Md Jasim Uddin

University of Malaya | UM · Department of Pharmacy

Host‐directed therapies (HDTs) have emerged as a promising strategy to combat viral infections by modifying host factors and immune responses to restrict viral replication and improve patient outcomes. This review summarizes the latest advances and future potential of HDTs in antiviral therapy. With developments in genomics and proteomics, new host...

Transdermal microneedles have demonstrated promising potential as an alternative to typical drug administration routes for the treatment of various diseases. As microneedles offer lower administration burden with enhanced patient adherence and reduced ecological footprint, there is a need for further exploitation of microneedle devices. One of the...

A groundbreaking nanotechnology is promised by the exosome application in brain disorder treatments due to its phenomenal characteristic of being able to cross the blood-brain barrier (BBB), along with greater biocompatibility, low immunogenicity, and minimal side effects. Exosomes are involved in intracellular communication as they are noted to be...

The use of data-driven high-throughput analytical techniques, which has given rise to computational oncology, is undisputed. The widespread use of machine learning (ML) and mathematical modeling (MM)-based techniques is widely acknowledged. These two approaches have fueled the advancement in cancer research and eventually led to the uptake of telem...

Skin wrinkles are an inevitable phenomenon that is brought about by aging due to the degradation of scleroprotein fibers and significant collagen reduction, which is the fundamental basis of anti-wrinkle technology in use today. Conventional treatments such as lasering and Botulinum toxin have some drawbacks including allergic skin reactions, cumbe...

3D printing (3DP) is a manufacturing technology that produces 3D objects from a design file using layer-by-layer deposition of material. It has already found applications in the healthcare and pharmaceutical industries, while its use in the field of topical delivery has been extensively studied in the last two decades. The aim of this study is to p...

Over the last 10 years, inkjet printing technologies have advanced significantly and found several applications in the pharmaceutical and biomedical sector. Thermal inkjet printing is one of the most widely used techniques due to its versatility in the development of bioinks for cell printing or biosensors and the potential to fabricate personalize...

Microneedle (MN) is a third-generation advanced drug delivery strategy for the skin. It can overcome the limitations for both additional transdermal patches (e.g., low absorption or permeability) and injections (e.g., less patient compliance due to painful administration). The main objective of this research is to establish the advanced 3D printed...

In this study, we have employed Digital Light Processing (DLP) printing technology for the fabrication of solid microneedle (MN) arrays. Several arrays with various geometries, such as cones, three-sided pyramids and four-sided pyramids, with different height to aspect ratios of 1:1, 2:1 and 3:1, were printed. Post-processing curing optimizations s...

To prevent the coronavirus disease 2019 (COVID-19) pandemic and aid restoration to pre-pandemic normality, global mass vaccination is urgently needed. Inducing herd immunity through mass vaccination has proven to be a highly effective strategy for preventing the spread of many infectious diseases, which protects the most vulnerable population group...

The ongoing search for biodegradable and biocompatible microneedles (MNs) that are strong enough to penetrate skin barriers, easy to prepare, and can be translated for clinical use continues. As such, this review paper is focused upon discussing the key points (e.g., choice polymeric MNs) for the translation of MNs from laboratory to clinical pract...

In recent years, we have observed a technology revolution in healthcare monitoring through the development of intelligent systems for vital signal monitoring. Sensors attached to computer-aided software can be used to track the activity of the medical devices, especially for chronic patients by providing high-quality data. Designing of personalized...

The long-term presence of stents can cause in-stent restenosis, up to 30% of cases of cardiac diseases, and this can be life-threatening. The next frontier for this is the multidisciplinary approach to nanotechnology and biotechnology. Moreover, Three-dimensional (3D) printing is an additive manufacturing technique that holds great significance in...

The emergence of transdermal drug delivery via hollow microneedles (MNs) can be used to combat the challenge of low permeability of drug molecules across the stratum cornuem and to tackle the challenge of trypanophobia which often hinders the adherence of the patient to the treatment regimen. In this current study, the 3D printed hollow MNs were fa...

The advancement of drug delivery devices is critical for the individualization of patient treatment and the improvement of healthcare. Here, we introduce the 3DMNMEMS, a novel device that combines 3D printing, microneedles (MNs) and Microelectromechanical Systems (MEMS), allowing versatile and controllable by the user transdermal drug delivery. Hol...

3D printed transdermal microneedles (MNs) are considered to be minimally invasive, painless devices that directly reach the upper portion of the dermis to administer small molecules, DNA, oligonucleotides, vaccines, hormones etc. 3D printed MN arrays were fabricated using a biocompatible resin through stereolithography (SLA) for the transdermal ins...

In the recent era, the novel percutaneous coronary intervention is bio-inspired stents due to the increasing demand for personalized devices in the treatment of atherosclerosis. Technologically engineered biodegradable 4-dimensional (4D) stents for atherosclerosis treatment have become a demanding area of research. However, the long-term existence...

Topical formulations are evidenced to be safe with improved patience compliance, but limits in the efficacy due to low penetration ability through SC. Moreover, injections are painful which increase the concern for needlephobia. To address these issues, microneedles (MNs) that can pierce the skin have been conceptualized and developed. To address t...

In this study, novel 3D printed polymeric microneedle arrays were fabricated for enhanced cisplatin delivery to A-431 epidermoid skin tumours for cancer treatment. The microneedles were built by selectively photopolymerising consecutive layers of a biocompatible photopolymer resin using stereolithography (SLA), followed by coating of cisplatin form...

Introduction: Transdermal microneedles (MNs) are microsized, minimally invasive, puncturing devices, that directly reach the dermal microcirculation to administer molecules, DNA, vaccines, hormones etc. painlessly. Microelectromechanical systems (MEMS) combine numerous advantages for drug delivery applications since they allow the spatiotemporal an...

3D printed microneedle arrays were fabricated using a biocompatible resin through stereolithography (SLA) for transdermal insulin delivery. Microneedles were built by polymerising consecutive layers of a photopolymer resin. Thin layers of insulin and sugar alcohol or disaccharide carriers were formed on the needle surface by inkjet printing. The op...

Introduction: The rare, often neglected, and incurable Niemann-Pick type C (NPC) disease is alysosomal storage disorder that occurs in many communities across the world, affecting largely youngsters. The slow neurodegeneration caused by this disease is the primary and eventual cause of death for NPC patients in most cases. Since NPC still remains...

Transmucosal buccal drug delivery system is considered as a future drug delivery technology, always assist to enhance patient compliance mainly for paediatric and geriatric community. The studies aim to develop buccal delivery for delivering a hydrophilic drug, flucloxacillin sodium, across the mucosal route. The buccal films are comprised of a bio...

Repetitive administrations of subcutaneous injection to the skin are painful for diabetic patients. Recently in 2017, Regulatory authority of US Food Drug and Administration has approved the microneedle device for the delivery of a wide range of pharmaceutical active ingredients to the patients. The aim of the research was to develop a painless met...

Microneedle (MN) is the latest generation of transdermal drug delivery system composed of micron-sized needles for the delivery of a wide range of biopharmaceuticals. In the recent era, MN provides a great flexibility toward the development of non-invasive insulin therapy by enhancing the transport of drug across the barrier stratum corneum. MN-med...

Transdermal drug delivery could be a better alternative to oral delivery as it has the advantages of better patient compliance. This study concentrates on developing a transdermal patch for prednisolone that will provide sustained release of the drug in patients. Prednisolone is a corticosteroid (model drug) that is used in inflammatory conditions,...

Latest developments in drug delivery technologies always facilitate the advanced drug delivery strategies across the mucosal layer of the oral cavity. Drug delivery via gingival route is one of the alternative for replacing oral drug delivery or painful injections. The objective of the research was to develop and characterise fluconazole loaded gin...

Transmucosal buccal drug delivery system is considered as a future drug delivery technology, always assist to enhance patient compliance mainly for paediatric and geriatric community. The studies aim to develop buccal delivery for delivering a hydrophilic drug, flucoxacillin sodium, across the mucosal route. The buccal films comprised of a bio-adhe...