
Mehdi Tehrani-DoostTehran University of Medical Sciences | TUMS · Department of Psychiatry
Mehdi Tehrani-Doost
M.D.
About
168
Publications
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Introduction
Additional affiliations
November 1991 - March 2020
Tehrani University of Medical Sciences
Position
- Professor
March 2002 - present
Publications
Publications (168)
Compared to typically developing people, children with autism spectrum disorder (ASD) have distinct cognitive and intelligence profiles. Some of these children require cognitive rehabilitation. Through the use of cutting-edge therapy and cognitive empowerment methods, some cognitive skills in children with ASD can be strengthened by digital game-ba...
Background: Obsessive-compulsive disorder (OCD) is characterized by alterations in brain connectivity, particularly within the default mode network (DMN) and the salience network (SN). Investigating these connectivity differences can provide a deeper understanding of the neural mechanisms underlying OCD. Methods: This cross-sectional study involved...
Objective: To investigate the accuracy of facial emotion recognition in the Iranian community, a face database validated in this community is required. To do this, we conducted a validation study on the Radboud face database. The primary objective of this study was to evaluate the accuracy of recognizing emotions through faces in an Iranian sample...
Background
Some pathological changes occur in patients with Alzheimer’s disease (AD) prior to the onset of clinical symptoms.
Objective
In the present study, we aimed to investigate the potential of event-related potential (ERP) components in error processing performance as a neuromarker of mild cognitive impairment (MCI) and transition to AD and...
Background: Individuals diagnosed with gaming disorder (GD) often exhibit increased arousal during gameplay. Objectives: This study aims to compare arousal levels among individuals with GD, problematic gamers (PG), and those with healthy gaming habits (HG) using a 14-stage hyper-casual racing game. It further investigates how game difficulty affect...
Objective: Early detection of autism spectrum disorder (ASD) can lead to earlier intervention and greater improvement of children’s quality of life and performance; hence, the use of screening tools is essential to facilitate the diagnosis process. The aim of the present study was to determine the clinical and differential validity of Social Respon...
Background
The ability to attribute mental states to others is called theory of mind (ToM) and is a substantial component of social cognition. This ability is abnormally developed in individuals with autism spectrum disorder (ASD). Several studies over the past decade have identified the oxytocin receptor gene (OXTR) and its variants as promising c...
Convergent evidence has suggested a significant effect of bumetanide exposure on brain connectivity in patients with autism spectrum disorder (ASD), yet the characteristics of favorable treatment outcome remains largely unknown. In this work, we aimed to elucidate the primary group distinctions in the temporal pattern of dynamic functional connecti...
Background: Decision-making is a complex process, and most studies showed that patients with mild cognitive impairment (MCI) make worse decisions than healthy people. Objectives: This study aims to evaluate the effect of rivastigmine on the decision-making of MCI patients using the Cambridge Neuropsychological Test Automated Battery (CANTAB) tests....
Social cognition impairments in autism are supposed to be related to impairments in Theory of Mind (ToM), which is the ability to attribute mental states to oneself and others. Language and ToM are intertwined components, and higher-order ToM manifestations cannot be achieved without language competencies. CNTNAP2 gene is associated with language a...
Objective: This study aimed to investigate neurocognitive functioning, quality of life, and global functional performance in Ultra-High Risk (UHR) individuals compared to Familial High-Risk (FHR) individuals for developing schizophrenia.
Method : An observational cross-sectional study was conducted using a convenient sampling method at Roozbeh Hosp...
Objective: Social interaction and communication impairments in autism spectrum disorder (ASD) are supposed to be related to impairments in Theory of Mind (ToM), which is the ability to attribute mental states to oneself and other social agents. Language and ToM are intertwined cognitive components, and higher-order manifestations of the ToM cannot...
Background: The precise identification of attention deficit-hyperactivity disorder (ADHD) is one of the challenging clinical processes. Disorganizations in functional neural networks revealed via functional magnetic resonance imaging have recently been contributing. Machine learning approaches, particularly classification methods, have commonly bee...
Background
The ability to attribute mental states to others is called theory of mind (ToM) and is a substantial component of social cognition. This ability is abnormally developed in individuals with autism spectrum disorder (ASD). Several studies over the past decade have identified the oxytocin receptor gene (OXTR) and its variants as promising c...
Objective
The fronto-cerebellar circuit is involved in ADHD pathophysiology. Methylphenidate, as a first-line medication for ADHD, affects different brain regions, however, its effect on the fronto-cerebellar circuit is not investigated sufficiently. We aimed to investigate the effect of 8-week treatment with methylphenidate on neurometabolite rati...
Introduction: Children with Autism Spectrum Disorder (ASD) have diferent cognitive and intelligence profles than
typical developing individuals. Some of these children need cognitive rehabilitation. This study’s main purpose is to
provide a systematic review about applying computerized cognitive games for autistic children and to determine the
e...
Background: There is a growing need for predicting Alzheimer disease (AD) based on emerging neurocognitive dysfunction before the onset of the disease. Objectives: According to neuropathological changes in the mesial temporal lobe (MTL) before the onset of clinical symptoms and the relationship between the function of these structures and cognitive...
Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent neurodevelopmental disorders, characterized by specific cognitive and behavioral symptoms. A fronto-cerebellar circuit is implicated in ADHD, and despite its role in cognitive/behavioral aspects, the neurochemical alterations in this circuit are not well understood. The pr...
Introduction: Frontoparietal (FPN) and cingulo-opercular (CON) networks control cognitive functions needed in deductive and inductive reasoning via different functional frameworks. The FPN is a fast intuitive system while the CON is slow and analytical. The default-interventionist model presents a serial view on the interaction between intuitive an...
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with its symptoms appearing from early childhood. Behavioral modifications, special education, and medicines are used to treat the ASD; however, the effectiveness of the treatments depends on early diagnosis of the disorder. The main approach in diagnosing ASD is currently based on cli...
Introduction: Cognitive Remediation Therapy (CRT) is used to improve cognitive functioning in patients with Schizophrenia Spectrum Disorders (SSDs). Most of the previous studies had incorporated a long rehabilitation program. This study aimed to evaluate the effects of a short and easy to implement computer-based CRT on cognitive performance in pat...
Several studies over the past two decades have investigated the neu- ropsychological deficits in children with attention deficit hyperactivity disorder (ADHD), but much less have been done on adults. This study aimed to assess the deficits in executive functions of adults with ADHD, especially in the areas of attention, inhibition, impulsivity, and...
There are three primary models to deal with literal/non-literal language processing. The first is the indirect access model proposed by Grice (1975) and Searle (1979). As indicated by this model, sentences are first processed literally when the literal meaning was not the adequate interpretation; at that point the look for the metaphorical interpre...
This study aimed to assess the validity and normative statistics of the Farsi version of the Social Responsiveness Scale-2 (SRS-2). Among the mainstream elementary schools, 191 boys and 342 girls with a mean age of 9.46 (+ 1.72) years were recruited. Teachers and parents completed the SRS-2. The parents also answered the Social Communication Questi...
Objective: Moving Shapes paradigm is a test that evaluates intentionality as a theory of mind (ToM) component. This study aimed to assess the normative data and reliability of this test in a community sample of 9-11-year-old children.
Method: A total of 398 children aged between 9 and 11 years were recruited from mainstream elementary schools thro...
Objective: The Social Responsiveness Scale-2 (SRS-2) is a well-known screening instrument to assess autistic spectrum symptoms quantitatively. This study assessed the different types of reliability of the Farsi translation of the scale.
Method: This scale was translated into Farsi and back translated considering all aspects of methodology in trans...
Introduction: Studies have documented both executive functions (EF) impairment in children with Attention Deficit / Hyperactivity Disorders (ADHD) and Theory of Mind (ToM), yielding mixed results, possibly because of a variety of tasks used, all requiring different levels of language skills.
Aim: To investigate the relationship between ToM and EF w...
Objective:
The aim of this study was to investigate the effects of zinc, vitamin D, and their co-supplementation versus placebo on changes in the Beck Depression Inventory II (BDI-II) score, serum cortisol level, and brain-derived neurotrophic factor (BDNF) in obese/overweight patients with depressive symptoms.
Method:
This 2 × 2 factorial, doub...
Objectives: More attention is now paid on the importance of emotional and mental well-being of the youth. To better plan for psychiatric health care and rehabilitation in this age group, we need to shed light on the epidemiological picture of their mental disorders. The present study aimed to evaluate the demographic and clinical characteristics of...
Background: Studies related to decision-making and choice preference in substance use behavior have less commonly focused on decision-making processes per se. Those processes include decision-making time, task-based complexity, and decision-making strategies.
Objectives: The objectives of this study was the production of a culturally modified vers...
Objective: A prominent challenge in modeling choice is specification of the underlying cognitive processes. Many cognitive-based models of decision-making draw substantially on algorithmic models of artificial intelligence and thus rely on associated metaphors of this field. In contrast, the current study avoids metaphors and aims at a first-hand i...
Introduction
Studies indicate that children with Attention Deficit Hyperactivity Disorder (ADHD) have deficits in social and emotional functions. It can be hypothesized that these children have some deficits in early stages of facial emotion discrimination. Based on this hypothesis, the present study investigated neural correlates of early visual p...
Highlights An imbalance in excitatory/inhibitory functions in the early development of brain can be considered as an etiological factor in developing autism spectrum disorder. In the early development of brain, GABA acts as an excitatory agent which leads to the accumulation of chloride inside the cell. Bumetanide, a loop diuretic, is an antago...
Introduction: Autism Spectrum Disorder (ASD) is characterized by several impairments in
communications and social interactions, as well as restricted interests or stereotyped behaviors.
Interventions applied for this disorder are based on multi-modal approaches, including
pharmacotherapy. No definitive cure or medication has been introduced so far;...
Background: Although a growing body of evidence suggests an association between obesity and depressive disorder, the association remains inconclusive. Metabolically healthy obese (MHO) phenotype, defined by favorable lipid profile, and normal insulin sensitivity, blood pressure, may be considered as a possible explanation for these inconsistencies....
Background: Chronic abuse of methamphetamine and morphinemayresult in cognitive impairment with negative consequences
for patients’ treatment and rehabilitation.
Objectives:We applied Conner’s CPT II (continuous performance test) to determine the effect of methamphetamine and morphine
use on patient performance in terms of type of substance use.
Me...
Purpose
The purpose of this paper is to investigate the effects of combined risperidone (RIS) and pivotal response treatment (PRT) in children with autism spectrum disorder (ASD).
Design/methodology/approach
In all, 34 children diagnosed with ASD (mean age of 12.36 years) were randomly divided into two groups: an RIS treatment group ( n =18) and a...
The purpose of this study was to investigate the effects of combined risperidone (RIS) and pivotal response treatment (PRT) on children with autism spectrum disorder (ASD). A total of 34 children diagnosed with ASD according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V) (mean age of 12.36 years) were randomly a...
Evaluating the Effect of Positive and Negative Emotions on Face Recognition Memory
Investigating the effect of image blurring on facial emotion recognition
Background
The relationship between diabetes and academic performance have been of great interest to researchers during the year to date. Many studies have been conducted to discover this relationship during three recent decades. But, evaluation of the structural changes of brain in the context of diabetes is of paramount importance especially in c...
Objectives Attributing the intention to others’ behavior is one important factor in the theory of mind
development. This study aimed to assess validity of the “Moving shapes” paradigm in a group of Iranian
school-aged children to evaluate their understanding the intention of others’ behavior.
Methods Through randomized cluster sampling, students at...
اهداف یکی از بخش های مهم در درک ذهنیت دیگران، تشخیص نیّت و هدف آن ها از انجام رفتارهایشان است. این مطالعه با هدف تعیین روایی آزمون الگوی «شکل های متحرک» برای تعیین عملکرد کودکان دبستانی در فهم قصدمندی رفتار دیگران انجام گرفت. مواد و روش ها در یک بررسی مقطعی برای ارزیابی ابزارها، دانش آموزان دبستانی پایه های سوم تا پنجم شهر تهران با روش نمونه گیری خ...
Objectives Attributing the intention to others' behavior is one important factor in the theory of mind development. This study aimed to assess validity of the "Moving shapes" paradigm in a group of Iranian school-aged children to evaluate their understanding the intention of others' behavior. Methods Through randomized cluster sampling, students at...
Introduction
Children with attention-deficit/hyperactivity disorder (ADHD) have some impairment in emotional relationship which can be due to problems in emotional processing. The present study investigated neural correlates of early stages of emotional face processing in this group compared with typically developing children using the Gamma Band A...
Background:
There have been claims that community mental health principles leads to the maintenance of better health and functioning in patients and can be more economical for patients with severe and chronic mental disorders. Economic evaluation studies have been used to assess the cost-effectiveness of national health programs, or to propose eff...
Background and objective:
The Strange Stories test is one of the most commonly used tests to evaluate advanced "theory of mind," i.e. attribution of mental states. Normative data and psychometric properties of a new Farsi translation of this test were evaluated in a large community-based sample of Iranian school-aged children.
Methods:
Through r...
Background: Executive dysfunction has been proposed as a fundamental impairment in children with autism spectrum disorder (ASD), however, existing findings are inconsistent. Objectives: The present study aimed at evaluating the behavioral profile for executive functions (EF) in adolescents compared to healthy individuals using the Farsi translation...
Diabetes in children and adolescents is a chronic condition with an expanding trend in the community. Several studies have shown cognitive dysfunctions are the most important side effects of diabetes among individuals of younger ages. Due to cultural differences and their impact on cognitive issues, the authors decided to assess the cognitive funct...
Background: To investigates executive functioning in Conduct disorder with comorbid ADHD.
Methods: Participants were adolescent males with ADHD, CD with comorbid ADHD and healthy
controls. Executive functioning were assessed using Go/No go task, Iowa gambling test and selected
tests from CANTAB.
Results: During the SWM test, CD+ADHD group had the t...
Background: Various cognitive dysfunctions are reported in children and adolescents with bipolar disorder (BD) in manic, depressed, and euthymic phases. Among these deficits, the findings related to visual memory are more inconsistent. Objective: Given the limitations and inconsistencies, we aimed to compare visual memory in the euthymic phase of B...
Objective:
Children with attention deficit/hyperactivity disorder (ADHD) have some problems in social relationships which may be related to their deficit in recognizing emotional expressions. It is not clear if the deficit in emotion recognition is secondary to core symptoms of ADHD or can be considered as an independent symptom. This study aimed...
Objectives Attributing the intention to others' behavior is one important factor in the theory of mind development. This study aimed to assess validity of the "Moving shapes" paradigm in a group of Iranian school-aged children to evaluate their understanding the intention of others' behavior. Methods Through randomized cluster sampling, students at...
Objectives: Previous studies have shown that serum levels of vitamin D were lower in attention deficit hyperactivity disorder (ADHD) children compared to healthy controls. The aim of the study was to determine the effect of vitamin D supplementation as adjunctive therapy to methylphenidate on symptoms of children with ADHD.
Methods: Sixty-two child...
Background: Cognitive impairment is a chronic and disabling manifestation of schizophrenia. Objectives: This before-after study was conducted to examine the effect of a short course computer-assisted cognitive remediation on improving cognitive functions of patients with schizophrenia. Materials and Methods: Twenty patients with schizophrenia were...
Objective: This study evaluated the theory of mind (ToM) in adolescents diagnosed with bipolar disorder (BD) during their euthymic period compared to a typically developing (TD) group.
Method: The BD group consisted of thirty 11-18 year old inpatients in euthymic phase. The TD group included 30 age, gender, and IQ matched volunteer students. To...
Objective: Although the etiology of schizophrenia is unknown, it has a significant genetic component. A number of studies have indicated that neuregulin-1 (NRG1) gene may play a role in the pathogenesis of schizophrenia. In this study, we examined whether the rs2439272 of NRG1 is associated with schizophrenia and its negative symptoms in an Iran...
Introduction: This study was aimed to compare the efficacy and side effects of memantine, an antagonist of the NMDA receptor of glutamate, with risperidone given the fact that glutamate has been noted for its possible effects in the pathogenesis of autism. Risperidone, an atypical antipsychotic, has been approved by FDA for the management of irrita...
Introduction Diabetes mellitus type 1 (T1DM) affects nearly 15 million children worldwide and failure to achieve and maintain good glycaemic control in this group can lead to diabetes-related complications. Children with T1DM can experience impairment in cognitive function such as memory, attention and executive function. This study is designed to...
One of the main aspects of theory of mind is intentionality which refers to recognizing other people's intentions in their behaviors. The aim of this study was to investigate intentionality in children with attention-deficit/hyperactivity disorder (ADHD). Thirty children with ADHD were compared to thirty age- and IQ-matched normal children. All par...
Introduction:
We hypothesized that inappropriate attention during the period of abstinence in individuals with substance use disorder can result in an inadequate perception of emotion and unsuitable reaction to emotional scenes. The main aim of this research was to evaluate the attentional bias towards emotional images in former substance abusers...
Background:
The aim of the current study was to determine effects of probiotic yoghurt and multispecies probiotic capsule supplementation on biomarkers of oxidative stress and inflammatory factors in petrochemical workers.
Methods:
This randomized, double-blind, placebo-controlled trial was done among petrochemical workers. Subjects were randoml...
A great deal of scientific evidence suggests that there is a close relationship between mood and cognitive processes of human in everyday tasks. In this study, we have investigated the feasibility of determining mood from gaze, which is one of the human cognitive processes that can be recorded during interaction with computers. To do so, we have de...
Background: The main problem in ADHD patients is disinhibition, while ADD patients mostly suffer from slow cognitive speed. Although studies have shown that children with ADHD have deficits in executive function and working memory, and that acute use of Methylphenidate improves these functions, less study has been done on ADD patients. Methods: A f...
Objective:
The aim of this study was to determine effects of probiotic yogurt and multispecies probiotic capsule supplementation on mental health and hypothalamic-pituitary-adrenal axis in petrochemical workers.
Methods:
The present randomized double-blind, placebo-controlled trial was conducted on 70 petrochemical workers. Subjects were randoml...