Meenakshi Singh

Meenakshi Singh
University of Gothenburg | GU · Department of Medical Biochemistry and Cell Biology

M.Sc

About

11
Publications
2,710
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164
Citations
Introduction
Presently working on cancer drugs to decipher their effects on the mitochondrial genome.
Additional affiliations
October 2016 - January 2022
University of Gothenburg
Position
  • PhD Student
Description
  • Presently working on Cancer drugs and their effects on the mitochondrial genome.
September 2014 - May 2016
University of Gothenburg
Position
  • Research Associate
August 2010 - May 2014
All India Institute of Medical Sciences
Position
  • Fellow
Description
  • Project - Epilepsy in children
Education
August 2008 - August 2010
Amity University
Field of study
  • Biotechnology and Life Sciences
August 2005 - August 2008
Dolphin Institute of Bio-Medical & Natural Sciences
Field of study
  • Biotechnology and Life Sciences

Publications

Publications (11)
Article
Full-text available
Background Ovarian follicles, which are the basic units of female reproduction, are composed of oocytes and surrounding somatic (pre) granulosa cells (GCs). A recent study revealed that signaling in somatic preGCs controlled the activation (initial recruitment) of follicles in the adult ovaries, but it is also known that there are two waves of foll...
Article
Human mitochondria lack ribonucleotide excision repair pathways, causing misincorporated ribonucleotides (rNMPs) to remain embedded in the mitochondrial genome. Previous studies have demonstrated that human mitochondrial DNA polymerase γ can bypass a single rNMP, but that longer stretches of rNMPs present an obstacle to mitochondrial DNA replicatio...
Article
Full-text available
While >300 disease-causing variants have been identified in the mitochondrial DNA (mtDNA) polymerase γ, no mitochondrial phenotypes have been associated with POLRMT, the RNA polymerase responsible for transcription of the mitochondrial genome. Here, we characterise the clinical and molecular nature of POLRMT variants in eight individuals from seven...
Article
Full-text available
Telomere attachment to the nuclear envelope (NE) is a prerequisite for chromosome movement during meiotic prophase I that is required for pairing of homologous chromosomes, synapsis, and homolo-gous recombination. Here we show that Speedy A, a noncanonical activator of cyclin-dependent kinases (Cdks), is specifically localized to telomeres in proph...
Data
Schematic diagram of oocyte development in Cdk1+/SAF, OoCdk1+/AF; Gdf9-Cre and OoCdk1+/AF; Zp3-Cre mouse ovaries.
Data
Comparison of ovarian morphology and quantification of ovarian follicles.
Data
Increased ATM activation in GV stage OoCdk1+/AF; Zp3-Cre oocytes and quantification of ovarian follicles in OoCdk1+/AF; Zp3-Cre; Chk2−/− mice.
Article
Full-text available
A unique feature of female germ cell development in mammals is their remarkably long arrest at the prophase of meiosis I, which lasts up to 50 years in humans. Both dormant and growing oocytes are arrested at prophase I and completely lack the ability to resume meiosis. Here, we show that the prolonged meiotic arrest of female germ cells is largely...
Article
Full-text available
CYP1A1 gene is involved in estrogen metabolism, and previously, we have reported association of variant rs2606345 with altered anti-epileptic drugs (AED) response in North Indian women with epilepsy (WWE). The present study aims to replicate the pharmacogenetic association, perform functional characterization and study its distribution within ethni...
Article
The monitoring of antiepileptic drugs (AEDs) in clinical setting is important for measuring the efficacy of drugs and their safety and in personalizing drug therapy. We investigated the levels of AED, carbamazepine (CBZ), phenytoin (PHT) and phenobarbital (PHB), to understand their association in saliva compared with those in serum during the thera...
Article
Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) in serum is frequently used in clinical settings however saliva could be an alternative to measure free concentration of drugs. In the present study, we observed the possible correlation of VPA concentration between serum and saliva in persons with epilepsy (PWE). A total of 59 paired...

Questions

Questions (2)
Question
Can I get it in MCF 7 cells or should I expose my mcf7 cells to UV to get this protein? Can you please suggest me something? How much of UV should I expose to the cells to get phospho atm? This protein will express when there is a break in double strand of DNA.