Meaghan Cogswell

Meaghan Cogswell
Sanofi | SHANTHA

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7
Publications
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129
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Introduction
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Publications

Publications (7)
Article
Full-text available
Background: Brain-derived neurotrophic factor (BDNF) is a major signaling molecule that the brain uses to control a vast network of intracellular cascades fundamental to properties of learning and memory, and cognition. While much is known about BDNF signaling in the healthy nervous system where it controls the mitogen activated protein kinase (MA...
Preprint
Background Brain-derived neurotrophic factor (BDNF) is a major signaling molecule that the brain uses to control a vast network of intracellular cascades fundamental to properties of learning and memory, and cognition. While much is known about BDNF signaling in the healthy nervous system where it controls the mitogen activated protein kinase (MAPK...
Article
Full-text available
While the exact role of β1 subunit-containing GABA-A receptors (GABARs) in brain function is not well understood, altered expression of the β1 subunit gene (GABRB1) is associated with neurological and neuropsychiatric disorders. In particular, down-regulation of β1 subunit levels is observed in brains of patients with epilepsy, autism, bipolar diso...
Preprint
While the exact role of β1 subunit-containing GABA-A receptors (GABARs) in brain function is not well understood, altered expression of the β1 subunit gene (GABRB1) is associated with neurological and neuropsychiatric disorders. In particular, down-regulation of β1 subunit levels is observed in brains of patients with epilepsy, autism, bipolar diso...
Chapter
Epilepsy is a disease of complex etiology and mechanisms. Many types of brain injuries can lead to acquired epilepsy. Increasing evidence suggests that changes in GABAA Receptor (GABAR) subunit expression, specifically reduction in α1-and increase in α4-containing synaptic GABARs in the dentate gyrus of the hippocampus, produce a change in receptor...
Article
Objective Temporal lobe epilepsy (TLE) is frequently medically intractable and often progressive. Compromised inhibitory neurotransmission due to altered γ-aminobutyric acid (GABA)A receptor α4 subunit (GABAARα4) expression has been emphasized as a potential contributor to the initial development of epilepsy following a brain insult (primary epilep...
Article
Pilocarpine-induced status epilepticus (SE), which results in temporal lobe epilepsy (TLE) in rodents, activates the JAK/STAT pathway. In the current study, we evaluate whether brief exposure to a selective inhibitor of the JAK/STAT pathway (WP1066) early after the onset of SE effects the severity of SE or reduces later spontaneous seizure frequenc...

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