Megan Gina Massa

Megan Gina Massa
University of California, Los Angeles | UCLA · NSIDP

Bachelor of Arts

About

13
Publications
4,129
Reads
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308
Citations
Additional affiliations
September 2017 - March 2018
University of California, Los Angeles
Position
  • Fellow
Description
  • Developed section curricula for high-level analysis of scholarly sources in bio, sociology, evo psych, & neuro. Taught collegiate writing process; developed course paper prompt for students to apply academic framework to a current social movement.
September 2016 - present
University of California, Los Angeles
Position
  • PhD Student
August 2015 - May 2016
Ruhr-Universität Bochum
Position
  • Researcher
Education
October 2016 - June 2022
University of California, Los Angeles
Field of study
  • Neuroscience
September 2010 - May 2014
Bowdoin College
Field of study
  • Neuroscience

Publications

Publications (13)
Article
The high female-to-male sex ratio of multiple sclerosis (MS) prevalence has continuously confounded researchers, especially in light of male patients' accelerated disease course at later stages of MS. Although multiple studies have concentrated on estrogenic mechanisms of disease modulation, fairly little attention has been paid to androgenic effec...
Article
Full-text available
Homeotherms maintain a stable internal body temperature despite changing environments. During energy deficiency, some species can cease to defend their body temperature and enter a hypothermic and hypometabolic state known as torpor. Recent advances have revealed the medial preoptic area (MPA) as a key site for the regulation of torpor in mice. The...
Article
Neuronal interactions at the level of vagal, homeostatic, and hedonic circuitry work to regulate the neuronal control of feeding. This integrative system appears to vary across sex and gender in the animal and human worlds. Most feeding research investigating these variations across sex and gender focus on how the organizational and activational me...
Article
Full-text available
Oestrogen receptor alpha (ERα) signalling in the ventromedial hypothalamus (VMH) contributes to energy homeostasis by modulating physical activity and thermogenesis. However, the precise neuronal populations involved remain undefined. Here, we describe six neuronal populations in the mouse VMH by using single-cell RNA transcriptomics and in situ hy...
Article
Short-chain fatty acids are processed from indigestible dietary fibers by gut bacteria and have immunomodulatory properties. Here, we investigate propionic acid (PA) in multiple sclerosis (MS), an autoimmune and neurodegenerative disease. Serum and feces of subjects with MS exhibited significantly reduced PA amounts compared with controls, particul...
Article
Full-text available
Liver X receptors limit cellular lipid uptake by stimulating the transcription of inducible degrader of the low-density lipoprotein receptor (IDOL), an E3 ubiquitin ligase that targets lipoprotein receptors for degradation. The function of IDOL in systemic metabolism is incompletely understood. Here we show that loss of IDOL in mice protects agains...
Preprint
Full-text available
Estrogen signaling in the central nervous system promotes weight loss by increasing thermogenesis and physical activity in the ventromedial hypothalamus (VMH), but the precise neuronal populations regulating these aspects of energy expenditure remain unclear. Here we define the molecular and functional heterogeneity of the VMH using single cell RNA...
Article
Though several functional properties of laquinimod have been identified, our understanding of the underlying mechanisms is still incomplete. Since the compound elicits similar immunomodulatory effects to ligands of the aryl hydrocarbon receptor (AhR), we compared the efficacy of laquinimod in experimental autoimmune encephalomyelitis (EAE)-afflicte...
Article
Full-text available
As multiple sclerosis research progresses, it is pertinent to continue to develop suitable paradigms to allow for ever more sophisticated investigations. Animal models of multiple sclerosis, despite their continuing contributions to the field, may not be the most prudent for every experiment. Indeed, such may be either insufficient to reflect the f...
Data
Representative negative control stainings. (A) Neuronal cultures do not exhibit oligodendrocyte lineage markers a, O4 and b, MBP. (B) Cultures show limited presence of astrocytes, with MSiPNs showing 3.63 (1.22) and HCiPN 0.13 (0.13) percent (SEM) of GFAP-positive, tubulin-negative cells. Error bars depict SEM. (C) a, Negative controls of biotin in...
Data
Overview images of HC, MSiPN characterization stainings. Representative pictures of β-III-Tubulin, neurogenin, SMI-32R, ChAT, and TH stainings from Fig 4; scale bar 100 μm. (TIF)
Conference Paper
Full-text available
The relationship between sex and multiple sclerosis (MS) has long been of interest. Though MS is traditionally viewed as a primary autoinflammatory, demyelinating affliction of the central nervous system, recent research has demonstrated that neurodegenerative processes occur throughout disease course and contribute to patients' steady neurological...

Questions

Question (1)
Question
Hi all.  I'm looking to use female tail blood to measure serum concentrations of 17beta-E2.  However, I cannot find a reliable ELISA kit only requiring <15uL sample sizes (I have another assay I wish to run with the serum, leaving only 15uL left).  I know BioVendor has one for T but not E2... Does anyone have any suggestions?  

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