Mehmet Berkoz

• Van Yuzuncu Yil University

Purpose: Ursolic acid is a small pentacyclic triterpene molecule composed of isoprenoid units. Although ursolic acid has been shown to be effective in the treatment of rheumatoid arthritis in many studies, very little research has been conducted on bone diseases caused by bone loss. The present study aimed to evaluate the effects of ursolic acid on...

In our study, the antioxidant and anti-inflammatory effects of different lichen applications were investigated in rats using an experimental ethanol toxicity model. 48 rats were used in the study and they were divided into 6 groups with 8 rats in each group. These groups were: control, ethanol (2 g/kg), ethanol + Usnea longissima Ach. (200 mg/kg),...

In our study, the protective role of synthetic aromatase inhibitors anastrozole (ANS), letrozole (LTZ) and exemestane (EXM) and natural aromatase inhibitors resveratrol (RSV) and apigenin (APG) against testicular failure caused by exposure to Bisphenol A (BPA) was investigated. The epididymal sperm concentration, sperm motility and sperm morphology...

Cyclophosphamide (CYP) is a chemotherapeutic drug used to treat various cancers. However, its clinical use is limited due to severe organ damage, particularly to the kidneys. While several phytochemicals have been identified as potential therapeutic targets for CYP nephrotoxicity, the nephroprotective effects of boswellic acid (BOSW) and betulinic...

Background: Alcohol use disorder (AUD) is a chronic relapsing disorder associated with compulsive drinking of alcohol. Natural flavonoid fisetin affects a variety of transmitter systems relevant to AUD, such as aminobutyric acid, N-methyl-D-aspartate, and dopamine, as well as peroxisome proliferator-activated receptors.Objectives: This study invest...

The effect of various flavonoids against oxidative stress and inflammation caused by lead exposure has been investigated. However, the protective effects of myricetin (MYC) and fisetin (FST), which are known to have potent antioxidant properties, against nephrotoxicity caused by exposure to lead acetate (LA), the water-soluble form of lead, have no...

In this study, the protective roles of myricetin (MYC) and quercetin (QRS) against nephrotoxicity caused by malathion (MLT) intoxication were investigated. A total of 42 male rats were used and divided into 6 groups. The dose of MLT was fixed at 108 mg/kg/day and MYC or QRS were administered separately at doses of 100 and 200 mg/kg/day. All chemica...

Nigella sativa (also known as black seed) has recently become popular for its many effects and is among the most demanded herbs. Nigella sativa seeds, which are among the herbs used for medicinal purposes, are used in traditional medicine in Asia, Far East, and Middle East countries for purposes such as headache, abdominal pain, diarrhoea, asthma,...

Introduction:In this study, we investigated the etiopathogenesis of allergic rhinitis by analyzing the polymorphisms including GPx-1 Pro198Leu, CAT-262 C/T, and MnSOD Ala16Val.Methods:The diagnosis of allergic rhinitis was diagnosed by clinical history, examination, serum total immunoglobulin E levels and skin prick test. Five mL of peripheral bloo...

Alcohol addiction or alcoholism constitutes a significant risk factor worldwide for morbidity and mortality. Moxidectin is a recently approved anthelmintic drug, which also activates the gamma-aminobutyric acid receptors. The objective of the present study was to examine the impact of moxidectin on rewarding effects of ethanol in the conditioned pl...

The toxicological risk assessment (TRA) of elemental impurities (EI) in especially herbal medicinal products (HMP) is a significant challenge for pharmaceutical industry. In Europe very popular are traditional HMP with Valerian root ( Valeriana officinalis L., radix) for relief of mild symptoms of mental stress and to aid sleep. The aim of our uniq...

For elemental impurities that have been studied for transcutaneous absorption, the available data are rarely suitable for proper toxicological risk assessment – there are multiple factors that can influence this dermal absorption. Hence, in our studies we applied generic and conservative approach - cutaneous permitted daily exposure (CPDE) describe...

Essential elements like Cu, Mn and Zn are extremely important for herbs growth and physiological functions, however from a toxicological point of view, the exposure of these elements (as essential elemental impurities) can exhibit potential harmful effects for patients. In Europe very popular are ointments with Marjoram herb extract (Majoranae herb...

One of the aspects of biological activity of vanadium is its influence on carbohydrate metabolism. For more than 30 years, various vanadium complexes have been tested as antidiabetic agents. This study researched organic vanadium complexes with bipyridinium ligands and their influences on metabolic rate, as well as on the antioxidant activity of ad...

Studies related to the toxicological risk assessment (TRA) of heavy metals impurities (HMIs) in pharmaceuticals is an important issue but there is a lack of refereed literature around the safety of Valeriana officinalis L., radix (Valerian root) as herbal medicinal product (HMP) for the relief of mild nervous tension and sleep disorders according t...

Objectives The aim of this study was to investigate the cellular changes caused by Bisphenol A (BPA) exposure in salivary gland cells and to examine the protective role of resveratrol (RSV) and apigenin (APG) molecules against the negative effects of BPA. Materials and Methods Forty-two rats were randomly divided into 6 groups as; (i) control, (ii...

Background Liver has an important role in the initiation and progression of multiple organ failure that occurs in sepsis. Many natural active substances can be used to reduce the liver injury caused by sepsis. For this aim, the effects of myricetin and apigenin on mice model of acute liver injury was evaluated in this study. Methods and results Th...

Objectives Olive ( Olea europaea L.) plays a promising role in pharmaceutical, nutraceutical, and cosmetic production. On the other hand, olive leaf is widely used in folk medicine due to its antihyperglycemic activity. For this aim, possible effects of olive leaf extract (OLE) in the brain tissue of streptozotocin-induced diabetic rats were invest...

Elemental impurities (EIs) profiling in final pharmaceutical products is often not adequately treated, however it is crucial problem in pharmaceutical analysis by reason of the various regulatory authorities (like ICH Q3D guideline). EIs in pharmaceuticals may arise from numerous sources of which the herbal ingredients are not a frequent subject of...

Aim: Major side effects of cyclophosphamide administration are immunosuppression and myelosuppression. The immunomodulatory effects of plant bioactive compounds on chemotherapy drug-induced immunosuppression may have significant effects in cancer treatment. For this reason, we investigated the immunomodulatory effect of myricetin, apigenin, and hes...

Background: Pomegranate is a rich source of many polyphenolic compounds including ellagitannins (punicalagin, punicalin and others). Aim: The effects of punicalagin and punicalin on adipogenesis were investigated in this study. Materials and methods: To examine the effect of punicalagin and punicalin on adipocyte differentiation, various conce...

Background Melanoma is a life-threatening cancer characterized with a potentially metastatic tumor of melanocytic origin. Improved methods or novel therapies are urgently needed to eliminate the development of metastases. Artesunate is a semi-synthetic derivative of artemisinin used for trarment of malaria and cancer. The purpose of this study was...

Objectives: The aim of this study was to assess the influence of plasminogen activator inhibitor-1 (PAI-1) 4G/5G or tissue plasminogen activator (tPA) I/D polymorphisms in chronic obstructive pulmonary disease (COPD) cases in a sample of Turkish population. Methods: PAI-1 4G/5G and tPA Alu-repeat I/D genetic polymorphisms in 153 COPD subjects an...

Lung cancer is the most common cause of cancer-related deaths worldwide. Punicalagin is an ellagitannin mostly found in pomegranate husk and shows very strong antitumoral activity. The purpose of this study was to investigate the mechanism in which punicalagin acts as an antiproliferative agent on A549 cell line (adenocarcinomic human alveolar basa...

Objective: The aim of this study was to assess the influence of plasminogen activator inhibitor-1 (PAI-1) 4G/5G or tissue plasminogen activator (tPA) I/D polymorphisms in chronic obstructive pulmonary disease (COPD) cases in a sample of Turkish population. Methods: PAI-1 4G/5G and tPA Alu-repeat I/D genetic polymorphisms in 153 COPD subjects and 1...

The protein hydrolysates of fishes have been reported to be a potential source of many health benefits components for pharmaceutical or nutritional applications. The aim of this study is to examine the possible antiproliferative function of roe protein hydrolysates of Alburnus tarichi using enzymatic hydrolysis against breast cancer cells and explo...

Aim/Purpose of the study:Inhibition of microglial activation using phytochemicals may be a potential candidate for the prevention of neurodegenerative diseases caused by neuroinflammation and oxidative stress. The goal of this study was to investigate the protective role of Biochanin A on lipopolysaccharide (LPS)-stimulated BV2 microglial cells. BV...

Background: Rheum ribes L. is a perennial plant that belongs to the family of Polygonaceae, which is often used in traditional therapy because it possesseses many bioactivities, such as antioxidant and antibacterial ones. Here we examined the effect of different Rheum ribes L. extracts on oxidative stress in experimental diabetic rats. Methods: Thi...

Nitric oxide is known as relaxing factor because it acts as a vasodilator, increases blood flow, and inhibits platelet aggregation and adhesion, on the other hand nitric oxide can modulate cellular and physiological processes to limit oxidative injury, limiting processes such as leukocyte adhesion. As the complete mechanism of myricetin and its car...

Amaç: Bu çalışmada, meme kanseri geni partner ve lokalizeri-2’nin (PALB2) üç farklı tek nükleotid polimorfizminin (rs249954, rs249935 ve rs16940342) meme kanseri predispozisyonu üzerindeki etkileri araştırılmıştır.Gereç ve Yöntem: Bu amaçla, çalışmamıza meme kanseri tanısı almış 150 hasta ve 150 sağlıklı birey dahil edilmiştir. Gerçek zamanlı polim...

The present studies are focused to explore the antioxidant and anti-lipoxygnease activities in crude extract, aqueous and organic fractions (ethyl acetate, chloroform, butanol) of dry fruit of Cydonia oblonga. For determining the antioxidant activity; total phenolic content and 1,1-diphenyl-2-picryl-hydrazil (DPPH) radical scavenging assay were per...

Introduction Catalase (CAT), an antioxidant enzyme, catalyzes conversion of hydrogen peroxide to water and molecular oxygen, protecting cells against oxidative stress. The aim of this study was to investigate the possible association between CAT C262T polymorphism in the promoter region of the CAT gene and leukemia risk and to determine the relatio...

Methyl parathion (MP) is an organophospho- rus pesticide that can induce hepatotoxicity in liv- ing organisms. Although many plant extracts have been utilized againts MP injury liver injury, it has not yet known whether 􏰆􏰓􏰄􏰂􏰔􏰔􏰌 􏰁􏰌􏰖􏰓􏰇􏰌 L. extract (NSE) has protective effects or not. We aim to investigate the hepatoprotective effect of 􏰆􏰋􏰏 through th...

Objective: Juniperus communis L. is a shrub belonging to family Cupressaceae L. mainly growth in Eurasia. The antioxidant and antidiabetic activity of aqueous extract of J. communis L. berries indicated benefits as a potent antidiabetic in streptozotocin induced diabetic albino rats. This study was carried out to determine whether J. communis L. oi...

The present study investigated the effects of the prebiotic inulin on the growth parameters, digestive enzyme activities and antioxidant status of rainbow trout (Oncorhynchus mykiss). After acclimation, fish (34±0.22 g; n = 135) were assigned into 9 tanks (15 fish per tank) and triplicate groups were fed a control diet (G-0) or diets containing 1%...

Amaç: Bu çalışmada stres ve menopozun birlikte, öğrenme işlevi üzerindeki etkileri araştırılmıştır. Yöntem: Çalışmada, 60 adet dişi Wistar-Albino sıçan kullanılmıştır. Bu sıçanlar randomize olarak kontrol (Grup I), deneysel immobilizasyon stres modeli (Grup II), deneysel menopoz modeli (Grup III) ve deneysel menopoz modeli + deneysel stres modeli (...

The commonly used pesticides in agriculture cause enzyme inactivation and DNA damage via reacting with macromolecules and may also initiate peroxidation of poly-unsaturated fatty acids (PUFA) by generating of the reactive oxygen species (ROS), as a consequence they can lead to the oxidative stress. The objective of this study was to determine the o...

Context: The inhibition of adipocyte differentiation has a significant role on the prevention of obesity and obesity-associated complications. Objective: In this study, we aimed to detect whether hyperoside is able to inhibit the conversion of pre-adiposits into mature adiposits. Design and methods: 3T3-L1 pre-adipocytes were stimulated so as...

In this study, it was evaluated Glutathione S transferase (GST), Adenosine deaminase (ADA), and paraoxonase (PON) activities in liver tissue of Oncorhynchus mykiss fed with nucleotide yeast base protein supplemented diet. Throughout the 60-day period the control group was fed a fish meal based basal diet, and three other groups were fed diets in wh...

Epilepsy is one of the most complicated neurological disorders associated with a brain disorder in which, after an in itial physiological insult, the networks of neurons regroup and communicate abnormally that can be defined as the neuronal hyper - synchronizayion. The affected part of brain defines the patient’s abnormality behavior. Unlike the yo...

Radio-frequency electromagnetic radiation (RF-EMR) represents one of the environmental factor that influence animal organism to stress. In this study we determined the oxidative stress parameters from rat liver, kidney and brain tissues that were exposed to chronic 1800 MHz RF-EMR. Our study was designed in 3 groups as 9 animals in each group. Thes...

In this study, antioxidant enzyme activities and immun system parameters of liver tissue of Oreochromis niloticus fed with organic (Sel-Plex®-2000, Alltech, USA) and inorganic selenium (Na2SeO3.5H2O - Sodium selenite pentahydrate-FLUCA) supplemented feed were investigated. The fish with average weights of 12.62 ± 0.11 g were placed in aquariums and...

Natural resources right from the beginning of the human civilization has paved the way to human being to combat different challenges. The big challenge was to safe the human being from diseases and shortage of food. Plants helped the man in both areas very efficiently. No doubt when plants are used as food actually we are also taking lot of compoun...

Paraoxonase 1 (PON1) is an important antioxidant enzyme which has a role in preventing the effects of systemic oxidative stress. The purpose of our study was to investigate the possible association between PON1 L55M polymorphism and leukemia development and to determine the relationship between PON1 genotypes and PON1 enzyme activities. Genotypes o...

Punicalagin, a natural occuring phytochemical extracted from pomegranate (Punica granatum) husk shows antioxidant and anti-tumoral activities. Previous studies have shown that Punica granatum can scavenge reactive oxygen intermediates (ROIs) and suppress the biosynthesis of prostaglandins (PGs). However, the anti-inflammatory property of punicalagi...

INTRODUCTION: Inflammation is an innate immune response that protects host organism from external injuries and pathogens. The increased inflammatory response in organism can cause many diseases, especially cancer. Many natural and synthetic substances are used for annihilating the inflammatory response. Hypericin and hyperforin, isolated from Hyper...

In this study, effects of sublethal concentrations of fenbutatin oxide on catalase (CAT) and superox-ide dismutase (SOD) activities and lipid peroxida-tion in muscle, liver, kidney and brain tissues of Cy-prinus carpio were investigated. The 96-hours LC50 value for fenbutatin oxide was determined as 1.544 mg/L for C. carpio in this study. 0.15 mg/L...

Strontium ranelate is one of the most common post-menopausal osteoporosis medications that have been used in recent years. The effects of strontium ranelate treatment on the free radical-antioxidant balance of the skin have not been fully elucidated. In this study, we investigated the effects of strontium ranelate treatment on oxidative stress para...

Background Nasal polyposis (NP) is the most frequent cause of nasal masses. Despite considerable research on the subject, its etiology has not been fully elucidated, and effective treatment methods have not been developed. Some etiological factors causing low or high expression of genes in genetically predisposed individuals may play a role in the...

Background Use of a hookah (a type of water pipe) is a traditional way of smoking tobacco, particularly in the Middle East. In Turkey, its popularity has been growing in recent years, especially among young people. It is known that cigarette smoking has genotoxic effects and causes mutations, but no comprehensive study has been done on the genotoxi...

We investigated the antioxidant effects of curcumin in an experimental rat model of allergic rhinitis (AR). Female Wistar albino rats (n = 34) were divided randomly into four groups: healthy rats (control group, n = 8), AR with no treatment (AR + NoTr group, n = 10), AR with azelastine HCl treatment (AR + Aze group, n = 8), and AR with curcumin tre...

Objectives: This study aimed to explore the effects of curcumin on experimental allergic rhinitis in rats. Methods: Twenty-eight male Wistar albino rats were randomly divided into four groups: a control group; a group in which allergic rhinitis was induced and no treatment given; a group in which allergic rhinitis was induced followed by treatme...

Cytokines and genetic factors play important roles in the pathogenesis of chronic hepatitis B (CHB) and chronic hepatitis C (CHC) infections. Variations in cytokine genes may effect the gene expression and may lead to changes in the clinical manifestations of diseases. One of the single nucleotide polymorphisms in the promoter region of tumor necro...

This study aimed at demonstrating the effects of dietary supplementation of nucleotide yeast base protein (Nu-Pro®) (NP) on the antioxidant enzyme activities and immune response in liver and blood tissues of rainbow trout (Oncorhynchus mykiss). Fish with an average initial weight of 27.75±0.26 g were randomly assigned to four groups with three repl...

Objective: Cytokines has an important role in the immunopathogenesis of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, lnterleukin-2 (IL-2) secreted by Thl cells which plays an important role in regulating both in activation of the immune system and homeostasis, is a cytokine having a wide spectrum of effects on the immune system....

Brucellosis is a zoonotic disease of worldwide and still remains endemic in some developing countries, especially in Turkey. Milk is the main food product serving as a vector for Brucella. In this study we aimed to investigate the seroprevalence of human and animal brucellosis. The study group consisted of 358 subjects who had high risk occupations...

In this study, effects of sublethal concentrations of methidathion on catalase (CAT), superoxide dismutase (SOD), glutathion peroxidase (GSH-Px) activities and lipid peroxidation with expression of heat shock protein (HSP70) gene in liver tissues of Oreochromis niloticus were investigated. The 96-h LC50 value for methidathion was determined as 0.10...

In this study, it was evaluated paraoxonase activity (PON) and malondialdehyde (MDA) level in liver tissue of Oreochromis niloticus fed with mannan oligosaccharide (MOS) supplemented diet. For this purpose, fish were fed commercial diet supplemented with 0.25%, 0.35% and 0.45% dietary MOS for 60 days. At the end of experiment, PON activity of liver...

Capsaicin is a spicy ingredient of Capsicum annuum and a lipophilic, crystalline, odorless and colorless alkaloid. Although the effect of capsaicin on adipocyte differentiation is well-known, the role of capsaicin on transcription factors while adipocyte differentiation is not clear. The aim of this study is thus to identify and characterize the tr...

Cornelian cherry (Cornus mas) is a valuable source of phenolic antioxidants. Flavonoid derivatives as nonenzymatic antioxidants are important in the pathophysiology of many diseases including neurological disorders (e.g., Alzheimer's disease) or heart disease. In this study, we examined the effect of an addition of freeze-dried fruit of cornelian c...

Introduction: Gene polymorphisms have a broad range of analysis, but are of particular use in molecular medicine due to their potential in revealing the genetic tendency in diseases such as cancer, heart attack etc. These studies basically depend on mutations that can be detected by proper techniques. The genes coding the insulin receptor substrat...

In this study, we aimed to investigate the impact of non-alcoholic hepatic steatosis on the liver volume. As investigating hepatic steatosis, we utilized computed tomography (CT) to determine the degree of steatosis and we utilized hepatobiliary ultrasonography (USG) for densitometry and correlation. As hepatosteatosis group, 35 patients over 18 ye...

The naphthylamine derivative sertraline is a potent and selective inhibitor of serotonin reuptake into presynaptic terminals and the most widely used that has been shown to have both antidepressant and antianxiety effects. In the present study the possible role of sertraline (acute and chronically doses) was evaluated on lipid peroxidation levels a...

This 60 day study investigated the effects of organically certified nucleotide yeast-derived protein source (Nu-Pro®) on growth, feed efficiency, fillet proximate composition and digestive enzymes in rainbow trout (Onchorhyncus mykiss). Diets were isonitrogenous and isocaloric. Three experimental diets wherein 20%, 40% and 60% of the fish meal cont...

Objective: Chronic HCV infection is a dynamic state of the interactions between virus and host immune response, and the natural course varies greatly among different individuals. So currently, most studies investigating the underlying mechanisms of HCV infection have focused on genetic variations in the human population. Specially, polymorphisms of...

In this study was evaluated potential protective effect of organic selenium (Se) on heavy metal stress induced by lead (Pb) in Cyprinus carpio. For this reason, C. carpio was exposed to sublethal concentration of Pb (1.5 mg/L Pb(NO3)2) for 14 days. The fish were fed a basal (control; measured 0.55 mg/kg Se) diet or a basal diet supplemented with 2....

Retinitis pigmentosa is a retinal disease that leads to blindness. It has an unclear etiology and no known cure available in literature. The aim of this study is to study the role of free radicals on retinitis pigmentosa. This study was conducted on a test group composed of subjects who have been diagnosed with retinitis pigmentosa for ten years; a...

Unlabelled: Abstract Purpose: The aim of the present study was to evaluate the electrophysiological, biochemical and ultrastructural changes on the rat sciatic nerve after radiotherapy. Material and methods: Thirty male Wistar albino rats were divided into three groups as: Control group (n = 10), Group I: 3 months after radiotherapy (n = 10), an...

Methotrexate (MTX), a widely used cytotoxic chemotherapeutic agent, is often limited by its severe toxicity. Regarding the mechanisms of its adverse effects, several hypotheses have been put forward, among which oxidative stress is highly noticeable. Additive effect of oxidative damage caused by MTX to oxidative stress induced by cancer makes the s...

Adenosine deaminase is an enzyme present in a great number of plants and animals, found from simple intervebrates to human beings. Adenosine deaminase and deoxyadenosine deaminase activities increase substantially during mitogenic and antigenic responses of lymphocytes and conversely lymphocytes blastogenesis. Various diseases characterized by the...

Aim: To investigate the effect of ovariectomy on the skin using biomechanical, biochemical, and histological techniques in the ovariectomized rat model. Ovariectomy causes significant changes in the physical characteristics of the skin. Materials and methods: Twenty female Wistar albino rats were divided into 2 groups, with each group consisting of...

Osteoporosis is the most common skeletal disorder and is considered a risk of fracture. Most medication used for the treatment of osteoporosis is antiresorptive; however, strontium ranelate (Sr) therapy in postmenopausal women has shown a double effect on resorption and bone formation. In this study, the effect of Sr on status of the oxidative stre...

Objective: Environmental exposure to deltamethrin can cause alterations in structure and function of different organs. F. Trogii, a white-rot fungus, has antioxidative enzymes such as superoxide dismutase, catalase and glutathione reductase. It is hypothesized that there is an antioxidative role of F. trogii resulting in reducing the extent of hear...

Ability of ascorbic acid (vitamin C) to attenuate oxidative damage was evaluated in liver and brain tissues of Oreochromis niloticus (O. niloticus) experimentally exposed to sublethal concentrations of chlorpyrifos (CPF). O. niloticus was exposed to sublethal concentrations of CPF at 12 μg/L (CPF1) and 24 μg/L (CPF2) for 96 h. The fish of vitamin C...

This study aims to investigate the relationship between the risk for the development of osteoarthritis and Cyclooxygenase-2 (COX 2) -765G>C gene polymorphism. We included a total of 100 osteoarthritis patients (18 males, 82 females; mean age 60.4±8.4 years; range 41 to 81 years) who were treated in the Physical Therapy Clinic and 100 healthy subjec...

Acute lymphoblastic leukemia is the major pediatric cancer in developed countries. To date most association studies of acute lymphoblastic leukemia have been based on the candidate gene approach and have evaluated a restricted number of polymorphisms. Such studies have served to highlight difficulties in conducting statistically and methodologicall...

This experiment was conducted to understand the effects of organic selenium on rainbow trout, Oncorhynchus mykiss. Fish (33.47±0.15 g; n = 216) were randomly assigned to four treatment groups consisting of three replicates of 18 fish each in 100 x 100 x 125 cm cages. The fish were fed a basal diet supplemented with 2, 3, or 4 mg/kg organic Se (Sel-...

The genotoxic effects of sublethal doses of cadmium in peripheral erythrocytes of Oreochromis niloticus was investigated using micronucleus (MN) and nuclear abnormalities (NAs) tests. For this reason, the fish were exposed to medium changes of 0.5 and 1.0 mg/L doses of cadmium (Cd) during an average treatment period of 10 days. On the 2nd, 4th, 6th...

The aim of this study was to investigate the propensity of chlorpyrifos (CPF) to induce formation of protein carbonyl (PC) in the liver and genotoxic effects in peripheral erythrocytes of Oreochromis niloticus by using micronucleus (MN) and nuclear abnormalities (NAs) tests. Also, possible attenuation by vitamin C (Vit C) on these parameters was in...

The effects of three inclusion levels of mannan oligosaccharides (MOS) derived from the outer cell wall of a select strain of Saccharomyces cerevisiae (Bio-Mos, Alltech Inc, USA) on growth, feed utilization, body composition, and antioxidant enzyme activity of tilapia (Oreochromis niloticus) were determined. Specimens (12 g) were fed a commercial d...

Calcitonin is one of the active substances which is recently used effectively in osteoporosis treatment. In literature there is no information whether calcitonin cause oxidative stress or not. In this study, subcutaneous calcitonin is applied to rats having experimental postmenopausal osteoporosis and the effects of calcitonin on lipid peroxidation...