Medha Jaimini Gunaratna

Medha Jaimini Gunaratna
University of Kelaniya · Department of Chemistry

PhD, Organic Chemistry

About

10
Publications
359
Reads
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65
Citations
Citations since 2016
8 Research Items
64 Citations
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2016201720182019202020212022051015
2016201720182019202020212022051015
2016201720182019202020212022051015

Publications

Publications (10)
Article
Full-text available
Gastrointestinal tract infection caused by Helicobacter pylori is a common virulent disease found worldwide, and the infection rate is much higher in developing countries than in developed ones. In the pathogenesis of H. pylori in the gastrointestinal tract, the secretion of the urease enzyme plays a major role. Therefore, inhibition of urease is a...
Article
Firefly luciferase is used in high-throughput screening based on the detection of chemiluminescence. It catalyzes an esterification reaction of luciferin with adenosine 5'-triphosphate (ATP) followed by decarbonylation with oxygen and concomitance of light. Previously, we reported that firefly luciferase also possesses acyl-CoA synthetase activity...
Conference Paper
Corrosion is an oxidation-reduction process where a metal is oxidized to a more consistent form such as its oxide, hydroxide, or sulfide by atmospheric oxygen. Corrosion is an excessively costly issue that is reported to cause significant economic damage globally each year. Therefore, the discovery of novel corrosion inhibitors is highly desirable....
Conference Paper
Corrosion is an oxidation-reduction process where a metal is oxidized to a more consistent form such as its oxide, hydroxide, or sulfide by atmospheric oxygen. Corrosion is an excessively costly issue that is reported to cause significant economic damage globally each year. Therefore, the discovery of novel corrosion inhibitors is highly desirable....
Article
Full-text available
A dysregulation in function of neuronal low-voltage-activated T-channel causes neuropathic pain. A group of ten 1,4-disubstituted and 1,4,4-trisubstituted piperidines were synthesized through short sequences of reactions from 4-cyanopiperidine, which may potentially produce a library of analogs. Inhibitions of T-channel in rat dorsal root ganglion...
Article
Neuropathic pain, epilepsy, insomnia, and tremor disorder may arrive from an increase of intracellular Ca2+ concentration through a dysfunction of T-type Ca2+ channels. Thus, T-type calcium channels could be a target in drug discovery for the treatments of neuropathic pain and epilepsy. From rational drug design approach, a group of 2,5-disubstitut...
Article
A new class of poly-N-vinylpyrrolidinones containing an asymmetric center at C5 of the pyrrolidinone ring were synthesized from L-amino acids. The polymers, particularly 17, were used to stabilize nanoclusters such as Pd/Au for the catalytic asymmetric oxidations of 1,3- and 1,2-cycloalkanediols and alkenes, and Cu/Au for C-H oxidation of cycloalka...
Article
The proteolytic activity of cathepsin B in complex breast cell lysates have been measured with alternating current voltammetry (ACV) using ferrocene (Fc)-labeled-tetrapeptides immobilized on nanoelectrode arrays (NEAs) fabricated with vertically aligned carbon nanofibers (VACNFs). Four types of breast cells have been tested, including normal breast...
Article
Various condensation and ring-closing reactions were used for the syntheses of 3-[(alkylamino)methylene]-6-methylpyri-dine-2,4(1H,3H)-diones, bicyclic pyridinones, and tricyclic morpholinopyrones. For instance, 3-[(dialkylamino)methylene]-6-methylpyridine-2,4(1H,3H)-diones were synthesized from the condensation of dialkylamines and 3-formyl-4-hydro...

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