5) fetus. Samples were collected between July 2009 and September 2010...

Meme tümörleri, köpeklerde deri tümörlerinden sonra en sık görülen tümörlerdir ve meme kanserlerinin yıllık insidens oranı yaklaşık 198/100000’dir. Köpek meme tümörlerinin insidensindeki artışa paralel olarak teşhisinde kullanılan histolojik sınıflandırma da önem kazanmaktadır. Bu derlemede, köpek meme tümörlerinde WHO-AFIP tarafından kullanılan sı...

Objective To define a novel experimental model with maternal intravenous (i.v.) granulocyte-colony stimulating factor (G-CSF) followed by a single- and high-dose of 20 mg intra-amniotic (IA) endotoxin to induce fetal brain injury in the preterm fetal goat. Materials and Methods Pregnant goats (n=4) were given 50 microg/day G-CSF into the maternal...

Listeriosis is an important public health problem in the world. It can cause abortion, encephalitis, septicemia, conjunctivitis and mastitis in ruminants. The development of central nervous system lesions is not fully understood in encephalitic listeriosis. We performed a retrospective analysis of 15 sheep with encephalitic listeriosis. Hyperemia a...

Background: Neonatal enteritis is an important disease that causes deaths of animals before 3 weeks of age, and results in significant economic losses. Viral agents can predispose the young animals to secondary infections in the gastrointestinal tract, especially in lambs and goat kids younger than 21 days. Although the neonatal diarrhea is common...

We investigated the expression of bcl-2, estrogen receptor alpha (ER-alpha), caspase-3, −8, −9, proliferating cell nuclear antigen (PCNA) and Ki-67 in canine mammary carcinomas. We used 65 paraffin embedded and re-diagnosed archival canine mammary tumor samples to which we applied the routine streptavidin-biotin-peroxidase technique. Seventeen case...

Fibrous osteodystrophy is a metabolic disease that characterized marked bone resorption with fibrous tissue proliferations, cysts formations and insufficient mineralization of immature bone. Nutritional fibrous osteodystrophy was developed in 37 goats from two different goat flocks in Isparta in Turkey. The aim of this study was to examine clinicop...

The objective of this immunohistochemical study was to examine the expression of caspase-3,-5,-7, and -9 in sheep pox lesions in 15 naturally infected crossbred merino lambs. Sheep pox was diagnosed based on typical gross and histopathological lesions in the skin and visceral organs that were evaluated pathologically and immunohistochemically. Macr...

Clinical signs, blood parameters, postmortem and histopathological findings in sheep that were accidentally poisoned with Catharanthu sroseus are described. Affected animals (40 sheep) showed acute clinical signs such as salivation, dyspnea, anorexia, bloody diarrhea and dehydration. Blood samples were collected from 5 sheep prior to death. Marked...

Objectives: Diabetes mellitus (DM) is a global epidemic with increasing prevalence. The disease is chronic in nature, and patients must use antidiabetic drugs or insulin during their lifespan. Because of the difficulty of using injectable insulin preparations, patients and practitioners prefer to use oral antidiabetic drugs for prophylaxis and tre...

Osteopontin (OPN) is a glycoprotein expressed by various tissues and cells. It is also implicated in tumor progression. The protein can mediate cell adhesion and is strongly associated with transformation and tumorigenesis. Overexpression of OPN influences invasion and metastasis of different human tumors, and OPN expression may be use as a possibl...

A case of vaginal xanthoma in a 3-year-old Holstein cow is described on the basis of macroscopic, microscopic and immunohistochemical findings. A pink-colored mass surgically excised from the vagina was hard, nodular and 328g in weight. Histopathologically, the mass was consisted of lobular areas surrounded by a stroma and composed of numerous foam...

Ameloblastic carcinoma (AC) is a malignant odontogenic epithelial tumor and reported rarely in domestic animals. An 8-year-old, mix breed, male dog presented to Lara Antalya Veterinary Hospital for examination of a mass on the right molar teeth of the maxilla. Oral radiographs did not show clear borders of the mass. Clinically and macroscopically,...

The present study was aimed at the detection and describing the lesions of akabane virus in foetal and new-born calves tissues using immunohistochemical and immunofluorescence techniques. Akabane virus lesions were evaluated in 12 foetuses and three new-born calves using serological and pathological methods and immunohistochemistry and immunofluore...

The aim of this study was to describe the pathological findings in budgerigars simultaneously infected under field conditions with coccidiosis and megabacteriosis. Severe diarrhea and vomiting were observed in a budgerigar flock. Affected birds showed inappetence and loss of condition, with a flock mortality rate of 30%. At necropsy, the proventric...

This study describes the parasites and related pathologic observations in the house sparrow (Passer domesticus). In total, 48 birds were examined and 41 sparrows were found to be infected with one or more endoparasites (85.4%). The most common parasites were liver trematodes identified as Brachydistomum microscelis and Brachydistomum gracupicae. In...

The aim of this study was to examine the expression of caspase-3, caspase-7, caspase-9 and cytokeratin AE-1/AE-3 using the avidin-biotin complex (ABC) immunoperoxidase technique in 20 goats with enzootic nasal adenocarcinoma (ENA). Clinically, dyspnoea and nasal discharge were observed in all cases. Macroscopically, polypoid and sessile masses were...

This report presents a case of malignant melanoma without a confirmed primary tumor in a six-year-old, female, hairy goat (Capra hircus). Macroscopically, multicentric localizations of tumor lesions were seen in liver, hepatic lymph nodes, spleen and lungs. Histopathologically, these lesions were diagnosed as malignant melanoma. Variable intracytop...

A nestling starling (Sturnus vulgaris) which had fallen from its nest was presented to the Department of Pathology in comatose situation. During the physical examination, the bird died and necropsy was performed. At the microscopical examination of the blood smears, numerous Leucocytozoon agents were observed. At necropsy, there was no remarkable l...

Fetal lung maturation is an extremely important process that is necessary for the survival of the neonates. Conventionally, corticosteroids are administered maternally for inducing fetal lung maturation in preterm fetuses. Alternatively, single-dose intra-amniotic (IA) treatment might be speculated to improve lung maturity. In the goat model, we re...

Liver and kidney commonly affected by diabetes in chronic cases but pathogenetic mechanisms are not fully understood in early stages of the disease. The aim of this study was to investigate the immunohistochemical expression of caspase-3, cyclooxygenase (COX)-1 and-2, calcium sensing receptor (CSR), and hypoxia inducible factor-1α (HIF-1α) in pancr...

To evaluate the effects of intra-amniotic (IA) and fetal injections of a single ultra-high dose of betamethasone (BM) 48 h before preterm delivery on neonatal pulmonary function, using an experimental goat model. Eighteen date-mated singleton pregnant Hair goats were randomized into four groups. At gestational day 118 (alveolar phase, term 150-155...

Coccidiosis is a protozoan disease characterized by acute or chronic diarrhea in lambs and kids. It causes important economical losses. The disease is generally seen in young animals and may result in death because of the hemorrhagic enteritis. Inflammatory mediators play an important role in the pathogenicity of the disease. Numerous studies are a...

Seven adenocarcinomas of apocrine sweat glands among the 67cutaneous tumours of cats were evaluated between 1980 and 2005. Histopathologically, three tumours were solid, tubular, tubular-ductal, tubular-cystic and papillar-cystic types were also diagnosed each one. Cuboidal and squamous epithelial cells surrounding the cystic lumina and their papil...

The study aims to investigate the lung expression of some positive acute phase proteins (APPs) such as CRP (C reactive Protein), SAA (Serum amyloid A) and SAP (Serum amyloid P) and of the cytokine TNF-alpha and its receptor according to the pneumonia severity in sheep and goats. After conventional histopathology, the lung tissue samples were classi...

This report describes a case of a subcutaneous xanthoma of the sacral region in a 2-year-old female Saanen goat. The tan-coloured mass was 8.5 cm × 4.0 cm × 0.5 cm in size. Yellow-white areas were present across the cut surface. Histopathologically, the mass was composed of foamy macrophages, numerous giant cells, abundant lipid material and choles...

The aim of this study was to examine the coagulation profile in peste des petits ruminant (PPR) in kids. Five kids from a group of 150 animals (72 goats and 78 kids) were brought to the Veterinary Medical Teaching Hospital from a farm in Burdur province (Turkey) with nasal and ocular discharges and diarrhea. Fifteen goats and 41 kids had died due t...

This study was conducted in order to investigate some haematological and biochemical parameters as well as the thyroid function in pregnant cows with or without abortion and in stillborn, premature and aborted calves chronically intoxicated with nitrate in a dairy flock in Turkey. Frequent reproductive disorders (infertility, abortion, high mortali...

Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of several central nervous system (CNS) diseases. In this study, we investigated the presence of Listeria monocytogenes antigens and detected the expression of MMP-9 and MMP-7 in the brains of 22 sheep with clinical signs and histopathological findings characteristic of liste...

Congenital secundum atrial septal defect (ASD) and membranous ventricular septal defect (VSD) were diagnosed in a 1-day-old Holstein-Friesian calf necropsied in the Department of Pathology of Mehmet Akif Ersoy University. Th e secundum atrial septal defect was 32.9 × 23.1 mm in width and was elliptical. Th e membranous ventricular septal defect was...

Systemic cladosporiosis is described in 25 merino sheep from a flock consisting 250 animals. The fungal pneumonia appeared after an intensive antibiotic treatment, because of a respiratory system disorder. The pen of the flock was humid and crowded, and animals had signs of respiratory distress, coughing, fever and anorexia. All of the ill animals...

The purpose of the study was to evaluate cystic endometrial hyperplasia pyometra complex (CEH-P) by clinical, pathomorphological and immunohistological findings. The 35 uterine horns of bitches aged from 2 to 11 years and different breeds were studied. Clinically polyuria, polydipsia, vomiting, anorexia and fever were seen and in some bitches diste...

A contagious disease characterized with severe pruritis, weight loss and alopecia was observed in laboratory mice in Experimental Animal Breeding Unit in University of Akdeniz, Turkey, after recently transferring the animals from Israel. Twenty out of 100 mice were referred to the clinics of the Department of Internal Medicine, Faculty of Veterinar...

The objectives of this study were to evaluate clinicopathological, immunohistochemical and electron microscopical findings of Enzootic Nasal Adenocarcinoma (ENA) in five goats and examine the immunoreactivity of these tumors with different markers. At the histopathological examination, tubular, papillary and acinar subtypes were diagnosed in this s...

A case of abnormal lobulation of spleen in a three years old Holstein cow was described after slaughter. Post mortem evaluation of the cow revealed three lobes and two projections at the spleen. The color of the spleen was normal but lymphoid hyperplasia was observed at the cut surface. Hilus of the spleen was located on 1/3 of the facies viscerali...

Because of the possible role of matrix metalloproteinases (MMP) and the epidermal growth factor receptor (EGFR) in the Pox virus dissemination within epithelia, the aim of this study was to compare the expression of MMPs, of specific inhibitors (T1MP) and of the EGF receptor (EGFR) in skin and lungs from Pox virus infected sheep (n = 15) with tissu...

In this study, pathological, serological and virological examinations were performed on 15 sheep from a flock of 250 sheep and lambs that suffer from simultaneous naturally occurring BTV, PPRV and SPV outbreaks. SPV was diagnosed macroscopically and histopathologically, BTV was diagnosed by ELISA, and PPRV was diagnosed pathologically and by ELISA....

Twenty 3- to 7-week-old New Zealand rabbits from 2 different production facilities were presented to the Department of Pathology, Faculty of Veterinary Medicine, University of Mehmet Akif Ersoy, with symptoms of abdominal distension, diarrhea, and bruxism. The rabbit production facilities maintain approximately 1500 and 200 animals, respectively. T...

An adult, female common buzzard (Buteo buteo) with paraplegia due to shooting wound on the sacral region was diagnosed with Leucocytozoon toddi, Haemoproteus elani, and Histomonas meleagridis. This is the first report of simultaneous naturally occurring Leucocytozoon toddi, Haemoproteus elani, and Histomonas meleagridis identification in a buzzard.

The objectives of this study are immunohistochemical detection of the viral antigen and structure of fowl pox virus and developmental stage of inclusion bodies by electron microscopy in experimentally infected chorioallantoic membrane (CAM). Lyophilized fowl pox virus, strain 92 which was obtained from the Veterinary Central Laboratory in Weybirdge...

The aim of this study was to examine the clinical and pathological findings in sheep naturally infected with severe encephalitic sarcocystosis and to evaluate the prophylactic effect of amprolium on the disease. From a flock of approximately 350 animals, 10 sheep were referred to the Veterinary Faculty Clinic with neurological symptoms that develop...

The aim of this study is to examine, chnicopafhological findings of naturally occurring diarrhea in dogs and correlate clinical sings with pathological findings of canine parvovirus and coronavirus infection. Hematology, biochemistry, pathology and immunohistochemistry were applied. Vomiting and diarrhea were prominent findings in all affected dogs...

A case of coccidiosis in a young, red male squirrel (Sciurus vulgaris L.) has been described in this report. The squirrel was found dead and presented to the department of pathology for necropsy. A traumatic lesion was observed on the face that could have caused death. At necropsy the large and small intestines were swollen due to fluid and gas. Du...

After very hot summer, 22 sheep from 5 different flocks consisting of approximately 150-200 animals each were diagnosed with facial eczema in September 2005, in southwest Turkey. Photophobia, corneal opacity, severe ulcers of the facial skin, especially localized around the eyes and mouth, and 3% mortality were the most prominent clinical symptoms....

Contents A 13‐year‐old female Pointer dog was presented for evaluation of mammary tumours and bloody vaginal discharge at the Veterinary Teaching Hospital of Mehmet Akif Ersoy University, Faculty of Veterinary Medicine. On the history, owner complained of mammary tumours and bloody vaginal discharge. Three mammary tumours and lymphadenopathy at the...

The pathomorphological and immunohistochemical features of cholangiocarcinoma in an 11-year-old female Van cat were described. At necropsy, the primary tumour was determined in the liver. The tumour was greyish-white, firm, and multinodular. The size of these nodules ranged between 1 cm and 3 cm. There were metastases in the mesentery, portal lymph...

Clinical, pathomorphological and immunohistological findings of generalised tuberculosis diagnosed in a 1-year-old male tabby cat were evaluated. Macroscopic examination revealed greyish-white nodules, exceeding the surface of the organ, in the meninges and kidneys. The meninges nodules were of the size of a pinhead and those in the kidneys were 0....

A two-month-old male non-diabetic Holstein Friesian calf with numerous decubital ulcers due to arthrogryposis and a history of inability to stand since birth was diagnosed with emphysematous cystitis. The diagnosis was based on the necropsy and the histopathological findings. No glucosuria was detected and Escherichia coli was isolated from the uri...

In this study, clinical, parasitological, macroscopical, histopathological and immunohistochemical examinations were performed on 19 kids and 11 lambs (30 animals) with neonatal diarrhoea to detect the presence of Coronavirus, Cryptosporidium parvum and Giardia intestinalis. Clinically, severe dehydration, yellowish-green to brown coloured diarrhoe...

Using magnetic resonance imaging (MRI) together with clinical, pathomorphological and immunohistological methods, a ependymoma is described in a 9-year-old German Shepherd dog, which presented with behavioural and oculocephalic responses and generalised ataxia. The ependymoma, 9 x 6 x 5mm in size, was localised intra-axially in the right interventr...

Pituitary glands of normal-termed stillborn goat kids with congenital goitre and normal-termed stillborn goat kids without congenital goitre were examined macroscopically, histopathologically and immunohistochemically. Thyroid glands of these animals were also examined grossly and microscopically. The pituitary glands of kids with goitre were large...

Twelve sheep from 7 different flocks consisting of approximately 150-250 animals each were diagnosed with coenurosis caused by the larval stage of Taenia multiceps. Ataxia, incoordination, drowsiness, hind leg paralysis and coma were the most prominent clinical symptoms. Monocytosis and lymphocytosis were observed upon hematological examination. Cr...

A rhabdomyosarcoma could be identified at the head of a fourteen-year-old male Doberman dog, together with metastases in the lungs. The sarcoma mass at the head predominantly consisted of oval, roundish, and polygonal cells of different size with hyperchromatic nuclei, including an eosinophilic border of the cytoplasm. Mitotic figures were also vis...

The present study describes pathomorphological and immunohistochemical findings on uterine serosal inclusion cysts. The material obtained from two female dogs after postpartal ovariohysterectomy. Macroscopically: the cysts with 1-4 mm diameter were present dorsally on the left uterine horn of one of the two animals, whereas cysts of 2-5 mm diameter...

Cell proliferation and apoptosis in canine cutaneous histiocytomas and transmissible venereal tumours were examined in twenty cases. The Ki-67 immunohistochemistry and Tunel methods were used to detect mitotic activity and apoptosis, respectively. The number of Ki-67 immunoreactive cells was 11.65 (+/- 1.1706) in canine cutaneous histiocytomas and...