Mehmet Nuri Atalar

• Assistant Professor
• Iğdır Üniversitesi

Purpose: Galectin-3 is associated with the process of inflammation and fibrosis. The aim of this study was both to evaluate of galectin-3, methylated arginines and hs-CRP in subjects with type 2 diabetes and prediabetes and to investigate a relation between serum galectin-3, methylated arginines and hs-CRP levels. Methods: In this study, all sub...

Objectives Our aim was to validate a mass spectrometric creatinine method and compare this method with Jaffe and enzymatic serum creatinine methods. Methods 90 samples were included. The levels were classified into three groups according to serum creatinine results as Group 1: Lower (n=30) (0.16–0.59 mg/dL), Group 2: Normal (n=30) (0.62–1.18 mg/dL...

The plasma levels of homoarginine (h-Arg) and methylated arginine have proven to be an independent cardiovascular risk factor. We aimed to determine the h-Arg and methyl arginine levels in serums of high-risk pregnancy causing potential complications. These participants were divided into four groups as the control group with quadruple test, the hig...

Various studies conducted on Centaurea species indicate that the relevant plant is good source of bioactive phytochemicals. In this study, in vitro studies were used to determine bioactivity properties of methanol extract of Centaurea mersinensis - endemic species in Turkey - on extensive basis. Furthermore, the interaction of target molecules, ide...

Novel quinazoline–sulfonamide derivatives (4a‐n) were synthesized and evaluated for their enzyme inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) which are associated with Alzheimer's diseases (AD). The target quinazoline–sulfonamides (4a‐n) were obtained via one‐pot multicomponent reaction of 5‐amino‐1,3,4...

Natural products play an essential role in food and pharmaceuticals. Quantification of bioactive compounds in plants is essential for the drug development process. Moreover, the presentation of the antioxidant effects of plants gains great interest for their therapeutic effect. A new and efficient technique was advanced for the determination of bio...

Achillea millefolium (A. millefolium) is one of the medicinal plants growing naturally in Anatolia and widely used in the treatment of many diseases, especially infectious diseases and digestive diseases. In this study, the determination of phenolic compounds, antioxidant, cytotoxic, and antimicrobial effects of plant extract of traditional A. mill...

Trifolium pratense L. flowers (TPF) were collected and dried in shade in this study. After extraction in methanol, a diluted solution was applied to the liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) device to determine the bioactive compounds quantitatively. Isoquercitrin (38.64 mg/g extract), coumarin (13.66...

Background of the Study: Angiotensin-converting enzyme 2 (ACE2) plays a key role in the entry of coronavirus disease into cells and in the regulation of the renin-angiotensin system (RAS). Modulation of ACE2 mRNA level is an important approach to control other processes in which ACE2 participates and to reduce viral invasion.

The phenolic composition, antioxidant, antimicrobial activity, enzyme inhibition activity, and cytotoxic activity potentials of the plant Rumex acetosella L. (R. acetosella) were examined in this study. Materials and Methods: The chemical composition of R. acetosella methanol extract was identified by the LC–MS/MS method. The antioxidant activity w...

The Allium turcicum L. (Zuzubak) plant as a cultivated vegetable have various health benefits and consumed as a food. Due to the shortcoming evidence in literature and the importance of this plant in folk medicine, in the present study, for the first time, we evaluated the bioactive profile of components (using LC-MS/MS), cytotoxicity, anticancer,...

Toxoplasma gondii is a single-celled parasite that causes a disease called toxoplasmosis. It can reach the central nervous system, but the mechanism of T. gondii disrupting the functioning of these brain regions occurs in bradyzoite stage of parasite, causing brain damage by forming tissue cysts in brain. In our study, the effects of T. gondii o...

Arum elongatum has various bioactive compounds including phenolic acids and flavonoids that may have beneficial effects on human health. The main objectives of this study were to determine the phenolic profile of the A. elongatum plant together with the total phenolic (TPC), total flavonoid contents (TFC), and total antioxidant capacities of A. elo...

Verbascum thapsus (Mullein) is a medicinal plant used in folk medicine to treat various ailments. For this study, the biological functions of Verbascum thapsus (VT) methanol extract were determined in vitro. The plant's methanol extract was created through the maceration process. The phytochemical composition of plant extracts was investigated usin...

The essential oil obtained from the aerial part of Chenopodium botrys plant by steam distillation was obtained. The remaining aqueous part was extracted with the solvent ethylacetate and n-butanol, respectively. In the end, five extracts were obtained: essential oil (CB-EO), untreated aqueous extract (CB-F), ethylacetate (CB-EA), n-butanol (CB-nBu)...

The use of botanical antioxidants to protect human skin from the harmful effects of ultraviolet radiation (UVR) opens the door to new and exciting avenues of research in photoprotection. Besides, for the sake of long-term sustainability, this strategy is both environmentally and human-friendly. To that end, the current study focuses on the polar ex...

The current work’s main objective was to determine the chemical composition of Amygdalus communis (AC) leaf extract and examine the antibacterial and cytotoxic properties of biosynthesized gold nanoparticles (AuNPs). The chemical composition of AC leaf extract was determined using LC-ESI/MS/MS to detect compounds that may be responsible for the red...

In this study, the synthesis and characterization of newly designed compounds containing pyrazole, acridine, and benzothiazole groups with their biological activity potentials were evaluated. For this purpose, the starting compound of our study, 1-(benzo[d]thiazol-2-yl)-3-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde (4), was synthesized according to...

Cyclotrichium origanifolium is a medicinal plant belonging to the Lamiaceae family. In this study, phenolic content analysis, antimicrobial effects, and cytotoxic effects of extracts of C. origanifolium were investigated. In the extracts, phenolic compound analysis by the LC‐ESI‐MS/MS method, antimicrobial effect by the MIC method, and cytotoxic ef...

Oxidative stress is the state of the formation of some pathophysiological condition with the excessive increase of the normal amount of free radicals in the organism. In this study, the in vivo genotoxic and antigenotoxic effects of methanol and water extract and phenolic content of Hypericum perforatum flower, fruit, and seed methanol extracts wer...

ÖNSÖZ “Ben herkesin kendi çalışmasında yapması gerekeni yaptım: Öncellerimin başarılarını minnettarlıkla karşılamak, onların yanlışlarını ürkmeden doğrulatmak, kendisine gerçek olarak görüneni gelecek kuşağa ve sonrakilere emanet etmek”. (El-Bîrûnî, öl. 1048) İnsanın doğa ile mücadelesinde şartları kendi lehine değiştirdiği ve bir tür Neolitik Devr...

United Nations (UN) Food and Agriculture Organization (FAO) defined food loss as healthy edible substances produced for humans that appear, thrown, lost, spoiled or consumed by insects at any point in the food supply chain. Stuart (2009) added to this definition of FAO, food by-products formed in food establishments and foods deliberately reserved...

In recent years, people in search of healthy food have turned to different alternatives such as "natural food", "organic food", "preservative-free food". For this reason, studies to increase the taste, aroma and shelf life of foods with plants and natural substances of plant origin have intensified. Secondary metabolites (polyphenols, terpenoids, a...

The toxic effects of mercury in earthworms and the potential alleviation effect of hydrogen-rich water (HRW) using ATR-FTIR and LC–MS analysis methods were investigated. Different concentrations of mercury chloride (H1: 5 µg/mL, H2: 10 µg/mL, H3: 20 µg/mL, H4: 40 µg/mL, and C1: control) and mercury chloride prepared in hydrogen-rich water (H5: 5 µg...

Abstract Aim: In this study, environmentally friendly synthesis of gold nanoparticles was carried out by using the extract obtained from the flowers of the lavender (Lavandula officinalis) plant. Materials and Methods: In the metal solution used in the study, gold nanoparticles (AuNPs) were obtained. by precipitation with the help of high-speed cen...

Introduction. Fighting against cancer and antibiotic resistance are important challenges of healthcare systems, and developing new treatment methods has become the most concentrated area of researchers. Method and Materials. Green synthesis, characterization, and some biological activities of gold nanomaterials (AuNPs) obtained with Gundelia tourne...

Astragalus ponticus Pall. species was investigated for its antiproliferative effects on HeLa cells. Two new chalcones (B5 and B8) along with eight known compounds (B1, B2, B3, B6, B7, B10, B14 and B15) were isolated by following bioactivity guided isolation methods. In addition, from non-active fraction, three cycloartane glycosides (B11, B12 and B...

Although notable medicinal value and biological activities such as antioxidant, antibacterial, antimicrobial and antifungal of Limoniastrum guyonianum have been reported, identification and quantification of phytoconstituents of CHCl3, EtOAC, and n-BuOH extracts from the aerial parts of the halophyte medicinal plant from Algerian Sahara was not wel...

In this study, silver nanoparticles (AgNPs) were synthesized using Prunus spinosa (PS) fruit extract in an easy, low-cost and environmentally friendly way. According to the Ultraviolet (UV)-visible Spectrophotometer analysis data, the nanocrystals showed a characteristic peak at 438.3 nm. Field Emission Scanning Electron Microscopy (FE-SEM), Transm...

In this study, silver nanoparticles (AgNPs) were synthesized using Prunus spinosa (PS) fruit extract in an easy, low-cost and environmentally friendly way. According to the Ultraviolet (UV)-visible Spectrophotometer analysis data, the nanocrystals showed a characteristic peak at 438.3 nm. Field Emission Scanning Electron Microscopy (FE-SEM), Transm...

In this study, in vitro activities as antioxidant, antimicrobial, anticholinesterase and chemical profile of Scilla mesopotamica speta different solvent extracts were determined in detail. In vitro antioxidant activities and total phenolic and flavonoid contents of plant extracts obtained with different solvents were tested in terms of 2.2‐diphenyl...

Daucus carota L. ssp. major (DCM) plant is widely used in traditional medicine to treat some types of cancer and various diseases. Therefore, we evaluated the biological activities of this plant to define its effects against prostate cancer (PCa), Alzheimer’s disease (AD), oxidation, and diabetes mellitus (DM) as well as identified its phenolic com...

A B S T R A C T In this study to be presented, the BAPMB molecule was synthesized and structurally characterized. All calculations were applied using the detailed DFT/B3LYP method with 6-311G (d, p) and SDD depended on the stable phase geometry of the molecule. Also, various HOMO-LUMO energy gaps, inter-orbital intramolecular interactions of the na...

The COVID-19 pandemic continues infecting people causing deaths globally. Although various medicines have been tried to combat with COVID-19, there is no medicine or treatment that has been validated yet. People have been using natural products for centuries against bacterial and viral illnesses. This study aimed to test the effects of the biomolec...

In this study, Centaurea sivasica Wageitz (Asteraceae) methanol extract was examined regarding phytochemical composition, in vitro antioxidant properties, ability to inhibit tyrosinase, α-amylase, α-glucosidase enzymes, and antimicrobial effects. Also, possible binding and interactions of phytochemicals with enzymes by molecular docking were determ...

In this study, silver nanoparticles (AgNPs) were synthesized economically and simply using an the environmentally friendly method with the extract obtained from agricultural waste olive leaves. AgNPs synthesized according to the analysis data were determined to have maximum absorbance at 433.5 nm wavelength, spherical appearance, 7.2 nm crystal nan...

Senecio angulatus L.f. is a flowering plant from the Asteraceae family that is native to South Africa and which was observed recently in the north and the east of Algeria. This study was aimed for the first time, to evaluate concomitantly phytochemical profiles, using LC-ESI/MS analysis, following by testing and assessing in vitro antioxidant and a...

Many plant species have a large diversity of secondary metabolites with different biological activities. This study aims to assess the phenolic constituent, enzyme inhibitory and antioxidant activities of the aqueous (water) and methanol extracts of Inula discoidea. The enzyme assays showed effective enzyme inhibition of the methanol extract agains...

The fact that AgNPs are obtained by biosynthesis applications are simple, economical and environmentally friendly are the reasons why the interest in these synthesis methods is increasing day by day. In this study, AgNPs were rapidly synthesized using the extract created from Morus nigra L. leaves. The application stages were carried out in room co...

The identification and quantification of the volatile organic compounds profile of the plants is an important tool for food quality and authenticity assessment. In that context, herewith the study, we aimed at quantifying the volatile compounds of three plants Artemisia campestris L. subsp. glutinosa, Lavandula angustifolia Mill., and Zingiber offi...

Nanoparticles are used in many areas due to their superior properties. Recently, producing these particles using environmentally friendly synthesis methods has become very popular. Within this context, in this study, gold nanoparticles (AuNPs) were synthesized by using a quick, eco-friendly method with the green leaf extract of Artemisia absinthium...

In this chapter, we review the effects of some avermectins, benzimidazole, antibiotics, and other groups of agents on glutathione S-transferase (GST), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes. The enzyme inhibition of these compounds can be expressed as the toxicological effect. GST is one of the enzymes responsible for...

In this study, new 1,2,3-triazole derivatives containing chalcone core (1-7) were synthesized. Obtained compounds were characterized by IR, ¹H-NMR, ¹³C-NMR, and mass studies. Characterized compounds (1-7) inhibitory effects were tested against the glutathione S-transferase (GST), acetylcholinesterase (AChE), and Butyrylcholinesterase (BChE). Their...

Medicinal plants have been used traditionally since ancient times as alternative medications to treat various human diseases. In this work, we examined the chemical constituent, antioxidant activity, and enzyme inhibition of an endemic plant Thymus migricus. The plant extracts showed remarkable inhibition effects against the acetylcholinesterase (A...

In this study, we report a facile and effective production process of palladium nanoparticles supported on polypyrrole/reduced graphene oxide (rGo/pd@ppy nps). A novel electrochemical sensor was fabricated by incorporation of the prepared nps onto glassy carbon electrode (Gce) for the simultaneous detection of ascorbic acid (AA), dopamine (DA) and...

Bu çalışmada Mardin, Diyarbakır ve Gaziantep kuru üzümlerinin yağ asit düzeyleri belirlendi. Mardin kuru üzümünün yağ asit düzeyleri ΣPUFA % 49.60, ΣMUFA % 29.61, ΣUSFA % 79.21 ve ΣSFA % 22.02 olarak, Diyarbakır kuru üzümünün yağ asit düzeyleri ΣPUFA % 22.80, ΣMUFA % 37.72, ΣUSFA % 60.58, ΣSFA % 40.45 ve Gaziantep kuru üzümünün yağ asit düzeyleri Σ...

Herein, the biogenic platinum nanoparticles (Pt NPs) were synthesized by using black cumin seed (Nigella sativa L.) extract as a reducing agent. The biogenic platinum nanoparticles synthesized by black cumin seed extract was characterized in detail by Transmission Electron Microscopy (TEM), UV-Vis spectrophotometer, X-ray diffraction (XRD), X-ray p...

Achillea schischkinii Sosn. is an endemic plant species and it belongs to Asteraceae family. It is distributed widely in the Central and East Anatolia. This study was carried out for evaluation of the antioxidant activity, enzyme inhibition effect, elemental and phenolic content of A. schischkinii. Briefly, acetylcholinesterase (AChE), butyrylcholi...

In this study, silver nanoparticles (AgNP) were synthesized using the biological method Hypericum triquetrifolium Turra. The synthesized silver nanoparticles (AgNP) were illuminated using spectroscopic methods such as Fourier transform infrared spectroscopy (FT-IR), Ultraviolet/visible light absorption spectrophotometer (UV-vis), X-ray diffraction...

Obesity plays a role in the pathogenesis of various diseases such as especially inflammatory process and metabolic syndrome. Herein, we aimed to determine levels of adiponectin, asymmetric dimethylarginine, zinc, and copper in obese as well as the evaluation of the relationship among them because we could not find any study evaluated together that...

In current work our main objective was to search the chemical components of volatiles in Acorus Calamus L. was identified by gas chromatography-tandem mass spectrometry (GC-MS\MS) combined with headspace (HS) technique. The technique is a very valuable in terms of the extraction yield, sample work up time, and profiling analysis. According to the o...

During chronic hyperglycaemia increased production of methylglyoxal occurs which may result in excessive production of advanced glycation end products (AGEs). Methylglyoxal (MG) is a reactive dicarbonyl intermediate and a precursor of advanced glycation end products (AGEs). Recent studies suggested a role for MG in insulin resistance and beta-cell...

Glutathione S-transferase (GST) enzymes detoxify a broad spectrum of xenobiotics, including chemotherapeutic drugs, environmental carcinogens, and endogenous molecules. Glutathione transferases catalyze the conversion of some metabolites into less toxic substances. Phase II reactions, which often result in detoxification, are conjugation reactions...

Glutathione S-transferase (GST) enzymes detoxify a broad spectrum of xenobiotics, including chemotherapeutic drugs, environmental carcinogens, and endogenous molecules. Glutathione transferases catalyze the conversion of some metabolites into less toxic substances. Phase II reactions, which often result in detoxification, are conjugation reactions...

Neutrophillymphocite ratio values in patients with systemic lupus erythematosus (SLE)

MATRIX AND CARRYOVER EFFECT ON SERUM CREATININE MEASUREMENT BY LC-MS/MS METHOD

Objective: Melatonin is synthesized in pineal gland and plays a role in energy metabolism and the weight-reducing effects. Dehydroepiandrosterone (DHEA) is synthesized primarily by the zona reticularis of adrenal cortex and to a lesser degree by the gonads. DHEA has antioxidant, antilipidperoxidative, antiinflammatory, antiatherogenic, antiaging an...

70 ÖZET Amaç: Melatonin pineal bezde sentezlenir, enerji metabolizmasında rol alır ve kilo azaltıcı etkiye sahiptir. Dehidroepiandrosteron (DHEA) esas olarak adrenal korteksin zona retikülarisinde, daha az bir miktarda gonadlarda sentezlenir. DHEA antioksidan, antilipidperoksidatif, antiinflamatuvar, antiaterojenik, yaşlanmayı engelleyici ve kilo a...

Serum Asymmetric Dimethyl Arginine Levels In Patients With Diabetes Mellitus

balkan journal of clinical laboratory xxıv,16,1

One-step synthesis of the triblock copolymers was carried out by reversible addition–fragmentation chain transfer (RAFT) polymerization of methyl methacrylate (MMA) and ring-opening polymerization (ROP) of β-butyrolactone (BL) or -caprolactone (CL) using a novel difunctional macro-RAFT agent. For this purpose, primarily PEG-Br (polyethylene glycol...

Synthesis of poly(vinyl chloride-graft-2-vinylpyridine) graft copolymers was carried out by reversible addition-fragmentation chain transfer (RAFT) polymerization of 2-vinylpyridine using a novel macroinitiator (RAFT macroinitiator). For this purpose, RAFT macroinitiator was obtained from the potassium salt of ethyl xanthogenate and poly(vinyl chlo...

One-step synthesis of star copolymers by reversible addition–fragmentation chain transfer (RAFT) and ring-opening polymerization (ROP) by using a novel dual initiator is reported. Triarm block copolymers comprising one polystyrene (or polyacrylamide) arm and two poly(β-butyrolactone) arms were synthesized in one-step by simultaneous RAFT polymeriza...