Md. Mizanur Rahman Moghal

Mawlana Bhashani Science and Technology University | MBSTU · Department of Pharmacy

The mechanism of entry of cell-penetrating peptides (CPPs) into the cytosol of various cells has been studied by examining the interaction of CPPs with lipid bilayers and their entry into lipid vesicle lumens using various methods. Here we describe a single giant unilamellar vesicle (GUV) method to study CPPs. In this new method, we use GUVs contai...

Objective: This study is aimed to identify the awareness and behavioral perspective on COVID-19 between urban and rural people of Bangladesh during the period of outbreak. Methods: A community-based cross-sectional descriptive study was conducted in 30 districts of Bangladesh, where 322 participants from urban and 312 from rural area. Participants...

Aim: This study is aimed to identify the awareness and behavioral perspective on COVID-19 between urban and rural people of Bangladesh during the period of outbreak. Methods: A community-based cross-sectional descriptive study was conducted in 30 districts of Bangladesh, where 322 participants from urban and 312 from rural area. Participants were s...

Though the prevalence of autism spectrum disorder (ASD) is increasing day by day, there is still a lack of a proper way to diagnose or prevent ASD. There is no study carried out in the Bangladeshi children with ASD to evaluate the association of Transferrin ( TF ) and Transcription Factor 4 ( TCF4 ) genetic polymorphisms. This genetic association s...

Aim This study is aimed to identify the awareness and behavioral perspective on COVID-19 between urban and rural people of Bangladesh during the period of outbreak. Methods A community-based cross-sectional study was conducted in 30 districts of Bangladesh, where 322 participants from urban and 312 from rural area. Participants were selected throu...

Objective: Cervical cancer is a gynecological health problem, affecting nearly 500,000 women each year worldwide. Genome-wide association studies have revealed multiple susceptible genes and their polymorphisms for cervical carcinoma risk. We have carried out this case-control study to investigate the association of INSIG2 rs6726538 (A; T), HLA-DR...

The effect of membrane potential on plasma membrane damage generated by antimicrobial peptides (AMPs) is an important, yet poorly characterized, process. Here, we studied the effect of membrane potential (φm) on pore formation by magainin 2 (Mag) in single giant unilamellar vesicles (GUVs) composed of dioleoylphosphatidylglycerol (DOPG)/dioleoylpho...

The entry of cell-penetrating peptides (CPPs) into live cells and lipid vesicles has been monitored using probe (e.g., fluorescent dye)-labeled CPPs. However, probe-labeling may alter the interaction of CPPs with membranes. We have developed a new method to detect the entry of non-labeled CPPs into the lumens of single giant unilamellar vesicles (G...

Membrane potential plays various key roles in live bacterial and eukaryotic cells. So far, the effects of membrane potential on action of antimicrobial peptides (AMPs) and cell-penetrating peptides (CPPs) have been examined using cells and small lipid vesicles. However, due to the technical drawbacks of these experiments, the effect of membrane pot...

Cell-penetrating peptides (CPPs) have an activity to translocate across plasma membranes to enter cytosol of eukaryotic cells without decreasing cell viability. To reveal the mechanism of their translocation, we examined the effect of membrane potential, φm, on the entry of a CPP, transportan 10 (TP10) into the lumen of single giant unilamellar ves...

Cell-penetrating peptides (CPPs) can translocate across plasma membranes to enter the cytosol of eukaryotic cells without decreasing cell viability. We revealed the mechanism underlying this translocation by examining the effect of membrane potential, φm, on the entry of a CPP, transportan 10 (TP10), into the lumen of single giant unilamellar vesic...

Lactoferricin B (LfcinB) is a cationic antimicrobial peptide, and its capacity to damage the bacterial plasma membrane is suggested to be a main factor in LfcinB's antimicrobial activity. However, the specific processes and mechanisms in LfcinB-induced membrane damage are unclear. In this report, using confocal laser-scanning microscopy, we examine...

For antimicrobial peptides (AMPs) with antimicrobial and bactericidal activities and cell-penetrating peptides (CPPs) with activity to permeate through plasma membrane, their interactions with lipid bilayer region in plasma membrane play important roles in these functions. However, the elementary processes and mechanisms of their functions have not...

Background and objectives: Obesity is associated with metabolic dysfunction and over nutrition. Increased body mass index and obesity are strongly amalgamated with changes in the physiological function of adipose tissue, leading to altered secretion of adipocytokines, inflammatory mediators release as well as chronic inflammation and insulin resis...

Using ramipril as a model active pharmaceutical ingredient, the focus of the present study was to fabricate low-cost controlled release tablets using combinations of biopolymer and semi-synthetic polymers. Cellulose derivatives are more viscous where biopolymers form gels more easily. Xanthan gum can’t shape a solid gel, result in fragmentation of...

Entry of cell-penetrating peptides (CPPs) into living cells by translocating across plasma membranes is an important physiological phenomenon. To elucidate the mechanism of the translocation of CPPs across lipid bilayers, it is essential to reveal its elementary processes. For this purpose, here, we have developed a new method for the continuous, q...

Mastitis is an important constraint that accounts for high economic loss in dairy farms across the world. The prevalence and distribution of mastitis in dairy cows in Bangladesh is well-documented while most of thesefarms are confronted with problems of clinical and subclinical mastitis. This research was conducted to assess the rapid detection of...

Objective: The present epidemiological study was conducted with the objectives of providing an insight into the current use of antidiabetic medications to diabetics and hypertensive diabetics in urban areas and determining how the patient factors influence the prescribing of antidiabetic medications. Methodology: Data of patients of past two years...

Mastitis is an important constraint that accounts for high economic loss in dairy farms across the world. The prevalence and distribution of mastitis in dairy cows in Bangladesh is well-documented while most of these farms are confronted with problems of clinical and subclinical mastitis. This research was conducted to assess the rapid detection of...

To cite this paper : Rahamana, M.S., Rahman, M.M., Moghal, M.M.R., Rakib, T.M. and A.M.A.M.Z. Siddiki,. 2017. Characterization of bacteria causing bovine mastitis by amplified ribosomal DNA restriction analysis (ARDRA) method. Mastitis is an important constraint that accounts for high economic loss in dairy farms across the world. The prevalence an...

p>The objective of this study was to analysis in vitro release kinetics of Azithromycin from bi-layer tablets prepared by direct compression using high viscosity to low viscosity grades of hydroxypropyl methyl cellulose (HPMC K15M, HPMC K4M, HPMC 50 cps), Carbopol 934p and Carbopol 974p. In addition, it also includes evaluating the effect of formul...

Objectives: The present study was intended to investigate possible phytochemical nature (group determinant of plant extract) and to reveal in-vitro thrombolytic, membrane stabilizing and cytotoxic activities of crude methanolic extracts of Bruguiera cylindrica leaves. Methods: Collected plant parts were cleaned, dried, and ground to obtain powdery...

Objectives: The present study was intended to investigate possible phytochemical nature (group determinant of plant extract) and to reveal in-vitro thrombolytic, membrane stabilizing and cytotoxic activities of crude methanolic extracts of Bruguiera cylindrica leaves. Methods: Collected plant parts were cleaned, dried, and ground to obtain powdery...

The present study was cherished to investigate in vitro thrombolytic, membrane stabilizing and antibacterial activities of Allamanda neriifolia and Aegialitisrotundifolia. Different types methanolic extracts of these two medicinal plants were tested for determining membrane stabilizing activity at a hypotonic solution and heat induce condition by c...

Aim: The present study was commenced to investigate the methanolic extracts of Launaea sarmentosa (Willd.) and Bruguiera cylindrical (L.) for antibacterial properties. Launaea sarmentosa (Willd.) is a plant of Asteraceae family while Bruguiera cylindrical (L.) belongs to the family of Rhizophoraceae. Materials and Method: The study was performed by...

Objectives: The present study was intended to investigate possible phytochemical nature (group determinant of plant extract) and to reveal in-vitro thrombolytic, membrane stabilizing and cytotoxic activities of crude methanolic extracts of Bruguiera cylindrica leaves. Methods: Collected plant parts were cleaned, dried, and ground to obtain powdery...

p>The objective of the current study was to develop a bilayer tablet of Azithromycin containing both immediate and sustained layer and evaluate the effect of formulation variables on drug release. Thirty different formulations (F-1 to F-30) were prepared by direct compression. When the fraction of polymer was increased from 5.55% to 10%, the rate o...

In this study textile industry effluents was physico-chemically analyzed and their effect on seed germination and seedling growth of some important crops like Ridge Gourd, Amarnaths, Black Gram and Black Mustard were studied. The Textile industry effluent was collected from Tusuka jeans limited which is situated at Konabari, Gajipur. Concentrations...

In the present study, a phytochemical investigation has been carried out for isolation and characterization of chemical constituents from the leaves of Malva verticillata L. The powder of dried leaves of Malva verticillata L. was extracted with petroleum ether and ethyl acetate. Attempt has been taken for isolation of compounds from petroleum ether...

Excoecaria agallocha plant (Leaves) was analyzed to explore in-vitro antimicrobial and membrane stabilizing activities as a crude methanolic extract. Antimicrobial activity was performed against a wide range of Gram positive (+Ve) and Gram negative (-Ve) bacteria by using disc diffusion method and various methanolic extracts of leaves of E.agalloch...

Crude methanolic extracts of Crinum latifolium plant (Leaves) was assayed to identify various pharmacological properties. Antimicrobial potential of crude methanolic extracts of C. latifolium was accomplished by most commonly used disc diffusion method against a wide range of Gram positive (+ve) and Gram negative(-ve) bacteria. Extracts showed slig...

This study was carried out to evaluate the thrombolytic and membrane stabilizing activities of Launaea sarmentosa plants. The crude methanolic extract of L. sarmentosa (whole plants) was investigated for in vitro thrombolytic and membrane stabilizing activities at five different concentrations of 2, 4, 6, 8 and 10 mg/ml respectively. In case of thr...

p>The study was carried out to evaluate the release modification of indomethacin press coated tablets through different polymers. Several batches of press coated tablets were prepared with indomethacin and Avicel PH 102. The core tablet was compression coated with minimal compression pressure. Formulation IX was modified by incorporating PEG 6000,...

p> Amorphophallus campanulatus (Roxb.) , Avicennia marina (Forssk.) and Launaea sarmentosa (Willd.) are widely used plants in Asian folk and traditional medicines. In the present study, we have tried to find out the phytoconstituents, anthelmintic activity and cytotoxicity of the methanolic extracts of these plants. Anthelmintic activity was assess...

Objectives To assess community pharmacists’/ pharmacy technicians’ knowledge and perceptions about adverse drug reactions and barriers towards the reporting of such reactions in Dhaka, Bangladesh. Method A cross-sectional study was planned to approach potential respondents for the study. A self-administered questionnaire was delivered to community...

The present study was commenced to judge ethnomedicinal worth of the plant. We tried to analyze in vitro thrombolytic and membrane stabilising activities of methanolic extracts of Avicennia marina. Crude methanolic extracts of A. marina leaves & barks at numerous conc. were used for in vitro thrombolytic and membrane stabilising activities. Just in...

The present study was commenced to investigate the methanolic extracts of Avicennia marina for antimicrobial screening. A. marina is a plant of Acanthaceae family. The methanolic extracts of A. marina produced good antimicrobial activity against Gram negative (-ve) bacteria & was resistant against Gram positive (+ve) bacteria. The study was perform...

p>The main objective of the study was to formulate fast dissolving tablets of allopurinol to achieve better dissolution rate and further improving the bioavailability to provide a quick onset of action. Nine formulations of fast dissolving tablets of allopurinol were prepared by direct compression technique using croscarmellose sodium (Group A), so...

Lagerstroemia Speciosalinn is an important medicinal plant for its traditional uses against different types of diseases. Therefore, the present study was conducted to detect possible chemicals (phytoconstituents), prove ethno-medicinal value of the plant, and investigate gastrointestinal motility & anticonvulsant activities of crude methanolic extr...

Lagerstroemia Speciosalinn is an important medicinal plant for its traditional uses against different types of diseases. Therefore, the present study was conducted to detect possible chemicals (phytoconstituents), prove ethno-medicinal value of the plant, and investigate gastrointestinal motility & anticonvulsant activities of crude methanolic extr...

p>In the present work, several batches of indomethacin press coated tablets were prepared with drug and Avicel PH 102 utilizing the press coating technology. The core tablet was compression coated with minimal compression pressure. The compression coating mixture was formulated using various amount of lactose and xanthan gum which was used as the r...

Objectives: Preeclampsia is a hypertensive disorder of pregnancy which is one of the leading causes of maternal and perinatal mortality and pre-term delivery, especially in low and middle income countries. Selenium is an important constituent of selenoproteins that act as antioxidant and have several metabolic functions. The present study was cond...

This study was conducted to evaluate the rate of vaccination and its impacts on the children in four upazilas which were Noakhali sadar, Begumgonj, Companygonj and Chatkhil of Noakhali district. The study was carried out during the period of November 15, 2011 to December 15, 2011. Data were collected through questionnaire interviews, focus group di...

The present study was conducted to detect possible phytochemicals and evaluate antioxidant, antimicrobial, thrombolytic, anthelmintic and cytotoxic activities of the extract of Ardisia solanacea. Phytochemical screening was carried out using the standard test methods of different chemical group. For investigating the antioxidant activity, two compl...

The present study was conducted to detect possible chemicals (phytoconstituents), and investigate antioxidant, antimicrobial and thrombolytic activities of the extract of Aphanamixispolystachyastem bark.Phytochemical screening was carried out using the standard test methods of different chemical group. For investigating the antioxidant activity, tw...

The present study was conducted to detect possible chemicals (phytoconstituents), and investigate antioxidant, antimicrobial and thrombolytic activities of the extract of a medicinal herb, Polygonum viscosum (leaves). Phytochemical screening was carried out using the standard test methods of different chemical group. For investigating the antioxida...

Context: Thrombus formation inside the blood vessels obstructs blood flow through the circulatory system leading hypertension, stroke to the heart, anoxia, and so on. Thrombolytic drugs are widely used for the management of cerebral venous sinus thrombosis patients, but they have certain limitations. Medicinal plants and their components possessing...

The present study was designed and conducted to detect possible phytochemicals, and investigate antioxidant, antimicrobial, thrombolytic, cytotoxic and anthelmintic activity of the methanolic extract of Alocasia macrorrhizos and its different fractions. Phytochemical screening was carried out using the standard test methods of different chemical gr...

The current study aims at evaluating the analgesic, anti-pyretic and anti-inflammatory properties of methanolic extract of the stem, bark and leaves of Launaea sarmentosa and Aegialitis rotundifolia roxb. The AELS and AEAR extract presented a significant (***p < 0.001) dose dependent increase in reaction time in writhing method and showed inhibitio...

Background: The study was conducted to evaluate the in vitro antimicrobial activity, cytotoxic, and membrane stabilization activities, and in vivo antiemetic and antipyretic potentials of ethanolic extract, n-hexane and ethylacetate soluble fractions of Spilanthes paniculata leaves for the first time widely used in the traditional treatments in Ban...

ABSTRACT The present study was conducted to detect possible chemicals (phytoconstituents), and investigate antioxidant, antimicrobial and thrombolytic activities of the extract of Aphanamixispolystachyastem bark.Phytochemical screening was carried out using the standard test methods of different chemical group. For investigating the antioxidant act...

Purpose: Crinum latifolium is a widely used plant in Asian folk and traditional medicine.In the present study, we have tried to find out the anthelmintic activity, total phenolic contents and cytotoxicity of the methanolic extract of the target plant. Methods: Anthelmintic activity was assessed applying five different concentrations of the plant...

Purpose: The present study was explored to develop a sustained release matrix tablet of Indapamide, a low-dose thiazide-type diuretic, using hydroxylpropyl methylcellulose (Methocel K15MCR) in various proportions as release controlling factor. Methods: The tablets were formulated using direct compression method. The powers for tableting were eva...

The present study was designed to investigate in vitro anthelmintic and cytotoxic activities of crude methanolic extract of two plants(Polygonum viscosum and Aphanamixis polystachya) grown in Bangladesh. Evaluation of cytotoxic activity was done using the brine shrimp lethality bioassay. The crude methanolic extract of Polygonum viscosum showed sig...

Background: Hepatitis B virus surface antigen (HBsAg) is used for the detection of Hepatitis B virus (HBV) infection and to predict disease progression. Objectives: The main objective of this study was to observe the pattern of HBV viral load levels among people in terms of age and sex distribution in Bangladesh. Method: Blood specimen was collecte...

The study was designed to explore possible phytochemical characteristics (group determinant of plant extract) and to investigate the cytotoxic and anthelmintic potential in vitro, using the methan olic extract of bark of Dillenia indica growing in coastal region of Bangladesh. Phytochemical analysis of the crude extract revealed the presence of alk...

Objective: The present study was conducted to detect possible chemicals (phytoconstituents), prove ethno-medicinal value of the plant, and investigate antimicrobial, anthelmintic, and total phenolic content of crude methanolic extract of the Solanum violaceum plant. Materials and Methods: Phytochemical screening was carried out using different che...