Mehdi Nikfar

Mehdi Nikfar
Johns Hopkins University | JHU · Department of Biomedical Engineering

Doctor of Philosophy

About

27
Publications
1,977
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216
Citations

Publications

Publications (27)
Preprint
Full-text available
Computational fluid dynamics (CFD) simulations are broadly applied in engineering and physics. A standard description of fluid dynamics requires solving the Navier-Stokes (N-S) equations in different flow regimes. However, applications of CFD simulations are computationally-limited by the availability, speed, and parallelism of high-performance com...
Article
Red blood cell (RBC)-hitchhiking, in which different nanocarriers (NCs) shuttled on the erythrocyte membrane and disassociated from RBCs to the first organ downstream of the intravenous injection spot, has recently been introduced as a solution to enhance target site uptake. Several experimental studies have already approved that cellular hitchhiki...
Article
Intracellular drug delivery by rapid squeezing is one of the most recent and simple cell membrane disruption-mediated drug encapsulation approaches. In this method, cell membranes are perforated in a microfluidic setup due to rapid cell deformation during squeezing through constricted channels. While squeezing-based drug loading has been successful...
Article
Full-text available
Knowing the environmental spreading pathway of COVID-19 is crucial for improving safety practices, particularly for health care workers who are more susceptible to exposure. This paper focuses on the possible secondary transmission due to resuspension of virus-laden droplets from common surfaces, which several studies have shown to be possible unde...
Article
The ongoing COVID-19 pandemic has infected millions of people, claimed hundreds of thousands of lives, and made a worldwide health emergency. Understanding the SARS-CoV-2 mechanism of infection is crucial in the development of potential therapeutics and vaccines. The infection process is triggered by direct binding of the SARS-CoV-2 receptor-bindin...
Preprint
Full-text available
The ongoing COVID-19 pandemic has infected millions of people, claimed hundreds of thousands of lives, and made a worldwide health emergency. Understanding the SARS-CoV-2 mechanism of infection is crucial in the development of potential therapeutics and vaccines. The infection process is triggered by direct binding of the SARS-CoV-2 receptor-bindin...
Conference Paper
Liposome nano-extrusion is a popular technique to produce small liposomes by squeezing large lipid vesicles through an array of nanochannels. There is little understanding of such a small-scale dynamic process. An implicit solvent, coarse-grained (CG) model is utilized to study nanoscale topological changes of lipid vesicles. The CG model is couple...
Conference Paper
Recent studies show that shear-induced drug loading methods in the microfluidic device is an efficient intracellular drug loading approach. In this study, a cellular-scale numerical model based on dissipative Lattice Boltzmann Method and spring connected network is utilized for modeling the drug encapsulation into a compound cell after rapid squeez...
Conference Paper
Dental professionals are exposed to contaminated aerosols and droplets produced during dental procedures. To prevent airborne disease transmission, extraoral suction is needed. Due to its bulky size, high cost, and loud noise, current Extraoral Suction Units are not widely adopted in dental offices. To fulfill this need, a smart extraoral suction c...
Article
Full-text available
Red blood cells or erythrocytes, constituting 40 to 45 percent of the total volume of human blood are vesicles filled with hemoglobin with a fluid-like lipid bilayer membrane connected to a 2D spectrin network. The shape, volume, hemoglobin mass, and membrane stiffness of RBCs are important characteristics that influence their ability to circulate...
Article
Transient pore formation on the membrane of red blood cells (RBCs) under high mechanical tensions is of great importance in many biomedical applications, such as RBC damage (hemolysis) and mechanoporation-based drug delivery. The dynamic process of pore formation, growth, and resealing is hard to visualize in experiments. We developed a mesoscale c...
Article
Full-text available
In this paper, we propose a multiscale numerical algorithm to simulate the hemolytic release of hemoglobin (Hb) from red blood cells (RBCs) flowing through sieves containing micropores with mean diameters smaller than RBCs. Analyzing the RBC damage in microfiltration is important in the sense that it can quantify the sensitivity of human erythrocyt...
Article
In this paper, natural convection due to two heated cylinders inside a rhombus enclosure with lower temperature with respect to the cylinders is investigated. Here, Cu-water is the working nanofluid. The numerical algorithm is based on an iterative direct immersed boundary method (IBM). The focus of this article is on stability, instability, symmet...
Article
This work introduces a new Lagrangian strain‐based model to predict the shear‐induced hemolysis in biomedical devices. Current computational models for device‐induced hemolysis usually utilize empirical fitting of the released free hemoglobin (Hb) in plasma from damaged red blood cells (RBCs). These empirical correlations contain parameters that de...
Article
Purpose The present study aims to perform inverse analysis of a conjugate heat transfer problem including conduction and forced convection via the quasi-Newton method. The inverse analysis is defined for a heat source that is surrounded by a solid medium which is exposed to a free stream in external flow. Design/methodology/approach The objective...
Article
In this study, a new coupled surface shape design (SSD) methodology named direct design method is presented for the solution of problems containing different types of convection heat transfer in which a specific distribution of either heat flux or temperature is given instead of the shape of a boundary. In the proposed method, the governing equatio...
Article
This paper presents a new element-based finite volume discretization approach for the solution of incompressible flow problems on co-located grids. The proposed method, called the method of proper closure equations (MPCE), employs a proper set of physically relevant equations to constrain the velocity and pressure at integration points. These equat...
Article
The purpose of this paper is to introduce a new physical-based computational approach for the solution of convection heat transfer problems on co-located non-orthogonal grids in the context of an element-based finite volume method. The approach has already been presented in the context of two-dimensional incompressible flow problems without heat tr...
Article
In part I of the paper, a new physical-based computational approach for the solution of convection heat transfer problems on co-located non-orthogonal grids in the context of an element-based finite volume method was discussed. The test problems are presented here, in part II of the paper. These problems include five steady two-dimensional convecti...
Article
Full-text available
One of the interesting and practical problems in thermo-fluid sciences is referred to finding the shape of a boundary on which a specific distribution of pressure, temperature or heat flux is known. Because solving such problems using experimental, semi-experimental and analytical methods is time-consuming or even impossible in some practical situa...
Article
Full-text available
The meshless local Petrov-Galerkin (MLPG) method is extended to analyze the mixed convection and fluid flow in an inclined two-dimensional lid-driven cavity. The enclosure considered comprises two insulated vertical walls and a wavy bottom wall which is subjected to a higher constant temperature than its top counterpart, the sliding lid. For the pr...
Article
Buoyancy-driven heat transfer, due to a square-shaped heater placed inside a square cavity �lled with TiO2-water nano uid, is investigated numerically. The heater is maintained at a constant temperature, Th, while the cavity walls are kept at a lower constant temperature, Tc. The governing equations are solved using the �nite volume method and the...
Article
Inverse shape design in the context of fluid flow problems is commonly referred to the determination of the boundary shape corresponding to a given target surface pressure. Designers naturally turn to this class of problems whenever there are concerns regarding pressure-related phenomena such as cavitation, separation, shock waves, surface loading,...
Article
A stabilised meshless local Petrov–Galerkin (MLPG) method with unity as the test function is extended to simulate the buoyancy-driven fluid flow and heat transfer in a right-angled, triangular enclosure filled with a nanofluid composed of a mixture of Al2O3 spherical nanoparticles in water. A cold source with a constant temperature Tc and a hot sou...
Article
The problem of laminar natural convection of Al2O3–water nanofluid in a cavity with wavy side walls has been investigated using the meshless local Petrov–Galerkin method. The considered cavity is a square enclosure having left and right wavy side walls. The left and right vertical wavy walls of the enclosure are maintained at constant temperatures...
Article
Procuring a numerical solution through an application of the meshless local Petrov-Galerkin method (MLPG) on the fluid flow and mixed convection in a complex geometry cavity filled with a nanofluid is the scope of the present study. The cavity considered is a square enclosure having a lower temperature sliding lid at the top, a differentially highe...
Article
As some new applications of the meshless local Petrov-Galerkin method (MLPG) with unity as the test function, a number of buoyancy-driven fluid flow natural convection heat transfer problems in cavities with differentially-heated wavy side walls were analyzed. Cavities with a single wavy wall on one side as well as two wavy walls erected on both si...

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Project (1)
Project
To predict blood cell deformation and damage in complex flow conditions, which will also provide new guidance to the design of blood-wetting devices to avoid potential hemolysis.