Md. Moklesur Rahman Sarker

Md. Moklesur Rahman Sarker
State University of Bangladesh | SUB · Department of Pharmacy

Post Doctoral Fellow (Diabetes Research), Ph D (Immunopharmacology), M Pharm (Ethnopharmacology), B Pharm (Hons)
Looking for research collaborators and research positions in USA/Canada

About

122
Publications
150,698
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1,211
Citations
Introduction
I have 21 years of teaching and research experience in Pharmaceutical Sciences. I am experienced with the supervision of PhD, Master and funded research projects. I have registered with 3 patents on Antidiabetic, Anticancer and Immunomodulating alternative medicines. Research interests: Diabetes & anti-diabetic agents, Anticancer agents, Immunomodulants, Prophetic Medicines, Functional Foods & Nutraceuticals, Herbal medicines, Lipid-lowering agents, Complementary & Alternative Medicines
Additional affiliations
January 2017 - present
State University of Bangladesh
Position
  • Head of Department
Description
  • I have been working as a Professor and Head of Academic and Research Affairs in the Department of Pharmacy in State University of Bangladesh since January 2017
December 2014 - March 2016
Lincoln University College, Malaysia
Position
  • Associate Professor and Chair, Department of Pharmacology
December 2014 - November 2016
Lincoln University College, Malaysia
Position
  • Head of Department
Education
August 2013 - November 2014
University Malaya
Field of study
  • High Impact Research on Diabetes
April 2007 - March 2010
Okayama University
Field of study
  • Major: Immunopharmacology (Pharmaceutical Sciences)
January 1998 - February 2001
Jahangirnagar University
Field of study
  • Pharmacy

Publications

Publications (122)
Article
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Drowning is one of the major public health concerns, and children are the most vulnerable victims of drowning death in Bangladesh, which has been a paramount threat to child survival. Based on available data, we intend to underline the prevalence and associated risk factors for child drowning deaths in Bangladesh. According to the Center for...
Article
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Gynura nepalensis D.C. (family: Asteraceae) has abundant uses in the alternative medicinal practice, and this species is commonly used in the treatment of diabetes, rheumatism, cuts or wounds, asthma, kidney stones, cough, urinary tract bleeding, gall bladder stones, hepatitis, diarrhea , hemorrhoids, constipation, vomiting, fertility problems, blo...
Article
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Objectives: This current study aims to assess the prevalence and factors associated with body mass index (BMI), dietary patterns, and the extent of physical activities among university students following the prolonged coronavirus disease 2019 (COVID-19) lockdown in Bangladesh. Methods: A cross-sectional web-based survey was conducted between July...
Article
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Objectives The study aimed to synthesize and evaluate the potential anti-inflammatory and analgesic activities of rationally designed hybrid molecules of imidazolone and indole nuclei linked through a methylene bridge. Methods Indolyl-imidazolone hybrids were synthesized in three simple steps starting from 2-phenyl-1H-indole (1). In the first step...
Article
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Diabetes, a chronic physiological dysfunction affecting people of different age groups and severely impairs the harmony of peoples' normal life worldwide. Despite the availability of insulin preparations and several synthetic oral antidiabetic drugs, there is a crucial need for the discovery and development of novel antidiabetic drugs because of th...
Article
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Severe session jam phobia (SJP), the extent of underprivileged online education, and subsequent mental health disorders among students have emerged as distinguished global problems due to the overwhelming effects of coronavirus disease 2019 (COVID-19). The purpose of this research was to evaluate the impact of extended COVID-19 lockdown and its med...
Article
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The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has been a healthcare disaster because of the unique and distinct characteristics of the pathogen, the easy and rapid transmission of the virus from humans to humans, the challenges in diagnosis and confirmation of the disease and the inability to invent and distribute safe and effective drugs...
Article
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Coriandrum sativum (C. sativum), belonging to the Apiaceae (Umbelliferae) family, is widely recognized for its uses in culinary and traditional medicine. C. sativum contains various phytochemicals such as polyphenols, vitamins, and many phytosterols, which account for its properties including anticancer, anti-inflammatory, antidiabetic, and analges...
Article
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Vaccine willingness among the mass populace, as well as their proper knowledge and perception regarding vaccines and the vaccination process, may contribute extensively towards attaining their anticipated vaccination rates. The current study endeavored to ascertain the Bangladeshi population’s knowledge, perception, and willingness towards COVID-19...
Article
Several theories for aging are constantly put forth to explain the underlying mechanisms. Oxidative stress, DNA dysfunction, inflammation, and mitochondrial dysfunction, along with the release of cytochrome c are some of these theories. Diseases such as type 2 diabetes mellitus, intestinal dysfunction, cardiovascular diseases, hepatic injury, and e...
Article
A novel polysaccharide obtained from Enteromorpha prolifera (EPP) was purified through diethylaminoethyl cellulose-52 and Sephadex G-75 chromatography. Fourier transform infrared spectroscopy, high-performance liquid chromatography, and nuclear magnetic resonance (NMR) spectroscopy were employed to analyse the structure of EPP. It mainly comprised...
Article
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Nigella sativa L. is one of the most extensively used traditional medicinal plants. This widely studied plant is known to display diverse pharmacological actions, including antimicrobial activities. Current literature has documented its multi-target mode of antimicrobial actions. N. sativa or its bioactive compounds, such as thymoquinone, can induc...
Article
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Citrus grandis or Citrus maxima, widely recognized as Pomelo is widely cultivated in many countries because of their large amounts of functional, nutraceutical and biological activities. In traditional medicine, various parts of this plant including leaf, pulp and peel are used for generations as they are scientifically proven to have therapeutic p...
Article
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Aristolochic acid (AA) is an abundant chemical substance commonly present in the genus, Aristolochia. In term of stereoisomerism, Aristolochic acid I (AA-I) is known to cause nephrotoxicity, genotoxicity, and carcinogenicity. Therefore, the determination of AA-I in the herbal products is imperative to avoid the unwanted adverse drug reaction. Hence...
Article
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Background: The Oxford-AstraZeneca vaccine (Covishield) was the first to be introduced in Bangladesh to fight the ongoing global COVID-19 pandemic. As this vaccine had shown some side-effects in its clinical trial, we aimed to conduct a study assessing short-term adverse events following immunization (AEFIs) in Bangladesh. Method: A cross-sectio...
Article
Background: The Oxford–AstraZeneca vaccine (Covishield) was the first to be introduced in Bangladesh to fight the ongoing global COVID-19 pandemic. As this vaccine had shown some side effects in its clinical trial, we aimed to conduct a study assessing short-term adverse events following immunization (AEFIs) in Bangladesh. Method: A cross-sectional...
Article
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COVID-19, transmitted by SARS-CoV-2, is one of the most serious pandemic situations in the history of mankind, and has already infected a huge population across the globe. This horrendously contagious viral outbreak was first identified in China and within a very short time it affected the world’s health, transport, economic, and academic sectors....
Article
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SARS-CoV-2 is the latest worldwide pandemic declared by the World Health Organization and there is no established anti-COVID-19 drug to combat this notorious situation except some recently approved vaccines. By affecting the global public health sector, this viral infection has created a disastrous situation associated with high morbidity and morta...
Article
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Background Colocasia gigantea , locally named as kochu is well-known due to its various healing power. This research is to investigate the antidiarrheal, antimicrobial and antioxidant possibilities of the methanol soluble extract of Colocasia gigantea . Methods The antidiarrheal investigation was performed by using in vivo castor oil-induced diarr...
Article
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Dengue, a very widespread mosquito-borne infectious disease caused by Aedes aegypti virus, has been occurring during the monsoons every year. The prevalence and incidence of dengue fever and death due to its complications have been increased drastically in these recent years in Bangladesh, Philippines, Thailand, Brazil, and India. Recently, dengue...
Article
Herbal products are used globally for their perceived health benefits, and as a complement to alternative therapy to Western medicines. Herbal products can be beneficial, although they can also be harmful in several circumstances. Aristolochic acids (AA) are a compound that is abundant in Aristolochia plants. Previous studies have reported that AAs...
Article
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Immunostimulants are greatly required for the upregulation of immunity to fight against viral and bacterial infections and cancers. Bell peppers (Capsicum annuum L.), eaten as vegetables, are rich sources of vitamin C and E, provitamin A, β-carotene, and numerous phenolic compounds. Antimicrobial, antioxidant, anti-mutagenic and anti-inflammatory p...
Article
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Clinical characteristics are essential for the correct diagnosis of diseases. The current review aimed to summarize the global clinical characteristics of the COVID-19 patients systematically and identify their diagnostic challenges to help the medical practitioners properly diagnose and for better management of COVID-19 patients. We conducted a sy...
Article
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Neurodegenerative diseases (ND) can be characterized by degradation and subsequent loss of neurons. ND has been identified as the leading cause of disability-adjusted life years (DALYs) worldwide and is associated with various risk factors such as ageing, certain genetic polymorphisms, inflammation, immune and metabolic conditions that may induce e...
Article
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Background Various parts i.e., stem bark, leaf, root and flower of Neolamarckia cadamba (Roxb.) Bosser has been extensively used by traditional practitioners to treat all types of diabetes. Our present study investigated the antidiabetic property of the extract from its flower and evaluated its traditional use for diabetes. Results Phenolic conten...
Article
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citation: Ullah K, Sarker MDMR, Khan MS, Mustapha MS, Ullah MK.Anti-diabetic Activity of Compound "2-[(trimethylsilyl) oxy]-Methyl Ester (cas) Methyl-o-trim-ethyl-silylsalicylate" Isolated from Pericampylus glaucus(Lam) Merr in STZ-Induced Diabetic Rats. J Basic Clin Pharma 2017;8:68-73. This is an open access article distributed under the terms of...
Article
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Aims: The aim of this study was to determine the dispensing errors that occurred during the dispensing process in a selected community pharmacies in the capital Sana'a, Yemen. Methodology: A prospective study was conducted among community pharmacies in the capital Sana'a, Yemen over three months period from mid-January till mid-April 2017. Dispensi...
Article
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Growing evidence showed the increased prevalence of cancer incidents, particularly colorectal cancer, among type 2 diabetic mellitus patients. Antidiabetic medications such as, insulin, sulfonylureas, dipeptyl peptidase (DPP) 4 inhibitors and glucose-dependent insulinotropic peptide (GLP-1) analogues increased the additional risk of different cance...
Article
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Gymnema sylvestre is a plant included in Apocynaceae family and is located in many regions of Asia, Africa and Australia. This plant is widely used as a traditional therapy for different purposes. Even now it is being used as a dietary supplement due to its numerous therapeutic uses. It is known to have blood glucose lowering potential and, thus, i...
Article
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Counterfeit and substandard medicines are recognized as one of serious threats to public health. The product quality of antibacterial medicine will compromise patients’ recovery and increase the chance of antibacterial resistance. The review aims to provide a summary of low quality levofloxacin issues and the risk factors as well as suggesting the...
Article
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Background: It has been observed that the various part of Baccaurea ramiflora plant is used in rheumatoid arthritis, cellulitis, abscesses, constipation and injuries. This plant also has anticholinergic, hypolipidemic, hypoglycemic, antiviral, antioxidant, diuretic and cytotoxic activities. The present studyaimed to assess the cytotoxic, analgesic,...
Article
GFP-N, a novel heteropolysaccharide with a molecular weight of 1.26 × 10 ⁷ Da, was isolated from maitake mushroom and purified by anion-exchange chromatography on a DEAE cellulose-52 column and gel-filtration chromatography on a Sephadex G-100 column. Its structure was characterized by Fourier transform infrared spectroscopy and one-dimensional ( ¹...
Article
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Uncontrolled hyperglycaemia can lead to macro- and microvascular complications. Adolescents with T2DM develop similar complications as in adults, including cardiovascular disease, stroke, myocardial infarction, renal insufficiency, and chronic renal failure. Although regular medical follow-up is essential to avoid long-term complications, patients...
Article
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Polymethoxylavones (PMFs) are known to exhibit significant anti-inflammatory and neuroprotective properties. Nicotiana plumbaginifolia, an annual Bangladeshi herb, is rich in polymethoxyflavones that possess significant analgesic and anxiolytic activities. The present study aimed to determine the antinociceptive and neuropharmacological activities...
Article
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Background: It has been observed that the various part of Baccaurea ramiflora plant is used in rheumatoid arthritis, cellulitis, abscesses, constipation and injuries. This plant also has anticholinergic, hypolipidemic, hypoglycemic, antiviral, antioxidant, diuretic and cytotoxic activities. The present studyaimed to assess the cytotoxic, analgesic...
Article
Despite various anticancer reports, antiproliferative and apoptosis inducing activity of citral in HCT116 and HT29 cells have never been reported. This study aimed to evaluate the cytotoxic and apoptosis inducing effects of citral in colorectal cancer cell lines. The citral-treated cells were subjected to MTT assay followed by flow cytometric Annex...
Article
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The increase in Muslim parents’ refusal and hesitancy to accept childhood vaccination was identified as one of the contributing factors in the increase of vaccine-preventable diseases cases in countries such as Afghanistan, Malaysia and Pakistan. The spread of inaccurate and irresponsible information by the antivaccination movement may inflict more...
Article
Amounting scientific evidences have revealed the antitumor, antimetastatic, antiangiogenic, antiproliferative, chemopreventive and neo-adjuvant efficacy of Prophetic Medicine in various in vitro, in vivo and clinical cancer models. Prophetic Medicine includes plants, dietary materials or spices that were used as remedy recipes and nutrition by the...
Article
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Microbial anti-cancer enzymes have been proven to be effective and economical agents for cancer treatment. Aeromonas veronii has been identified as a microorganism with the potential to produce L-glutaminase, an anticancer agent effective against acute lymphocytic leukaemia. In this study, a selective medium of Aeromonas veronii was used to culture...
Data
Complete genome of Aeromonas veronii strain TH0426. The complete genome of Aeromonas veronii TH0426 consists of 4923009 nucleotide base pairs. (PDF)
Article
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Ciprofloxacin, a second-generation broad spectrum fluoroquinolone, is active against both Gram-positive and Gram-negative bacteria. Ciprofloxacin has a high oral bioavailability and a large volume of distribution. It is used for the treatment of a wide range of infections including urinary tract infections caused by susceptible bacteria. However, t...
Article
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Female sex workers are usually at high risk of transmission of HIV/AIDS. The aim of the study was to identify factors related to HIV testing behavior among FSWs in Rajshahi city, Bangladesh. A cross-sectional survey was conducted on 200 FSWs. The present study revealed that sixty-eight percent of FSWs in Rajshahi city have been tested for HIV. It w...
Article
Ethnopharmacological relevance: Clinacanthus nutans (Burm. f.) Lindau, a widely used medicinal plant, is extensively grown in tropical Asia and Southeast Asian countries. C. nutans, with its broad spectrum of pharmacological activities, has been traditionally used to treat cancer, inflammatory disorders, diabetes, insect bites, and skin problems,...
Article
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Background Type 2 diabetes mellitus (T2DM) is associated with hyperglycemia, inflammatory disorders and abnormal lipid profiles. Several functional foods have therapeutic potential to treat chronic diseases including diabetes. The therapeutic potential of pomegranate has been stated by multitudinous scientists. The present study aimed to evaluate t...
Article
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Glutathione is a potent antioxidant as well as has important role for DNA synthesis and repair, protein synthesis, amino acid transport, and enzyme activation. Besides this, Glutathione products are now mainly selling as whitening agent which are mainly marketing through social media (Facebook) and different websites. Information is not available w...
Article
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Labisia pumila is a traditional medicinal plant which has wide therapeutic application including induction of labor and treatment of dysentery, dysmenorrhea and gonorrhea. We aimed for systematic review of the efficacy andsafety of L. pumila extract or its other commercial products availabe in Malaysian market. The marketed 500 mg capsule is compos...
Article
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Objective: This study was designed to elucidate the acute and sub acute toxicity of the widely used plant Brassica oleracea var. Italica in SD rats. Method: Ethanolic extract isolated from the Brassica oleracea var. Italica was taken and their toxic effects were studied. Acute, sub acute and LD50 values were determined in experimental rats accordin...
Article
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Objective: To assess the immunopotentiality of Ayurvedic polyherbal preparations, “Saribadi” and “Anantamul Salsa”. Methods: Freshly prepared BALB/c mice splenocytes were cultured with “Saribadi” or “Anantamul Salsa” treatment [doses of 0.25%, 0.50%, 0.75%, 1.00%, 1.50%, 2.00%, 3.00% and 4.00% (v/v)] at 37 °C for 5 days. The immunoglobulin M (IgM)...
Article
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Now-a-days functional foods are considered as the most convenient means for the prevention and management of chronic diseases with minimal or no side effects. Brassica oleracea var. Italica (family Brassiceae) is a popular dietary vegetable eaten all over the world. It has been reported to exhibit antimicrobial and anticancer properties but antidia...
Article
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Drug counterfeiting and production of substandard drug is a global problem. Substandard or counterfeit drugs are threat for the effective treatment of diseases and highly worsen the quality of life of patients. This study was aimed to assess the pharmaceutical quality of ranitidine hydrochloride tablets manufactured in Bangladesh. Tablets were coll...