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January 1997 - present
Publications
Publications (40)
Los modelos numéricos para predecir el efecto mecánico de las prótesis de cadera en el hueso humano suelen considerar a este último como un material estático, sin cambios ante la presencia del implante. Esto limita su capacidad predictiva a largo plazo a nivel del tejido, generando dudas sobre el éxito mecánico del diseño de la prótesis. Para un an...
This study aims to investigate the impact of hormonal imbalances during menopause, compounded by the natural ageing process, on bone health. Specifically, it examines the effects of increased bone turnover and focal bone balance on bone mass. A three-dimensional computational bone remodeling model was employed to simulate the response of the femur...
The roof of a family home introduces important amounts of heat into the house. In Santa Fe city (Argentina), the attic of social family houses is not designed with thermal optimization purposes. In this work, a low Reynolds number k-e turbulent model is computationally implemented to show that a proper selection of constructive parameters of a vent...
In this work, a computational model of thin film lubrication applied to a knee prosthesis was designed in order to make a comparison between three constitutive models, i.e. a power law, the Carreau-Yasuda model and the Cross model. The equivalent model of the knee prosthesis was modeled as a rigid cylinder on a deformable plane. The mechanical beha...
Bone mechanical and biological properties are closely linked to its internal tissue composition and mass distribution, which are in turn governed by the purposeful action of the basic multicellular units (BMUs). The orchestrated action of osteoclasts and osteoblasts, the resorbing and forming tissue cells respectively, in BMUs is responsible for ti...
Background
The expression of embryonic Homeobox (HOX) genes is tightly regulated based on anatomic location in human adult dermal and synovial fibroblasts. Previously, we showed that HOX-D10,-D11 and -D13 are higher expressed in synovial fibroblasts from small distal joints from the hands and feet, in particular in digits II-V and wrists compared t...
El proyecto FITR 009/2013 de FONARSEC-ANPCyT “Desarrollo y Prototipado de Bioimplantes Forjados” fue reconocido como proyecto PDTS por el MINCyT y se ejecuta entre la Facultad de Ingeniería de la Universidad Nacional de Entre Ríos y la empresa Implantes FICO Alemana S.A., para el diseño de un vástago de prótesis de cadera con características innova...
En la ciudad de Santa Fe de la Vera Cruz, Argentina, se está construyendo un edificio de altura que incluye elementos de arquitectura sustentable, eficiencia energética y confort logrado en base a la utilización de recursos naturales. Particularmente, un diseño de doble fachada en los frentes que dan al exterior para lograr una cámara de aire que i...
![Figura 1. (a) Prótesis total de rodilla [18]. (b) Representación...](profile/Brenda-Weiss-4/publication/326143862/figure/fig1/AS:644110587293696@1530579339648/Figura-1-a-Protesis-total-de-rodilla-18-b-Representacion-equivalente-en-un_Q320.jpg)
En el estudio de la mecánica de contacto de las articulaciones humanas, la deformación de las superficies en contacto es fundamental porque posibilita un canal por el que fluye el lubricante reduciendo el desgaste. Para determinar la validez de las predicciones de los desplazamientos de estas superficies a partir de distintos métodos, estos se apli...
Cr-Co-Mo (ASTM F75) alloy has been used in the medical environment, but its use as a rigid barrier membrane for supporting bone augmentation therapies has not been extensively investigated. In the present study, Cr-Co-Mo membranes of different heights were placed in New Zealand white, male rabbit tibiae to assess the quality and volume of new bone...
Ventricular assist devices are a technological solution for patients who suffer from cardiac insufficiency and await a transplant. In this work, a new design of an implantable pulsatile blood pump is analyzed in terms of blood damage, by means of finite elements on a simplified geometry. It is a double effect volumetric pump, which has a noncontact...
![Simplified scheme of the bone-remodelling computational model [21]
Note...](publication/315308299/figure/fig2/AS:11431281256797604@1719570943668/Simplified-scheme-of-the-bone-remodelling-computational-model-21-Note-that-for_Q320.jpg)
Bone is a living tissue whose main mechanical function is to provide stiffness, strength and protection to the body. Both stiffness and strength depend on the mineralization of the organic matrix, which is constantly being remodelled by the coordinated action of the bone multicellular units (BMUs). Due to the dynamics of both remodelling and minera...
Values of the parameter of the model presented in supporting information.
(DOCX)
Results of the model by using the Specific Surface from Martin [30] (?srM) and from Adams et al.(2014) measurements (?srAZ), compared with other data from Zioupos et al.[13].
Derivation of different model outputs depending on different inputs for the bone surface density function. Note that the smaller specific surface from Adams et al.[28] implies...
Appendix to the main text describing the early evolution of the model.
(DOCX)
Apparent bone density vs ash density.
Comparison of the model output to recent data in the literature. Measurements extracted from Schileo et al. [38] superimposed to numerical results derived from the present model for (?sr = 150). Note that the ash density is defined as the ratio of mineral mass to the reference bone volume (?mVm/Vt).
(TIF)
Histomorphometry of human elephant and human femoral cancellous samples in comparison.
Plots of Tb.Th, Tb.N, Tb.Sp and BS/TV versus BV/TV. The histomorphometry of these two species is very similar and thus the full ranges of samples used here allowed us to build a more generic model. This model has been validated for the present elephant samples bu...
![Table 1 . Parameters used in the simulations, extracted from [21]....](profile/Peter-Zioupos/publication/315806515/figure/tbl1/AS:667031468785677@1536044103690/Parameters-used-in-the-simulations-extracted-from-21-Parameter-Reference-Range_Q320.jpg)
Bone is a living tissue whose main mechanical function is to provide stiffness, strength and protection to the body. Both stiffness and strength depend on the mineralization of the organic matrix, which is constantly being remodelled by the coordinated action of the bone multicellular units (BMUs). Due to the dynamics of both remodelling and minera...
The lubricated contact zone in a total knee prosthesis is modeled, where femoral and tibial components are supposed to be made of hard materials (high stiffness and hardness) and lubricated by a non Newtonian fluid (synovial liquid). To determine optimal relations among geometric parameters, load and film thickness, a generalized Reynolds equation...
Prosthetic in-contact surfaces wear is one of the main causes of hip replacements fallure. Lubrication is essen- tial to reduce the friction and consequently the wear. A two- dimensional model based on a modified Reynolds equation, was used to aoalyze the lubricated contact In a hypothetical hip prosthesis. It is assumed that prosthesis is made of...
Patients that suffer congestive cardiac insuffi-ciency need to be assisted with assist devices (VAD) as a temporal solution when the cardiac transplantation is not possible. For that reason it is of great interest to know the performance of such devices, especially the potential blood damage that they can produce. In this work, a computational two-...
A preliminary study of a new pulsatile pump that will work to a frequency greater than 1 Hz, is presented. The fluid-structure interaction between a Newtonian blood flow and a piston drive that moves with periodic speed is simulated. The mechanism is of double effect and has four valves, two at the input flow and two at the output flow; the valves...
![Table 1 . Mechanical properties of cortical femur bone [7], where...](profile/Sebastian-Ubal/publication/262892816/figure/tbl1/AS:667860837888017@1536241840853/Mechanical-properties-of-cortical-femur-bone-7-where-directions-correspond-to-the_Q320.jpg)
Hip spacers are temporary implants having a geometry similar to the femoral component of a hip prosthesis, and they are manufactured with antibiotic-impregnated bone cement. The use of spacers in two stage revisions is the most effective treatment to eradicate infections and to avoid limb shortening. The most frequent complication associated with s...
Polyethylene wear of the tibial component is recognized as the main problem limiting the duration of these implants. The difficulty of in vivo measurements of the variables that influence wear, has motivated the numerical study of theoretical models. Previous works focused on studying the lubricant film thickness, the pressure field and friction co...
In this work the dip coating process when an insoluble surfactant is adsorbed at the interface is numerically studied. The work centers in the applicability of the linear approximation usually employed to model the relationship between surface tension and the concentration of the surface active agent. Reported solutions show that film thicknesses p...
Atherosclerosis causes partial or total arterial blockage;
this is the leading cause of death in developed coun-tries. Numerous clinical observations suggest that fluid
dynamics plays an important role in the development
and evolution of this disease.
A research using non-invasive methods allows the
systematic study without exposing people to exper...
La enfermedad cardiovascular (ECV) es la principal causa de morbilidad y mortalidad en
los países occidentales y un problema de salud pública significativo en la mayoría de las naciones
industrializadas. Si bien existen tratamientos para re ducir los efectos de esta enfermedad
frecuentemente a largo plazo la ECV deriva en insuficiencia cardiaca...
Resumen— Cada año se realizan alrededor de 500.000 artroplastias o reemplazos totales de cadera en el mundo, de las cuales entre el 1 y el 4% de los casos se observan complicaciones por infección. La artroplastia de revisión en dos tiempos consiste en la colocación de un espaciador de polimetilmetacrilato (PMMA) inpregnado de antibióticos en el int...
This work addresses the problem of heat transfer through the roof of a family home with the purpose of improving air-conditioning energy savings during hot summer days. To this end, the air natural convection in a right-angle triangular cavity, resembling an attic, is numerically analyzed. The air cavity is assumed as naturally ventilated through t...
Tibial component of knee prostheses, made of ultra high molecular weight polyethylene (UHMWPE), experiences a high degree of wear and may be expected to last twelve years on average. In this work, a steady state one-dimensional lubrication model of a knee prosthesis is solved through a nu-merical technique based on the Finite Element Method. The mo...
Polyethylene (UHMWPE) wear in current knee prosthesis causes prosthesis loosening after no more than 15 years. In this work, a steady state one-dimensional lubrication model with non- Newtonian fluid, porous elastic layer on tibial component, ultra-filtration mechanism of fluid and some features of the surface roughness is studied through a numeric...
Los catéteres angioplásticos son ampliamente utilizados en el diagnóstico y tratamiento de la patología ateroesclerótica. Este tipo de afección del aparato circulatorio consiste en la reducción localizada del calibre de algunos vasos sanguíneos (en general arterias) como consecuencia de la acumulación de distintas sustancias y tipos celulares en la...
The tibial component of current knee prostheses made of ultra high molecular weight polyethylene (UHMWPE) has a high degree of wear that causes knee inflammation, prosthesis loosening and subsequent replacement in not more than 15 years. In order to know which UHMWPE material properties have more influence on wear, a steady state lubrication model...
RESUMEN La ateroesclerosis provoca obstrucción parcial o total de arterias, constituyéndose en una de las principales causas de decesos en los países desarrollados. Numerosas observaciones clínicas indican que la fluidodinámica juega un papel importante en el desarrollo y evolución de esta patología. La investigación mediante métodos no invasivos p...
Palabras claves: Elementos finitos, prótesis de cadera, desgaste, sustrato poroso. 1 INTRODUCCIÓN Ante un estado de movimiento pleno y bajo la acción de cargas, la articulación de la cadera humana permite el movimiento relativo entre los huesos que la componen con un mínimo de fricción entre las superficies en contacto. De esta manera, se preserva...
