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September 2018 - August 2019
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Introduction As the paramedic profession continues to grow and evolve, a shift from purely reactive to holistic patient care models is required. As the first and often the only point of medical contact for many patients from marginalised and under-served populations, the paramedic role and its potential future implications in caring for these patie...
Introduction: As the paramedic profession continues to grow and evolve, a shift from reactive to holistic patient care models is required. As the first and often the only point of medical contact for many patients from marginalized and under-served populations, the paramedic role, and its potential future implications in caring for these patients n...
PAC has partnered with the CSA Group to manage the renewal of the existing National Occupational Competency Profile (NOCP) and incorporate it into a new standard following accredited processes of the Standards Council of Canada – the National Occupational Standard for Paramedics (NOSP). In this article we will provide a further update on the develo...
PAC has partnered with the CSA Group to manage the renewal of the existing National Occupational Competency Profile (NOCP) and incorporate it into a new standard following accredited processes of the Standards Council of Canada – the National Occupational Standard for Paramedics (NOSP). Following on from our earlier update in March, in this article...
Due to the nature of EMS work, with high call volumes, quick turnover rates, chaotic and highly variable scenes and patients, the spread of contaminated and/or infectious material is common. This poses a serious health risk not only to patients but to paramedics and other EMS personnel as well. Knowledge of infection control basics and adherence to...
Telomeres are DNA-protein complexes that cap the ends of eukaryotic chromosomes. They have a dynamic secondary structure that binds and interacts with a large network of telomere-associated proteins that protect the genomic integrity and maintain the proliferative success of cells. When telomeres are destabilized, chromosome ends are misrecognized...
We have recently shown that caspase-8 (CASP8) promotes Retinal Ganglion Cell (RGC) degeneration and contributes to regenerative failure after optic nerve axotomy or crush. However, the activators and targets of CASP8 remain unclear. Previous studies have shown that CASP8 activation is associated with Tumor Necrosis Factor-Receptor 1 (TNF-R1) signal...
Retinal ganglion cell (RGC) degeneration is an important cause of visual impairment and can be modeled by optic nerve transection, which causes the death of 90% of RGCs within 14 days postaxotomy. We performed a proteomic study to identify and quantify proteins in the rat retina after optic nerve transection. Our goal was to isolate potential targe...
Recent studies have identified anti-apoptotic functions for vascular endothelial growth factor (VEGF) in the central nervous system (CNS). However, VEGF therapy has been hampered by a tendency to promote vascular permeability, edema, and inflammation. Recently, engineered zinc finger proteins (ZFPs) that upregulate multiple forms of VEGF in their n...